公开(公告)号：US20070054936A1

公开(公告)日：2007-03-08

申请号：US11360084

申请日：2006-02-23

申请人： Nareshkumar Jain ,  Jiayi Xu ,  Zhihua Sui

发明人： Nareshkumar Jain ,  Jiayi Xu ,  Zhihua Sui

IPC分类号： A61K31/47 ,  C07D215/38

CPC分类号： C07D215/54

摘要： The present invention is directed to novel quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to ion channels such as potassium channels.

摘要翻译： 本发明涉及新颖的喹啉衍生物，含有它们的药物组合物及其在治疗与离子通道如钾通道有关的病症中的用途。

公开(公告)号：US20070054935A1

公开(公告)日：2007-03-08

申请号：US11360726

申请日：2006-02-23

申请人： Nareshkumar Jain ,  Jiayi Xu ,  Zhihua Sui

发明人： Nareshkumar Jain ,  Jiayi Xu ,  Zhihua Sui

IPC分类号： A61K31/4741 ,  A61K31/455 ,  C07D491/02 ,  C07D211/82

CPC分类号： C07D213/48 ,  C07D213/30 ,  C07D213/50 ,  C07D213/57 ,  C07D215/54 ,  C07D491/04 ,  C07F7/1804

摘要： The present invention is directed to novel pyridine derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to ion channels such as potassium channels.

摘要翻译： 本发明涉及新颖的吡啶衍生物，含有它们的药物组合物及其用于治疗与离子通道如钾通道有关的疾病的用途。

公开(公告)号：US07074779B2

公开(公告)日：2006-07-11

申请号：US10612138

申请日：2003-07-02

申请人： Zhihua Sui ,  Xuqing Zhang

发明人： Zhihua Sui ,  Xuqing Zhang

IPC分类号： A61K31/58 ,  C07J71/00

CPC分类号： C07J71/00 ,  A61K31/58 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention is directed to novel estrieno[3,2-b]/[3,4-c]pyrrole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and diseases mediated by an estrogen receptor.

摘要翻译： 本发明涉及新颖的estrieno [3,2-b] / [3,4-c]吡咯衍生物，含有它们的药物组合物及其在治疗由雌激素受体介导的病症和疾病中的用途。

公开(公告)号：US20060111427A1

公开(公告)日：2006-05-25

申请号：US11255444

申请日：2005-10-21

申请人： Weiqin Jiang ,  James Fiordeliso ,  Zhihua Sui

发明人： Weiqin Jiang ,  James Fiordeliso ,  Zhihua Sui

IPC分类号： A61K31/404 ,  C07D209/36

CPC分类号： C07D209/30

摘要： The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment or prevention of disorders and diseases mediated by agonists and antagonists of the progesterone receptor. The clinical uses of these compounds are related to contraception, the treatment and/or prevention of secondary amenorrhea, dysfunctional bleeding, uterine leiomyomata, endometriosis; polycystic ovary syndrome, carcinomas and adenocarcinomas of the endometrium, ovary, breast, colon, prostate, or minication of side effects of cyclid menstrual bleeding. Additional uses of the invention include stimulation of food intake.

摘要翻译： 本发明涉及新颖的吲哚衍生物，含有它们的药物组合物及其在治疗或预防由孕酮受体的激动剂和拮抗剂介导的病症和疾病中的用途。 这些化合物的临床应用与避孕，继发性闭经，功能障碍性出血，子宫平滑肌瘤，子宫内膜异位症的治疗和/或预防有关; 多囊卵巢综合征，子宫内膜癌，卵巢癌，乳腺癌，结肠癌，前列腺癌，腺瘤，子宫内膜异位症，副周围性月经出血副作用。 本发明的额外用途包括刺激食物摄取。

公开(公告)号：US20060111391A1

公开(公告)日：2006-05-25

申请号：US11255361

申请日：2005-10-21

申请人： Weiqin Jiang ,  James J. Fiordeliso ,  Zhihua Sui

发明人： Weiqin Jiang ,  James J. Fiordeliso ,  Zhihua Sui

IPC分类号： A61K31/4745 ,  C07D471/04 ,  C07D471/02

CPC分类号： C07D471/10 ,  C07D471/04

摘要： The present invention is directed to novel heteroatom containing tetracyclic derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders mediated by one or more estrogen receptors. The compounds of the invention are useful in the treatment of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.

公开(公告)号：US20050250740A1

公开(公告)日：2005-11-10

申请号：US11096673

申请日：2005-04-01

申请人： James Lanter ,  Zhihua Sui ,  James Fiordeliso ,  Weiqin Jiang ,  Xuqing Zhang

发明人： James Lanter ,  Zhihua Sui ,  James Fiordeliso ,  Weiqin Jiang ,  Xuqing Zhang

IPC分类号： A61K31/343 ,  A61K31/381 ,  A61K31/405 ,  A61K31/695 ,  C07D209/12

CPC分类号： C07D209/12 ,  C07D405/04

摘要： The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.

