公开(公告)号：US20110260075A1

公开(公告)日：2011-10-27

申请号：US13159304

申请日：2011-06-13

Applicant: Leslie Bromberg ,  Ching Wu

Inventor： Leslie Bromberg ,  Ching Wu

IPC: H01J27/02

CPC classification number: H01J49/147

Abstract: A non-radioactive source for Atmospheric Pressure Ionization is described. The electron-beam sealed tube uses a pyroelectric crystal(s). One end of the crystal is grounded while the other end has a metallic cap with sharp feature to generate an electron beam of a given energy. The rate of heating and/or cooling of the crystal is used to control the current generated from a tube. A heating and/or cooling element such as a Peltier element is useful for controlling the rate of cooling of the crystal. A thin window that is transparent to electrons but impervious to gases is needed in order to prolong the life of the tube and allow the extraction of the electrons. If needed, multiple crystals with independent heaters can be used to provide continuous operation of the device. Dielectric shielding of the pyroelectric crystal is used to minimize discharge of the crystal.

Abstract translation: 描述了用于大气压电离的非放射源。 电子束密封管使用热电晶体。 晶体的一端接地，而另一端具有尖锐特征的金属盖，以产生给定能量的电子束。 使用晶体的加热和/或冷却速度来控制从管产生的电流。 诸如珀尔帖元件的加热和/或冷却元件可用于控制晶体的冷却速率。 需要对电子透明但不透气体的薄窗，以延长管的寿命并允许电子的提取。 如果需要，可以使用具有独立加热器的多个晶体来提供设备的连续操作。 热电晶体的介电​​屏蔽用于使晶体的放电最小化。

公开(公告)号：US20100224776A1

公开(公告)日：2010-09-09

申请号：US12723439

申请日：2010-03-12

Applicant: Ching Wu

Inventor： Ching Wu

IPC: H01J49/26 ,  H01J49/04

CPC classification number: G01N27/622 ,  H01J49/062

Abstract: An ion mobility spectrometer includes a protective housing. A drift tube having at least one inlet and at least one outlet confines a drift gas. An ion gate is positioned in the drift tube. The ion gate defines a reaction region and a drift region in the drift tube. An ion detector is positioned in the drift tube downstream of the ion gate at an end of the drift region. A helical resistive wire coil is positioned around the drift tube. A power supply generates an electric field in the helical resistive wire coil that rapidly controls the temperature of the drift gas.

Abstract translation: 离子迁移谱仪包括保护壳体。 漂移管具有至少一个入口和至少一个出口限制漂移气体。 离子门位于漂移管中。 离子门限定了漂移管中的反应区和漂移区。 离子检测器位于漂移管的漂移区末端的离子门下游。 螺旋电阻线圈位于漂移管周围。 电源在螺旋电阻线圈中产生电场，其迅速地控制漂移气体的温度。

公开(公告)号：US20100200746A1

公开(公告)日：2010-08-12

申请号：US12764808

申请日：2010-04-21

Applicant: Mark A. Osgood ,  Ching Wu

Inventor： Mark A. Osgood ,  Ching Wu

IPC: H01J49/26 ,  H01J49/04

CPC classification number: H01J49/004 ,  C07B63/00 ,  G01N27/622 ,  H01J49/0027 ,  H01J49/0031 ,  H01J49/0495 ,  H01J49/067

Abstract: The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used.

Abstract translation: 本发明涉及提高连字的仪器分析从具有第一仪器对相同样品的分析而受益的样品的能力。 可以将快速切换机制用作离子迁移谱仪（IMS）和质谱仪（MS）之间的界面，使得所获得的IMS光谱被转换成时序图，其在中性分析期间动态地控制真空入口的尺寸， /或带电的化学和/或生物物质，使得可以使用较小的泵送系统。

公开(公告)号：US20100148058A1

公开(公告)日：2010-06-17

申请号：US12577062

申请日：2009-10-09

Applicant: Clinton Alawn Krueger ,  Ching Wu ,  Christopher K. Hilton

Inventor： Clinton Alawn Krueger ,  Ching Wu ,  Christopher K. Hilton

IPC: H01J49/00

CPC classification number: G01N27/622

Abstract: The present invention describes a method and apparatus for separating chemical and/or biological samples based on selective ion-molecular interactions in the gas phase. A chemical modifier is added to the drift gas that interacts selectively with a targeted molecule in at least one component of the sample in a drift tube. The component may be impurities and/or interferences in the sample whereby the chemical modifier enhances sample resolution by shifting the components drift times. In addition, reagents can be added to the sample prior to, during, or after ionization to form a complex with selected components in the sample. In addition, one or more internal and/or external standard can also be added to the sample as a calibration for the measurement.

