公开(公告)号：US20150252002A1

公开(公告)日：2015-09-10

申请号：US14432768

申请日：2013-09-17

Applicant: INSTITUT NATIONAL DE LA SANTEET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITE PAUL SABATIER TOULOUSE III ,  UNIVERSITÉ PARIS-SUD ,  UNIVERSITE D'ORLEANS

Inventor： Frank Lezoualc'h ,  Rodolphe Fischmeister ,  Malik Bisserier ,  Pascal Bouyssou ,  Jean-Paul Blondeau ,  Delphine Courilleau

IPC: C07D215/14

CPC classification number: C07D215/14 ,  A61K31/47 ,  C07D215/08 ,  C07D215/18

Abstract: The invention relates to tetrahydroquinoline derivatives and their use in the treatment and/or the prevention of a disease wherein the Epac protein is involved, such as inflammation, cancer, vascular diseases, kidney diseases, cognitive disorders and cardiac diseases.

Abstract translation: 本发明涉及四氢喹啉衍生物及其用于治疗和/或预防涉及Epac蛋白的疾病，例如炎症，癌症，血管疾病，肾脏疾病，认知障碍和心脏病。

公开(公告)号：US20140016247A1

公开(公告)日：2014-01-16

申请号：US14030271

申请日：2013-09-18

Applicant: UNIVERSITE D'ORLEANS ,  CNRS

Inventor： Francois BEGUIN ,  Laurent Demarconnay ,  Encarnacion Raymundo-Pinero

IPC: H01G9/035 ,  H01G9/145

CPC classification number: H01G9/035 ,  H01G9/038 ,  H01G9/145

Abstract: An electrochemical capacitor includes a first electrode connected to a positive terminal of a power source during the charge of the electrochemical capacitor and a second electrode connected to a negative terminal of a power source during the charge of the electrochemical capacitor. The first and the second electrodes each have a carbon material. The electrochemical capacitor further includes a porous separator to separate the first and second electrodes and to be impregnated with an almost neutral aqueous electrolyte situated between the two electrodes. The neutral aqueous electrolyte has a salt formed by a metallic cation and an anion.

Abstract translation: 电化学电容器包括在电化学电容器充电期间连接到电源的正极端的第一电极和在电化学电容器充电期间连接到电源的负极端子的第二电极。 第一和第二电极各自具有碳材料。 电化学电容器还包括多孔分离器，以分离第一和第二电极并且浸渍在位于两个电极之间的几乎中性的含水电解质。 中性水性电解质具有由金属阳离子和阴离子形成的盐。

公开(公告)号：US12065124B2

公开(公告)日：2024-08-20

申请号：US17260777

申请日：2019-07-09

Applicant: RENAULT S.A.S. ,  UNIVERSITE D'ORLEANS

Inventor： Guillaume Colin ,  Souad Hadj-Said ,  Ahmed Ketfi-Cherif

IPC: B60W20/13 ,  B60W10/06 ,  B60W10/08 ,  B60W10/26 ,  B60W10/30 ,  B60W50/00

CPC classification number: B60W20/13 ,  B60W10/06 ,  B60W10/08 ,  B60W10/26 ,  B60W10/30 ,  B60W50/00 ,  B60W2050/0013 ,  B60W2050/0019 ,  B60W2510/083 ,  B60W2710/242

Abstract: Disclosed is a method for controlling a hybrid vehicle power train, including a thermal drive chain and an electric drive chain, the electric drive chain including a traction battery, a voltage modulator, an inverter, first and second electrical machines. The voltage modulator is designed to modulate a supply voltage of an electric current from the traction battery to the first and second electrical machines. The method includes: a step of analytically calculating an optimal supply voltage using a mathematical expression that corresponds to the resolution of an equation expressed as







∂

P

b
⁢
a
⁢
t




∂

U
e



=
0

,




where Ue is the supply voltage, Pbat is the electrical power supplied by the traction battery, and where the electrical power supplied by the traction battery is expressed as a quadratic function of the supply voltage; and a step of controlling the voltage modulator in such a way that it outputs the optimal supply voltage.

