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公开(公告)号：US11541240B2
公开(公告)日：2023-01-03
申请号：US16848580
申请日：2020-04-14
发明人： Elizabeth Mary Annoni , Jianwen Gu , Rosana Esteller , Bryan Allen Clark , Pramodsingh Hirasingh Thakur , Kyle Harish Srivastava
摘要： This document discusses, among other things, systems and methods for managing pain of a subject. A system includes one or more physiological sensors configured to sense a physiological signal indicative of patient brain activity. The physiological signals may include an electroencephalography signal, a magnetoencephalography signal, or a brain-evoked potential. The system may extract from the brain activity signal one or more signal metrics indicative of strength or pattern of brain electromagnetic activity associated with pain, and generate a pain score using the one or more signal metrics. The pain score can be output to a patient or a process. The system may select an electrode configuration for pain-relief electrostimulation based on the pain score, and deliver a closed-loop pain therapy according to the selected electrode configuration.
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62.发明申请公开(公告)号：US20220359060A1
公开(公告)日：2022-11-10
申请号：US17765259
申请日：2020-09-30
申请人： Jin Hyung LEE , Qin LIU , Onur Cezmi MUTLU , The Board of Trustees of the Leland Stanford Junior University
发明人： Jin Hyung Lee , Qin Liu , Onur Cezmi Mutlu
摘要： Methods, systems, and devices, including computer programs encoded on a computer storage medium are provided for combined dynamic causal modeling and biophysics modeling of brain function. In particular, the disclosed methods of modeling brain function can be used to integrate brain function measurements by two or more methods, such as functional neuroimaging and electrophysiology. Sequential model fitting is used to improve modeling accuracy to generate a more comprehensive model of brain neuronal circuitry.
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63.发明申请公开(公告)号：US20220313140A1
公开(公告)日：2022-10-06
申请号：US17708936
申请日：2022-03-30
申请人： EEG Harmonics, LLC
发明人： Cana Selen Atasoy
摘要： A system and method for determining a type of sensory feedback to be applied to a subject. The system and method can include acquiring brain data, estimating from the brain data a plurality of harmonic brain states, determining a feedback variable based on the plurality of harmonic brain states, mapping the feedback variable to one or more types of sensory feedback, and applying the sensory feedback to the subject with one or more types of sensory feedback devices.
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64.发明授权公开(公告)号：US11379039B2
公开(公告)日：2022-07-05
申请号：US16977751
申请日：2019-03-21
申请人： SOUTHEAST UNIVERSITY
发明人： Aiguo Song , Wenbin Zhang , Hong Zeng , Baoguo Xu
摘要： Brain-computer interface method and system include displaying and providing a motor imagery task to a subject, and collecting a generated digital electroencephalogram signal; reading the digital electroencephalogram signal, performing interception if a preset time period is exceeded, and performing continuous reading if not; performing band-pass filtering, obtaining time-frequency characteristics of the digital electroencephalogram signal, and extracting a frequency value with highest frequency energy as a main frequency; obtaining an instantaneous phase of the digital electroencephalogram signal; generating predicted sine waves by respectively using the main frequency and the instantaneous phase as a frequency and an initial phase of sine waves, and predicting and obtaining real-time phase information; and judging whether the real-time phase is in a vibration stimulation application phase interval, generating and outputting a control instruction, and controlling a vibration motor to vibrate and to stimulate a sensory channel of the subject according to the control instruction.
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公开(公告)号：US20220192579A1
公开(公告)日：2022-06-23
申请号：US17691491
申请日：2022-03-10
发明人： Nicholas Sinclair , Hugh McDermott , James Fallon , Thushara Perera , Arthur Wesley Thevathasan , Kristian Bulluss
摘要： A method for monitoring neural activity responsive to a stimulus in a brain includes applying a first stimulus to at least one electrode implanted in the brain. The first stimulus includes a first plurality of bursts of stimulation. The method also includes detecting high frequency oscillations (HFOs) between about 200 Hz and about 500 Hz due to neuronal activity at one or more of the at least one electrode implanted in the brain at least partially during application of the first stimulus, and determining one or more waveform characteristics of the HFOs. The method further includes generating a second stimulus comprising a second plurality of bursts of stimulation, wherein one or more waveform characteristics of the second stimulus is dependent on the one of more waveform characteristics of the HFOs, and applying the second stimulus to one or more of the at least one electrode implanted in the brain.