Abstract translation: 本发明描述了一种基于气相中选择性离子 - 分子相互作用分离化学和/或生物样品的方法和装置。 添加到漂移气体中的化学改性剂，其与漂移管中样品的至少一个组分中的目标分子选择性相互作用。 该组分可以是样品中的杂质和/或干扰物，由此化学改性剂通过移动组分漂移时间来提高样品分辨率。 此外，可以在电离之前，期间或之后将试剂加入到样品中以与样品中所选组分形成复合物。 此外，还可以将一个或多个内部和/或外部标准作为测量的校准添加到样品中。

公开(公告)号：US20100127166A1

公开(公告)日：2010-05-27

申请号：US12695111

申请日：2010-01-27

Applicant: Clinton Alawn Krueger ,  Ching Wu

Inventor： Clinton Alawn Krueger ,  Ching Wu

IPC: B01D59/44 ,  H01J49/00

CPC classification number: G01N27/622

Abstract: The present invention involves a series of shifting reagents that selectively interact with a targeted functional group of biological molecules, pharmaceutical drugs, small molecules, chemicals, chemical agents, or explosives resulting in a structure selective based drift time shift in the IMS. The invention allows detecting and confirming samples using one or more ion mobility based spectrometers.

Abstract translation: 本发明涉及一系列转移试剂，其选择性地与生物分子，药物，小分子，化学品，化学试剂或爆炸物的目标官能团相互作用，导致IMS中基于结构选择性的漂移时间偏移。 本发明允许使用一种或多种基于离子迁移率的光谱仪检测和确认样品。

公开(公告)号：US07696474B2

公开(公告)日：2010-04-13

申请号：US12026192

申请日：2008-02-05

Applicant: Ching Wu ,  Leslie Bromberg

Inventor： Ching Wu ,  Leslie Bromberg

IPC: H01J49/42 ,  H01J49/26 ,  H01J49/10

CPC classification number: G01N27/624

Abstract: The present invention describes apparatuses and methods that provide energy to ions in a non-thermal manner. The elevated ion energy minimizes or eliminates interferences due to clustering with polar molecules, such as water. The energized ions are separated in an ion mobility spectrometer. During the ion transportation and separation process, the elevated energy level of ions prevents them from clustering with neutral molecule inside the spectrometer. The additional electric field component only causes ions to reach elevated energy level, whereby the spectrometer can preserve its normal performance, meanwhile avoiding interference from water and other neutral molecules. A RF electric field is applied to the ions in ionization, reaction and separation region of ion mobility spectrometers.

Abstract translation: 本发明描述了以非热方式向离子提供能量的装置和方法。 升高的离子能量最小化或消除由于与极性分子（例如水）聚集而产生的干扰。 激发离子在离子迁移谱仪中分离。 在离子运输和分离过程中，提高的离子能级防止它们与分光计内部的中性分子聚集。 额外的电场分量仅使离子达到提高的能量水平，由此光谱仪可以保持其正常性能，同时避免水和其他中性分子的干扰。 离子迁移谱仪的电离，反应和分离区域中的离子被施加RF电场。

