公开(公告)号：US08575568B2

公开(公告)日：2013-11-05

申请号：US12997705

申请日：2009-06-25

Applicant: Benoit Merchez ,  Patrick Brunel ,  Philippe Nerin

Inventor： Benoit Merchez ,  Patrick Brunel ,  Philippe Nerin

IPC: G01J1/58 ,  G01N21/00 ,  G01N21/49

CPC classification number: G01N15/1434 ,  G01N2015/0073 ,  G01N2015/0076 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/1037 ,  G01N2201/1241

Abstract: The invention relaters to a device (100) for biological analysis by measurement of photoluminescence in a fluid in a measurement tank (111). This device (100) comprises at least two light sources (121, 131) adapted to emit in different spectral areas respectively appropriate for measurement of absorption and fluorescence, and a sensor device (140) comprising a sensor (141), an optical system (142), and filter means (144), which three elements are mutualized in accordance with the invention to enable absorption and/or fluorescence to be measured. In accordance with the invention the internal gain of the sensor (141) is configurable to enable the fluorescence and absorption measurements to be executed sequentially.

Abstract translation: 通过测量测量罐（111）中的流体中的光致发光，本发明与用于生物分析的装置（100）相对。 该装置（100）包括适于发射在分别适于测量吸收和荧光的不同光谱区域中的至少两个光源（121,131），以及传感器装置（140），包括传感器（141），光学系统 142）和过滤器装置（144），根据本发明，这三个元件互相互相互相通以使得能够测量吸收和/或荧光。 根据本发明，传感器（141）的内部增益可配置成能够顺序执行荧光和吸收测量。

公开(公告)号：US20110089340A1

公开(公告)日：2011-04-21

申请号：US12997705

申请日：2009-06-25

Applicant: Benoit Merchez ,  Patrick Brunel ,  Philippe Nerin

Inventor： Benoit Merchez ,  Patrick Brunel ,  Philippe Nerin

IPC: G01J1/58 ,  G01N21/00

CPC classification number: G01N15/1434 ,  G01N2015/0073 ,  G01N2015/0076 ,  G01N2015/008 ,  G01N2015/0084 ,  G01N2015/1037 ,  G01N2201/1241

Abstract: The invention relaters to a device (100) for biological analysis by measurement of photoluminescence in a fluid in a measurement tank (111). This device (100) comprises at least two light sources (121, 131) adapted to emit in different spectral areas respectively appropriate for measurement of absorption and fluorescence, and a sensor device (140) comprising a sensor (141), an optical system (142), and filter means (144), which three elements are mutualized in accordance with the invention to enable absorption and/or fluorescence to be measured. In accordance with the invention the internal gain of the sensor (141) is configurable to enable the fluorescence and absorption measurements to be executed sequentially.

Abstract translation: 通过测量测量罐（111）中的流体中的光致发光，本发明与用于生物分析的装置（100）相对。 该装置（100）包括适于发射在分别适于测量吸收和荧光的不同光谱区域中的至少两个光源（121,131），以及传感器装置（140），包括传感器（141），光学系统 142）和过滤器装置（144），根据本发明，这三个元件互相互相互相通以使得能够测量吸收和/或荧光。 根据本发明，传感器（141）的内部增益可配置成能够顺序执行荧光和吸收测量。

公开(公告)号：US20110051131A1

公开(公告)日：2011-03-03

申请号：US12941432

申请日：2010-11-08

Applicant: Koichi TANIGUCHI ,  Masayuki Ochi ,  Shuichi Chikamatsu ,  Shigehisa Nozawa

Inventor： Koichi TANIGUCHI ,  Masayuki Ochi ,  Shuichi Chikamatsu ,  Shigehisa Nozawa

IPC: G01N21/00

CPC classification number: G01N21/9501 ,  G01N2021/8887 ,  G01N2021/8896 ,  G01N2201/1241

Abstract: An inspection device for inspecting defects of an inspection object including a light source for irradiating a luminous flux to the inspection object; an optical system for guiding reflected light from the inspection object; a photoelectric image sensor having a plurality of photoelectric cells arranged, for converting the light guided to detection signals; a detection signal transfer unit having channels each constituted by a signal correction unit, a converter and an image formation unit, and corresponding to each of a plurality of regions formed by dividing the photoelectric image sensor, respectively; and an image synthesis unit for forming an image of the surface of the object by synthesizing partial images outputted; the inspection device inspecting defects of the object by processing the synthesized image; whereby it becomes possible to correct a detection signal from said photoelectric cell close to a predetermined reference target value.

