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公开(公告)号：US6103169A
公开(公告)日：2000-08-15
申请号：US153134
申请日：1998-09-15
Applicant: Gregory Mathus , Paul M. Szlosek , William J. Lacey
Inventor： Gregory Mathus , Paul M. Szlosek , William J. Lacey
IPC: G01N1/00 , B01L3/00 , B29C45/14 , B29D99/00 , B29K105/32 , B29L22/00 , B29L31/00 , B32B27/30 , C08L27/12 , C12M1/32 , G01N1/10 , G01N21/03 , G01N21/25 , G01N21/33
CPC classification number: B01L3/5085 , B29C45/1418 , B29C45/14344 , B29C45/14778 , G01N21/03 , G01N21/25 , G01N21/33 , B01L2300/0829 , B01L2300/12
Abstract: Microplates and methods for manufacturing microplates. The microplate is designed to allow UV radiation to pass through the bottom wells of the microplate so that the microplate can be used for assaying samples by use of UV absorbance. In one embodiment, the microplate comprises at least first and second wells, each well having a UV permeable bottom. In another embodiment, the microplate comprises a frame having an upper portion and a lower portion contiguous with the upper portion and a sheet disposed between the upper portion and the lower portion and defining the bottom of at least one well of the microplate. One embodiment of the method includes steps of inserting a sheet of UV permeable material into a mold cavity that includes sections shaped to form the sidewalls of the plurality of wells, injecting molten plastic material into the mold cavity, and cooling the plastic material to form the microplate with the plastic material forming the sidewalls of each of the first and second wells and the sheet of UV permeable material forming the bottom of each of the first and second wells. Another embodiment of the method includes providing an upper plate defining sidewalls of at least one well, adhering an intermediate layer to the upper plate and adhering a sheet of UV permeable material to the intermediate layer. A further embodiment of the method includes inserting a sheet of material having at least one hole into a mold cavity, injecting a molten plastic material into the mold cavity and cooling the plastic material to form a microplate.
Abstract translation: 微孔板和微孔板制造方法。 微孔板被设计成允许紫外线辐射通过微板的底部孔，使得微孔板可以用于通过使用UV吸光度来测定样品。 在一个实施方案中，微板包括至少第一和第二孔，每个孔具有可UV透过的底部。 在另一个实施例中，微孔板包括具有与上部邻接的上部和下部的框架，以及设置在上部和下部之间并限定微板的至少一个孔的底部的框架。 该方法的一个实施例包括以下步骤：将一片UV可渗透材料插入到模腔中，该模腔包括成形为形成多个孔的侧壁的部分，将熔融的塑料材料注入模腔中，并冷却塑料材料以形成 微板与塑料材料形成第一和第二阱中的每一个的侧壁以及形成第一和第二孔中每一个的底部的UV透过材料片。 该方法的另一实施例包括提供限定至少一个阱的侧壁的上板，将中间层粘附到上板并将一片UV可渗透材料粘合到中间层。 该方法的另一实施例包括将具有至少一个孔的材料片插入模腔中，将熔融的塑料材料注入模腔并冷却塑料以形成微板。
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公开(公告)号：US5759851A
公开(公告)日：1998-06-02
申请号：US510852
申请日：1995-08-03
Applicant: Gregory Mathus
Inventor： Gregory Mathus
CPC classification number: C12M25/04 , Y10S435/809
Abstract: A device and method for growing tissue or cells on both sides of a membrane includes a cylindrical body which may be stood on either end in a culture well. A frame is slidably mounted in the body and carries a membrane, on both sides of which tissue or cells are to be grown. A tissue or cell sample is placed on the upper surface of the membrane and media is supplied to the well on the outside of the body. Passages at the bottom of the body allow the media to flow to the membrane and nurture the sample to cause its growth. When the first monolayer is grown, the body is inverted and the frame is pushed to the other end of the body, preferably by a jig supplied for that purpose. A second cell sample is deposited on the other side of the membrane, again on top of the membrane and it is nurtured by media supplied primarily from the reservoir on top and secondarily through the membrane.
Abstract translation: 用于在膜的两侧生长组织或细胞的装置和方法包括可以位于培养井中的任一端的圆柱体。 框架可滑动地安装在主体中并且在其组织或细胞将要生长的两侧上承载膜。 将组织或细胞样品放置在膜的上表面上，并将介质提供给身体外部的孔。 身体底部的通道允许介质流到膜上并培养样品以使其生长。 当第一单层生长时，主体被倒置并且框架被推动到主体的另一端，优选地通过为此目的提供的夹具。 第二个细胞样品沉积在膜的另一侧，再次沉积在膜的顶部，并且由主要从储存器供应的介质在上部和第二次通过膜培养。
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公开(公告)号：US5508005A
公开(公告)日：1996-04-16
申请号：US142520
申请日：1993-10-26
Applicant: Gregory Mathus
Inventor： Gregory Mathus
CPC classification number: B01L3/5085 , C12M23/12
Abstract: A laboratory article, and in particular a cluster plate is provided including a plurality of wells supported by a structural framework including a peripheral wall. At locations in the structural framework a plurality of protrusions are provided so as to support the cluster plate on a support surface, such as a benchtop, in a point-to-point manner. Such point-to-point support allows the article to be moved across the support surface without the generation of unpleasant audible vibrations. According to a preferred embodiment, a cluster plate having protrusions extending from the lower edge of a peripheral wall is provided.
