公开(公告)号：US06693113B2

公开(公告)日：2004-02-17

申请号：US10185387

申请日：2002-06-27

Applicant: Kyle J. Lindstrom

Inventor： Kyle J. Lindstrom

IPC: A61K314375

CPC classification number: C07D471/04 ,  A61K31/4745 ,  A61K45/06 ,  C07D471/14 ,  A61K2300/00

Abstract: The imidazonaphthyridine compound, 2-methyl-1-(2-methylpropyl)-1H-imidazo[4,5-c][1,5]naphthyridin-4-amine, induces the biosynthesis of cytokines such as interferon and tumor necrosis factor. The compound exhibits antiviral and antitumor properties. Methods of preparing the compound and intermediates useful in the preparation of the compound are also disclosed.

Abstract translation: 咪唑并吡啶化合物2-甲基-1-（2-甲基丙基）-1H-咪唑并[4,5-c] [1,5]萘啶-4-胺诱导细胞因子如干扰素和肿瘤坏死因子的生物合成。 该化合物显示抗病毒和抗肿瘤性质。 还公开了制备化合物的方法和可用于制备化合物的中间体。

公开(公告)号：US06525064B1

公开(公告)日：2003-02-25

申请号：US10165002

申请日：2002-06-07

Applicant: Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

Inventor： Joseph F. Dellaria ,  Chad A. Haraldson ,  Philip D. Heppner ,  Kyle J. Lindstrom ,  Bryon A. Merrill

IPC: A61K31437

CPC classification number: C07D471/04

Abstract: Imidazopyridine compounds that contain sulfonamide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

Abstract translation: 在1位含有磺酰胺官能团的咪唑并吡啶化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。

公开(公告)号：US06451810B1

公开(公告)日：2002-09-17

申请号：US09589580

申请日：2000-06-07

Applicant: Patrick L. Coleman ,  Stephen L. Crooks ,  Kyle J. Lindstrom ,  Bryon A. Merrill ,  Michael J. Rice

Inventor： Patrick L. Coleman ,  Stephen L. Crooks ,  Kyle J. Lindstrom ,  Bryon A. Merrill ,  Michael J. Rice

IPC: A01N4342

CPC classification number: C07D471/04 ,  A61K31/4745

Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

Abstract translation: 在1位含有酰胺官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。

公开(公告)号：US5395937A

公开(公告)日：1995-03-07

申请号：US11405

申请日：1993-01-29

Applicant: Nick Nikolaides ,  Kyle J. Lindstrom

Inventor： Nick Nikolaides ,  Kyle J. Lindstrom

IPC: C07D215/22 ,  C07D215/42 ,  C07D471/04 ,  C07D215/20 ,  C07D215/36 ,  C07D215/38

CPC classification number: C07D215/22 ,  C07D215/42 ,  C07D471/04

Abstract: A process that involves reacting a 3-nitroquinoline-2,4-disulfonate with an amine or a substituted amine to selectively aminate at the 4-position to yield 1H-imidazo[4,5-c]quinolin-4-amines is disclosed.

Abstract translation: 公开了涉及使3-硝基喹啉-2,4-二磺酸酯与胺或取代的胺反应以在4-位上选择性胺化以得到1H-咪唑并[4,5-c]喹啉-4-胺的方法。

公开(公告)号：US09880322B2

公开(公告)日：2018-01-30

申请号：US13985058

申请日：2012-04-25

Applicant: Bryan V. Hunt ,  Kyle J. Lindstrom ,  Maureen C. Nelson

Inventor： Bryan V. Hunt ,  Kyle J. Lindstrom ,  Maureen C. Nelson

IPC: G02B1/04 ,  C08F220/18 ,  C08J7/16 ,  C09D133/06

CPC classification number: G02B1/04 ,  C08F220/18 ,  C08J7/16 ,  C09D133/06

Abstract: Presently described are optical films comprising a polymerized (e.g. microstructured) surface that comprises the reaction product of a polymerizable resin composition and polymerizable resin compositions that comprise nanoparticles; at least one first monomer comprising at least two (meth)acrylate groups; and at least one second (meth)acrylate monomer having following the structure (I); wherein at least one R1 comprises an aromatic substituent, t is an integer from 1 to 4, and R2 is hydrogen or methyl.

公开(公告)号：US08846710B2

公开(公告)日：2014-09-30

申请号：US11884982

申请日：2006-02-22

Applicant: Tushar A. Kshirsagar ,  Bryon A. Merrill ,  Scott E. Langer ,  Kyle J. Lindstrom ,  Sarah C. Slania ,  Gregory J. Marszalek ,  Joshua R. Wurst ,  Karl J. Manske ,  Shri Niwas ,  Gregory D. Lundquist, Jr. ,  Philip D. Heppner ,  George W. Griesgraber ,  Michael E. Danielson

Inventor： Tushar A. Kshirsagar ,  Bryon A. Merrill ,  Scott E. Langer ,  Kyle J. Lindstrom ,  Sarah C. Slania ,  Gregory J. Marszalek ,  Joshua R. Wurst ,  Karl J. Manske ,  Shri Niwas ,  Gregory D. Lundquist, Jr. ,  Philip D. Heppner ,  George W. Griesgraber ,  Michael E. Danielson

IPC: A61K31/4745 ,  C07D471/04 ,  C07D471/14

CPC classification number: A61K31/4745 ,  C07D471/04 ,  C07D471/14 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/481

Abstract: A method of preferentially inducing IFN-α biosynthesis in an animal comprising administering certain imidazo[4,5-c] ring compounds with a hydroxymethyl or hydroxyethyl substituent at the 2-position or pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of using these compounds a immunomodulators for treatment of diseases including viral and neoplastic diseases comprising preferentially inducing IFN-α biosynthesis in an animal are disclosed.

