公开(公告)号：US20080291441A1

公开(公告)日：2008-11-27

申请号：US11571810

申请日：2005-07-08

申请人： David Klug ,  Paul Donaldson

发明人： David Klug ,  Paul Donaldson

IPC分类号： G01N21/01

CPC分类号： G01N21/35 ,  G01N21/01

摘要： A porous sample support provides a matrix into the pores or interstitial spaces of which a sample to be subjected to a spectroscopic analysis can be introduced. 2 D infrared spectroscopy can then be carried out on the sample at higher concentrations with minimized background.

摘要翻译： 多孔样品载体在孔或间隙空间中提供基质，可以引入待进行光谱分析的样品。 然后可以以最小的背景在较高浓度下对样品进行2 D红外光谱。

公开(公告)号：US20080288493A1

公开(公告)日：2008-11-20

申请号：US11886241

申请日：2006-03-16

申请人： Guang-Zhong Yang ,  Benny Ping Lai Lo ,  Surapa Thiemjarus

发明人： Guang-Zhong Yang ,  Benny Ping Lai Lo ,  Surapa Thiemjarus

IPC分类号： G06F17/30

CPC分类号： G06K9/00973 ,  G06K9/00335 ,  G06K9/6251

摘要： A method of classifying a data record as belonging to one of a plurality of classes, the data records comprising a plurality of data samples, each sample comprising a plurality of features derived from a value sampled from a sensor signal at a point in time, the method including: defining a selection variable indicative of the temporal variation of the sensor signals within a time window; defining a selection criterion for the selection variable; comparing a value of the selection variable to the selection criterion to select an input representation for a self organising map, the map having a plurality of input and output units, and deriving an input from the data samples within the time window in accordance with the selected input representation; and applying the input to a self organising map corresponding to the selected input representation and classifying the data record based on a winning output unit of the self organising map.

摘要翻译： 将数据记录分类为属于多个类中的一个的方法，所述数据记录包括多个数据样本，每个样本包括从在某个时间点的传感器信号采样的值导出的多个特征， 方法包括：在时间窗内定义指示传感器信号的时间变化的选择变量; 定义选择变量的选择标准; 将所述选择变量的值与所述选择标准进行比较，以选择用于自组织映射的输入表示，所述映射具有多个输入和输出单元，以及根据所选择的时间窗从所述时间窗口内的数据样本导出输入 输入表示; 以及将所述输入应用于与所选择的输入表示相对应的自组织图，并且基于所述自组织图的获胜输出单元对所述数据记录进行分类。

公开(公告)号：US07419908B2

公开(公告)日：2008-09-02

申请号：US11352517

申请日：2006-02-10

申请人： Mino Green

发明人： Mino Green

IPC分类号： H01L21/302 ,  H01L21/461

CPC分类号： H01L21/31144 ,  H01L21/0331 ,  H01L21/0332 ,  H01L21/0337 ,  H01L21/3081 ,  H01L21/3086

摘要： A method of fabricating electronic, optical or magnetic devices requiring an array of large numbers of small feature in which regions defining individual features of the array are foamed by the steps of: (a) depositing a very thin film of a highly soluble solid onto a flat hydrophilic substrate; (b) exposing he film to solvent vapor under controlled conditions so that the film reorganizes into an array of discrete hemispherical islands on the surface; (c) depositing a film of a suitable resist material over the whole surface; (d) removing the hemispherical structures together with their coating of resist leaving a resist layer with an array of holes corresponding to the islands; and (e) subjecting the resulting structure to a suitable etching process so as to form a well at the position of each hole. The wells which are formed by this process may be used to fabricate various types of devices, including arrays of semiconductor devices, and crystalline heterostructures in which the lattice constants of the component materials are different.

摘要翻译： 一种制造需要大量小特征的阵列的电子，光学或磁性器件的方法，其中限定阵列的各个特征的区域通过以下步骤发泡：（a）将非常薄的高溶解性固体沉积到 平面亲水基材; （b）在受控条件下将膜暴露于溶剂蒸气，使得膜重新组装成表面上的离散半球形岛阵列; （c）在整个表面上沉积合适的抗蚀剂材料的膜; （d）除去半球形结构及其抗蚀剂涂层，留下具有对应于岛的孔阵列的抗蚀剂层; 和（e）对所得到的结构进行适当的蚀刻工艺，以便在每个孔的位置处形成井。 通过该方法形成的阱可以用于制造各种类型的器件，包括半导体器件的阵列，以及其中元件材料的晶格常数不同的晶体异质结构。