Abstract translation: 提供实验室物品，特别是集群板，其包括由包括周壁的结构框架支撑的多个井。 在结构框架中的位置处，设置有多个突起，以便以点对点方式将簇板支撑在诸如台面的支撑表面上。 这种点对点支撑允许物品跨过支撑表面移动，而不会产生不愉快的可听见的振动。 根据优选实施例，提供了具有从周壁的下边缘延伸的突起的簇板。
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公开(公告)号：US4683058A
公开(公告)日：1987-07-28
申请号：US841583
申请日：1986-03-20
Applicant: George F. Lyman , Gregory Mathus
Inventor： George F. Lyman , Gregory Mathus
CPC classification number: B01L3/5021 , B01D33/15 , B04B5/0414 , B01D2201/285
Abstract: A filter for a centrifuge tube including a pressure filter for separating a mixture under centrifugal force. The filter tube is adapted to fit within the upper portion of a standard plastic centrifuge tube. The filter tube has a pressure filter at its lower end and an opening at its upper end adapted to be sealed by a cap extending from the centrifuge tube to hold the filter tube securely in position within the centrifuge tube. The filter tube is filled with a mixture of permeable and non-permeable materials and when the composite centrifuge tube and filter tube is spun in the centrifuge, the centrifugal force causes the permeable materials to flow through the filter and collect in the bottom of the centrifuge tube while the non-permeable materials are retained in the filter tube.
Abstract translation: 一种用于离心管的过滤器，包括用于在离心力下分离混合物的压力过滤器。 过滤管适于装配在标准塑料离心管的上部。 过滤管在其下端具有压力过滤器，其上端的开口适于由从离心管延伸的盖密封，以将过滤管牢固地固定在离心管内的适当位置。 过滤管填充有可渗透和不可渗透材料的混合物，当复合离心管和过滤管在离心机中旋转时，离心力使渗透材料流过过滤器并收集在离心机的底部 而不可渗透的材料保留在过滤管中。
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公开(公告)号：USD245300S
公开(公告)日：1977-08-09
申请号：US672780
申请日：1976-04-01
Applicant: Gregory Mathus , George Lyman , David Roche
Designer： Gregory Mathus , George Lyman , David Roche
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Patent Agency Ranking
公开(公告)号：US4015790A
公开(公告)日：1977-04-05
申请号：US602076
申请日：1975-08-05
Applicant: Anthony L. Gelardi , Gregory Mathus
Inventor： Anthony L. Gelardi , Gregory Mathus
CPC classification number: G11B23/07
Abstract: A cartridge for an endless magnetic tape with a reel having (1) a tape deck and an upwardly and inwardly tapered column with a wide cap to support the tape on the deck; (2) ribs and openings in the deck to crown the tape on the deck and allow particles to drop below the deck; (3) a tapered cam post to support the tape loop at one end across its width at the front of the cartridge; (4) a contoured pressure pad to support the tape loop at the front of the cartridge; (5) a guide to support the tape loop at an angle between the deck and cam post; and (6) supports for retaining the convolutions of tape on the deck and the loop when it becomes slack.
Abstract translation: 一种用于具有卷轴的环形磁带的盒，具有（1）带甲板和具有宽帽的向上和向内锥形的支架，以将带支撑在甲板上; （2）甲板上的肋骨和开口，以使甲板上的胶带冠上，并允许颗粒落在甲板下面; （3）锥形凸轮柱，以在其一端横跨其在盒的前部的宽度支撑带环; （4）成形压力垫，用于支撑盒的前部的带环; （5）用于以甲板和凸轮柱之间的角度支撑磁带环的引导件; 和（6）支撑用于在松弛时将带子的卷圈保持在甲板和环上。
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公开(公告)号：US08501118B2
公开(公告)日：2013-08-06
申请号：US12578714
申请日：2009-10-14
Applicant: Gregory Mathus , Terrence Kelly , Richard Cote
Inventor： Gregory Mathus , Terrence Kelly , Richard Cote
IPC: B01L3/02
CPC classification number: B01L3/0217 , B01L3/0275 , B01L3/0279 , B01L2200/023 , B01L2200/025 , B01L2200/0689 , B01L2200/087 , B01L2300/027 , Y10T137/0318 , Y10T436/2575
Abstract: A disposable pipette tip having that is configured to mount on a tip mounting shaft having a locking section and a separate sealing section. The locking section has outwardly extending locking lobes circumferentially spaced around the mounting shaft and located above a stop member that separates the lower sealing section from the upper locking section. The collar flexes out of round when it is mounted over the locking lobes on the mounting shaft. The circumferential shelf on the tip isolates the tip barrel from distortion to enable robust sealing in the barrel below the shelf.
