公开(公告)号：US10220003B2

公开(公告)日：2019-03-05

申请号：US15455080

申请日：2017-03-09

Applicant: InCube Labs, LLC

Inventor： Mir Imran ,  Joel Harris

IPC: A61K9/48 ,  A61K35/12 ,  A61K9/00 ,  A61K9/06 ,  A61M25/10 ,  A61B5/00 ,  A61B5/145 ,  A61M31/00 ,  A61K35/28 ,  A61K35/30 ,  A61K35/39

Abstract: Embodiments provide swallowable devices, preparations and methods for delivering viable cells (VC) into the GI tract including GI wall tissue or other tissue site. Particular embodiments provide a swallowable device such as a capsule for delivering VC into an intestinal wall or other site. The VC can be contained within a tissue-penetrating shell disposed in the capsule that protects the VC as they pass through the GI tract until they are inserted into GI tract tissue or other location. The shell desirably has shape, size and material consistency to be contained in a swallowable capsule, delivered from the capsule into solid tissue by the application of force on the shell and biodegrade within the solid tissue to release the VC into the tissue. Within the shell or other structure the VC can be maintained in a viability-sustaining gel that preserves the viability of the VC for selected time periods.

公开(公告)号：US10178483B2

公开(公告)日：2019-01-08

申请号：US15383626

申请日：2016-12-19

Applicant: Earlens Corporation

Inventor： Marco Teran ,  Mark Bishop ,  Torsten Kimura ,  Paul Rucker ,  Sunil Puria ,  Marshall Scott Jones

IPC: H04R25/00 ,  H02J7/00 ,  C09D5/00 ,  C09D163/00 ,  H01M2/10 ,  H01M10/42 ,  H01M10/48 ,  H01M10/46

Abstract: Embodiments of the present invention include a method of aligning the elements of a tympanic lens, the method comprising the steps of: forming mold of a user's ear canal, including the user's tympanic membrane; digitally scanning the ear canal mold to create a digital model of the user's ear canal; using the digital data to size a chassis for the tympanic lens; manufacturing a chassis; manufacturing an ear canal mold, manufacturing an alignment tool, including a chassis alignment feature and a photodetector alignment feature; mating the ear canal mold and alignment tool; placing the chassis into the mold, using the alignment tool to fix the position of the chassis with respect to a model of the user's tympanic membrane and features thereof; mounting a microactuator and photodetector to the chassis; and using the photodetector alignment feature to position the photodetector prior to fixing the photodetector in place.

公开(公告)号：US10130514B2

公开(公告)日：2018-11-20

申请号：US13627346

申请日：2012-09-26

Applicant: InCube Labs, LLC

Inventor： Mir Imran ,  Joel Harris

IPC: A61F11/00 ,  A61K9/00

Abstract: Embodiments of the invention provide systems and methods for delivering therapeutic compositions to the inner-ear to treat inner-ear disorders. An embodiment of such a system comprises a sheath for insertion into the auditory canal and a cannula which can be inserted through the sheath. The cannula can include a tip for piercing the tympanic membrane and delivering the composition to an inner-ear tissue surface. The system may also include a therapeutic composition comprising a therapeutic agent and a thixotropic material which allows the composition to be delivered (e.g., by injection) through the cannula in liquid form and transition to gel-form once delivered to the tissue surface. A method for using the system comprises introducing the sheath into the ear, introducing the cannula through the sheath to pierce the tympanic membrane and position the tip adjacent an inner-ear tissue surface; and delivering the composition through the cannula to adhere to the tissue surface.

公开(公告)号：US10123800B2

公开(公告)日：2018-11-13

申请号：US13665160

申请日：2012-10-31

Applicant: ZipLine Medical, Inc.

Inventor： Amir Belson ,  Eric Storne ,  Eric T. Johnson ,  Robert R. Ragland ,  Phillip C. Burke ,  Luke Clauson

IPC: A61B17/08 ,  A61B17/00 ,  A61B17/02 ,  A61B17/04

Abstract: Apparatus for closing a surgical incision comprise a base having left and right panels, a force distribution structure coupled to each panel, and a closure component which releasably attaches to the force distribution structure to draw the inner edges of the panels together in order to close adhered tissue edges. The force distribution structures allow the inner edges of the panels to expand while restraining expansion of the outer edges of the panels and limiting elongation of the lateral dimension of the panels. The incision closure appliance may be placed on skin or other tissue prior to forming the incision to be available to close said incision at the end of the surgical procedure.

公开(公告)号：US10098644B2

公开(公告)日：2018-10-16

申请号：US15058999

申请日：2016-03-02

Applicant: HOCOR Cardiovascular Technologies LLC

Inventor： Paul C. Ho

IPC: A61M29/00 ,  A61B17/12 ,  A61F2/24 ,  A61B17/00 ,  A61M25/10

Abstract: Methods and systems for regulating aortic regurgitation during aortic valve replacement or repair procedures utilize a temporary aortic valve (TAV) catheter and a controller. The temporary aortic valve catheter has an expandable occlusion device which can partially occlude the aortic lumen during ventricular diastole with a lesser occlusion during ventricular systole. Exemplary balloon structures include multiple, independently inflatable balloons which are inflated in synchrony with the cardiac cycle by the controller. By controlling aortic regurgitation, the repair or replacement protocols can be conducted with less interference from blood flow.

