公开(公告)号：US20130324703A1

公开(公告)日：2013-12-05

申请号：US13860029

申请日：2013-04-10

Applicant: Avaxia Biologics Incorporated

Inventor： Barbara S. Fox

IPC: C07K16/24

CPC classification number: C07K16/241 ,  A61K2039/505 ,  C07K2317/12 ,  C07K2317/20 ,  C07K2317/41 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/70

Abstract: In accordance with the invention, the development and use of antibodies within the digestive tract is provided. Antibodies are described that are used to treat disorders associated with altered permeability of the digestive tract. Antibodies are described with increased stability within the environment of the digestive tract. Antibodies are described with enhanced permeability to a compromised digestive tract.

公开(公告)号：US20130243773A1

公开(公告)日：2013-09-19

申请号：US13795637

申请日：2013-03-12

Applicant: MERUS B.V.

Inventor： Patricius Hendrikus Van Berkel ,  Ronald Hendrik Peter Brus ,  Ton Logtenberg ,  Abraham Bout

IPC: A61K39/395

CPC classification number: C12P21/005 ,  A61K39/39558 ,  C07K16/00 ,  C07K16/10 ,  C07K16/2803 ,  C07K16/2833 ,  C07K16/2851 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/12 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/50 ,  C07K2317/51 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2319/30 ,  Y02P20/582

Abstract: Provided is methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.

Abstract translation: 提供了从单个宿主细胞克隆产生抗体混合物的方法，其中编码轻链的核酸序列和编码不同重链的核酸序列在重组宿主细胞中表达。 根据本发明的混合物中重组产生的抗体适当地包含与能够与轻链配对的不同重链配对的相同的轻链，从而形成功能性抗原结合结构域。 重组产生的抗体的混合物也由本发明提供。 这种混合物可用于各种领域。

公开(公告)号：US20130224216A1

公开(公告)日：2013-08-29

申请号：US13817414

申请日：2011-08-17

Applicant: Yaron Ilan ,  Gadi Lalazar ,  Tomer Adar ,  Meir Mizrahi ,  Ami Ben-Ya'acov

Inventor： Yaron Ilan ,  Gadi Lalazar ,  Tomer Adar ,  Meir Mizrahi ,  Ami Ben-Ya'acov

IPC: A61K39/40

CPC classification number: A61K39/40 ,  A61K2039/505 ,  C07K16/1203 ,  C07K2317/12

Abstract: Methods and compositions for treating conditions including liver dysfunction, e.g., associated with fatty liver; glucose intolerance; and others, by administering compositions comprising anti-LPS immunoglobulin enriched colostrum preparations.

Abstract translation: 用于治疗包括肝功能障碍的病症的方法和组合物，例如与脂肪肝相关; 葡萄糖不耐症; 和其他，通过施用包含抗LPS免疫球蛋白的初乳制剂的组合物。

公开(公告)号：US20130058943A1

公开(公告)日：2013-03-07

申请号：US13564566

申请日：2012-08-01

Applicant: Barbara S. Fox ,  Eileen F. Bostwick ,  Daniel E. Tracey ,  Lisa D. Schlehuber ,  Michael S. Quesenberry

Inventor： Barbara S. Fox ,  Eileen F. Bostwick ,  Daniel E. Tracey ,  Lisa D. Schlehuber ,  Michael S. Quesenberry

IPC: C07K16/24 ,  C07K1/36 ,  A61P1/00 ,  A61K39/395 ,  A61P29/00

CPC classification number: C07K16/241 ,  C07K2317/12 ,  C07K2317/34 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention provides a composition comprising polyclonal antibodies that specifically bind to with human tumor necrosis factor (hTNF) wherein the polyclonal antibodies are derived from the serum, milk or colostrum of a bovine animal that has been immunized hTNF or an immunogenic portion thereof. The antigenic specificity analysis of the anti-hTNF polyclonal antibodies of the invention is unique and has not been previously described for anti-hTNF polyclonal or monoclonal antibodies of the prior art.

