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公开(公告)号：US20170372883A1
公开(公告)日：2017-12-28
申请号：US15697333
申请日：2017-09-06
申请人： LECO Corporation
CPC分类号： H01J49/282 , H01J49/0031 , H01J49/0036 , H01J49/062 , H01J49/40 , H01J49/401 , H01J49/406 , H01J49/4245
摘要： An apparatus 41 and operation method are provided for an electrostatic trap mass spectrometer with measuring frequency of multiple isochronous ionic oscillations. For improving throughput and space charge capacity, the trap is substantially extended in one Z-direction forming a reproduced two-dimensional field. Multiple geometries are provided for trap Z-extension. The throughput of the analysis is improved by multiplexing electrostatic traps. The frequency analysis is accelerated by the shortening of ion packets and either by Wavelet-fit analysis of the image current signal or by using a time-of-flight detector for sampling a small portion of ions per oscillation. Multiple pulsed converters are suggested for optimal ion injection into electrostatic traps.
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公开(公告)号：US09768008B2
公开(公告)日：2017-09-19
申请号：US14798206
申请日：2015-07-13
申请人： LECO Corporation
CPC分类号： H01J49/282 , H01J49/0031 , H01J49/0036 , H01J49/062 , H01J49/40 , H01J49/401 , H01J49/406 , H01J49/4245
摘要： An ion trap mass spectrometer including an ion trap analyzer, an ion packet injector, and an ion detector is disclosed, along with a method of mass spectrometry. The ion packet injector injects packets of ions into a field of the ion trap analyzer. The ion packets move along isochronous oscillations according to their mass-to-charge ration. The ion detector may be implemented as a novel image current detector, a novel time-of-flight detector, or a combination of the two. The novel image current detector may comprise segments along an X-axis or a Z-axis of the mass spectrometer. The novel time-of-flight detector may sample a portion of ions of the ion packet per each isochronous oscillation.
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公开(公告)号：US09673036B2
公开(公告)日：2017-06-06
申请号：US15087534
申请日：2016-03-31
申请人： LECO Corporation
CPC分类号： H01J49/406 , H01J49/0036 , H01J49/06 , H01J49/282 , H01J49/40 , H01J49/401 , H01J49/4245 , H01J49/48
摘要： An open electrostatic trap mass spectrometer is disclosed for operation with wide and diverging ion packets. Signal on detector is composed of signals corresponding to multiplicity of ion cycles, called multiplets. Using reproducible distribution of relative intensity within multiplets, the signal can be unscrambled for relatively sparse spectra, such as spectra past fragmentation cell of tandem mass spectrometer, past ion mobility and differential ion mobility separators. Various embodiments are provided for particular pulsed ion sources and pulsed converters such as orthogonal accelerators, ion guides, and ion traps. The method and apparatus enhance the duty cycle of pulsed converters, improve space charge tolerance of the open trap analyzer and extends the dynamic range of time-of-flight detectors.
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公开(公告)号：US09595431B2
公开(公告)日：2017-03-14
申请号：US14790716
申请日：2015-07-02
申请人： LECO Corporation
CPC分类号： H01J49/282 , H01J49/0031 , H01J49/0036 , H01J49/062 , H01J49/40 , H01J49/401 , H01J49/406 , H01J49/4245
摘要： An electrostatic analyzer including at least one first set of electrodes, at least one second set of electrodes, and a field free space separating the two sets of electrodes is disclosed. The two sets of electrodes form two-dimensional electrostatic fields of ion mirrors and are arranged to provide isochronous ion oscillations in an x-y plane. Both sets of electrodes are curves at a constant curvature radius R along a third locally orthogonal Z-direction to form a torroidal field region. A related method is also disclosed.
摘要翻译： 公开了一种静电分析仪，其包括至少一个第一组电极，至少一组第二组电极和分离两组电极的场自由空间。 两组电极形成离子反射镜的二维静电场，并被设置成在x-y平面上提供等时离子振荡。 两组电极是沿着第三局部正交Z方向的恒定曲率半径R处的曲线，以形成环形场区域。 还公开了相关方法。
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65.发明申请Multi-Reflecting Time-of-Flight Mass Spectrometer with Axial Pulsed Converter 有权具有轴向脉冲转换器的多反射飞行时间质谱仪公开(公告)号：US20170032952A1
公开(公告)日：2017-02-02
申请号：US15300998
申请日：2015-03-31
申请人： LECO Corporation
CPC分类号： H01J49/403 , G01N30/72 , H01J49/0031 , H01J49/406 , H01J49/44
摘要： Apparatuses (41, 91, 111, 115, 121, 151) and methods (31) for time-of-flight mass spectrometry providing effective pulsed conversion of continuous ion beams into pulsed ion packets is disclosed. Bunching of energetic continuous ion beams forms ion packets, which are filtered by a subsequent isochronous energy filter (49, 79, 81-84, 110). The bunching method is particularly suitable for ion sources with relatively large spatial emittance, otherwise unable to fir the acceptance of orthogonal accelerators. The method is particularly suitable for multi-reflecting TOF MS, which accommodates small size ion packets and where the duty cycle advantage of orthogonal accelerators is minor.