公开(公告)号：US12006525B2

公开(公告)日：2024-06-11

申请号：US16495874

申请日：2018-03-21

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE D'ORLEANS

Inventor： Lucie Pigeon ,  Rachid A. Rahmouni ,  Harivony Chantal Pichon-Rabenandrasana ,  Patrick Midoux

IPC: C12P19/34 ,  A61K31/7088 ,  C07K14/395 ,  C12N15/81

CPC classification number: C12P19/34 ,  A61K31/7088 ,  C07K14/395 ,  C12N15/81

Abstract: The application relates to the production of RNA of interest, more specifically of messenger RNA of interest or of long non-coding RNA of interest, by yeasts with recombinant pseudo-viral particles. The recombinant yeasts have been genetically modified in order to produce the RNA of interest in the form of a complex, particularly in the form of recombinant pseudo-viral particles. These recombinant pseudo-viral particles are produced from certain elements of yeast Ty retrotransposon, but do not retrotranscribe the RNA that they contain. Thus, the application relates to the components that are thus capable of being implemented or produced, and particularly to the nucleic acid constructs, kits, bacteria cells, yeast cells, culture or transfection media containing them, as well as to a method for producing a pharmaceutical composition, particularly for medical applications, more specifically for vaccines, anti-tumour and pro-regenerative applications.

公开(公告)号：US20240058481A1

公开(公告)日：2024-02-22

申请号：US18253953

申请日：2021-11-23

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ,  UNIVERSITÉ DE TOURS ,  UNIVERSITE D'ORLEANS

Inventor： Sylvain ROUTIER ,  Frédéric BURON ,  Franck SUZENET ,  Nuno RODRIGUES ,  Sylvie CHALON ,  Johnny VERCOUILLIE ,  Denis GUILLOTEAU ,  Patrick EMOND ,  Hamid MARZAG

IPC: A61K51/04 ,  C07D211/14 ,  C07F5/02

CPC classification number: A61K51/0455 ,  C07D211/14 ,  C07F5/025

Abstract: The present invention relates to the radiolabelled compound of enantiomer (R,R) of 5-fluoro-3-4(-phenylpiperidin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-ol, and to this compound for use thereof in an in vivo diagnosis method, in particular of a cholinergic neurodegenerative disease selected for example from the group formed by Alzheimer's disease, dysmnesia, learning disability, schizophrenia, cognitive dysfunction, hyperactivity disorder, anxiety neurosis, depression, analgesia and Parkinson's disease.

公开(公告)号：US11661910B2

公开(公告)日：2023-05-30

申请号：US17048243

申请日：2019-04-18

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE D'ORLEANS ,  UNIVERSITE D'EVRY-VAL D'ESSONNE

Inventor： Luc Leger ,  Vladeta Zmijanovic ,  Mohamed Sellam ,  Amer Chpoun

IPC: F02K9/97 ,  F02K1/28 ,  F02K9/82 ,  F02K1/30

CPC classification number: F02K9/97 ,  F02K1/28 ,  F02K1/30 ,  F02K9/82 ,  F05D2220/323 ,  F05D2240/128 ,  F05D2250/324 ,  F05D2250/713

Abstract: A mixing tube with multiple shapes is provided, allowing additional injection of gas in order to keep the flow detached from the second shape in an ascent phase and to bring about, in a descent phase, a controlled detachment as a result of the change of slope between the two shapes. A propulsion nozzle for an engine of a spacecraft or aircraft is provided including such a mixing tube and a method for controlling the speed transition of the propulsion gases in such a nozzle in accordance with the altitude. Also, a method is provided for vectorising the thrust in such a nozzle by radial and asymmetrical injection of gas and a control method which prevents re-attachment of the jet to the second shape of such a propulsion nozzle for an engine of a spacecraft when it is in the take-off or landing phase.

