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公开(公告)号：US10463608B2
公开(公告)日：2019-11-05
申请号：US15350718
申请日：2016-11-14
发明人： Martin J. D'Souza
IPC分类号： A61K9/00 , A61K9/16 , A61K39/095 , A61K39/00 , C12N7/00 , A61K39/145 , A61K39/12 , A61K39/155 , A61M37/00 , B29C41/00 , B29C41/04 , A61K39/165 , A61K39/39 , A61K31/727 , C12N5/071 , C12N15/88 , B29C33/42 , B29C39/02 , A61K35/39 , B29K29/00 , B29K105/00 , B29L31/00
摘要： A transdermal delivery system of microneedles containing a bioactive material, comprising at least one layer of a support material; at least one biodegradable needle associated with the support material, each needle comprising at least one biodegradable polymer and at least one sugar, wherein each biodegradable needle is hollow and is adapted to retain a bioactive material.
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公开(公告)号：US10786558B2
公开(公告)日：2020-09-29
申请号：US16017542
申请日：2018-06-25
发明人： Martin J. D'Souza
IPC分类号： A61K39/00 , A61K39/155 , C12N7/00 , A61K39/165 , A61K39/095 , A61K9/00 , A61K9/51 , A61K31/245 , A61K31/46 , A61K31/5383 , A61K31/7036 , A61K31/7048 , A61K31/7088 , A61K31/727 , C12N15/88 , A61K9/16 , C12N5/071 , A61K48/00
摘要： A method for forming microspheres containing bioactive material, comprising dissolving a polymer matrix, such as albumin or beta-cyclodextrin, in an aqueous medium in a first vessel; contacting the dissolved polymer matrix with a crosslinking agent, such as glutaraldehyde, to crosslink the polymer matrix and the crosslinking agent; neutralizing with sodium bisulfate any excess crosslinking agent remaining after crosslinking is substantially complete; solubilizing in a second vessel a bioactive material in an aqueous solution; mixing the solubilized bioactive material together with the neutralized crosslinked polymer matrix in solution to form a mixture; and, spray drying the mixture to produce nanospheres, whereby substantial bioactivity of the biomaterial is retained upon cellular uptake.
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公开(公告)号：US10004790B2
公开(公告)日：2018-06-26
申请号：US14874978
申请日：2015-10-05
发明人： Martin J. D'Souza
IPC分类号： A61K48/00 , A61K39/00 , A61K39/155 , C12N7/00 , A61K39/165 , A61K39/39 , A61K39/095 , A61K9/00 , A61K9/16 , A61K9/51 , A61K31/245 , A61K31/46 , A61K31/5383 , A61K31/7036 , A61K31/7048 , A61K31/7088 , A61K31/727 , C12N15/88
CPC分类号： A61K39/00 , A61K9/0021 , A61K9/1652 , A61K9/5161 , A61K9/5169 , A61K9/5192 , A61K31/245 , A61K31/46 , A61K31/5383 , A61K31/7036 , A61K31/7048 , A61K31/7088 , A61K31/727 , A61K39/0008 , A61K39/0011 , A61K39/095 , A61K39/155 , A61K39/165 , A61K48/00 , A61K2039/52 , A61K2039/54 , A61K2039/55555 , A61K2039/55594 , A61K2039/57 , C12N5/0677 , C12N7/00 , C12N15/88 , C12N2533/72 , C12N2533/74 , C12N2760/18434 , C12N2760/18534
摘要： A method of transdermal delivery of a vaccine, comprising preparing microparticles of encapsulated vaccine by spray drying a mixture of the vaccine and at least one polymer, and injecting the microparticles transdermally using a microneedle delivery apparatus.
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4.发明授权公开(公告)号：US11628208B2
公开(公告)日：2023-04-18
申请号：US17107468
申请日：2020-11-30
发明人： Martin J. D'Souza
IPC分类号： A61K39/00 , C12N7/00 , A61K39/165 , A61K39/095 , A61K9/00 , A61K9/51 , A61K31/245 , A61K31/46 , A61K31/5383 , A61K31/7036 , A61K31/7048 , A61K31/7088 , A61K31/727 , C12N15/88 , A61K9/16 , C12N5/071 , A61K39/155 , A61K48/00
摘要： A method for producing at least one microneedle containing a vaccine for transdermal delivery of the vaccine to a patient includes preparing microparticles or nanoparticles of encapsulated vaccine by preparing a solution comprising a vaccine antigen and a biocompatible polymer matrix; and spray drying the solution to form the microparticles or nanoparticles. The method includes the further steps of preparing a film composition including at least one pre-polymer solution; preparing a suspension comprising the microparticles or nanoparticles and the film composition; loading the suspension into a 3D printer; printing, via the 3D printer, at least one microneedle made from the suspension; and, converting the pre-polymer solution into a cross-linked biopolymer by exposing the at least one microneedle to UV light. Also disclosed are microneedles containing a vaccine for transdermal delivery.
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公开(公告)号：US11524058B2
公开(公告)日：2022-12-13
申请号：US17034858
申请日：2020-09-28
发明人： Martin J. D'Souza
IPC分类号： A61K39/00 , C12N7/00 , A61K39/165 , A61K39/095 , A61K9/00 , A61K9/51 , A61K31/245 , A61K31/46 , A61K31/5383 , A61K31/7036 , A61K31/7048 , A61K31/7088 , A61K31/727 , C12N15/88 , A61K9/16 , A61K39/155 , A61K48/00 , C12N5/071
摘要： An oral dissolving film containing nano- or micro-encapsulated bioactive material and methods of forming the film. The film may be prepared by dispensing a mixture of a film-forming agent, a crosslinking agent, a solution of nano- or micro-encapsulated bioactive material, and a photoinitiator into a plurality of wells in a tray using a 3D printer. The dispensed material is exposed to radiation in order to crosslink the material and form a film.
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公开(公告)号：US10849962B2
公开(公告)日：2020-12-01
申请号：US16171465
申请日：2018-10-26
发明人： Martin J. D'Souza
IPC分类号： A61K39/00 , A61K9/00 , A61K35/747 , A61M5/32 , A61K9/50 , A61K9/16 , A61K9/51 , A61K31/245 , A61K31/46 , A61K31/5383 , A61K31/7036 , A61K31/7048 , A61K31/7088 , A61K31/727 , A61K39/095 , A61K39/155 , A61K39/165 , C12N5/071 , C12N7/00 , C12N15/88 , A61K48/00
摘要： A method for forming microspheres containing bioactive material, comprising dissolving a polymer matrix, such as albumin or beta-cyclodextrin, in an aqueous medium in a first vessel; contacting the dissolved polymer matrix with a crosslinking agent, such as glutaraldehyde, to crosslink the polymer matrix and the crosslinking agent; neutralizing with sodium bisulfate any excess crosslinking agent remaining after crosslinking is substantially complete; solubilizing in a second vessel a bioactive material in an aqueous solution; mixing the solubilized bioactive material together with the neutralized crosslinked polymer matrix in solution to form a mixture; and, spray drying the mixture to produce nanospheres, whereby substantial bioactivity of the biomaterial is retained upon cellular uptake.
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