Abstract translation: 本发明提供包含与人肿瘤坏死因子（hTNF）特异性结合的多克隆抗体的组合物，其中所述多克隆抗体衍生自已被免疫的hTNF或其免疫原性部分的牛动物的血清，牛奶或初乳。 本发明的抗hTNF多克隆抗体的抗原特异性分析是独特的，以前没有描述过用于现有技术的抗hTNF多克隆或单克隆抗体。

公开(公告)号：US20120315280A1

公开(公告)日：2012-12-13

申请号：US13452026

申请日：2012-04-20

Applicant: Barbara S. Fox

Inventor： Barbara S. Fox

IPC: A61K39/395 ,  C12Q1/37 ,  G01N33/566 ,  A61P1/04

CPC classification number: C07K16/241 ,  A61K2039/505 ,  C07K2317/12 ,  C07K2317/20 ,  C07K2317/41 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/70

Abstract: In accordance with the invention, the development and use of antibodies within the digestive tract is provided. Antibodies are described that are used to treat disorders associated with altered permeability of the digestive tract. Antibodies are described with increased stability within the environment of the digestive tract. Antibodies are described with enhanced permeability to a compromised digestive tract.

Abstract translation: 根据本发明，提供消化道内的抗体的开发和使用。 描述了用于治疗与改变的消化道通透性相关的疾病的抗体。 描述抗体在消化道环境中具有增加的稳定性。 描述抗体对增强的易感性消化道具有增强的渗透性。

公开(公告)号：US07932360B2

公开(公告)日：2011-04-26

申请号：US11593280

申请日：2006-11-06

Applicant: Patrick H. C. Van Berkel ,  Ronald Hendrik Peter Brus ,  Ton Logtenberg ,  Abraham Bout

Inventor： Patrick H. C. Van Berkel ,  Ronald Hendrik Peter Brus ,  Ton Logtenberg ,  Abraham Bout

IPC: C12P21/08 ,  A61K39/395

CPC classification number: C12P21/005 ,  A61K39/39558 ,  C07K16/00 ,  C07K16/10 ,  C07K16/2803 ,  C07K16/2833 ,  C07K16/2851 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/12 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/50 ,  C07K2317/51 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2319/30 ,  Y02P20/582

Abstract: The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.

公开(公告)号：US07927834B2

公开(公告)日：2011-04-19

申请号：US12221021

申请日：2008-07-29

Applicant: Patrick H. C. Van Berkel ,  Ronald Hendrik Peter Brus ,  Ton Logtenberg ,  Abraham Bout

Inventor： Patrick H. C. Van Berkel ,  Ronald Hendrik Peter Brus ,  Ton Logtenberg ,  Abraham Bout

IPC: C12N15/00 ,  C12N5/06 ,  C12N5/16 ,  C12P21/06 ,  C12P21/02

CPC classification number: C12P21/005 ,  A61K39/39558 ,  C07K16/00 ,  C07K16/10 ,  C07K16/2803 ,  C07K16/2833 ,  C07K16/2851 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/32 ,  C07K2317/12 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/50 ,  C07K2317/51 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/626 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2319/30 ,  Y02P20/582

Abstract: The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.

Abstract translation: 本发明提供从单个宿主细胞克隆产生抗体混合物的方法，其中编码轻链的核酸序列和编码不同重链的核酸序列在重组宿主细胞中表达。 根据本发明的混合物中重组产生的抗体适当地包含与能够与轻链配对的不同重链配对的相同的轻链，从而形成功能性抗原结合结构域。 重组产生的抗体的混合物也由本发明提供。 这种混合物可用于各种领域。

公开(公告)号：US07807863B2

公开(公告)日：2010-10-05

申请号：US12231873

申请日：2008-09-05

Applicant: James M. Robl ,  Yoshimi Kuroiwa ,  Kazuma Tomizuka ,  Isao Ishida

Inventor： James M. Robl ,  Yoshimi Kuroiwa ,  Kazuma Tomizuka ,  Isao Ishida

IPC: A01K67/027 ,  C12N15/00 ,  C12N5/00

CPC classification number: C12N15/8509 ,  A01K67/0271 ,  A01K67/0276 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2217/072 ,  A01K2227/101 ,  A01K2267/01 ,  A01K2267/02 ,  C07K16/00 ,  C07K2317/12 ,  C07K2317/21 ,  C12N2800/30

Abstract: The invention provides cloned transgenic ungulates (e.g., bovines) in which prion protein activity is reduced by one or more genetically engineered mutations. Desirably, these transgenic bovines are also genetically modified to express xenogenous (e.g., human) antibodies. Because of their resistance to prion-related diseases such as bovine spongiform encephalopy (also known as mad cow disease), these bovines are a safer source of human antibodies for pharmaceutical uses and a safer source of agricultural products.