摘要翻译： 公开了用于飞行时间质谱的装置（41,91,111,115,121,151）和方法（31），其提供连续离子束到脉冲离子包的有效脉冲转换。 能量连续离子束的聚束形成离子包，其被随后的等时能量过滤器（49,79,81-84,110）过滤。 聚束法特别适用于具有较大空间发射度的离子源，否则不能使正交加速器的接受性降低。 该方法特别适用于容纳小尺寸离子包的多反射TOF MS，其中正交加速器的占空比优点较小。
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公开(公告)号：US09406493B2
公开(公告)日：2016-08-02
申请号：US14506270
申请日：2014-10-03
申请人： LECO Corporation
CPC分类号： H01J49/401 , H01J49/0031 , H01J49/0036 , H01J49/22 , H01J49/40 , H01J49/406
摘要： A method, apparatus and algorithms are disclosed for operating an open electrostatic trap (E-trap) or a multi-pass TOF mass spectrometer with an extended flight path. A string of start pulses with non equal time intervals is employed for triggering ion packet injection into the analyzer, a long spectrum is acquired to accept ions from the entire string and a true spectrum is reconstructed by eliminating or accounting overlapping signals at the data analysis stage while using logical analysis of peak groups. The method is particularly useful for tandem mass spectrometry wherein spectra are sparse. The method improves the duty cycle, the dynamic range and the space charge throughput of the analyzer and of the detector, so as the response time of the E-trap analyzer. It allows flight extension without degrading E-trap sensitivity.
摘要翻译： 公开了用于操作具有扩展飞行路径的开放静电捕集器（E-trap）或多遍TOF质谱仪的方法，装置和算法。 采用一串具有不等时间间隔的起始脉冲来触发分析仪中的离子包注入，获取长谱以接收整个串中的离子，并通过在数据分析阶段消除或计算重叠信号来重建真实的光谱 同时使用峰值组的逻辑分析。 该方法对于其中光谱稀疏的串联质谱特别有用。 该方法提高了分析仪和检测器的占空比，动态范围和空间电荷吞吐量，以及E-trap分析仪的响应时间。 它允许飞行延长，而不会降低E-trap灵敏度。
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公开(公告)号：US09343284B2
公开(公告)日：2016-05-17
申请号：US14795453
申请日：2015-07-09
申请人： LECO Corporation
CPC分类号： H01J49/282 , H01J49/0031 , H01J49/0036 , H01J49/062 , H01J49/40 , H01J49/401 , H01J49/406 , H01J49/4245
摘要： An electrostatic mass spectrometer and a method of mass spectrometric analysis utilizing novel traps are disclosed. The mass spectrometer includes an ion source, an ion pulse injector, an ion detector, a set of analyzer electrodes connected to a set of power supplies, and a vacuum chamber enclosing the set of analyzer electrodes. The analyzer electrodes have multiple sets of elongated slits forming an array of elongated volumes. Each elongated volume is formed by a single set of slits aligned between the electrodes, and each volume forms a two-dimensional electrostatic field in an X-Y plane and is extended in a locally orthogonal Z-direction. Each two-dimensional field is arranged to trap moving ions in the X-Y plane and to enable isochronous ion motion along a mean ion trajectory within the X-Y plane.
