Invention Grant
- Patent Title: Recombinant production of mixtures of antibodies
- Patent Title (中): 重组产生抗体混合物
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Application No.: US12221021Application Date: 2008-07-29
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Publication No.: US07927834B2Publication Date: 2011-04-19
- Inventor: Patrick H. C. Van Berkel , Ronald Hendrik Peter Brus , Ton Logtenberg , Abraham Bout
- Applicant: Patrick H. C. Van Berkel , Ronald Hendrik Peter Brus , Ton Logtenberg , Abraham Bout
- Applicant Address: NL Utrecht
- Assignee: Merus B.V.
- Current Assignee: Merus B.V.
- Current Assignee Address: NL Utrecht
- Agency: TraskBritt, P.C.
- Priority: EP02077953 20020718
- Main IPC: C12N15/00
- IPC: C12N15/00 ; C12N5/06 ; C12N5/16 ; C12P21/06 ; C12P21/02

Abstract:
The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.
Public/Granted literature
- US20090263864A1 Recombinant production of mixtures of antibodies Public/Granted day:2009-10-22
Information query
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