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    HORIZONTAL FLUID FLOW BIOREACTOR FOR CANCER RESEARCH
    43.
    发明公开
    HORIZONTAL FLUID FLOW BIOREACTOR FOR CANCER RESEARCH 审中-公开

    公开(公告)号：US20230357694A1

    公开(公告)日：2023-11-09

    申请号：US18300178

    申请日：2023-04-13

    申请人： NDSU RESEARCH FOUNDATION

    发明人： DINESH RAMANATH KATTI ,  KALPANA S. KATTI ,  HANEESH JASUJA

    IPC分类号： C12M1/00 ,  C12M1/12 ,  C12M3/00

    CPC分类号： C12M29/12 ,  C12M29/20 ,  C12M25/14 ,  C12M23/46

    摘要： A horizontal flow bioreactor facilitates continuous flow conditions to cells grown on a tissue engineered scaffold. More particularly, interstitial fluid flow conditions are mimicked around cells inside the body, thereby improving the mass transfer rates of cells and providing physical stimulus to the cells. Unlike the available perfusion based vertical bioreactors where flow is vertical through scaffolds, the horizontal flow reactor enables studies on attachment of cells to substrates, tissues, and bone mimetic scaffolds. The horizontal bioreactor further aides study of cell proliferation, cell migration, cell clustering, biology of cell growth, cell response, cell filtration techniques for capturing tumor cells, the testing of drugs, and drug delivery under flow conditions. The horizontal bioreactor can mimic in vivo conditions, epithelial to mesenchymal transition (EMT), and mesenchymal to epithelial transition (MET).

    AMPHIPHILIC SILOXANE-POLYURETHANE FOULING-RELEASE COATINGS AND USES THEREOF
    45.
    发明申请
    AMPHIPHILIC SILOXANE-POLYURETHANE FOULING-RELEASE COATINGS AND USES THEREOF 有权

    公开(公告)号：US20210348021A1

    公开(公告)日：2021-11-11

    申请号：US17191035

    申请日：2021-03-03

    申请人： NDSU RESEARCH FOUNDATION

    发明人： Dean C. WEBSTER ,  Alireza RAHIMI

    IPC分类号： C09D175/08 ,  C08G18/62 ,  C08G18/72 ,  C08G18/75 ,  C08G18/79 ,  C08G18/80 ,  C08G18/28 ,  C09D175/04 ,  C09D5/16

    摘要： The invention is directed to curable polyurethane coating compositions which may be used to form fouling release coatings, e.g., for use in protecting boat hulls. A curable coating composition of the invention comprises a) at least one amphiphilic additive; b) at least one polyisocyanate; c) at least one polyol; and d) optionally, at least one amphiphilic PEG-PDMS isocyanate prepolymer. Another curable coating composition of the invention comprises the at least one polyisocyanate, b), the at least one polyol, c), and the at least one amphiphilic PEG-PDMS isocyanate prepolymer, d). The invention further relates to methods for reducing or preventing biofouling of a surface exposed to an aqueous environment comprising the steps of coating the surface with the curable coating compositions of the invention to form a coated surface, and curing the coating composition on the coated surface.

    ACETOACETYLATED AND (METH)ACRYLATED RESIN COMPOSITIONS AND THERMOSETS AND FOAMS THEREFROM
    46.
    发明申请
    ACETOACETYLATED AND (METH)ACRYLATED RESIN COMPOSITIONS AND THERMOSETS AND FOAMS THEREFROM 有权

    公开(公告)号：US20210171720A1

    公开(公告)日：2021-06-10

    申请号：US17106866

    申请日：2020-11-30

    申请人： NDSU RESEARCH FOUNDATION

    发明人： Dean C. WEBSTER ,  Eric M. KRALL ,  Kelly M. SUTKO ,  Alexander T. HART ,  Karan BANSAL ,  Mohiuddin QUADIR

    IPC分类号： C08H7/00 ,  C08L97/00 ,  C08J9/14

    摘要： The invention relates to acetoacetylated lignin resin compositions comprising the reaction product of lignin and an acetoacetate ester. The invention also relates to (meth)acrylated lignin resin compositions comprising the reaction product of lignin and a (meth)acrylic compound. The invention also relates to methods of making the acetoacetylated and (meth)acrylated lignin resin compositions. The invention also relates to curable coating compositions comprising the acetoacetylated and (meth)acrylated lignin resin compositions. The invention also relates to methods of making the curable coating compositions of the invention. The invention also relates to methods of applying curable coating compositions of the invention to substrates. The invention also relates to articles of manufacture comprising a curable coating composition of the invention and a method of making such article. The invention also relates to foam materials comprising the reaction product of an acetoacetylated resin composition, a polyamine compound, and a physical blowing agent and/or a polysiloxane compound.

    Non-isocyanate siloxane-modified glycidyl carbamate resins and coatings containing them
    47.
    发明授权
    Non-isocyanate siloxane-modified glycidyl carbamate resins and coatings containing them 有权

    公开(公告)号：US10759950B2

    公开(公告)日：2020-09-01

    申请号：US16076395

    申请日：2017-02-28

    申请人： NDSU RESEARCH FOUNDATION

    发明人： Dean C. Webster ,  Madhura Pade

    IPC分类号： C09D5/16 ,  C09D183/10 ,  C08G77/455 ,  C08G77/08 ,  C08G77/388 ,  C09D183/08 ,  C08G77/00

    摘要： This invention relates to novel non-isocyanate siloxane-modified glycidol carbamate (GC) resins and coating compositions containing them. The non-isocyanate siloxane modified GC resins of the invention comprise the reaction product of at least one organic polyisocyanate, glycidol, and at least one bis(hydroxyl alkyl)-terminated polydimethylsiloxane. The coating compositions of the invention comprise at least one non-isocyanate siloxane modified GC resin of the invention and at least one curing agent. The invention also relates to methods of making the resins of the invention and coatings containing them. The invention also relates to a fouling-release (FR) coating system comprising the coating compositions of the invention and methods of applying said FR coating systems to substrates. The invention also relates to articles of manufacture comprising a coating composition of the invention and a method of making such articles.

    Bio-based resins with high content of ethylenically unsaturated functional groups and thermosets thereof
    49.
    发明授权
    Bio-based resins with high content of ethylenically unsaturated functional groups and thermosets thereof 有权

    公开(公告)号：US10323119B2

    公开(公告)日：2019-06-18

    申请号：US15034312

    申请日：2014-11-07

    申请人： NDSU RESEARCH FOUNDATION

    发明人： Dean C. Webster ,  Lindsey Bultema ,  Jingling Yan

    IPC分类号： C09D147/00 ,  C08G59/17 ,  C08F290/06 ,  C08G65/22 ,  C08G65/26 ,  C08F290/04 ,  C08G59/32

    摘要： The invention provides poiyfunctionai bio-based methacrylate oligomers, which are synthesized via the ring-opening reaction between at least one ethyienicaliy unsaturated acid selected from methacrylic acid, acrylic acid, and crotonic acid, and a poiyfunctionai bio-based epoxy resin, such as epoxidized sucrose soyate. The extent of reaction may be varied to generate a family of methacrylate oligomers with differing degrees of methacryiation. These methacrylate oligomers can optionally be mixed with a reactive diluent, such as styrene, and cured using, for example, a thermally-activated free radical initiator to form a thermoset polymer with high modulus. The thermosets can be used to form composites, adhesives, coatings, and dental restorative materials. Methods of making the methacrylate oligomers are disclosed as are coating compositions and coated objects, such as dental restorative materials, using the methacrylate oligomers.