公开(公告)号：US07387442B2

公开(公告)日：2008-06-17

申请号：US10509083

申请日：2003-03-24

申请人： Hugh Alexander Spikes

发明人： Hugh Alexander Spikes

IPC分类号： F16C32/06

CPC分类号： G11B5/6005 ,  F16C17/04 ,  F16C33/043 ,  F16C33/10 ,  F16C33/12 ,  F16C33/201 ,  F16C2370/12 ,  G11B5/40 ,  G11B19/2018 ,  G11B21/21

摘要： A bearing includes a contact region (2) filled with lubricant (8) between two otherwise rubbing surfaces (4, 6). One surface moves relative to a stationary other. The moving surface entrains the lubricant into the contact region to generate pressure within the lubricant enabling support of a load whilst the lubricant slips against the stationary surface.

摘要翻译： 轴承包括在两个否则摩擦表面（4,6）之间填充有润滑剂（8）的接触区域（2）。 一个表面相对于静止的其他表面移动。 运动表面将润滑剂带入接触区域，以在润滑剂内产生压力，从而能够在润滑剂抵靠固定表面滑动时支撑负载。

公开(公告)号：US20080138357A1

公开(公告)日：2008-06-12

申请号：US11722690

申请日：2005-12-23

申请人： Christoph Marcel Tang ,  Yanwen Li

发明人： Christoph Marcel Tang ,  Yanwen Li

IPC分类号： A61K39/095 ,  C07K14/00 ,  C12N15/11 ,  A61P37/00 ,  A61K31/70 ,  C12P21/04

CPC分类号： A61K39/095 ,  A61K38/00 ,  A61K2039/53 ,  C07K14/22

摘要： Various polypeptides, or a variant or fragment thereof or a fusion of these are described which are useful in a vaccine. The polypeptide may be a polypeptide comprising the amino acid sequence selected from any one of SEQ ID Nos (2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68); or a fragment or variant thereof or a fusion of such fragment or variant, and is useful in a vaccine against Neisseira meningitidis.

摘要翻译： 描述了可用于疫苗的各种多肽或其变体或片段或这些的融合物。 多肽可以是包含选自SEQ ID No（2， 32,34,36,38,40,42,44,46,48,50,52,54,56,58,60,62,64,66,68）; 或其片段或变体或这种片段或变体的融合物，并且可用于针对脑膜炎奈瑟氏球菌的疫苗。

公开(公告)号：US20080026985A1

公开(公告)日：2008-01-31

申请号：US11712311

申请日：2007-02-28

申请人： Lakjaya Buluwela ,  Simak Ali

发明人： Lakjaya Buluwela ,  Simak Ali

IPC分类号： A61K31/7088 ,  A61K38/00 ,  A61P43/00 ,  C12N1/00 ,  C12N1/21 ,  C12N15/09 ,  C12N5/04 ,  C12N5/06 ,  C12N5/10

CPC分类号： C07K14/4702 ,  A61K38/00 ,  A61K48/00

摘要： A method of suppressing the expression of a selected gene in a eukaryotic cell the method comprising introducing into the cell (a) a polypeptide comprising a DNA binding portion which binds to a site at or associated with the selected gene which site is present in a plant or animal genome and a chromatin inactivation portion, or (b) a polynucleotide encoding said polypeptide.

摘要翻译： 一种抑制真核细胞中所选择的基因表达的方法，该方法包括向细胞（a）中引入多肽，所述多肽包含与所选择的基因存在于植物中的位点结合的位点或与其结合的DNA结合部分 或动物基因组和染色质失活部分，或（b）编码所述多肽的多核苷酸。

公开(公告)号：US20070191496A1

公开(公告)日：2007-08-16

申请号：US10581773

申请日：2004-12-06

申请人： Hans Stauss ,  Liquan Gao ,  Shao-An Xue

发明人： Hans Stauss ,  Liquan Gao ,  Shao-An Xue

IPC分类号： C11D3/48

CPC分类号： C07K14/7051 ,  A61K35/17 ,  C12N5/0636 ,  C12N7/00 ,  C12N15/86 ,  C12N2740/10043

摘要： A T cell receptor molecule (TCR) containing an alpha chain portion and a beta chain portion wherein the alpha chain portion contains three complementarity determining regions (CDRs): CDR1α: SSYSPS CDR2α: YTSAATL CDR3α: VVSPF-SGGGADGLT or comprising or consisting of SPFSGGGADGLT and the beta chain portion contains three complementarity determining regions (CDRs): CDR1β: DFQATT CDR2β: SNEGSKA CDR3β: comprising SARDGGEG or comprising or consisting of RDGGEGSETQY, or wherein up to three amino acid residues in one or more CDRs are replaced by another amino acid residue. The invention also includes polynucleotides encoding the TCR molecules, and host cells containing the said polynucleotides. Patient derived T cells may have the polynucleotides encoding the TCR molecules introduced therein, and the engineered T cells may be introduced into the patient in order to combat a WT1-expressing malignancy.

