公开(公告)号：US10807943B2

公开(公告)日：2020-10-20

申请号：US15670298

申请日：2017-08-07

申请人： Wisconsin Alumni Research Foundation

发明人： Helen E. Blackwell ,  Christine E. McInnis

IPC分类号： C07C235/80 ,  A61K31/164 ,  C07C233/11 ,  A61K31/165 ,  A61K31/167 ,  A61K31/22 ,  A61K31/245 ,  A61K31/341 ,  A61K31/381 ,  A61K31/405 ,  A61K31/415 ,  C07C233/51 ,  C07C235/34 ,  C07C323/62 ,  C07D231/40 ,  C07D307/52 ,  C07D333/36 ,  C07D409/12 ,  C07C233/10 ,  A01N37/22 ,  A01N37/42 ,  A01N43/08 ,  A01N43/10 ,  A01N43/38 ,  A01N43/56 ,  A61K31/221 ,  A61K31/404 ,  A61K45/06 ,  C07D209/18

摘要： Non-lactone carbocyclic modulators of bacterial quorum sensing. Pharmaceutical composition containing such modulators. Methods employing such modulators for modulation of quorum sensing. Compounds are exemplified by those of formula: A-[Z]n-L1-[Y]—NH-L2-HG, where A is an optionally substituted aryl or heteroaryl group having one or two 5- or 6-member rings with up to 1-3 heteroatoms in a ring, or a substituted or unsubstituted C1-C12 acyclic aliphatic group and HG is an optionally substituted cyclopentyl group. Compounds include those where n is 1 or 0, Z is —CO—, —O—CO—, —CO—O—, —NH—CO—, —CO—NH—, —NH—CO—NH—, —O—, —S—, or —NH2, Y is —NH—CO—, —CO—CH2—C(Y1)-, or —SO2—, where Y1 is —OH, —SH, —NH2 or —F; and L1 and L2 independently are —[CH2]p1- and —[CH2]p2-, where p1 and p2, independently, are 0 or integers ranging from 1-3.

公开(公告)号：US10786558B2

公开(公告)日：2020-09-29

申请号：US16017542

申请日：2018-06-25

申请人： THE CORPORATION OF MERCER UNIVERSITY

发明人： Martin J. D'Souza

IPC分类号： A61K39/00 ,  A61K39/155 ,  C12N7/00 ,  A61K39/165 ,  A61K39/095 ,  A61K9/00 ,  A61K9/51 ,  A61K31/245 ,  A61K31/46 ,  A61K31/5383 ,  A61K31/7036 ,  A61K31/7048 ,  A61K31/7088 ,  A61K31/727 ,  C12N15/88 ,  A61K9/16 ,  C12N5/071 ,  A61K48/00

摘要： A method for forming microspheres containing bioactive material, comprising dissolving a polymer matrix, such as albumin or beta-cyclodextrin, in an aqueous medium in a first vessel; contacting the dissolved polymer matrix with a crosslinking agent, such as glutaraldehyde, to crosslink the polymer matrix and the crosslinking agent; neutralizing with sodium bisulfate any excess crosslinking agent remaining after crosslinking is substantially complete; solubilizing in a second vessel a bioactive material in an aqueous solution; mixing the solubilized bioactive material together with the neutralized crosslinked polymer matrix in solution to form a mixture; and, spray drying the mixture to produce nanospheres, whereby substantial bioactivity of the biomaterial is retained upon cellular uptake.

公开(公告)号：US20200289452A1

公开(公告)日：2020-09-17

申请号：US16817515

申请日：2020-03-12

申请人： Antoine VARANI

发明人： Antoine VARANI

IPC分类号： A61K31/245 ,  A61K31/573 ,  A61K9/00

摘要： A composition, and method for using the same, for treating a canker sore includes 10-30% of an ester local anesthetic, 0.5-2% of a corticosteroid, and a carrier for the ester local anesthetic and the corticosteroid. The carrier is formulated as a paste so as to be applied topically to the canker sore to deliver the ester local anesthetic and the corticosteroid simultaneously to the canker sore.

公开(公告)号：US10765650B2

公开(公告)日：2020-09-08

申请号：US16179846

申请日：2018-11-02

申请人： Forward Science Technologies, LLC

发明人： Brian Pikkula ,  Robert J. Whitman

IPC分类号： A61K31/167 ,  A61P1/02 ,  A61Q11/00 ,  A61K31/245 ,  A61K47/02 ,  A61K45/06 ,  A61K9/08 ,  A61K9/00 ,  A61K8/24 ,  A61K8/42 ,  A61K8/44 ,  A61K8/19 ,  A61K33/42 ,  A61K33/06 ,  A61K33/00

摘要： A composition for mixing with water for use as an oral rinse, comprising monobasic sodium phosphate, dibasic sodium phosphate, sodium chloride, calcium chloride, and an analgesic/anaesthetic such as benzocaine/lidocaine.

