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公开(公告)号：US5476484A
公开(公告)日：1995-12-19
申请号：US338090
申请日：1994-11-09
申请人： Sven-Erik Hedberg
发明人： Sven-Erik Hedberg
IPC分类号： A61B5/0215 , A61N1/365 , A61B5/02
CPC分类号： A61N1/36564
摘要： An apparatus for determining a physical condition in a living subject by determining peripheral resistance to flow is wherein peripheral resistance to flow is determined by measuring changes in the pressure drop characteristic in an artery during diastole. The pressure drop characteristic can be determined by measuring absolute pressure, relative pressure or dimensional changes in the artery during diastole. The apparatus can advantageously be used in a rate-responsive heart stimulator.
摘要翻译： 通过测定周围的流动阻力来确定生物体内的身体状况的装置，其特征在于，通过测量舒张期内的动脉压降特性的变化，来决定周围的流动阻力。 压降特性可以通过测量舒张期间动脉的绝对压力，相对压力或尺寸变化来确定。 该装置可以有利地用于速率响应心脏刺激器中。
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公开(公告)号：US5431682A
公开(公告)日：1995-07-11
申请号：US114922
申请日：1993-09-02
申请人： Sven-Erik Hedberg
发明人： Sven-Erik Hedberg
CPC分类号： A61N1/3956
摘要： An implantable heart defibrillator is equipped with at least one intracardiac defibrillation electrode. A post-therapy apparatus is arranged to emit, after a defibrillation pulse, at least one stimulation pulse through the defibrillation electrode, the stimulation pulse having energy far higher than the energy in a normal heart stimulation pulse for cardiac pacing, but less energy than a normal defibrillation pulse.
摘要翻译： 植入式心脏除颤器配备有至少一个心内除颤电极。 治疗后装置被布置成在除颤脉冲之后通过除颤电极发射至少一个刺激脉冲，所述刺激脉冲的能量远远高于用于心脏起搏的正常心脏刺激脉冲中的能量，但是能量小于 正常除颤脉冲。
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公开(公告)号：US4722341A
公开(公告)日：1988-02-02
申请号：US910999
申请日：1986-09-24
CPC分类号： A61N1/3622
摘要： An atrium controlled heart pacemaker has a switching stage which is controlled in dependence upon the appearance of atrial signals. The switching stage switches the heart pacemaker to a VVI mode for a predetermined number of stimulation pulses or natural ventricular events, or a predetermined time, upon the appearance of at least one atrial signal before a selected time limit. The time limit is derived from the difference between a smallest synchronous interval and the AV delay.
摘要翻译： 心房控制的心脏起搏器具有切换阶段，其根据心房信号的出现进行控制。 在选择的时间限制之前出现至少一个心房信号时，切换台将心脏起搏器切换到预定数量的刺激脉冲或自然心室事件或预定时间的VVI模式。 时间限制是从最小同步间隔和AV延迟之间的差值得出的。
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公开(公告)号：US4714079A
公开(公告)日：1987-12-22
申请号：US910998
申请日：1986-09-24
CPC分类号： A61N1/368 , A61N1/3682
摘要： An atrium-controlled heart pacemaker operates using set parameters including a smallest synchronous interval (SSI) between two stimulation pulses, a minimum atrial-ventricular delay time (AVmin) and a maximum atrial-ventricular delay time (AVmax). A control unit, dependent upon the appearance of an atrial signal, controls operation of the pacemaker such that the pacemaker operates with a variable pulse rate (DDD mode) when the atrial signal appears after a point in time SSI-AVmin, operates the pacemaker with a highest synchronous pulse rate when the atrial signal is between the points in time SSI-AVmin and SSI-AVmax, and causes no stimulation pulses to be emitted when the atrial signal appears before the point in time SSI-AVmax.