Abstract translation: 一种检查装置，用于检查包括用于向检查对象照射光通量的光源的检查对象的缺陷; 用于引导来自检查对象的反射光的光学系统; 光电图像传感器，其具有布置用于将被引导的光转换成检测信号的多个光电单元; 检测信号传送单元，其具有各自由信号校正单元，转换器和图像形成单元构成的信道，并且分别对应于通过划分光电图像传感器形成的多个区域中的每一个; 以及图像合成单元，用于通过合成输出的部分图像来形成对象的表面的图像; 检查装置通过处理合成图像来检查物体的缺陷; 从而可以将来自所述光电单元的检测信号校正为接近预定的基准目标值。

公开(公告)号：US20090230291A1

公开(公告)日：2009-09-17

申请号：US12388300

申请日：2009-02-18

Applicant: Taku SAKAZUME ,  Kantaro Suzuki

Inventor： Taku SAKAZUME ,  Kantaro Suzuki

IPC: H01J40/14 ,  H01J43/04

CPC classification number: G01N21/76 ,  G01N21/274 ,  G01N2201/1241

Abstract: A photomultiplier tube is susceptible to noise at a low concentration and to saturation at a high concentration. It is necessary to make a measurement with an appropriate intensity of light to provide good reproducibility and linearity. Only adjustment of reagent concentration and constituents are not sufficient to apply the photomultiplier tube to a wide range of concentration.When the sensitivity of the photomultiplier tube is to be adjusted by voltage, measurement is performed under the optimum condition by setting a voltage to be applied suitable for measurement according to a concentration range specified for measurement items and adjusting the voltage based on selected items, previous values for the selected items, diagnostic information, etc.

Abstract translation: 光电倍增管易受低浓度的噪声和高浓度的饱和。 有必要用适当的光强进行测量，以提供良好的重现性和线性度。 只有调整试剂浓度和组分不足以将光电倍增管应用于宽范围的浓度。 当通过电压调节光电倍增管的灵敏度时，通过根据测量项目规定的浓度范围设定适合于测量的适用电压，根据所选择的项目调整电压，在最佳条件下进行测量，以前 所选项目的值，诊断信息等

公开(公告)号：US20070145243A1

公开(公告)日：2007-06-28

申请号：US11426514

申请日：2006-06-26

Applicant: Dmitry Sagatelyan ,  Tor Slettnes

Inventor： Dmitry Sagatelyan ,  Tor Slettnes

IPC: H03F3/08

CPC classification number: G01N21/274 ,  G01J1/42 ,  G01N21/645 ,  G01N2201/1241 ,  H03F3/08 ,  H04N5/235 ,  H04N5/2353 ,  H04N5/2355 ,  H04N5/243 ,  H04N5/35581

Abstract: A photo-detector generated signal is measured as a sample set comprising a long signal and a short signal. The short signal is scaled to the value of the long signal if the long signal exceeds a dynamic range associated with the photo detector. In one embodiment, the short signal is obtained during a short time interval that is at the approximate middle of a long time interval such that the short and long intervals share a common median time value. Given such symmetry, an approximately linear signal yields a proportionality parameter between the long and short signals thereby allowing the short signal to be scaled. The proportionality parameter facilitates determination of an integration independent component of the photo detector signal that should be removed from the measured long and short signals before scaling. A plurality of sample sets can also be processed such that each sample set overlaps with its neighboring sample set, thereby increasing the effective number of sample sets.