Abstract translation: 一种在动物中优先诱导IFN-α生物合成的方法，其包括在2-位上给予某些咪唑并[4,5-c]环化合物与羟甲基或羟乙基取代基或含有化合物，中间体，制备方法和 公开了使用这些化合物的免疫调节剂用于治疗包括病毒和肿瘤疾病在内的疾病的方法，其包括在动物中优先诱导IFN-α生物合成。

公开(公告)号：US20130038939A1

公开(公告)日：2013-02-14

申请号：US13639902

申请日：2011-05-03

Applicant: Christopher B. Walker, JR. ,  Christopher P. Tebow ,  Tri D. Pham ,  Steven H. Kong ,  Joseph T. Aronson ,  Kyle J. Lindstrom ,  Michael K. Gerlach ,  Michelle L. Toy ,  Taun L. McKenzie ,  Anthony M. Renstrom ,  Robert A. Yapel ,  Mitchell A.F. Johnson

Inventor： Christopher B. Walker, JR. ,  Christopher P. Tebow ,  Tri D. Pham ,  Steven H. Kong ,  Joseph T. Aronson ,  Kyle J. Lindstrom ,  Michael K. Gerlach ,  Michelle L. Toy ,  Taun L. McKenzie ,  Anthony M. Renstrom ,  Robert A. Yapel ,  Mitchell A.F. Johnson

IPC: G02B1/11

CPC classification number: G02B1/118 ,  G02B5/0242

Abstract: The present invention concerns antireflective films comprising a high refractive index layer (60) and low refractive index layer (80) disposed on the high refractive index layer. The antireflective films have a microstructured surface (70) that can be derived from a microreplicated tool.

Abstract translation: 本发明涉及包括设置在高折射率层上的高折射率层（60）和低折射率层（80）的抗反射膜。 抗反射膜具有可从微复制工具衍生的微结构化表面（70）。

公开(公告)号：US08080608B2

公开(公告)日：2011-12-20

申请号：US12936552

申请日：2009-05-19

Applicant: Bryan V. Hunt ,  Kyle J. Lindstrom ,  James P. DiZio

Inventor： Bryan V. Hunt ,  Kyle J. Lindstrom ,  James P. DiZio

IPC: C08L33/10 ,  C08L33/08 ,  C08F20/30 ,  C08F20/10

CPC classification number: C08F220/40 ,  B29K2033/12 ,  Y10S977/773

Abstract: Presently described are (e.g. microstructured) optical films and polymerizable resin compositions comprising at least one (meth)acrylate monomer comprising an unsubstituted or substituted phenyl ethylene group referred to as phenyl ethylene (meth)acrylate monomers.

Abstract translation: 目前描述的是（例如微结构的）光学薄膜和包含至少一种（甲基）丙烯酸酯单体的可聚合树脂组合物，所述单体包含被称为苯乙烯（甲基）丙烯酸酯单体的未取代或取代的苯基亚乙基。

公开(公告)号：US07897597B2

公开(公告)日：2011-03-01

申请号：US10595103

申请日：2004-08-27

Applicant: Kyle J. Lindstrom ,  Hugues M. H. Martin ,  Bryon A. Merrill ,  Michael J. Rice ,  Joshua R. Wurst ,  Chad A. Haraldson ,  Tushar A. Kshirsagar ,  Philip D. Heppner ,  Shri Niwas ,  George W. Griesgraber ,  Matthew R. Radmer

Inventor： Kyle J. Lindstrom ,  Hugues M. H. Martin ,  Bryon A. Merrill ,  Michael J. Rice ,  Joshua R. Wurst ,  Chad A. Haraldson ,  Tushar A. Kshirsagar ,  Philip D. Heppner ,  Shri Niwas ,  George W. Griesgraber ,  Matthew R. Radmer

IPC: A61K31/541 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/4745 ,  C07D471/02

CPC classification number: C07D471/04

Abstract: Imidazoquinoline compounds with an aryloxy or arylalkyleneoxy or hydroxy substituent at the 6, 7, 8, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.

Abstract translation: 在6,7,8或9位含有芳氧基或芳基亚烷基氧基或羟基取代基的咪唑并喹啉化合物含有这些化合物作为免疫调节剂的化合物，中间体和使用方法，用于调节动物中的细胞因子生物合成 公开了包括病毒和肿瘤疾病在内的疾病的治疗。

公开(公告)号：US20090023722A1

公开(公告)日：2009-01-22

申请号：US12165014

申请日：2008-06-30

Applicant: Patrick L. Coleman ,  Stephen L. Crooks ,  George W. Griesgraber ,  Kyle J. Lindstrom ,  Bryon A. Merrill ,  Michael J. Rice

Inventor： Patrick L. Coleman ,  Stephen L. Crooks ,  George W. Griesgraber ,  Kyle J. Lindstrom ,  Bryon A. Merrill ,  Michael J. Rice

IPC: A61K31/5377 ,  A61K31/437 ,  A61K31/496 ,  A61P35/00 ,  A61P31/12

CPC classification number: C07D471/04 ,  A61K31/4745

Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.

Abstract translation: 在1位含有酰胺官能团的咪唑并喹啉和四氢咪唑并喹啉化合物可用作免疫应答调节剂。 本发明的化合物和组合物可以诱导各种细胞因子的生物合成，并且可用于治疗各种病症，包括病毒性疾病和肿瘤性疾病。