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![CYCLOALKANE[B]AZAINDOLE ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS](/abs-image/US/2011/12/08/US20110301168A1/abs.jpg.150x150.jpg)
61.发明申请公开(公告)号：US20110301168A1
公开(公告)日：2011-12-08
申请号：US13127219
申请日：2009-11-05
IPC分类号： A61K31/4985 , C07D487/04 , A61K31/437 , A61K31/519 , A61P29/00 , A61P37/08 , A61P11/06 , A61P11/00 , A61P9/12 , A61P19/02 , A61P17/06 , A61P9/10 , A61P9/00 , A61P35/00 , A61P43/00 , A61P1/00 , A61P11/02 , A61P11/12 , A61P11/14 , A61P11/08 , A61P7/10 , C07D471/04
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4427
摘要： Described herein are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是PGD 2受体的拮抗剂。 还描述了包括本文所述化合物的药物组合物和药物，以及使用PGD2受体单独和与其它化合物组合的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症的方法 或疾病。
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![CYCLOALKANE[B]INDOLE ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS](/abs-image/US/2011/06/23/US20110152338A1/abs.jpg.150x150.jpg)
62.发明申请CYCLOALKANE[B]INDOLE ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS 失效CYCLOALKANE [B]包含PROSTAGLANDIN D2受体的拮抗剂公开(公告)号：US20110152338A1
公开(公告)日：2011-06-23
申请号：US12999133
申请日：2009-06-23
IPC分类号： A61K31/403 , C07D209/80 , A61P11/06 , A61P11/00 , A61P37/08 , A61P19/02 , A61P17/06 , A61P1/00
CPC分类号： C07D209/88 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0043 , A61K9/0048 , A61K9/0056 , A61K9/006 , A61K9/0078 , A61K9/06 , A61K9/4866
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括作为PGD 2受体的拮抗剂的本文所述的化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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![CYCLOALKANE[B]AZAINDOLE ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS](/abs-image/US/2010/05/06/US20100113503A1/abs.jpg.150x150.jpg)
63.发明申请公开(公告)号：US20100113503A1
公开(公告)日：2010-05-06
申请号：US12613424
申请日：2009-11-05
IPC分类号： A61K31/437 , C07D471/04 , A61P11/00 , A61P37/08 , A61P29/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4427
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物，以及将PGD2受体单独或与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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64.发明申请NOVEL BENZODIAZEPINONES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR FUNCTIONS AND NEUROLOGICAL USES THEREOF 有权新戊酰胆碱作为代谢谷氨酸受体功能的调节剂及其神经用途公开(公告)号：US20150025064A1
公开(公告)日：2015-01-22
申请号：US14342339
申请日：2012-08-29
IPC分类号： C07D403/04 , A61K45/06 , C07D417/04 , A61K31/551 , C07D243/12
CPC分类号： C07D403/04 , A61K31/551 , A61K45/06 , C07D243/12 , C07D243/14 , C07D409/14 , C07D417/04
摘要： The present invention relates to novel benzodiazepinone compounds of Formulae (I) wherein R1, R2, R4, R6, R7, R8, R9, and R10 are as defined herein. The invention also relates to pharmaceutical compositions containing such compounds, methods of use of such compounds and compositions, and methods for preparing the compounds and compositions. The compounds are Group II metabotropic glutamate antagonists or allosteric modulators and are useful for the treatment of a variety of CNS disorders.
摘要翻译： 本发明涉及式（I）的新的苯并二氮杂酮化合物，其中R 1，R 2，R 4，R 6，R 7，R 8，R 9和R 10如本文所定义。 本发明还涉及含有这些化合物的药物组合物，这种化合物和组合物的使用方法，以及制备化合物和组合物的方法。 化合物是II族代谢型谷氨酸拮抗剂或变构调节剂，可用于治疗各种CNS疾病。
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![Cycloalkane[B]indole antagonists of prostaglandin D2 receptors](/abs-image/US/2013/08/06/US08501959B2/abs.jpg.150x150.jpg)
公开(公告)号：US08501959B2
公开(公告)日：2013-08-06
申请号：US12999133
申请日：2009-06-23
IPC分类号： C07D209/94 , A61K31/40
CPC分类号： C07D209/88 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0043 , A61K9/0048 , A61K9/0056 , A61K9/006 , A61K9/0078 , A61K9/06 , A61K9/4866
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括作为PGD 2受体的拮抗剂的本文所述的化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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66.发明申请公开(公告)号：US20120232031A1
公开(公告)日：2012-09-13
申请号：US13502488
申请日：2010-10-19
IPC分类号： A61K31/404 , A61K31/4709 , A61K31/47 , A61K31/506 , A61K31/444 , A61K31/381 , A61K31/4245 , A61K31/4178 , A61K31/662 , A61K31/222 , A61K31/4745 , A61K31/196 , A61K31/265 , A61K31/4045 , A61K31/427 , A61K31/726 , A61K31/7008 , A61P19/02 , A61P29/00 , A61P31/04 , A61P31/10 , A61P37/08 , A61P31/12 , A61P9/00 , A61P35/00 , A61P23/00 , A61K31/405
CPC分类号： A61K31/00 , A61K9/0019 , A61K31/40 , A61K31/404 , A61K31/44 , A61K31/4709 , A61K45/06 , A61K47/34 , A61K47/36 , A61K2300/00
摘要： Described herein are injectable formulations for intra-articular or peri-articular administration, wherein the formulation is administered to treat joint pain. An injectable formulation for intra-articular or peri-articular administration disclosed herein comprises a therapeutically-effective amount of a leukotriene synthesis inhibitor compound formulated for intra-articular or peri-articular administration.
