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公开(公告)号：US20230042722A1
公开(公告)日：2023-02-09
申请号：US17950400
申请日：2022-09-22
发明人： ALEX K. WONG , YOUNG-KWON HONG
IPC分类号： A61K9/00 , A61K47/06 , A61K31/203
摘要： A method of treating post-surgical edema includes a step of administering an effective amount of a pharmaceutical composition to a subject identified a risk of post-surgical edema. The pharmaceutic composition include a retinoic acid component selected from the group consisting of 9-cis retinoic acid, geometric isomers of 9-cis retinoic acid, metabolites of 9-cis retinoic acid, substituted derivatives thereof, and combinations thereof. An implantable pellet including the retinoic acid component is also provided.
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公开(公告)号：US11571494B2
公开(公告)日：2023-02-07
申请号：US17123735
申请日：2020-12-16
发明人： Charles Zelen , David G. Armstrong , Paul Glat , Jarrod Kaufman , Marco Mehr , Lothar Schloesser , Mark Spilker
摘要： A method, material, and kit for promoting neutrophils and monocytes to localize at a chronic ulcer site, promoting formation of a multi-layered cell structure in the ulcer site, promoting conversion of monocytes to macrophages, promoting secretion of the patient's own growth factors, promoting tissue proliferation and cell migration, promoting production and cross-linking of collagen at the chronic ulcer site, promoting growth of endothelial cells, promoting angiogenesis that was stalled at the chronic ulcer site, promoting formation of a vascular network and granulation, promoting oxygenation of the chronic ulcer site, and reducing one or more of purulent drainage, erythema, pain, warming, tenderness, induration, and bleeding at the chronic ulcer site.
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63.发明申请公开(公告)号：US20220406416A1
公开(公告)日：2022-12-22
申请号：US17843341
申请日：2022-06-17
摘要： A method for selecting a material having a desired molecular property comprises generating a combinatorial library of molecule structures derived from a core molecular structure, splitting the library into a training set configured to train a graph neural network (GNN) machine learning (ML) model, a test set configured to test the validity of and assess accuracy of the GNN model, and a prediction set where predictions are made using the GNN model, optimizing geometries of the molecular structures, computing excited state energies of the optimized geometries, encoding molecular structure information into a matrix, determining three mutually orthogonal principal axes, transforming spatial coordinates into mutually orthogonal coordinates, constructing a molecular graph with n nodes, feeding the molecular graph into the GNN model as an input, and selecting a material having a suitable desired molecular property based on the output of the GNN model.
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公开(公告)号：US11532830B2
公开(公告)日：2022-12-20
申请号：US16785715
申请日：2020-02-10
发明人： Sri Narayan , Surya G. K. Prakash , Bo Yang , Lena Hoober-Burkhardt , Sankarganesh Krishnamoorthy
摘要： A flow battery includes a positive electrode, a positive electrode electrolyte, a negative electrode, a negative electrode electrolyte, and a polymer electrolyte membrane interposed between the positive electrode and the negative electrode. The positive electrode electrolyte includes water and a first redox couple. The first redox couple includes a first organic compound which includes a first moiety in conjugation with a second moiety. The first organic compound is reduced during discharge while during charging the reduction product of the first organic compound is oxidized to the first organic compound. The negative electrode electrolyte includes water and a second redox couple. The second couple includes a second organic compound including a first moiety in conjugation with a second moiety. The reduction product of the second organic compound is oxidized to the second organic compound during discharge.
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公开(公告)号：US11523939B2
公开(公告)日：2022-12-13
申请号：US16418899
申请日：2019-05-21
摘要： A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.
