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    Electrically anesthetizing a peripheral nerve with on-demand electrical nerve block for chronic pain management
    42.
    发明授权
    Electrically anesthetizing a peripheral nerve with on-demand electrical nerve block for chronic pain management 有权

    公开(公告)号：US11617884B2

    公开(公告)日：2023-04-04

    申请号：US16820035

    申请日：2020-03-16

    申请人： Case Western Reserve University

    发明人： Tina L. Vrabec ,  Kevin L. Kilgore ,  Jesse S. Wainright ,  Niloy Bhadra

    IPC分类号： A61N1/20 ,  A61N1/05

    摘要： Chronic pain management can be achieved by electrically anesthetizing a peripheral nerve with on-demand electrical nerve block (OD-ENB). OD-ENB can be provided by an implantable capsule. Externally, at least a portion of the capsule can be constructed of a conductive membrane and the rest of the capsule comprises a biocompatible material. A blocking electrode contact, a return electrode contact, and a powering/communication component can be within the capsule. The blocking electrode contact can deliver a direct current (DC) through a portion of the conductive membrane to block conduction in the neural tissue to provide the OD-ENB. The return electrode contact can receive a return current from the neural tissue through another portion of the conductive membrane. The powering/communication component can communicate with one or more external components located external to the patient's body to receive a power signal. Notably the capsule has no internal battery.

    Slurry electrodes for direct current nerve conduction block
    43.
    发明授权
    Slurry electrodes for direct current nerve conduction block 有权

    公开(公告)号：US11426585B2

    公开(公告)日：2022-08-30

    申请号：US16957808

    申请日：2018-12-28

    申请人： Case Western Reserve University

    发明人： Tina L. Vrabec ,  Jesse S. Wainright ,  Niloy Bhadra ,  Kevin L. Kilgore

    IPC分类号： A61N1/36 ,  A61N1/04 ,  A61N1/20 ,  A61N1/05

    摘要： The present disclose relates to slurry electrodes that can deliver direct current (DC) nerve conduction block to neural tissue. Such slurry electrodes can include an ionically conductive membrane having a first side and a second side. Slurry electrodes can also include a mechanism that is configured to encapsulate a slurry against the first side of the ionically conductive membrane. The slurry can include an ionically conductive material and a plurality of electrically conducting high surface area particles. The mechanism and the first side of the ionically conductive membrane make up a housing for the slurry. Slurry electrodes can also include a connector configured to establish an electrical connection between the slurry and the DC generator.

    SYSTEMS FOR TREATMENT OF A NEUROLOGICAL DISORDER USING ELECTRICAL NERVE CONDUCTION BLOCK
    44.
    发明申请
    SYSTEMS FOR TREATMENT OF A NEUROLOGICAL DISORDER USING ELECTRICAL NERVE CONDUCTION BLOCK 有权

    公开(公告)号：US20210113840A1

    公开(公告)日：2021-04-22

    申请号：US17117228

    申请日：2020-12-10

    申请人： Case Western Reserve University

    发明人： Niloy Bhadra ,  Narendra Bhadra ,  Kevin L. Kilgore ,  Scott Lempka ,  Jesse Wainright ,  Tina Vrabec ,  Manfred Franke

    IPC分类号： A61N1/36

    摘要： One aspect of the present disclosure is a system including a waveform generator, a controller, and an electrical contact. The waveform generator is for generating an electrical nerve conduction block (ENCB). The controller is coupled with the waveform generator. The controller is configured to receive an input comprising at least one parameter to adjust the ENCB. The electrical contact is coupled with the waveform generator. The electrical contact is configured to be placed into contact with a nerve. The electrical contact comprises a high charge capacity material that prevents formation of damaging electro-chemical products at a charge delivered by the ENCB. The electrical contact is configured to deliver the ENCB to the nerve to block transmission of a signal related to a pain through the nerve.