公开(公告)号：US11096761B2

公开(公告)日：2021-08-24

申请号：US17028596

申请日：2020-09-22

Applicant: Gynesonics, Inc.

Inventor： Michael Munrow ,  Jordan Bajor ,  Malcolm G. Munro

IPC: A61B90/00 ,  A61B18/14 ,  A61B10/00 ,  A61M5/46 ,  A61B90/11 ,  A61B34/10 ,  A61B10/04

Abstract: Needles are deployed in tissue under direct ultrasonic or other imaging. To aid in deploying the needle, a visual needle guide is projected on to the image prior to needle deployment. Once the needle guide is properly aligned, the needle can be deployed. After needle deployment, a safety boundary and treatment region are projected on to the screen. After confirming that the safety boundary and treatment regions are sufficient, the patient can be treated using the needle.

公开(公告)号：US10898719B2

公开(公告)日：2021-01-26

申请号：US15916023

申请日：2018-03-08

Applicant: Nalu Medical, Inc.

Inventor： Daniel Pivonka ,  Anatoly Yakovlev ,  Michael J. Partsch ,  Lee Fason Hartley ,  James C. Makous ,  Brett Daniel Schleicher ,  Lakshmi Narayan Mishra

IPC: A61N1/36 ,  A61N1/05 ,  A61N2/00 ,  A61N1/37 ,  A61N1/00 ,  A61N1/372 ,  A61N1/378 ,  A61N5/06 ,  G16H40/67 ,  G16H40/63 ,  A61N1/375 ,  A61N2/02 ,  H01Q1/27

Abstract: Provided herein are methods of treating a patient comprising providing a medical apparatus comprising an external system and an implantable system, implanting the implantable system, and delivering at least one of power or data to the implantable system with the external system. The external system comprises: at least one external antenna configured to transmit a first transmission signal to the implantable system; an external transmitter configured to drive the at least one external antenna; an external power supply; and an external controller. The implantable system comprises: at least one implantable antenna configured to receive the first transmission signal from the first external device; an implantable receiver; at least one implantable functional element configured to interface with the patient; an implantable controller; an implantable energy storage assembly; and an implantable housing surrounding at least the implantable controller and the implantable receiver. Medical apparatus are also provided.

公开(公告)号：US10863286B2

公开(公告)日：2020-12-08

申请号：US16682329

申请日：2019-11-13

Applicant: Earlens Corporation

Inventor： Rodney C. Perkins ,  Sunil Puria ,  Jonathan P. Fay

IPC: H04R25/00 ,  H04R1/26 ,  H04R29/00

Abstract: Systems, devices, and methods for communication include an ear canal microphone configured for placement in the ear canal to detect high frequency sound localization cues. An external microphone positioned away from the ear canal can detect low frequency sound, such that feedback can be substantially reduced. The canal microphone and the external microphone are coupled to a transducer, such that the user perceives sound from the external microphone and the canal microphone with high frequency localization cues and decreased feedback. Wireless circuitry can be configured to connect to many devices with a wireless protocol, such that the user can receive and transmit audio signals. A bone conduction sensor can detect near-end speech of the user for transmission with the wireless circuitry in a noisy environment. Noise cancellation of background sounds near the user can be provided.

公开(公告)号：US10743110B2

公开(公告)日：2020-08-11

申请号：US15425684

申请日：2017-02-06

Applicant: EARLENS CORPORATION

Inventor： Sunil Puria ,  Micha Rosen ,  Jonathan P. Fay ,  Paul Rucker ,  James Stone

IPC: H04R11/02 ,  H04R25/02 ,  H04R25/00 ,  H04R23/00 ,  H04R17/00

Abstract: A device to transmit an audio signal to a user comprises a transducer and a support. The support is configured for placement on the eardrum to drive the eardrum. The transducer is coupled to the support at a first location to decrease occlusion and a second location to drive the eardrum. The transducer may comprise one or more of an electromagnetic balanced armature transducer, a piezoelectric transducer, a magnetostrictive transducer, a photostrictive transducer, or a coil and magnet. The device may find use with open canal hearing aids.

公开(公告)号：US10688275B2

公开(公告)日：2020-06-23

申请号：US15724007

申请日：2017-10-03

Applicant: Jorge Neval Moll Neto

Inventor： Jorge Neval Moll Neto ,  Silvia Siag Oigman ,  Jeffrey J. Christian ,  Benjamin Scott Arnett

IPC: A61M21/02 ,  A61K36/74 ,  A61K9/00 ,  A61M15/00 ,  A61M15/06 ,  A61M15/08 ,  A61M11/00 ,  A61M11/04 ,  A24F47/00 ,  A61M21/00

Abstract: Devices, systems and methods are provided for delivering coffee-derived volatiles to a user, particularly for the treatment of addiction. The coffee volatiles are selected and delivered by devices and systems which allow for concentrated delivery to the olfactory system of the user in a controlled manner. The olfactory system is the part of the sensory system used for smelling or olfaction. Olfaction of such coffee volatiles in this prescribed fashion stimulates the reward system of the brain such that a specific desired outcome is achieved. In some embodiments, the desired outcome is a reduction in addiction symptoms or curbing of a sensation of addiction withdrawal.