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公开(公告)号：US20220098598A1
公开(公告)日：2022-03-31
申请号：US17552720
申请日：2021-12-16
发明人： Tamir TULLER , Hadas ZUR , Rachel COHEN-KUPIEC
IPC分类号： C12N15/67 , C12Q1/6809 , C12N15/79
摘要： Genetically modified cells with at least one codon substituted to a synonymous codon, and with modified replicative fitness as compared to the unmodified cell, wherein a slower translating synonymous codon increases replicative fitness and a faster translating codon decreased replicative fitness are provided. Further, vaccine composition comprising those cells as well as methods for modifying replicative fitness of a cell are provided.
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公开(公告)号：US11275083B2
公开(公告)日：2022-03-15
申请号：US16240839
申请日：2019-01-07
发明人： Ady Arie , Amos Danielli
IPC分类号： G01N33/543 , G01N21/17 , G01N21/64 , G01N33/58 , C12Q1/6818
摘要： A method of detecting a target within a population of molecules comprising: contacting a plurality of labeled probe molecules with the population of molecules potentially containing a target of the probe molecules; acquiring a probe specific signal emitted by said labeled probe molecules that bound to said target together with a background signal; preferentially modulating said probe specific signal by at least one of modulating said acquisition and modulating an emission of said probe specific signal; and detecting said probe specific signal over said background signal using said preferential modulation.
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公开(公告)号：US20220073733A1
公开(公告)日：2022-03-10
申请号：US17416766
申请日：2019-12-26
发明人： Reshef TENNE , Hila SHALOM , Noa LACHMAN SENESH
IPC分类号： C08L67/04 , B29C64/118 , B29C71/02
摘要： This invention is directed to nanocomposite comprising biodegradable polymers and inorganic nanoparticles or nanotubes, methods of preparation and uses thereof.
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公开(公告)号：US20220030866A1
公开(公告)日：2022-02-03
申请号：US17503581
申请日：2021-10-18
申请人： The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organization , Ramot at Tel-Aviv University Ltd. , Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
发明人： Einat SADOT , Roy WEINSTAIN , Joseph RIOV , Leor ESHED-WILLIAMS
摘要： Described herein are methods of enhancing formation and/or growth of an adventitious root in a plant and/or plant tissue, and/or for promoting grafting unification, enhancing fruit size and/or reducing flowering in a plant. The method comprises contacting at least a portion of the plant and/or plant tissue with a compound having Formula I: wherein X, Y and R1-R7 are as defined herein. Further described are compositions for enhancing formation and/or growth of an adventitious root in a plant and/or plant tissue, and/or for promoting grafting unification, enhancing fruit size and/or reducing flowering in a plant, comprising the abovementioned compound and a horticulturally acceptable carrier. Novel compounds having Formula I are also described herein.
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公开(公告)号：US20220010287A1
公开(公告)日：2022-01-13
申请号：US17467265
申请日：2021-09-05
发明人： Tamir TULLER , Eli GOZ , Shimshi ATAR , Hadas ZUR
摘要： Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.
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公开(公告)号：US20210395723A1
公开(公告)日：2021-12-23
申请号：US17444239
申请日：2021-08-02
发明人： Alexander Golberg , Arthur Robin
IPC分类号： C12N13/00 , C07K1/36 , C07K4/08 , C07K1/24 , C07K1/22 , B01D11/02 , C07K1/12 , C07K14/405 , C12M1/00
摘要： A method for improving a cell biomass includes de-ashing the cell biomass by applying pulsed electric field (PEF)- or constant electric field (CEF)-treatment to the cell biomass in a solvent, optionally under pressure higher than the ambient pressure, to thereby extract an ash fraction from the cell biomass into the solvent.
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公开(公告)号：US20210381022A1
公开(公告)日：2021-12-09
申请号：US17345248
申请日：2021-06-11
发明人： Ehud GAZIT , Dana LAOR
IPC分类号： C12Q1/02 , G01N33/569 , G01N33/50 , A61K49/00 , A61K31/122 , A61K31/353
摘要： The invention relates to in vivo systems and high throughput screening platform for drugs applicable in inborn error of metabolism (IEM) disorders. More specifically, the invention provides yeast screening system of candidate therapeutic compounds applicable in IEM disorders associated with accumulation of at least one metabolite. The systems of the invention comprise yeast cell/s that carry at least one manipulation in at least one yeast metabolic pathway, that leads to accumulation of said metabolite.
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公开(公告)号：US11193888B2
公开(公告)日：2021-12-07
申请号：US16499285
申请日：2018-03-29
发明人： Fernando Patolsky , Vadim Krivitsky
摘要： A system featuring a substrate and a multiplicity of nanostructures arranged on the substrate is provided. At least one portion of the nanostructures feature a capturing moiety covalently attached to a surface thereof and at least another portion of the nanostructures, which can be the same or different from the first portion, feature a light-activatable moiety covalently attached to a surface thereof. The capturing moiety is such that selectively interacts with an analyte, and the light-activatable moiety generates, upon exposure to light, a reactive moiety that interferes with an interaction of the capturing moiety and the analyte. Further provided are systems featuring a substrate and a multiplicity of nanostructures aligned generally vertically to the substrate, at least a portion of these nanostructures being branched nanostructures. Uses of the systems in extracting, and optionally identifying, the analyte from a sample are also provided.
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公开(公告)号：US11185572B2
公开(公告)日：2021-11-30
申请号：US16047129
申请日：2018-07-27
发明人： Avinoam Kadouri , Avihay Bar-Ilan , Eldad Melamed , Daniel Offen , Ofer Sadan , Merav Bahat-Stromza
摘要： An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generating same and uses of same are also disclosed.
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公开(公告)号：US11179482B2
公开(公告)日：2021-11-23
申请号：US16850333
申请日：2020-04-16
发明人： Doron Shabat , Ronit Satchi-Fainaro , Nir Hananya , Ori Green , Tal Eilon
IPC分类号： A61K49/00 , C07F5/04 , C07D321/00 , C09K11/06 , C07F9/655 , C07H15/26 , C09B11/24 , C09B23/04 , C09B23/08 , C07F9/12 , C09B23/01 , C07F5/02 , C07H15/203 , C07F7/18
摘要： The present invention provides dioxetane-based chemiluminescence probes, more specifically fluorophore-tethered dioxetane-based chemiluminescence probes and compositions thereof. The chemiluminescence probes disclosed are useful for both diagnostics and in vivo imaging.
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