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公开(公告)号：US11517405B2
公开(公告)日：2022-12-06
申请号：US17500651
申请日：2021-10-13
发明人： Behrokh Khoshnevis , Hongsheng Tong , Yong Chen , Philong John Pham , Robert Lee
摘要： An orthodontic appliance may include an archwire and multiple orthodontic brackets. The archwire may fit within a human mouth and contain multiple male connectors. Each orthodontic bracket may have a configuration that facilitates attaching the orthodontic bracket to a single tooth. Each orthodontic bracket may allow one of the male connectors to be locked into the orthodontic bracket with a snapping action. The male connector may be unable to slide with respect to the orthodontic bracket after being locked in the orthodontic bracket. A manual unlocking action may allow the male connector to disengage from the orthodontic bracket.
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67.发明授权公开(公告)号：US11503292B2
公开(公告)日：2022-11-15
申请号：US16074372
申请日：2017-02-01
发明人： Hilmi E. Egilmez , Yung-Hsuan Chao , Antonio Ortega , Bumshik Lee , Sehoon Yea
IPC分类号： H04N19/12 , H04N19/159 , H04N19/176 , H04N19/61
摘要： The present invention provides a method for encoding a video signal on the basis of a graph-based separable transform (GBST), the method comprising the steps of: generating an incidence matrix representing a line graph; training a sample covariance matrix for rows and columns from the rows and columns of a residual signal; calculating a graph Laplacian matrix for rows and columns on the basis of the incidence matrix and the sample covariance matrix for rows and columns; and obtaining a GBST by performing eigen decomposition of the graph Laplacian matrix for rows and columns.
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公开(公告)号：US11495213B2
公开(公告)日：2022-11-08
申请号：US14802760
申请日：2015-07-17
发明人： Kartik Audhkhasi , Osonde Osoba , Bart Kosko
摘要： A learning computer system may estimate unknown parameters and states of a stochastic or uncertain system having a probability structure. The system may include a data processing system that may include a hardware processor that has a configuration that: receives data; generates random, chaotic, fuzzy, or other numerical perturbations of the data, one or more of the states, or the probability structure; estimates observed and hidden states of the stochastic or uncertain system using the data, the generated perturbations, previous states of the stochastic or uncertain system, or estimated states of the stochastic or uncertain system; and causes perturbations or independent noise to be injected into the data, the states, or the stochastic or uncertain system so as to speed up training or learning of the probability structure and of the system parameters or the states.
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公开(公告)号：US11484625B2
公开(公告)日：2022-11-01
申请号：US16762398
申请日：2018-11-08
发明人： Yang Chai , Yong Chen , Yuan Yuan , Yuxing Guo , Xiangjia Li , Zoe Johnson
摘要： This invention relates to a bone regeneration product comprising at least one stem cell, at least one scaffold, and at least one stem cell. The stem cells suitable for this invention may comprise stem cells suitable for a dense bone regeneration, stem cells suitable for a spongy bone regeneration, or a combination thereof. The bone regeneration product may further comprise a growth factor. This invention also relates to a bone regeneration method and treatment of any bone that has a critical size defect. This invention also relates to a scaffold. This invention further relates to a 3D printed scaffold comprising hydroxyapatite (HA) and tricalcium phosphate (TCP). This invention also relates to a scaffold comprising a polymer. The polymer of this invention may be prepared by using photocurable polymers and/or monomers. The scaffold of this invention may comprise a growth factor and a small molecule. The small molecule N may be a Smurf1 inhibitor.
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公开(公告)号：US11478272B2
公开(公告)日：2022-10-25
申请号：US16280956
申请日：2019-02-20
发明人： Mark S. Humayun
摘要： A surgical instrument, and methods for its use, is described that includes clamp heads that can be nestled within or extended from a tubular sheath by longitudinal movement of the clamp heads' tines with respect to the tubular sheath. One of the tines includes an arch that slides against a mouth and inside wall of the tubular sheath, causing the clamp heads to open or close. The clamp heads close lightly, to within a predetermined (or zero) distance from one another, gently grasp an ultrathin polymer substrate seeded with cells, and pulls it within the sheath such that the substrate curls and folds to protect the cells.
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