Abstract translation: 具有该移液管尖头的一次性移液管尖端配置成安装在具有锁定部分和单独的密封部分的尖端安装轴上。 锁定部分具有沿安装轴周向间隔开的向外延伸的锁定凸角，并且位于将下部密封部分与上部锁定部分分离的止挡部件上方。 当套环安装在安装轴上的锁定凸角上时，套环会弹出。 尖端的圆周架子将尖端筒体分离，以防止变形，从而能够在机架下方的筒体上牢固地密封。
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公开(公告)号：US08029742B2
公开(公告)日：2011-10-04
申请号：US12115005
申请日：2008-05-05
Applicant: David E. Butz , Gregory Mathus , Richard Cote , George P. Kalmakis
Inventor： David E. Butz , Gregory Mathus , Richard Cote , George P. Kalmakis
CPC classification number: B01L3/0237 , B01L3/0217 , B01L3/0227 , B01L2200/022
Abstract: A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.
Abstract translation: 手持式多通道移液器具有电子控制电机，用于重新定位不同中心间距的吸头。 每个可重新定位的尖端配件组件具有凸轮跟随销，该凸轮跟随销由马达驱动滚筒中的凸轮轨道驱动。 用于多个抽吸气瓶的固定端口有策略地放置，以简化导向可重新定位的移液管尖端配件组件的柔性管的管理。 移液器具有可以用一只手方便地操作以重新定位移液器吸头的用户界面。 它具有带有正弦剥离器条的移液管尖端喷射机构。
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公开(公告)号：US20110076205A1
公开(公告)日：2011-03-31
申请号：US12568801
申请日：2009-09-29
Applicant: Terrence Kelly , Richard Cote , Gregory Mathus
Inventor： Terrence Kelly , Richard Cote , Gregory Mathus
IPC: B01L3/02
CPC classification number: B01L3/0279 , B01L3/021 , B01L2200/0689 , B01L2200/141 , B01L2400/0487
Abstract: A pipette tip mounting shaft includes outwardly circumferentially extending locking lobes over which the pipette tip collar is mounted. The locking lobes preferably include an inclining ramp portion that gently flexes and distorts the pipette tip collar out-of-round as the mounting shaft is inserted into the pipette tip, rather than the stretching tip collar. Each locking lobe also includes a declining ramp portion which extends upward along the mounting shaft. The peak of the lobes is preferably curved. When the pipette tip is fully mounted on the mounting shaft, a locking ring on the inside surface of the tip collar engages the declining ramp of the lobes to provide an over-center engagement, however, the required ejection force is small.
Abstract translation: 移液管尖端安装轴包括向外周向延伸的锁定凸耳，移液管尖端套环安装在该凸起上。 锁定凸耳优选地包括倾斜斜面部分，当倾斜安装轴插入移液管尖端而不是拉伸尖端套环时，倾斜斜坡部分轻轻地弯曲和扭曲移液管尖端轴环。 每个锁定凸耳还包括沿安装轴向上延伸的下降斜面部分。 裂片的峰最好是弯曲的。 当移液管末端完全安装在安装轴上时，尖端套环的内表面上的锁定环接合凸角的下降斜面以提供过中心接合，然而，所需的弹出力很小。
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公开(公告)号：US07662344B2
公开(公告)日：2010-02-16
申请号：US11934381
申请日：2007-11-02
Applicant: Gregory Mathus , Terrence Kelly , Richard Cote
Inventor： Gregory Mathus , Terrence Kelly , Richard Cote
IPC: B01L3/02
CPC classification number: B01L3/0217 , B01L3/0275 , B01L3/0279 , B01L2200/023 , B01L2200/025 , B01L2200/0689 , B01L2200/087 , B01L2300/027 , Y10T137/0318 , Y10T436/2575
Abstract: The invention relates to a pipette tip mounting shaft configuration and a disposable pipette tip having a matching configuration. The mounting shaft includes a locking section located above a lower sealing section. The locking section has outwardly extending locking lobes circumferentially spaced around the mounting shaft and located above a stop member that separates the lower sealing section from the upper locking section. In certain embodiments, the diameter of the mounting shaft below the stop member is reduced in order to lessen insertion and ejection forces, which is particularly helpful for hand-held multi-channel pipettors. In these embodiments, the lower sealing section contains either a frustoconical sealing section, or an annular groove and a sealing ring, such as a flouroelastomeric O-ring seal.
Abstract translation: 本发明涉及移液器吸头安装轴构造和具有匹配构型的一次性吸头。 安装轴包括位于下密封部分上方的锁定部分。 锁定部分具有沿安装轴周向间隔开的向外延伸的锁定凸角，并且位于将下部密封部分与上部锁定部分分离的止挡部件上方。 在某些实施例中，降低止动件下方的安装轴的直径以减小插入和弹出力，这对手持式多通道移液器特别有帮助。 在这些实施例中，下密封部分包含截头圆锥形密封部分或环形凹槽和密封环，例如光滑弹性O形环密封件。
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