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公开(公告)号：US20170073424A1
公开(公告)日：2017-03-16
申请号：US15341261
申请日：2016-11-02
Applicant: Genentech, Inc.
Inventor： Mark Dennis , Bonnee Rubinfeld , Paul Polakis
IPC: C07K16/30 , A61K47/48 , A61K31/537 , G01N33/574
CPC classification number: C07K16/30 , A61K31/537 , A61K45/06 , A61K47/6803 , A61K47/6809 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6857 , A61K47/6869 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K16/3023 , C07K16/3069 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57423 , G01N33/57449 , G01N33/57492
Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
Abstract translation: 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。
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公开(公告)号：US09556267B2
公开(公告)日：2017-01-31
申请号：US14466794
申请日：2014-08-22
Applicant: Genentech, Inc.
Inventor： Eric Bourhis , Rick Carano , Andrea Cochran , Mike Costa , Venita DeAlmeida , James Ernst , Yan Gong , Rami Hannoush , Paul Polakis , Bonnee Rubinfeld , Mark Solloway , Yan Wu
IPC: A61K39/395 , C07K16/28 , A61K39/00
CPC classification number: C07K16/28 , A61K39/3955 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/21 , C07K2317/31 , C07K2317/34 , C07K2317/526 , C07K2317/55 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2319/00
Abstract: The invention provides anti-LRP6 antibodies and methods of using the same. A particular aspect of the invention provides for bispecific anti-LRP6 antibodies that inhibit signaling by multiple Wnt isoforms.
Abstract translation: 本发明提供抗LRP6抗体及其使用方法。 本发明的一个特定方面提供了抑制多种Wnt同种型的信号通路的双特异性抗LRP6抗体。
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公开(公告)号：US20160017049A1
公开(公告)日：2016-01-21
申请号：US14718932
申请日：2015-05-21
Applicant: GENENTECH, INC.
Inventor： Paul Polakis , Youjun Chen
IPC: C07K16/30 , C07K16/28 , A61K51/10 , A61K47/48 , A61K39/395
CPC classification number: C07K16/303 , A61K39/39558 , A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6851 , A61K47/6859 , A61K47/6889 , A61K51/1057 , C07K2317/33 , C07K2317/34 , C07K2317/77 , G01N2333/4722
Abstract: The invention provides anti-GPC3 antibodies and immunoconjugates and methods of using the same.
Abstract translation: 本发明提供抗GPC3抗体和免疫缀合物及其使用方法。
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公开(公告)号：US20150183883A1
公开(公告)日：2015-07-02
申请号：US14418314
申请日：2013-08-01
Applicant: Genentech, Inc.
Inventor： Jyoti Asundi , Suzanna Clark , Paul Polakis
IPC: C07K16/30 , A61K31/551 , A61K45/06 , A61K47/48
CPC classification number: C07K16/3053 , A61K31/551 , A61K45/06 , A61K47/6803 , A61K47/6809 , A61K47/6849 , A61K47/6865 , A61K47/6889 , A61K2039/505 , C07K16/2869 , C07K2317/24 , C07K2317/56 , C07K2317/73
Abstract: The invention provides anti-ETBR antibodies and immunoconjugates and methods of using the same. In some embodiments, an immunoconjugate comprising an antibody that binds ETBR covalently attached to a cytotoxic agent is provided, wherein the antibody binds an epitope within amino acids 64 to 101 of SEQ ID NO: 10. In some embodiments, the cytotoxic agent is a pyrrolobenzodiazepine.
Abstract translation: 本发明提供抗ETBR抗体和免疫缀合物及其使用方法。 在一些实施方案中，提供了包含结合与细胞毒性剂共价连接的ETBR的抗体的免疫偶联物，其中所述抗体结合SEQ ID NO：10的氨基酸64至101内的表位。在一些实施方案中，细胞毒性剂是吡咯并苯并二氮杂 。
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公开(公告)号：US09029511B2
公开(公告)日：2015-05-12
申请号：US13963269
申请日：2013-08-09
Applicant: Genentech, Inc.
Inventor： Mark Dennis , Bonnee Rubinfeld , Paul Polakis
CPC classification number: C07K16/30 , A61K31/537 , A61K45/06 , A61K47/6803 , A61K47/6809 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6857 , A61K47/6869 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K16/3023 , C07K16/3069 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57423 , G01N33/57449 , G01N33/57492
Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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Patent Agency Ranking
66.发明申请公开(公告)号：US20150056132A1
公开(公告)日：2015-02-26
申请号：US14287826
申请日：2014-05-27
Applicant: Genentech, Inc.