公开(公告)号：US20070139531A1

公开(公告)日：2007-06-21

申请号：US11618501

申请日：2006-12-29

Applicant: Dmitry Sagatelyan ,  Tor Slettnes

Inventor： Dmitry Sagatelyan ,  Tor Slettnes

IPC: H03F3/08 ,  H04N5/228

CPC classification number: G01N21/274 ,  G01J1/42 ,  G01N21/645 ,  G01N2201/1241 ,  H03F3/08 ,  H04N5/235 ,  H04N5/2353 ,  H04N5/2355 ,  H04N5/243 ,  H04N5/35581

Abstract: A photo-detector generated signal is measured as a sample set comprising a long signal and a short signal. The short signal is scaled to the value of the long signal if the long signal exceeds a dynamic range associated with the photo detector. In one embodiment, the short signal is obtained during a short time interval that is at the approximate middle of a long time interval such that the short and long intervals share a common median time value. Given such symmetry, an approximately linear signal yields a proportionality parameter between the long and short signals thereby allowing the short signal to be scaled. The proportionality parameter facilitates determination of an integration independent component of the photo detector signal that should be removed from the measured long and short signals before scaling. A plurality of sample sets can also be processed such that each sample set overlaps with its neighboring sample set, thereby increasing the effective number of sample sets.

Abstract translation: 光检测器产生的信号被测量为包括长信号和短信号的样本集。 如果长信号超过与光电检测器相关联的动态范围，则短信号被缩放到长信号的值。 在一个实施例中，在短时间间隔内获得短信号，该短时间间隔在长时间间隔的大致中间处，使得短间隔和长间隔共享公共中值时间值。 给定这种对称性，近似线性的信号在长信号和短信号之间产生比例参数，从而允许短信号被缩放。 比例参数有助于确定光电探测器信号的积分独立分量，该分量在缩放之前应从测量的长信号和短信号中去除。 也可以处理多个样本集，使得每个样本集合与其相邻样本集重叠，从而增加样本集合的有效数量。

公开(公告)号：US20050145780A1

公开(公告)日：2005-07-07

申请号：US11059740

申请日：2005-02-17

Applicant: Dmitry Sagatelyan ,  Tor Slettnes

Inventor： Dmitry Sagatelyan ,  Tor Slettnes

IPC: G01J1/42 ,  G01N21/64 ,  H04N5/235 ,  H04N5/355 ,  H04N5/357 ,  H04N5/372 ,  H01J40/14

CPC classification number: G01N21/274 ,  G01J1/42 ,  G01N21/645 ,  G01N2201/1241 ,  H03F3/08 ,  H04N5/235 ,  H04N5/2353 ,  H04N5/2355 ,  H04N5/243 ,  H04N5/35581

Abstract: A photo-detector generated signal is measured as a sample set comprising a long signal and a short signal. The short signal is scaled to the value of the long signal if the long signal exceeds a dynamic range associated with the photo detector. In one embodiment, the short signal is obtained during a short time interval that is at the approximate middle of a long time interval such that the short and long intervals share a common median time value. Given such symmetry, an approximately linear signal yields a proportionality parameter between the long and short signals thereby allowing the short signal to be scaled. The proportionality parameter facilitates determination of an integration independent component of the photo detector signal that should be removed from the measured long and short signals before scaling. A plurality of sample sets can also be processed such that each sample set overlaps with its neighboring sample set, thereby increasing the effective number of sample sets.

Abstract translation: 光检测器产生的信号被测量为包括长信号和短信号的样本集。 如果长信号超过与光电检测器相关联的动态范围，则短信号被缩放到长信号的值。 在一个实施例中，在短时间间隔内获得短信号，该短时间间隔在长时间间隔的大致中间处，使得短间隔和长间隔共享公共中值时间值。 给定这种对称性，近似线性的信号在长信号和短信号之间产生比例参数，从而允许短信号被缩放。 比例参数有助于确定光电探测器信号的积分独立分量，该分量在缩放之前应从测量的长信号和短信号中去除。 也可以处理多个样本集，使得每个样本集合与其相邻样本集重叠，从而增加样本集合的有效数量。

公开(公告)号：US06310337B1

公开(公告)日：2001-10-30

申请号：US09366247

申请日：1999-08-03

Applicant: Joseph M. Chiapperi ,  Donald M. Josephson ,  Stuart G. MacDonald

Inventor： Joseph M. Chiapperi ,  Donald M. Josephson ,  Stuart G. MacDonald

IPC: G01J132

CPC classification number: G01J3/10 ,  G01N21/274 ,  G01N2021/3174 ,  G01N2201/0694 ,  G01N2201/1241 ,  G01N2201/12776

