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公开(公告)号：US10143187B2
公开(公告)日：2018-12-04
申请号：US15923928
申请日：2018-03-16
IPC分类号： A01K67/00 , A01K67/027 , C07K14/705 , G01N33/53 , G01N33/50
摘要： In some aspects, the present invention provides chimeric transferrin receptor (TfR) polynucleotides and polypeptides. In other aspects, this invention provides chimeric TfR transgenic animal models and methods of using the animal models to identify therapeutics that can cross the blood-brain barrier.
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公开(公告)号：US20180208582A1
公开(公告)日：2018-07-26
申请号：US15927920
申请日：2018-03-21
发明人： Anthony A. Estrada , Jianwen A. Feng , Joseph P. Lyssikatos , Zachary K. Sweeney , Javier de Vicente Fidalgo
IPC分类号： C07D403/12 , C07D498/04 , C07D491/20 , C07D417/14 , C07D413/14 , C07D401/14 , C07B59/00 , C07D409/14 , C07D405/14 , C07D403/14 , C07D487/04
摘要： The present disclosure relates generally to LRRK2 inhibitors, or a pharmaceutically acceptable salt, deuterated analog, prodrug, tautomer, stereoisomer, or mixture of stereoisomers thereof, and methods of making and using thereof.
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公开(公告)号：US20180099981A1
公开(公告)日：2018-04-12
申请号：US15721470
申请日：2017-09-29
发明人： Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Colin Philip Leslie , Joseph P. Lyssikatos , Alfonso Pozzan , Zachary K. Sweeney , Javier de Vicente Fidalgo
IPC分类号： C07D513/04 , C07D491/048 , C07D498/14 , C07D498/04 , C07D495/04 , C07D487/04 , C07D261/18 , C07D413/14 , C07D413/12 , C07D403/12 , C07D267/14 , C07D471/04 , C07D417/12
CPC分类号： C07D513/04 , C07D261/18 , C07D267/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D498/14
摘要： The present disclosure relates generally to compounds and compositions, and their use as kinase inhibitors.
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公开(公告)号：US20170362206A1
公开(公告)日：2017-12-21
申请号：US15624566
申请日：2017-06-15
发明人： Anthony A. Estrada , Jianwen A. Feng , Joseph P. Lyssikatos , Zachary K. Sweeney , Javier de Vicente Fidalgo
IPC分类号： C07D403/12 , C07D405/14 , C07B59/00 , C07D403/14 , C07D487/04 , C07D409/14
摘要： The present disclosure relates generally to LRRK2 inhibitors, or a pharmaceutically acceptable salt, deuterated analog, prodrug, tautomer, stereoisomer, or mixture of stereoisomers thereof, and methods of making and using thereof.
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公开(公告)号：US09802927B2
公开(公告)日：2017-10-31
申请号：US15178626
申请日：2016-06-10
发明人： Raksha Acharya , Duane A. Burnett , Matthew Gregory Bursavich , Andrew Simon Cook , Bryce Alden Harrison , Andrew J. McRiner
IPC分类号： C07D498/04 , C07D413/14 , A61K31/535 , C07D247/02 , C07D271/02 , C07D273/02 , C07D273/04 , C07D413/04 , C07D417/14 , C07D471/04
CPC分类号： C07D413/14 , A61K31/535 , C07D247/02 , C07D271/02 , C07D273/02 , C07D273/04 , C07D413/04 , C07D417/14 , C07D471/04
摘要： The present disclosure relates to oxadiazine compounds, pharmaceutical compositions comprising an effective amount of an oxadiazine compound and methods for using an oxadiazine compound in the treatment of a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of an oxadiazine compound.
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公开(公告)号：US09771378B2
公开(公告)日：2017-09-26
申请号：US15210927
申请日：2016-07-15
IPC分类号： C07D498/10 , C07D498/04 , C07D498/20 , A61K31/5383 , C07D498/14
CPC分类号： C07D498/04 , C07D498/10 , C07D498/14 , C07D498/20
摘要： The present disclosure relates to Fused Morpholinopyrimidines, pharmaceutical compositions comprising an effective amount of a Fused Morpholinopyrimidine and methods for using a Fused Morpholinopyrimidine in the treatment of a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of a Fused Morpholinopyrimidine.
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![SOLID FORMS OF 4-(3,3-DIFLUORO-2,2-DIMETHYL-PROPANOYL)-3,5-DIHYDRO-2H-PYRIDO[3,4-F][1,4]OXAZEPINE-9-CARBONITRILE](/abs-image/US/2024/09/26/US20240317776A1/abs.jpg.150x150.jpg)
57.发明公开公开(公告)号：US20240317776A1
公开(公告)日：2024-09-26
申请号：US18582522
申请日：2024-02-20
IPC分类号： C07D498/04
CPC分类号： C07D498/04 , C07B2200/13
摘要： Described herein are solid forms of 4-(3,3-difluoro-2,2-dimethyl-propanoyl)-3,5-dihydro-2H-pyrido[3,4-f][1,4]oxazepine-9-carbonitrile, the process of preparing the forms, pharmaceutical compositions comprising same, and methods of use thereof.
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公开(公告)号：US20240271326A1
公开(公告)日：2024-08-15
申请号：US18435766
申请日：2024-02-07
发明人： Xiaocheng Chen , Mark S. Dennis , Mihalis Kariolis , Adam P. Silverman , Ankita Srivastava , Robert C. Wells , Joy Yu Zuchero , Ryan J. Watts
CPC分类号： C07K16/2881 , C07K16/005 , C12N15/1058 , C40B20/00 , C40B30/04 , C40B50/00 , C07K2317/35 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C12N2320/10
摘要： Provided herein are polypeptides that bind to a transferrin receptor, methods of generating such polypeptides, and methods of using the polypeptides to target a composition to a transferrin receptor-expressing cell.
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公开(公告)号：US20240150376A1
公开(公告)日：2024-05-09
申请号：US18232435
申请日：2023-08-10
发明人： Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Colin Phillip Leslie , Joseph P. Lyssikatos , Alfonso Pozzan , Zachary K. Sweeney , Javier de Vicente Fidalgo
IPC分类号： C07D513/04 , C07D261/18 , C07D267/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D498/14
CPC分类号： C07D513/04 , C07D261/18 , C07D267/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D498/14
摘要： The present disclosure relates generally to compounds and compositions, and their use as kinase inhibitors.
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公开(公告)号：US20230406898A1
公开(公告)日：2023-12-21
申请号：US18299458
申请日：2023-04-12
发明人： Gilbert Di Paolo , Todd P. Logan , Kathryn M. Monroe , Ankita Srivastava , Bettina Van Lengerich
IPC分类号： C07K14/475
CPC分类号： C07K14/475 , A61K38/00
摘要： Provided herein are fusion proteins that comprise progranulin and an Fc polypeptide. Methods of using such proteins to treat progranulin-associated disorders (e.g., a neurodegenerative disease, such as frontotemporal dementia (FTD)) are also provided herein.
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