Inventor： Mark DENNIS , Jan Marik , Paul Polakis , Bonnee Rubinfeld , Simon Williams
CPC classification number: C07K16/40 , A61K47/6811 , A61K47/6871 , A61K51/1072 , A61K51/1075 , A61K51/1093 , A61K51/1096 , A61K2039/505 , C07B59/008 , C07B2200/05 , C07K16/3069 , C07K2317/24 , C07K2317/565 , C07K2317/92 , G01N33/534 , G01N33/57492 , G01N33/60 , G01N33/6893
Abstract: Anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of using anti-STEAP-1 antibodies and immunoconjugates thereof are provided. Methods of detecting or determining the presence of STEAP-1 proteins are provided.
Abstract translation: 提供抗STEAP-1抗体及其免疫偶联物。 提供了使用抗STEAP-1抗体及其免疫偶联物的方法。 提供检测或确定STEAP-1蛋白存在的方法。
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公开(公告)号：US20140341916A1
公开(公告)日：2014-11-20
申请号：US14354362
申请日：2012-10-24
Applicant: Genentech, Inc.
Inventor： Paul Polakis , Jyoti Asundi , Suzanna Clark
IPC: C07K16/28 , A61K39/395 , C07K16/30 , A61K31/437 , A61K31/4523
CPC classification number: C07K16/2869 , A61K31/437 , A61K31/4523 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/73 , A61K2300/00
Abstract: The invention provides therapeutic combinations of anti-ETBR antibodies and MAP kinase inhibitors and methods of using the same to treat melanoma.
Abstract translation: 本发明提供抗ETBR抗体和MAP激酶抑制剂的治疗组合以及使用该组合治疗黑色素瘤的方法。
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公开(公告)号：US20140322129A1
公开(公告)日：2014-10-30
申请号：US14207878
申请日：2014-03-13
Applicant: Genentech, Inc.
Inventor： Steven R. Leong , Andrew Polson , Paul Polakis , Yan Wu , Wei-Ching Liang , Ron Firestein
IPC: C07K16/28 , A61K45/06 , A61K51/10 , A61K38/05 , A61K31/704 , A61K47/48 , G01N33/574
CPC classification number: C07K16/3015 , A61K31/5377 , A61K31/5517 , A61K39/3955 , A61K45/06 , A61K47/6803 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/2827 , C07K16/3069 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/567 , C07K2317/77 , C07K2317/92 , G01N33/57492 , A61K2300/00
Abstract: The invention provides anti-B7-H4 antibodies and immunoconjugates and methods of using the same.
Abstract translation: 本发明提供抗B7-H4抗体和免疫缀合物及其使用方法。
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公开(公告)号：US20140314794A1
公开(公告)日：2014-10-23
申请号：US14108820
申请日：2013-12-17
Applicant: Genentech, Inc.
Inventor： Mark Dennis , William Mallet , Paul Polakis
IPC: A61K47/48 , A61K38/08 , A61K45/06 , A61K31/4025
CPC classification number: A61K47/6803 , A61K31/337 , A61K31/4025 , A61K31/4196 , A61K31/513 , A61K31/517 , A61K31/519 , A61K31/537 , A61K31/555 , A61K31/7068 , A61K31/7072 , A61K38/07 , A61K38/08 , A61K45/06 , A61K47/6817 , A61K47/6835 , A61K47/6851 , A61K2039/505 , C07K16/3015 , C07K16/303 , C07K16/3069 , C07K16/3092 , C07K2317/24 , C07K2317/55 , C07K2317/565 , Y10T428/13
Abstract: The invention is directed to antibody drug conjugate compositions of matter useful for the diagnosis and treatment of tumors in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20140079721A1
公开(公告)日：2014-03-20
申请号：US13963269
申请日：2013-08-09
Applicant: Genentech, Inc.
Inventor： Mark Dennis , Bonnee Rubinfeld , Paul Polakis
CPC classification number: C07K16/30 , A61K31/537 , A61K45/06 , A61K47/6803 , A61K47/6809 , A61K47/6813 , A61K47/6817 , A61K47/6849 , A61K47/6851 , A61K47/6857 , A61K47/6869 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K16/3023 , C07K16/3069 , C07K2317/14 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57423 , G01N33/57449 , G01N33/57492
Abstract: The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
Abstract translation: 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。
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