公开(公告)号：US20100065754A1

公开(公告)日：2010-03-18

申请号：US12251995

申请日：2008-10-15

Applicant: Leslie Bromberg ,  Ching Wu

Inventor： Leslie Bromberg ,  Ching Wu

IPC: H01J27/02

CPC classification number: H01J49/147

Abstract: A non-radioactive source for Atmospheric Pressure Ionization is described. The electron-beam sealed tube uses a pyroelectric crystal(s). One end of the crystal is grounded while the other end has a metallic cap with sharp feature to generate an electron beam of a given energy. The rate of heating and/or cooling of the crystal is used to control the current generated from a tube. A heating and/or cooling element such as a Peltier element is useful for controlling the rate of cooling of the crystal. A thin window that is transparent to electrons but impervious to gases is needed in order to prolong the life of the tube and allow the extraction of the electrons. If needed, multiple crystals with independent heaters can be used to provide continuous operation of the device. The energy of the electrons can be determined through the appropriate choice of the radius of curvature of the sharp feature and the gap between the sharp feature and the window, while the opposite side of the crystal is at low voltage. The size of the gap and the radius of curvature of the sharp feature are determined by the filling gas nature and pressure.

Abstract translation: 描述了用于大气压电离的非放射源。 电子束密封管使用热电晶体。 晶体的一端接地，而另一端具有尖锐特征的金属盖，以产生给定能量的电子束。 使用晶体的加热和/或冷却速度来控制从管产生的电流。 诸如珀尔帖元件的加热和/或冷却元件可用于控制晶体的冷却速率。 需要对电子透明但不透气体的薄窗，以延长管的寿命并允许电子的提取。 如果需要，可以使用具有独立加热器的多个晶体来提供设备的连续操作。 电子的能量可以通过适当选择尖锐特征的曲率半径和尖锐特征与窗口之间的间隙来确定，而晶体的相对侧处于低电压。 尖锐特征的间隙尺寸和曲率半径由填充气体的性质和压力决定。

公开(公告)号：US11417507B2

公开(公告)日：2022-08-16

申请号：US17107481

申请日：2020-11-30

Applicant: Mark A Osgood ,  Ching Wu

Inventor： Mark A Osgood ,  Ching Wu

IPC: H01J49/00 ,  G01N27/622 ,  H01J49/06 ,  C07B63/00 ,  H01J49/04

Abstract: The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used. In various operational modes of the IMS-MS device, mobility-separated ions are allowed to pass through an ion gate and the vacuum inlet for mass analysis.

公开(公告)号：US10794862B2

公开(公告)日：2020-10-06

申请号：US16430324

申请日：2019-06-03

Applicant: Ching Wu

Inventor： Ching Wu

IPC: G01N1/22 ,  G01N27/62 ,  H01J49/00 ,  H01J49/04 ,  H01J49/06 ,  G01N1/40

Abstract: The present invention relates to a preconcentrator for vapors and particles collected from air. The vapor preconcentrator is made from plural layer of coils. The coil is made of resistance alloy. The pitch size of the coil is made to precisely trap/filter out certain size of the particles during preconcentration. Multiple coils could be made with different pitch sizes to achieve multiple step filtrations. When the sample flow enters the preconcentrator chamber, it passes through the coils. The particles of different sizes are trapped on different layer of coils. The vapor sample can be trapped on any coils when interacted with the coil surface. They could be trapped without any affinitive coating as the preconcentrator is at relatively low temperature. Different coils or different sections of the coil can be coated with different material to trap chemicals of different classes. During the desorption process, the coils are flash heated with controlled temperature ramping speed to evaporate the trapped chemicals.

公开(公告)号：US20190285584A1

公开(公告)日：2019-09-19

申请号：US16430324

申请日：2019-06-03

Applicant: Ching Wu

Inventor： Ching Wu

IPC: G01N27/62 ,  H01J49/00 ,  H01J49/06 ,  H01J49/04

Abstract: The present invention relates to a preconcentrator for vapors and particles collected from air. The vapor preconcentrator is made from plural layer of coils. The coil is made of resistance alloy. The pitch size of the coil is made to precisely trap/filter out certain size of the particles during preconcentration. Multiple coils could be made with different pitch sizes to achieve multiple step filtrations. When the sample flow enters the preconcentrator chamber, it passes through the coils. The particles of different sizes are trapped on different layer of coils. The vapor sample can be trapped on any coils when interacted with the coil surface. They could be trapped without any affinitive coating as the preconcentrator is at relatively low temperature. Different coils or different sections of the coil can be coated with different material to trap chemicals of different classes. During the desorption process, the coils are flash heated with controlled temperature ramping speed to evaporate the trapped chemicals.