    CHARGE CAPACITY EXPANDING SEPARATED INTERFACE NERVE ELECTRODE (SINE)
    45.
    发明申请
    CHARGE CAPACITY EXPANDING SEPARATED INTERFACE NERVE ELECTRODE (SINE) 审中-公开

    公开(公告)号：US20200179710A1

    公开(公告)日：2020-06-11

    申请号：US16614951

    申请日：2018-05-24

    申请人： Case Western Reserve University

    发明人： Tina L. Vrabec ,  Jesse S. Wainright ,  Kevin L. Kilgore ,  Narendra Bhadra ,  Niloy Bhadra

    IPC分类号： A61N1/44 ,  A61N1/05 ,  A61N1/20 ,  A61N1/06

    摘要： The present disclosure relates to a capacity-expanding separated interface nerve electrode (SINE), which can be used to deliver a nerve conduction block to one or more nerves. The SINE can include a source electrode coupled to a waveform generator. The sour electrode can deliver an electrical neuromodulation signal (e.g., a direct current (DC) signal) to an ionically conductive medium. The SINE can also include a vessel holding the ionically conductive medium, which can include a material that facilitates a transformation of the electrical neuromodulation signal to an ionic neuromodulation signal with a high charge capacity. The SINE can also include a nerve interface that can deliver the ionic neuromodulation signal to a nerve. The SINE can be used in combination with a return electrode that is also coupled to the waveform generator.

    SYSTEMS FOR TREATMENT OF A NEUROLOGICAL DISORDER USING ELECTRICAL NERVE CONDUCTION BLOCK
    47.
    发明申请
    SYSTEMS FOR TREATMENT OF A NEUROLOGICAL DISORDER USING ELECTRICAL NERVE CONDUCTION BLOCK 审中-公开

    公开(公告)号：US20180361155A1

    公开(公告)日：2018-12-20

    申请号：US16060979

    申请日：2016-12-15

    申请人： Case Western Reserve University

    发明人： Niloy Bhadra ,  Narendra Bhadra ,  Kevin L. Kilgore ,  Scott Lempka ,  Jesse Wainright ,  Tina Vrabec ,  Manfred Franke

    IPC分类号： A61N1/36

    摘要： One aspect of the present disclosure is a system including a waveform generator, a controller, and an electrical contact. The waveform generator is for generating an electrical nerve conduction block (ENCB). The controller is coupled with the waveform generator. The controller is configured to receive an input comprising at least one parameter to adjust the ENCB. The electrical contact is coupled with the wave-form generator. The electrical contact is configured to be placed into contact with a nerve. The electrical contact comprises a high charge capacity material that prevents formation of damaging electro-chemical products at a charge delivered by the ENCB. The electrical contact is configured to deliver the ENCB to the nerve to block transmission of a signal related to a pain through the nerve.

    THERAPY DELIVERY DEVICES AND METHODS FOR NON-DAMAGING NEURAL TISSUE CONDUCTION BLOCK
    50.
    发明申请
    THERAPY DELIVERY DEVICES AND METHODS FOR NON-DAMAGING NEURAL TISSUE CONDUCTION BLOCK 有权
    治疗神经组织导管块非破坏性输送装置及方法

    公开(公告)号：US20160346533A1

    公开(公告)日：2016-12-01

    申请号：US15178633

    申请日：2016-06-10

    申请人： Case Western Reserve University

    发明人： Niloy Bhadra ,  Kevin L. Kilgore ,  Narendra Bhadra ,  Jesse Wainright ,  Tina Vrabec ,  Manfred Franke

    IPC分类号： A61N1/05 ,  A61N1/06 ,  A61N1/36 ,  A61N1/20

    CPC分类号： A61N1/0556 ,  A61N1/06 ,  A61N1/20 ,  A61N1/36064 ,  A61N1/36067 ,  A61N1/36071

    摘要： Devices and methods for blocking signal transmission through neural tissue. One step of a method includes placing a therapy delivery device into electrical communication with the neural tissue. The therapy delivery device includes an electrode contact having a high charge capacity material. A multi-phase direct current (DC) can be applied to the neural tissue without damaging the neural tissue. The multi-phase DC includes a cathodic DC phase and anodic DC phase that collectively produce a neural block and reduce the charge delivered by the therapy delivery device. The DC delivery can be combined with high frequency alternating current (HFAC) block to produce a system that provides effective, safe, long term block without inducing an onset response.

    摘要翻译： 通过神经组织阻断信号传导的装置和方法。 方法的一个步骤包括将治疗递送装置放置成与神经组织电连通。 治疗递送装置包括具有高电荷容量材料的电极接触。 可以将多相直流（DC）应用于神经组织而不损伤神经组织。 多相DC包括阴极DC相和阳极DC相，其共同产生神经阻滞并减少由治疗递送装置递送的电荷。 DC输送可以与高频交流（HFAC）模块组合，以产生提供有效，安全，长期阻挡的系统，而不会引发发作响应。