Abstract: A method of detecting an optical change in a series of test assays producing detectable results at varying efficiencies, the method comprising the steps of: a) selecting a test assay from the series, the selected assay having a known end-point photoresponse efficiency and a known filter center wavelength; b) providing a variable-intensity flash lamp illuminator comprising a lamp, a set of multiple filters with pre-selected center wavelengths assigned to particular assays, and a circuit for activating the lamp and comprising a capacitor, a power source, and a variable output voltage converter connected to the source and having its variable voltage output connected across the capacitor, the lamp and the filters providing a known level of system efficiency as a function of the center wavelength of the filter; c) providing a predetermined relationship of levels of illuminating intensities from the lamp as a function of photoresponse efficiencies of the assays and the system efficiencies, in which the photoresponse efficiencies of the assays are inversely proportional to the lamp intensities and the intensities are proportional to the square of the voltages applied to the lamp; d) selecting from the relationship a voltage applied to the lamp, and hence an intensity of the lamp, that corresponds to the known photoresponse efficiency of the assay selected in step (a) and its system efficiency based upon the filter center wavelength for the assay; and e) thereafter exposing the assay to the selected illuminating intensity.

Abstract translation: 一种检测一系列测试测定中的光学变化的方法，其以不同的效率产生可检测的结果，所述方法包括以下步骤：a）从该系列中选择测试测定，所选择的测定具有已知的终点光响应效率和 已知滤波器中心波长; b）提供可变强度的闪光灯照明器，其包括灯，一组具有分配给特定测定的预选中心波长的多个滤光器，以及用于激活灯的电路，并且包括电容器，电源和可变输出 电压转换器连接到源极并且具有连接在电容器两端的可变电压输出，灯和滤波器提供作为滤波器的中心波长的函数的已知的系统效率水平; c）提供来自灯的照明强度水平的预定关系作为测定的光响应效率和系统效率的函数，其中测定的光响应效率与灯的强度成反比，并且强度与 施加到灯的电压的平方; d）从所述关系中选择对应于步骤（a）中选择的测定的已知光响应效率的灯施加的电压，并因此选择灯的强度，并且基于用于测定的滤波器中心波长的系统效率 ; 和e）然后将测定暴露于所选择的照射强度。

公开(公告)号：US5316727A

公开(公告)日：1994-05-31

申请号：US936079

申请日：1992-08-28

Applicant: Yoshiro Suzuki ,  Hitoshi Tanaka ,  Noriyuki Kurihara ,  Yutaka Saito

Inventor： Yoshiro Suzuki ,  Hitoshi Tanaka ,  Noriyuki Kurihara ,  Yutaka Saito

IPC: G01N21/01 ,  G01N21/27 ,  G01N21/78 ,  G01N21/86

CPC classification number: G01N21/8483 ,  G01N21/272 ,  G01N2021/478 ,  G01N21/78 ,  G01N2201/0256 ,  G01N2201/1241 ,  G01N2201/126

Abstract: A measuring apparatus of the present invention measures the constituent concentration of a specimen after loading into the apparatus a test piece having a test material which develops coloring as a result of a reaction with the constituents of a specimen. When the apparatus detects that the test piece having the test material has been loaded, it automatically begins to measure the constituent concentration of the specimen. That is, after the loading of the test piece is detected, a predetermined time period is measured. During this time measurement, the time period is displayed at a predetermined time interval. After the time measurement of this predetermined time period is terminated, the test material is irradiated with a light, and the intensity of the light from the test material is detected. The constituent concentration of the specimen applied to the test material can be determined on the basis of the reflected light intensity thus detected. Furthermore, this measuring apparatus can detect a reverse insertion of a test piece, and is constructed so as to disable the measurement of the constituent concentration of a specimen if supplementary information to be stored along with measurement information has not been set.

Abstract translation: 本发明的测量装置测量在装入装置之后的样品的成分浓度，该试片具有由于与试样的组分的反应而产生着色的试验材料。 当设备检测到具有测试材料的测试件已经被加载时，其自动开始测量样品的组分浓度。 也就是说，在检测到试件的加载之后，测量预定时间段。 在该时间测量期间，以预定的时间间隔显示时间段。 在该预定时间段的时间测量结束之后，用光照射测试材料，并且检测来自测试材料的光的强度。 可以基于这样检测的反射光强度来确定施加到测试材料上的试样的组分浓度。 此外，该测量装置可以检测试件的反向插入，并且构造成如果尚未设置要与存储的补充信息一起设置的样本的成分浓度的测量，则不能进行测量。