摘要翻译： 心房控制的心脏起搏器使用设定参数进行操作，包括两个刺激脉冲之间的最小同步间隔（SSI），最小心房延迟时间（AVmin）和最大心房延迟时间（AVmax）。 根据心房信号的出现，控制单元控制起搏器的操作，使得起搏器以可变脉冲速率（DDD模式）操作，当心房信号在时间点SSI-AVmin后出现时，起搏器与 当心房信号在时间点SSI-AVmin和SSI-AVmax之间时最高的同步脉搏率，并且当心房信号在时间点SSI-AVmax之前出现时，不会发出刺激脉冲。
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公开(公告)号：US08798765B2
公开(公告)日：2014-08-05
申请号：US13471167
申请日：2012-05-14
申请人： Kjell Noren , Anders Bjorling , Tomas Svensson , Sven-Erik Hedberg , Allen Keel , Stuart Rosenberg , Kyungmoo Ryu
发明人： Kjell Noren , Anders Bjorling , Tomas Svensson , Sven-Erik Hedberg , Allen Keel , Stuart Rosenberg , Kyungmoo Ryu
CPC分类号： A61N1/36507 , A61N1/3682 , A61N1/3684 , A61N1/37252
摘要： CRT settings for an implantable medical device are determined by applying pacing pulses to heart chambers of a scheme of different combinations of interchamber delays. A respective width parameter value representing an R or P wave width is determined for each such delay combination based on an ECG representing signal and the width parameter values are employed to estimate a parametric model defining the width parameter as a function of interchamber delays. Candidate interchamber delays that minimize the width parameter are determined from the parametric model and employed to determine optimal CRT settings. The technique provides an efficient way of finding optimal CRT settings when multiple pacing sites are available in a heart chamber.
摘要翻译： 用于可植入医疗装置的CRT设置通过将不同组合的车间延迟的方案应用于心室来进行起搏脉冲来确定。 基于ECG表示信号为每个这样的延迟组合确定表示R或P波宽的相应宽度参数值，并且使用宽度参数值来估计定义作为间歇延迟的函数的宽度参数的参数模型。 从参数模型中确定最小化宽度参数的候选车间延迟，并用于确定最佳CRT设置。 该技术提供了一种在心室中可用多个起搏部位时可以找到最佳CRT设置的有效方式。
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公开(公告)号：US08620432B2
公开(公告)日：2013-12-31
申请号：US13171952
申请日：2011-06-29
IPC分类号： A61N1/00
CPC分类号： A61N1/3686 , A61N1/36521
摘要： An implantable medical device applies an electric signal over two electrodes and measures the resulting electric signal over a candidate pair of neighboring electrodes on a lead for a first heart ventricle or over a candidate electrode of the lead and a case electrode. An impedance signal is determined for each candidate pair or electrode based on the applied signal and the measured resulting signal. A time difference between start of contraction in a second ventricle and the timing of local myocardial contraction as identified from the impedance signal at the site of the candidate pair or electrode is determined for each candidate pair or electrode. An optimal pacing electrode is selected to correspond to one of the electrodes of the candidate pair having the largest time difference or the candidate electrode having largest time difference.
摘要翻译： 可植入医疗装置在两个电极上施加电信号，并且通过在第一心室的引线上或在引线的候选电极和外壳电极上的相邻电极的候选对测量所得到的电信号。 基于所施加的信号和测得的结果信号，为每个候选对或电极确定阻抗信号。 针对每个候选对或电极确定从候选对或电极的位置处的阻抗信号识别的第二心室的收缩开始与局部心肌收缩的定时之间的时间差。 选择最佳起搏电极以对应于具有最大时间差的候选对的电极之一或具有最大时间差的候选电极。
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公开(公告)号：US08346353B2
公开(公告)日：2013-01-01
申请号：US12531793
申请日：2007-04-24
申请人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindqvist , Urban Lönn
发明人： Sven-Erik Hedberg , Andreas Blomqvist , Karin Järverud , Karin Ljungström , Leif Lindqvist , Urban Lönn
IPC分类号： A61B5/05
CPC分类号： A61N1/05 , A61B5/0084 , A61B5/0086 , A61B5/08 , A61B5/1116 , A61B5/1118 , A61B5/4878 , A61B5/7207 , A61N1/025 , A61N1/056 , A61N1/362
摘要： An implantable medical system for detecting incipient edema has an implantable medical lead including an optical sensor having a light source and a light detector. The medical system further has an edema detection circuit that activates the light source to emit light, the light being directed into lung tissue of a patient and that obtains a light intensity value corresponding to an intensity of light received by the light detector, and that evaluates the light intensity value to detect a consistency with incipient edema.
