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41.发明授权公开(公告)号：US10591497B2
公开(公告)日：2020-03-17
申请号：US14723609
申请日：2015-05-28
Applicant: Randox Laboratories Limited
Inventor： Ivan McConnell , Elouard Benchikh , Philip Lowry , Peter Fitzgerald
IPC: G01N33/94 , A61K39/385 , C07D231/56 , C07K16/44
Abstract: An immunoassay method for detecting and determining adamantane substituted indazole and indole synthetic cannabinoids is described. Also described are components for use in implementing the method, namely, antibodies, detection agents, solid state devices and kits as well as immunogens used to raise the antibodies.
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公开(公告)号：US09863966B2
公开(公告)日：2018-01-09
申请号：US14048325
申请日：2013-10-08
Applicant: Randox Laboratories Limited
Inventor： Ivan McConnell , Elouard Benchikh , Philip Lowry , Peter Fitzgerald
CPC classification number: G01N33/94 , A61K47/643 , A61K47/646 , C07K16/44 , C07K2317/33
Abstract: The invention provides novel haptens and immunogens for the preparation of novel monoclonal antibodies, which detect the synthetic opioid meperidine and its active metabolite normeperidine. These antibodies enable methods and kits, which are useful in an immunoassay for therapeutic drug monitoring (TDM) and in extending the window of detection for cases of abuse and drug-facilitated sexual assault (DFSA).
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公开(公告)号：US09784752B2
公开(公告)日：2017-10-10
申请号：US13861093
申请日：2013-04-11
Applicant: Randox Laboratories, Limited
Inventor： Elouard Benchikh , Ivan McConnell , Philip Lowry , Peter Fitzgerald
IPC: G01N33/94 , C07C217/64
CPC classification number: G01N33/9466 , C07C217/64
Abstract: The invention describes antibodies that bind venlafaxine and O-desmethylvenlafaxine. The antibodies are derived from novel haptens and immunogens and are used in methods and kits to detect and quantify venlafaxine and O-desmethylvenlafaxine. The invention also describes novel detecting agents which can be used in the methods and kits of the invention.
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公开(公告)号：US09720005B2
公开(公告)日：2017-08-01
申请号：US14723724
申请日：2015-05-28
Applicant: Randox Laboratories Limited
Inventor： Ivan Robert McConnell , Elouard Benchikh , Peter Fitzgerald , Andrew Philip Lowry
CPC classification number: G01N33/94 , C07K16/44 , C07K2317/30 , C07K2317/33 , G01N33/946 , G01N2430/00
Abstract: An immunoassay method for detecting and determining ‘NBOMe’ family designer drugs is described. Also described are components for use in implementing the method, namely, antibodies, detection agents, solid state devices and kits as well as immunogens used to raise the antibodies.
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公开(公告)号：US20170184611A1
公开(公告)日：2017-06-29
申请号：US15457297
申请日：2017-03-13
Applicant: Randox Laboratories Ltd.
Inventor： John Lamont , Ivan Mc Connell , Peter Fitzgerald
IPC: G01N33/68
CPC classification number: G01N33/6893 , C12Q1/6883 , C12Q2600/158 , G01N33/6842 , G01N2333/4737 , G01N2333/5412 , G01N2333/70503 , G01N2333/70525 , G01N2333/70542 , G01N2333/70564 , G01N2333/7151 , G01N2800/2871 , G01N2800/32 , G01N2800/60
Abstract: The present invention provides biomarker-based methods for diagnosing stroke in a patient suspected of having suffered a stroke, and also for discriminating between ischemic stroke and transient ischemic attack. Substrates comprising probes for specific combinations of biomarkers useful in the methods of the invention are also described.
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Patent Agency Ranking
公开(公告)号：US09587035B2
公开(公告)日：2017-03-07
申请号：US13932087
申请日：2013-07-01
Applicant: Randox Laboratories Limited
Inventor： Elouard Benchikh , Ivan McConnell , Philip Lowry , Peter Fitzgerald
IPC: C07K16/44 , C07D295/096
CPC classification number: C07K16/44 , C07D295/096 , C07K2317/33 , C07K2317/76 , C07K2317/90
Abstract: The invention relates to the detection and quantification of 1-benzylpiperazine and its metabolites. The invention is underpinned by novel polyclonal antibodies with unique binding properties which enable immunoassay methods and kits for various applications.
Abstract translation: 本发明涉及1-苄基哌嗪及其代谢物的检测和定量。 本发明由具有独特结合特性的新型多克隆抗体支持，其能够进行各种应用的免疫测定方法和试剂盒。
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公开(公告)号：US20140147859A1
公开(公告)日：2014-05-29
申请号：US13861093
申请日：2013-04-11
Applicant: Randox Laboratories, Limited
Inventor： Elouard Benchikh , Ivan McConnell , Philip Lowry , Peter Fitzgerald
IPC: G01N33/94 , C07C217/64
CPC classification number: G01N33/9466 , C07C217/64
Abstract: The invention describes antibodies that bind venlafaxine and O-desmethylvenlafaxine. The antibodies are derived from novel haptens and immunogens and are used in methods and kits to detect and quantify venlafaxine and O-desmethylvenlafaxine. The invention also describes novel detecting agents which can be used in the methods and kits of the invention.
Abstract translation: 本发明描述了结合文拉法辛和O-去甲基文拉法辛的抗体。 抗体衍生自新型半抗原和免疫原，并用于方法和试剂盒中以检测和定量文拉法辛和O-去甲基文拉法辛。 本发明还描述了可用于本发明的方法和试剂盒中的新型检测剂。
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公开(公告)号：US12246323B2
公开(公告)日：2025-03-11
申请号：US17602826
申请日：2020-04-09
Applicant: RANDOX LABORATORIES LTD
Inventor： Marc Wharry , Martin Reid , Peter Fitzgerald
Abstract: An assay cartridge for use in a molecular diagnostics assay having an assay region; a first end comprising a first engagement member for engaging with a support housing; and a second end comprising a second engagement member for engaging with a support housing. The second engagement member has a clip, the clip being formed by a resilient element extending from the second end of the cartridge and a fastening element extending from said resilient element. The clip has a release element extending from the resilient element actuatable to release the clip from a caddy in use.
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公开(公告)号：US12214102B2
公开(公告)日：2025-02-04
申请号：US17602853
申请日：2020-04-09
Applicant: RANDOX LABORATORIES LTD
Inventor： Catherine McCooke , Peter Fitzgerald
Abstract: There is provided a sterilisation monitoring device for a molecular diagnostics analyser. The device comprises a sensor arranged in use to detect radiation; and an analysis unit connected to the sensor. The analysis unit is arranged in use to issue a signal when the radiation level incident on the sensor is lower than a threshold level.
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公开(公告)号：US20220160921A1
公开(公告)日：2022-05-26
申请号：US17602853
申请日：2020-04-09
Applicant: RANDOX LABORATORIES LTD
Inventor： Catherine McCooke , Peter Fitzgerald
Abstract: There is provided a sterilisation monitoring device for a molecular diagnostics analyser. The device comprises a sensor arranged in use to detect radiation; and an analysis unit connected to the sensor. The analysis unit is arranged in use to issue a signal when the radiation level incident on the sensor is lower than a threshold level.
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