摘要翻译： 本文描述了用于关节内或关节周围给药的可注射制剂，其中施用该制剂以治疗关节疼痛。 本文公开的关节内或周围关节内给药的可注射制剂包含治疗有效量的配制用于关节内或关节周围给药的白细胞三烯合成抑制剂化合物。
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67.发明申请TOPICAL FORMULATIONS OF FLAP INHIBITORS FOR THE TREATMENT OF DERMATOLOGICAL CONDITIONS 审中-公开用于治疗皮肤病症的瓣膜抑制剂的局限性制剂公开(公告)号：US20110311613A1
公开(公告)日：2011-12-22
申请号：US13141665
申请日：2009-12-21
IPC分类号： A61K9/127 , A61K31/444 , A61K31/4709 , A61K31/405 , A61K31/47 , A61K31/56 , A61K38/13 , A61P17/00 , A61P35/00 , A61P37/00 , A61P37/08 , A61P17/06 , A61P17/04 , A61P17/02 , A61P17/10 , A61K31/506 , B82Y5/00
CPC分类号： A61K31/00 , A61K9/0014 , A61K31/497 , A61K31/506 , A61K31/51 , A61L15/44 , A61L26/0066 , A61L2300/432
摘要： Described herein, are topical formulations for treating a dermatological disease, disorder, or condition. Topical formulations disclosed herein include a therapeutically-effective amount of a FLAP inhibitor formulated for dermal administration
摘要翻译： 本文描述的是用于治疗皮肤病，病症或病症的局部制剂。 本文公开的局部制剂包括治疗有效量的配制用于皮肤给药的FLAP抑制剂
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公开(公告)号：US20110112134A1
公开(公告)日：2011-05-12
申请号：US12991747
申请日：2009-01-15
IPC分类号： A61K31/4375 , C07D471/14 , A61P11/00 , A61P29/00 , A61P37/08 , A61P11/06 , A61P9/12 , A61P19/02 , A61P17/06 , A61P9/10 , A61P35/00 , A61P11/14 , A61P7/10
CPC分类号： C07D471/14
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括作为PGD 2受体的拮抗剂的本文所述的化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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69.发明授权Benzodiazepinones as modulators of metabotropic glutamate receptor functions and neurological uses thereof 有权苯二氮卓酮作为代谢型谷氨酸受体功能的调节剂及其神经用途公开(公告)号：US09193710B2
公开(公告)日：2015-11-24
申请号：US14342339
申请日：2012-08-29
IPC分类号： C07D403/04 , C07D409/14 , C07D243/14 , A61K31/551 , A61K45/06 , C07D243/12 , C07D417/04
CPC分类号： C07D403/04 , A61K31/551 , A61K45/06 , C07D243/12 , C07D243/14 , C07D409/14 , C07D417/04
摘要： The present invention relates to novel benzodiazepinone compounds of Formulae (I) wherein R1, R2, R4, R6, R7, R8, R9, and R10 are as defined herein. The invention also relates to pharmaceutical compositions containing such compounds, methods of use of such compounds and compositions, and methods for preparing the compounds and compositions. The compounds are Group II metabotropic glutamate antagonists or allosteric modulators and are useful for the treatment of a variety of CNS disorders.
摘要翻译： 本发明涉及式（I）的新的苯并二氮杂酮化合物，其中R 1，R 2，R 4，R 6，R 7，R 8，R 9和R 10如本文所定义。 本发明还涉及含有这些化合物的药物组合物，这种化合物和组合物的使用方法，以及制备化合物和组合物的方法。 化合物是II族代谢型谷氨酸拮抗剂或变构调节剂，可用于治疗各种CNS疾病。
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公开(公告)号：US08168678B2
公开(公告)日：2012-05-01
申请号：US12362439
申请日：2009-01-29
IPC分类号： A01N37/12
CPC分类号： A61K31/5375 , A61K31/17 , A61K31/192 , A61K31/27 , A61K31/277 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4196 , A61K31/421 , A61K31/4412 , A61K31/47 , A61K31/513 , A61K45/06 , C07C233/47 , C07C233/54 , C07C233/63 , C07C271/22 , C07C271/24 , C07C271/28 , C07C271/34 , C07C275/24 , C07C275/26 , C07C311/08 , C07C317/50 , C07C323/63 , C07C2601/02 , C07C2601/04 , C07C2601/08 , Y10S514/826
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
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