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    HISTOTRIPSY USING VERY SHORT ULTRASOUND PULSES
    51.
    发明公开
    HISTOTRIPSY USING VERY SHORT ULTRASOUND PULSES 审中-公开

    公开(公告)号：US20240033542A1

    公开(公告)日：2024-02-01

    申请号：US18485904

    申请日：2023-10-12

    申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    发明人： Charles A. CAIN ,  Adam D. MAXWELL ,  Zhen XU ,  Kuang-Wei LIN

    IPC分类号： A61N7/00

    CPC分类号： A61N7/00 ,  A61N2007/0039 ,  A61N2007/0065 ,  A61B2017/320069

    摘要： Apparatus and methods are provided for applying ultrasound pulses into tissue or a medium in which the peak negative pressure (P−) of one or more negative half cycle(s) of the ultrasound pulses exceed(s) an intrinsic threshold of the tissue or medium, to directly form a dense bubble cloud in the tissue or medium without shock-scattering. In one embodiment, a microtripsy method of Histotripsy therapy comprises delivering an ultrasound pulse from an ultrasound therapy transducer into tissue, the ultrasound pulse having at least a portion of a peak negative pressure half-cycle that exceeds an intrinsic threshold in the tissue to produce a bubble cloud of at least one bubble in the tissue, and generating a lesion in the tissue with the bubble cloud. The intrinsic threshold can vary depending on the type of tissue to be treated. In some embodiments, the intrinsic threshold in tissue can range from 15-30 MPa.

    COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING SARS-COV-2 INFECTION
    55.
    发明公开
    COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING SARS-COV-2 INFECTION 审中-公开

    公开(公告)号：US20240016901A1

    公开(公告)日：2024-01-18

    申请号：US17927093

    申请日：2021-05-26

    申请人： The Regents of the University of Michigan

    发明人： Jonathan Z. Sexton

    IPC分类号： A61K38/40 ,  A61K31/4706 ,  A61K31/675 ,  A61P31/14

    CPC分类号： A61K38/40 ,  A61K31/4706 ,  A61K31/675 ,  A61P31/14

    摘要： This invention is in the field of medicinal pharmacology. In particular, the present invention relates to pharmaceutical compositions capable of preventing, treating and/or ameliorating symptoms related to conditions caused by the SARS-CoV-2 vims (e.g., COVID-19). The invention further relates to methods of preventing, treating and/or ameliorating symptoms related to conditions caused by the SARS-CoV-2 vims (e.g., COVID-19), comprising administering to a subject (e.g., a human patient) a pharmaceutical composition comprising lactoferrin, S1RA, entecavir, lomitapide, metoclopramide, bosutinib, thioguanine, fedratinib, Z-FA-FMK, amiodarone, verapamil, gilteritinib, clofazimine, niclosamide, and remdesivir (alone or with additional agents).

    Pulse generator
    57.
    发明授权
    Pulse generator 有权

    公开(公告)号：US11870439B2

    公开(公告)日：2024-01-09

    申请号：US18077759

    申请日：2022-12-08

    申请人： The Regents of the University of Michigan

    发明人： Xin Zan ,  Al-Thaddeus Avestruz

    IPC分类号： H03K3/00 ,  H03K3/01 ,  H03K5/01

    CPC分类号： H03K3/01 ,  H03K5/01

    摘要： A pulse shaping device includes an inductor that is selectively output-coupled to a first port of a capacitor. The inductor is charged to a selected current throughput and then coupled to the first port to generate a first characteristic within the current flowing at a second port of the capacitor. The capacitor is charged until reaching a clamping voltage at the first port. A voltage clamp of the shaping device clamps the first port of the capacitor at the clamping voltage to generate a second characteristic within the current flowing at a second port of the capacitor.

    Ubiquitously Deployable Interactive Displays
    58.
    发明公开
    Ubiquitously Deployable Interactive Displays 审中-公开

    公开(公告)号：US20240004277A1

    公开(公告)日：2024-01-04

    申请号：US18216024

    申请日：2023-06-29

    申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN

    发明人： Alanson SAMPLE ,  Amani ALKAYYALI

    IPC分类号： G03B21/20 ,  G02B5/23

    CPC分类号： G03B21/2033 ,  G02B5/23

    摘要： Pervasive and interactive displays promise to present digital content seamlessly throughout a room. However, traditional display technologies do not scale to room-wide applications due to high per-unit-area costs and the need for constant wired power and data infrastructure. This disclosure proposes the use of photochromic paint as a display medium. Applying the paint to any surface or object creates ultra-low-cost displays, which can change color when exposed to specific wavelengths of light. New paint formulations are developed that enable wide area application of photochromic material. Along with a specially modified wide-area laser projector and depth camera that can draw custom images and create on-demand, room-wide user interfaces on photochromic enabled surfaces. System parameters such as light intensity, material activation time, and user readability are examined to optimize the display. Results show that images and user interfaces can last up to 16 minutes and can be updated indefinitely.

    DYNAMIC STANDING DESK
    59.
    发明公开
    DYNAMIC STANDING DESK 审中-公开

    公开(公告)号：US20240000224A1

    公开(公告)日：2024-01-04

    申请号：US18039685

    申请日：2021-12-01

    申请人： The Regents of the University of Michigan

    发明人： NICOLAAS IDA BOHNEN ,  MARTIJN L.T.M. MÜLLER

    IPC分类号： A47B21/03 ,  A47B21/02

    CPC分类号： A47B21/03 ,  A47B21/02 ,  A47B2200/0061 ,  A47B2200/0052

    摘要： A dynamic standing desk having a work surface configured to move with planar motion parallel with the ground and with a range of movement that adjusts as a function of the size of a user of the desk. The desk may include a base, a tabletop that includes the work surface, a frame that movably couples the tabletop to the base, and at least one actuator configured to provide the planar motion. The desk may be used to reduce lower musculoskeletal discomfort of a user of the desk by oscillating the work surface of the desk with a range of movement based on a length of a limb of the user.