摘要翻译： 公开了静电质谱仪和利用新型捕集阱的质谱分析方法。 质谱仪包括离子源，离子脉冲注入器，离子检测器，连接到一组电源的一组分析器电极，以及包围该组分析器电极的真空室。 分析器电极具有形成细长体积阵列的多组细长狭缝。 每个细长体积由在电极之间排列的单组狭缝形成，并且每个体积在X-Y平面中形成二维静电场，并在局部正交的Z方向上延伸。 每个二维场布置成捕获X-Y平面中的移动离子，并使得能够沿着X-Y平面内的平均离子轨迹进行同步离子运动。
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公开(公告)号：US09299551B2
公开(公告)日：2016-03-29
申请号：US14751809
申请日：2015-06-26
申请人： LECO Corporation
CPC分类号： H01J49/107 , H01J27/022 , H01J49/10 , H01J49/145 , H01J49/24
摘要： An ion detection system including an ion source and at least one ion detector is disclosed. The ion source includes a source housing, a reactor, first and second ionizers and a sampling channel. The first ionizer is a glow discharge ionizer. The ion detector communicates with the sampling channel. A conditioner, which is sized to remove fast diffusing electrons, connects the first glow discharge ionizer to the reactor. A corresponding method of ionization is also disclosed. The method includes ionizing and conditioning an ionizer gas, receiving the ionizer gas and analyte molecule ions into a reactor, and delivering a flow from the reactor. The conditioning of the ionizer gas removes fast diffusing electrons from the gas flow.
摘要翻译： 公开了一种包括离子源和至少一个离子检测器的离子检测系统。 离子源包括源壳体，反应器，第一和第二离子发生器以及采样通道。 第一台电离器是辉光放电电离器。 离子检测器与采样通道通信。 尺寸适于去除快速扩散电子的调理器将第一辉光放电电离器连接到反应器。 还公开了相应的电离方法。 该方法包括电离和调节电离器气体，将离子发生器气体和分析物分子离子接收到反应器中，并从反应器输送流。 电离器气体的调节从气流中去除快速扩散的电子。
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公开(公告)号：US20160013040A1
公开(公告)日：2016-01-14
申请号：US14798206
申请日：2015-07-13
申请人： LECO Corporation
CPC分类号： H01J49/282 , H01J49/0031 , H01J49/0036 , H01J49/062 , H01J49/40 , H01J49/401 , H01J49/406 , H01J49/4245
摘要： An ion trap mass spectrometer including an ion trap analyzer, an ion packet injector, and an ion detector is disclosed, along with a method of mass spectrometry. The ion packet injector injects packets of ions into a field of the ion trap analyzer. The ion packets move along isochronous oscillations according to their mass-to-charge ration. The ion detector may be implemented as a novel image current detector, a novel time-of-flight detector, or a combination of the two. The novel image current detector may comprise segments along an X-axis or a Z-axis of the mass spectrometer. The novel time-of-flight detector may sample a portion of ions of the ion packet per each isochronous oscillation.
摘要翻译： 公开了一种包括离子阱分析仪，离子分组注射器和离子检测器的离子阱质谱仪，以及质谱法。 离子包注射器将离子束注入离子阱分析仪的场中。 离子包根据其质量 - 电荷比例沿同步振荡移动。 离子检测器可以实现为新颖的图像电流检测器，新颖的飞行时间检测器或两者的组合。 新颖的图像电流检测器可以包括沿着质谱仪的X轴或Z轴的段。 新颖的飞行时间检测器可以对每个等时振荡的离子包的一部分离子进行采样。
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公开(公告)号：US20150380233A1
公开(公告)日：2015-12-31
申请号：US14798185
申请日：2015-07-13
申请人： LECO Corporation
CPC分类号： H01J49/282 , H01J49/0031 , H01J49/0036 , H01J49/062 , H01J49/40 , H01J49/401 , H01J49/406 , H01J49/4245
摘要： A novel MS-MS apparatus utilizing electrostatic traps is disclosed, along with an associated method of analysis. The apparatus may include a chromatograph, an ion source, a first mass spectrometer, a fragmentation cell, an ion guide, a pulsed converter, and a Z-directional elongated electrostatic trap. The electrostatic trap, which may be Z-elongated into a cylindrical electrostatic trap, includes at least one of an image current detector and a time-of-flight detector. The pulsed converter is Z-directionally elongated to match the electrostatic trap. Ion selection from electrostatic traps may be accomplished with an electrode that ejects ion from an oscillation space to a time-of-flight detector, a fragmentation surface, or a passage between E-trap regions.
摘要翻译： 公开了一种利用静电捕集器的新型MS-MS装置，以及相关的分析方法。 该装置可以包括色谱仪，离子源，第一质谱仪，碎裂单元，离子导向器，脉冲转换器和Z方向细长的静电阱。 可以将Z伸长成圆柱形静电捕获器的静电捕获器包括图像电流检测器和飞行时间检测器中的至少一个。 脉冲转换器是Z方向拉长以匹配静电阱。 来自静电捕集器的离子选择可以通过将离子从振荡空间喷射到飞行时间检测器，碎裂表面或E阱区域之间的通道来实现。
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