公开(公告)号：US11271230B2

公开(公告)日：2022-03-08

申请号：US16305666

申请日：2017-05-30

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITE D'ORLEANS

Inventor： Pascal Brault ,  Cédric Grolleau ,  Samuel Rouxel ,  Serge Gasnier ,  Amael Caillard ,  Thomas Lecas

IPC: H01M8/04537 ,  H01M8/04955 ,  H01M16/00 ,  H02J1/10

Abstract: Disclosed is a method for electrical supply of an apparatus by a system including an intermittent electrical source, electrical storage unit, a fuel cell, and an electrochemical unit for generating the fuel. The method includes steps of: determining a power balance of the system depending on the power consumed by the apparatus and supplied by the intermittent electrical source; receiving data representative of the stability of the power balance during a safety period; controlling the fuel cell and the electrochemical unit: to activate the electrochemical unit if the power balance is greater than a first threshold and the data are not characteristic of a subsequent decrease in the power balance; activating the fuel cell if the power balance is less than a second threshold, which is less than the first threshold, and the data are not characteristic of a subsequent increase in the power balance.

公开(公告)号：US20220033756A1

公开(公告)日：2022-02-03

申请号：US17277351

申请日：2019-09-18

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITE D'ORLEANS

Inventor： Anthony DELALANDE ,  Matthias LEBERTRE ,  Michaël DELALANDE ,  Chantal PICHON

IPC: C12M1/42 ,  C12N15/87 ,  C12M1/36

Abstract: The invention describes a device (10) for dispensing microbubbles (30) for cell sonoporation, comprising: a tube configured to receive a vial (20) containing a solution (26) of microbubbles (30), at least two catheters (11, 12) arranged inside the tube and opening into the vial (20) when the latter is received by the tube, wherein, when the first catheter (11) is connected to a first air injection source, air can be injected into the vial (20) via the first catheter so as to generate an overpressure therein, the microbubbles (30) contained in the vial (20) entering the second catheter (12) and moving toward its second end (122). The invention also relates to a sonoporation device, a sonoporation process and a computer program product.

公开(公告)号：US20210387949A1

公开(公告)日：2021-12-16

申请号：US17291791

申请日：2019-11-07

Applicant: UNIVERSITE DE NANTES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE D'ORLEANS

Inventor： Jean-Yves LE QUESTEL ,  Jérôme GRATON ,  Adèle LAURENT ,  Balaji SELVAM ,  Jacques LEBRETON ,  Monique MATHE-ALLAINMAT ,  Elodie LANDAGARAY ,  Steeve THANY ,  Alison CARTEREAU

IPC: C07D207/48 ,  C07D401/12 ,  A01N43/40 ,  A01N43/36

Abstract: The present invention relates to a compound having the following formula (I): wherein:—A is a (hetero)aryl radical comprising from 5 to 10 carbon atoms, possibly substituted by at least one substituent chosen from the group consisting of: halogen atoms, amino, azido, cyano, nitro, hydroxyl, formyl, carboxyl, amido, (C1-C6)alkyl groups, halo(C1-C6)alkyl groups, (C1-C6)alkoxy groups, alkenyl groups, cycloalkenyl groups, and alkynyl groups, and—R is H, CN or CF3, or their pharmaceutically acceptable salts, racemates, diastereomers or enantiomers.

公开(公告)号：US10906900B2

公开(公告)日：2021-02-02

申请号：US16336309

申请日：2017-09-26

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE D'ORLEANS ,  UNIVERSITE DE TOURS ,  CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE TOURS ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA MEDICALE)

Inventor： Sylvain Routier ,  Franck Suzenet ,  Sylvie Chalon ,  Frederic Buron ,  Johnny Vercouillie ,  Ronald Melki ,  Liliana Boiaryna ,  Denis Guilloteau ,  Laura Pieri

IPC: C07D471/04

Abstract: The invention relates to compounds of formula (II) for using in imaging and particularly for the diagnosis of neurodegenerative diseases.