摘要翻译： 含有α链部分和β链部分的AT细胞受体分子（TCR），其中α链部分含有三个互补决定区（CDR）：CDR1alpha：SSYSPS CDR2alpha：YTSAATL CDR3alpha：VVSPF-SGGGADGLT或包含或由SPFSGGGADGLT组成， β链部分包含三个互补决定区（CDR）：CDR1beta：DFQATT CDR2beta：SNEGSKA CDR3beta：包含SARDGGEG或包含或由RDGGEGSETQY组成，或其中一个或多个CDR中的多达三个氨基酸残基被另一个氨基酸残基替代。 本发明还包括编码TCR分子的多核苷酸和含有所述多核苷酸的宿主细胞。 患者衍生的T细胞可以具有编码其中引入的TCR分子的多核苷酸，并且可以将经工程化的T细胞引入患者体内，以抵抗表达WT1的恶性肿瘤。

公开(公告)号：US20070134763A1

公开(公告)日：2007-06-14

申请号：US11517763

申请日：2006-09-08

申请人： Donna Davies ,  Peter Wark ,  Stephen Holgate ,  Sebastian Johnston

发明人： Donna Davies ,  Peter Wark ,  Stephen Holgate ,  Sebastian Johnston

IPC分类号： C12Q1/68 ,  C12P21/06

CPC分类号： A61K38/21 ,  A61K31/56 ,  A61K31/7088 ,  A61K38/215 ,  A61K45/06 ,  A61M16/14 ,  A61K2300/00

摘要： The present invention provides the use of IFN-β, an agent that increases the expression of IFN-β, or a polynucleotide which is capable of expressing IFN-β or said agent for the manufacture of a medicament for the treatment of rhinovirus-induced exacerbation of a respiratory disease selected from asthma and chronic obstructive pulmonary disease, wherein said treatment is by airway delivery of said medicament, e.g. by use of an aerosol nebuliser. Also provided is IFN-λ for the same purpose.

摘要翻译： 本发明提供IFN-β的用途，IFN-β增加IFN-β的表达，或能够表达IFN-β的多核苷酸或用于制备用于治疗鼻病毒诱导的恶化的药物 选自哮喘和慢性阻塞性肺疾病的呼吸系统疾病，其中所述治疗是通过气道递送所述药物，例如， 通过使用气溶胶雾化器。 还提供了用于相同目的的IFN-λ。

公开(公告)号：US07214266B2

公开(公告)日：2007-05-08

申请号：US10680390

申请日：2003-10-02

申请人： Naomi E. Chayen

发明人： Naomi E. Chayen

IPC分类号： C30B1/06

CPC分类号： C07K14/43 ,  C07K14/42 ,  C07K2299/00 ,  C30B7/00 ,  C30B29/58

摘要： The present invention provides an automated method of optimising crystallisation conditions for macromolecules comprising forming a trial comprising a sample comprising a gel forming component and the macromelecule to be crystallized, wherein at least one component of the trial is dispensed using an automatic liquid dispensing system.

摘要翻译： 本发明提供了一种优化大分子的结晶条件的自动化方法，其包括形成包含凝胶形成组分和待结晶的大分子的样品的试验，其中使用自动液体分配系统分发试验的至少一种组分。

公开(公告)号：US11224349B2

公开(公告)日：2022-01-18

申请号：US14335680

申请日：2014-07-18

申请人： VOLCANO CORPORATION ,  IMPERIAL INNOVATIONS LIMITED

发明人： Justin Davies ,  Joseph Burnett

IPC分类号： A61B5/0215 ,  A61B5/02 ,  A61B5/107 ,  A61B5/00

摘要： Embodiments of the present disclosure are configured to assess the severity of a blockage in a vessel and, in particular, a stenosis in a blood vessel. In some particular embodiments, the devices, systems, and methods of the present disclosure are configured to assess the severity of a stenosis in the coronary arteries without the administration of a hyperemic agent. In some embodiments, the devices, systems, and methods of the present disclosure are configured to assess a vessel by automatically correcting for drift in the equipment utilized to obtain measurements related to the vessel.