摘要翻译： 本发明涉及新的吲哚衍生物，含有它们的药物组合物及其用于治疗由雄激素受体调节的病症和状况。

公开(公告)号：US20050107372A1

公开(公告)日：2005-05-19

申请号：US10953988

申请日：2004-09-29

申请人： James Lanter ,  Zhihua Sui ,  James Fiordeliso

发明人： James Lanter ,  Zhihua Sui ,  James Fiordeliso

IPC分类号： C07D491/153 ,  A61K31/5383 ,  A61K31/542 ,  A61P1/14 ,  A61P5/00 ,  A61P5/28 ,  A61P7/00 ,  A61P13/08 ,  A61P15/10 ,  A61P15/16 ,  A61P17/02 ,  A61P17/14 ,  A61P31/18 ,  A61P35/00 ,  C07D215/22 ,  C07D215/227 ,  C07D498/04 ,  C07D498/06 ,  C07D498/10 ,  C07D513/04 ,  C07D513/06 ,  A61K31/541 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  C07D413/02 ,  C07D417/02 ,  C07D43/02

CPC分类号： C07D215/227 ,  C07D513/04

摘要： The present invention is directed to novel 2-(quinolonyl)-fused heterocyclyl derivatives of the general formula (I) wherein R1, R2, R3, R3a, R4, R5, R6 and R7 are as herein defined, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.

摘要翻译： 本发明涉及通式（I）的2-（喹啉基） - 引入的杂环基衍生物，其中R 1，R 2，R 3， R 3，R 4，R 4，R 5，R 6和R 7， / SUP>如本文所定义，含有它们的药物组合物及其在治疗由雄激素受体调节的病症和状况中的用途。

公开(公告)号：US20050014952A1

公开(公告)日：2005-01-20

申请号：US10866591

申请日：2004-06-12

申请人： Raymond Ng ,  Zhihua Sui

发明人： Raymond Ng ,  Zhihua Sui

IPC分类号： A61P5/26 ,  C07D277/12 ,  C07D417/02 ,  C07D277/18

CPC分类号： C07D277/12

摘要： The present invention is directed to novel thiazoline derivatives of the general formula (I) wherein all variables are as herein defined, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.

摘要翻译： 本发明涉及通式（I）的新型噻唑啉衍生物，其中所有变量如本文所定义，含有它们的药物组合物及其用于治疗由雄激素受体调节的病症和状况。

公开(公告)号：US20050009799A1

公开(公告)日：2005-01-13

申请号：US10858435

申请日：2004-06-01

申请人： Nareshkumar Jain ,  Weigin Jiang ,  Mark Macielag ,  William Murray ,  Raymond Ng ,  Zhihua Sui

发明人： Nareshkumar Jain ,  Weigin Jiang ,  Mark Macielag ,  William Murray ,  Raymond Ng ,  Zhihua Sui

IPC分类号： A61P5/30 ,  C07C37/055 ,  C07C39/17 ,  C07C43/215 ,  C07C43/23 ,  C07C45/69 ,  C07C69/757 ,  C07C217/18 ,  C07D209/04 ,  C07D295/092 ,  A61K31/56

CPC分类号： C07D295/088 ,  C07C29/12 ,  C07C29/60 ,  C07C37/055 ,  C07C39/17 ,  C07C39/23 ,  C07C41/18 ,  C07C41/20 ,  C07C41/22 ,  C07C41/26 ,  C07C41/30 ,  C07C43/215 ,  C07C43/23 ,  C07C45/69 ,  C07C69/757 ,  C07C217/18 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/08 ,  C07C2602/10 ,  C07D209/04 ,  C07C49/683 ,  C07C47/47 ,  C07C43/225 ,  C07C33/38

摘要： The present invention is directed to novel cyclohexyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and diseases mediated by an estrogen receptor.

摘要翻译： 本发明涉及新颖的环己基衍生物，含有它们的药物组合物及其在治疗由雌激素受体介导的病症和疾病中的用途。

公开(公告)号：US20050004090A1

公开(公告)日：2005-01-06

申请号：US10612138

申请日：2003-07-02

申请人： Zhihua Sui ,  Xuqing Zhang

发明人： Zhihua Sui ,  Xuqing Zhang

IPC分类号： A61K31/58 ,  A61K45/06 ,  C07J71/00

CPC分类号： C07J71/00 ,  A61K31/58 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention is directed to novel estrieno[3,2-b]/[3,4-c]pyrrole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and diseases mediated by an estrogen receptor.

摘要翻译： 本发明涉及新颖的estrieno [3,2-b] / [3,4-c]吡咯衍生物，含有它们的药物组合物及其在治疗由雌激素受体介导的病症和疾病中的用途。