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公开(公告)号：US11344725B2
公开(公告)日：2022-05-31
申请号：US16380036
申请日：2019-04-10
申请人： CereGate GmbH
发明人： Bálint Várkuti
摘要： The present invention relates to a system for providing neuronal stimulation signals configured to elicit sensory percepts in the cortex of an individual, comprising means for obtaining spatial information relating to the actual or planned position of at least one neuronal stimulation means relative to at least one afferent axon targeting at least one sensory neuron in the cortex of the individual and means for determining at least one neuronal stimulation signal to be applied to at least one afferent axon via the at least one neuronal stimulation means based at least in part on the obtained spatial information.
The present invention further relates to a system for communicating conceptual information to an individual, comprising means for selecting at least one neuronal stimulation signal to be applied to at least one afferent axon targeting at least one sensory neuron in the cortex of the individual, wherein the at least one neuronal stimulation signal corresponds to the conceptual information to be communicated and means for transmitting the at least one neuronal stimulation signa to at least one neuronal stimulation means of the individual.-
公开(公告)号：US20220151537A1
公开(公告)日：2022-05-19
申请号：US17588373
申请日：2022-01-31
发明人： Omer NAOR , Adi BALAN , Hagai BERGMAN , Imad YOUNIS , Oren A. GARGIR , Zvi ISRAEL , Jubran ELFAR , Paul MCSHERRY , Steven SCOTT , Benjamin MATTER
摘要： A brain navigation device, comprising: a lead with an elongated lead body; at least one macro-electrode contact positioned on an outer surface on the lead; wherein the at least one macro-electrode contact is located at the distal part of said lead; and wherein the at least one macro-electrode contact is configured to be used during lead navigation.
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公开(公告)号：US11311725B2
公开(公告)日：2022-04-26
申请号：US14922022
申请日：2015-10-23
发明人： Jacob A. Levine , Michael A. Faltys
IPC分类号： A61N1/36 , A61N1/05 , A61N2/00 , A61N1/372 , A61N1/375 , A61B5/369 , A61N2/02 , A61B5/00 , A61N1/378 , A61B5/377
摘要： Described herein are methods and systems for using EEG recordings to improve vagus nerve stimulation (VNS) therapy. In particular, described herein are methods and systems for using EEG recordings to detect P300 and/or activation of the nucleus basalis and/or the locus coeruleus to determine the efficacy of VNS. The EEG recordings can be used to provide feedback control to help optimize stimulation parameters and to screen for patients that respond well to VNS therapy.
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公开(公告)号：US11298538B2
公开(公告)日：2022-04-12
申请号：US16454864
申请日：2019-06-27
摘要： A system may include at least one sensor configured to bilaterally sense neurophysiological signals from the patient to provide bilateral sensing data, and at least one processor configured to calibrate at least a first electrode contact and a second electrode contact on the least one neuromodulation lead, including: instruct the neuromodulation device to deliver neuromodulation energy using at least the first electrode contact to cause a first neurophysiological response and at least the second electrode contact to cause a second neurophysiological response; receive from the at least one sensor first bilateral sensed data corresponding to the first neurophysiological response and second bilateral sensed data corresponding to the second neurophysiological response; and determine based on the first and second neurophysiological responses at least one of: physiological midline information or electrode-tissue coupling information.
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公开(公告)号：US11298070B2
公开(公告)日：2022-04-12
申请号：US16616017
申请日：2018-05-21
发明人： Nicholas Sinclair , Hugh McDermott , James Fallon , Thushara Perera , Arthur Wesley Thevathasan , Kristian Bulluss
摘要： A method for monitoring neural activity responsive to a stimulus in a brain, the method comprising: a. applying a first stimulus to one or more of at least one electrode implanted in the brain, the first stimulus comprising a first plurality of bursts of stimulation, b. detecting high frequency oscillations (HFOs) between about 200 Hz and about 500 Hz due to neuronal activity at one or more of the at least one electrode implanted in the brain at least partially during application of the first stimulus; c. determining one or more waveform characteristics of the HFOs; and d. generating a second stimulus comprising a second plurality of bursts of stimulation, wherein one or more waveform characteristics of the second stimulus is dependent on the one of more waveform characteristics of the HFOs; and e. applying the second stimulus to one or more of the at least one electrode implanted in the brain.
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