公开(公告)号：US20200261343A1

公开(公告)日：2020-08-20

申请号：US16583421

申请日：2019-09-26

申请人： Q-Med AB

发明人： Åsa Wiebensjö ,  Katarina EDSMAN

IPC分类号： A61K8/60 ,  A61K47/61 ,  A61Q19/00 ,  A61K47/24 ,  A61K31/167 ,  A61K31/728 ,  A61K31/445 ,  A61K31/375 ,  A61K31/245 ,  A61K45/06 ,  A61Q19/08 ,  A61Q7/00 ,  A61L31/16 ,  A61L31/04 ,  A61L27/54 ,  A61L27/20 ,  A61K8/73 ,  A61K8/67 ,  A61K8/42

摘要： An injectable hyaluronic acid composition including a hyaluronic acid; a local anesthetic selected from the group of amide and ester type local anesthetics or a combination thereof; and an ascorbic acid derivative in an amount which prevents or reduces the effect on the viscosity and/or elastic modulus G′ of the composition caused by the local anesthetic upon sterilization by heat. Further, the medical and non-medical, such as cosmetic, use of such a composition, and to a method of manufacturing such a composition.

公开(公告)号：US20200179668A1

公开(公告)日：2020-06-11

申请号：US16735160

申请日：2020-01-06

申请人： NANOMED SKINCARE, INC.

发明人： Bai XU

IPC分类号： A61M37/00 ,  A61K9/00 ,  A61K9/127 ,  A61K9/70 ,  A61K38/21 ,  A61N1/30 ,  A61K31/337 ,  A61P35/00 ,  A61K31/245 ,  A61K31/167

摘要： A system and method of using a high-aspect ratio microdevice for treating, preventing or ameliorating a medical condition is provided.

公开(公告)号：US20200179558A1

公开(公告)日：2020-06-11

申请号：US16794963

申请日：2020-02-19

申请人： Edixomed Limited ,  First Water Limited

发明人： Hugh Munro ,  Nicholas Boote

IPC分类号： A61L15/44 ,  A61K9/70 ,  A61K31/167 ,  A61L26/00 ,  A61K31/445 ,  A61K31/46 ,  A61K31/245 ,  A61K33/00 ,  A61L15/24 ,  A61L15/28

摘要： The present invention relates to skin dressings that are useful in the treatment of conditions associated with tissue ischaemia and skin lesions including those that are infected, such as burns and surgical wounds and chronic wounds such as but not limited5 to diabetic foot ulcers and venous leg ulcers. The skin dressings are also useful to effect transdermal delivery of pharmaceutically active agents.

公开(公告)号：US10675234B1

公开(公告)日：2020-06-09

申请号：US16354667

申请日：2019-03-15

申请人： N.V. Perricone LLC

发明人： Christopher Cain Caires

IPC分类号： A61K31/60 ,  A61K31/194 ,  A61K31/198 ,  A61K31/245 ,  A61K31/7004 ,  A61K8/36 ,  A61K8/67 ,  A61K9/00

摘要： The present invention generally relates to skin care and, in particular, to systems and methods for treating and/or preventing acne. Acne is believed to be caused by a combination of factors, including Propionibacterium acnes bacteria, excess sebum production, and inflammation from the immune response (e.g., in response to P. acnes). Certain aspects of the invention are thus directed to one or more compositions that collectively target these factors, although it should be understood that a single composition may target more than one factor at a time. For instance, in one set of embodiments, a treatment may include a first composition that cleans the skin, a second composition that contains growth inhibitor of P. acnes (e.g., for use during the day), and a third composition that inhibits sebum production (e.g., for use during the night). One or more of these may contain other components, such as anti-inflammatory agents, moisturizers, topical anti-microbial agents (e.g., salicylic acid), or the like. Other aspects are generally directed to methods of making or use of such compositions, kits including such compositions, or the like.

公开(公告)号：US20200155503A1

公开(公告)日：2020-05-21

申请号：US16634781

申请日：2018-08-03

申请人： BIONOOX SA

发明人： Edward STARCKMANN

IPC分类号： A61K31/355 ,  A61K31/245 ,  A61P33/02 ,  A61K31/045

摘要： The invention relates to the use of a composition comprising dihydroquercetin, alpha-tocopherol, and optionally bisabolol and/or a compound of formula (I) for use in the treatment of leishmaniasis, especially cutaneous leishmaniasis. The invention further relates to the use of such a composition for treating inflammation induced by leishmaniasis, especially cutaneous leishmaniasis. The invention also relates to a method for treating leishmaniasis, especially cutaneous leishmaniasis, and/or the associated inflammation by administering an effective amount of a composition comprising dihydroquercetin, bisabolol, alpha-tocopherol and optionally bisabolol and/or a compound of formula (I) to a subject in need thereof.

公开(公告)号：US20200078330A1

公开(公告)日：2020-03-12

申请号：US16468229

申请日：2017-12-09

申请人： SANVIO,INC.

发明人： Tony GAY

IPC分类号： A61K31/245 ,  A61K36/87 ,  A61K36/886 ,  A61K36/534 ,  A61K31/593 ,  A61K31/592 ,  A61K31/355 ,  A61K31/05 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44

摘要： The present invention is directed to a composition that is suitable for the treatment of wounds and other dermatological conditions. The composition of the present invention comprises an anesthetic agent; an antipruritic agent; a mitotic agent; vitamin D or a derivative thereof; at least one of peppermint oil and thyme oil; one or more antioxidant agents; and a pharmaceutically acceptable carrier. The composition may further comprise one or more humectants and/or one or more emollients.