摘要翻译： 用于检测初期水肿的可植入医疗系统具有包括具有光源和光检测器的光学传感器的可植入医疗引线。 医疗系统还具有水肿检测电路，其激活光源发光，将光引导到患者的肺组织，并获得与由光检测器接收的光的强度对应的光强度值，并且评估 光强值检测与初期水肿的一致性。
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48.发明授权Implantable cardiac stimulator, system, device and method for monitoring cardiac synchrony 有权可植入式心脏刺激器，系统，装置和监测心脏同步的方法公开(公告)号：US08219194B2
公开(公告)日：2012-07-10
申请号：US13271548
申请日：2011-10-12
申请人： Karin Järverud , Kenth Nilsson , Sven-Erik Hedberg
发明人： Karin Järverud , Kenth Nilsson , Sven-Erik Hedberg
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61B5/1107 , A61B5/6869 , A61B2562/0219 , A61N1/36514 , A61N1/36578
摘要： In a system and method for monitoring cardiac synchrony in a human heart, a first sensor is positioned at a first cardiac wall location that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and measures the cardiac wall movements at the first cardiac wall location and a second sensor is positioned at a second cardiac wall location that is subject to movements related to longitudinal valve plane movements along the longitudinal axis of the heart, and measures the cardiac wall movements at the second cardiac wall location. A lead arrangement conducts respective output signals from the first and second sensors to processing circuitry that processes the first and second sensor output signals to produce a synchronization signal therefrom indicative of synchrony in the respective valve plane movements at the first and second cardiac wall locations.
摘要翻译： 在用于监测人心脏心脏同步的系统和方法中，第一传感器位于第一心脏壁位置，该第一心脏壁位置受到与心脏的纵向轴线的纵向瓣膜平面运动有关的运动，并且测量心脏壁移动 在第一心脏壁位置处，并且第二传感器定位在第二心脏壁位置处，所述第二心脏壁位置受到与沿着心脏的纵向轴线的纵向瓣膜平面运动相关的运动，并且测量第二心脏壁位置处的心脏壁运动。 引线装置将来自第一和第二传感器的相应输出信号传导到处理电路，处理电路处理第一和第二传感器输出信号以产生同步信号，表示在第一和第二心脏壁位置处的各个阀平面运动中的同步。
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公开(公告)号：US20120004700A1
公开(公告)日：2012-01-05
申请号：US13171952
申请日：2011-06-29
IPC分类号： A61N1/368
CPC分类号： A61N1/3686 , A61N1/36521
摘要： An implantable medical device applies an electric signal over two electrodes and measures the resulting electric signal over a candidate pair of neighboring electrodes on a lead for a first heart ventricle or over a candidate electrode of the lead and a case electrode. An impedance signal is determined for each candidate pair or electrode based on the applied signal and the measured resulting signal. A time difference between start of contraction in a second ventricle and the timing of local myocardial contraction as identified from the impedance signal at the site of the candidate pair or electrode is determined for each candidate pair or electrode. An optimal pacing electrode is selected to correspond to one of the electrodes of the candidate pair having the largest time difference or the candidate electrode having largest time difference.
摘要翻译： 可植入医疗装置在两个电极上施加电信号，并且通过在第一心室的引线上或在引线的候选电极和外壳电极上的相邻电极的候选对测量所得到的电信号。 基于所施加的信号和测得的结果信号，为每个候选对或电极确定阻抗信号。 针对每个候选对或电极确定从候选对或电极的位置处的阻抗信号识别的第二心室的收缩开始与局部心肌收缩的定时之间的时间差。 选择最佳起搏电极以对应于具有最大时间差的候选对的电极之一或具有最大时间差的候选电极。
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公开(公告)号：US20110144508A1
公开(公告)日：2011-06-16
申请号：US12809255
申请日：2007-12-21
IPC分类号： A61B5/053
CPC分类号： A61B5/053 , A61B5/0245 , A61B5/0452
摘要： An implantable medical device has an impedance determiner for determining a cardiogenic impedance signal based on electric signals sensed by connected electrodes. A parameter calculator processes the impedance signal to calculate an impedance parameter representative of the cardiogenic impedance in connection with the diastolic phase of a heart cycle. This parameter is then employed by the device for monitoring acute decompensated heart failure status of a subject.
摘要翻译： 可植入医疗装置具有用于基于由连接电极感测的电信号确定心源阻抗信号的阻抗确定器。 参数计算器处理阻抗信号以计算代表与心脏周期的舒张期相关的心源阻抗的阻抗参数。 该参数随后被该装置用于监测受试者的急性失代偿性心力衰竭状态。
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