Abstract translation: 本发明提供克隆的转基因有蹄类动物（例如牛），其中朊蛋白活性被一种或多种遗传工程改造的突变所减少。 理想地，这些转基因牛也被遗传修饰以表达异种（例如人）抗体。 由于它们对诸如牛海绵状脑病（也称为疯牛病）的朊病毒相关疾病的抵抗力，这些牛奶是用于制药用途和更安全的农产品源的人类抗体的更安全来源。

公开(公告)号：US20100129377A1

公开(公告)日：2010-05-27

申请号：US12596139

申请日：2008-04-16

Applicant: Ruprecht Jules Joost Van Neerven

Inventor： Ruprecht Jules Joost Van Neerven

IPC: A61K39/395 ,  C07K16/00 ,  A61P37/04

CPC classification number: C07K16/12 ,  A23L33/19 ,  A23L33/40 ,  C07K16/16 ,  C07K2317/12

Abstract: The invention relates to means and methods for obtaining an antigen specific antibody from milk from non-human mammals that have not been immunized with said antigen prior to collecting said milk. Non-human mammal derived antigen specific antibody was found to cross the mucosal side of the intestinal tract of an individual. The invention provides novel means and methods for the treatment of disease through antigen specific non-human mammal antibodies. Further provided are preparations for oral administration comprising said antigen specific antibody of a ruminant.

Abstract translation: 本发明涉及用于从收集所述牛奶之前未用所述抗原免疫的非人哺乳动物的乳获得抗原特异性抗体的方法和方法。 发现非人哺乳动物衍生的抗原特异性抗体穿过个体肠道的粘膜侧。 本发明提供了通过抗原特异性非人哺乳动物抗体治疗疾病的新颖手段和方法。 还提供了包含反刍动物的抗原特异性抗体的口服给药制剂。

公开(公告)号：US20090246131A1

公开(公告)日：2009-10-01

申请号：US12481233

申请日：2009-06-09

Applicant: Hans J. Hansen ,  Gary L. Griffiths ,  Shui-on Leung ,  William J. McBride ,  Zhengxing Qu

Inventor： Hans J. Hansen ,  Gary L. Griffiths ,  Shui-on Leung ,  William J. McBride ,  Zhengxing Qu

IPC: A61K51/10 ,  A61K47/42

CPC classification number: C07K16/468 ,  A61K47/6863 ,  A61K47/6899 ,  A61K51/1048 ,  A61K51/1063 ,  A61K2039/505 ,  B82Y5/00 ,  C07K16/18 ,  C07K16/30 ,  C07K16/3007 ,  C07K16/3046 ,  C07K16/44 ,  C07K2317/12 ,  C07K2317/13 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622 ,  C07K2319/00

Abstract: The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against a targetable conjugate. The targetable conjugate encompasses a hapten to which antibodies have been prepared. In preferred embodiments, the hapten is histamine-succinyl-glycine (HSG). In more preferred embodiments, the at least one arm comprises the CDR sequences of the HSG-binding 679 antibody. The targetable conjugate is attached to one or more therapeutic and/or diagnostic agents. The invention provides constructs and methods for producing the bispecific antibodies or antibody fragments, as well as methods for using them and kits comprising them.

Abstract translation: 本发明涉及一种双特异性抗体或抗体片段，该双特异性抗体或抗体片段具有至少一个对目标组织有反应性的臂和至少一种其它可靶向缀合物反应的其他臂。 可靶向缀合物包含已制备抗体的半抗原。 在优选的实施方案中，半抗原是组胺 - 琥珀酰甘氨酸（HSG）。 在更优选的实施方案中，所述至少一个臂包含HSG结合679抗体的CDR序列。 可靶向缀合物连接至一种或多种治疗和/或诊断剂。 本发明提供了用于产生双特异性抗体或抗体片段的构建体和方法，以及使用它们的方法和包含它们的试剂盒。