公开(公告)号：US10039880B2

公开(公告)日：2018-08-07

申请号：US13984038

申请日：2012-02-14

Applicant: Marc Holtwick ,  Ilona Eggert ,  James Alexander Davies ,  Simon Lewis Bilton ,  David Moore ,  Steven Wimpenny ,  Christopher Nigel Langley ,  Jeffrey Zajac

Inventor： Marc Holtwick ,  Ilona Eggert ,  James Alexander Davies ,  Simon Lewis Bilton ,  David Moore ,  Steven Wimpenny ,  Christopher Nigel Langley ,  Jeffrey Zajac

IPC: A61M5/168 ,  A61M5/50 ,  A61M5/24 ,  A61M5/19

Abstract: A dispense interface for use with a drug delivery device. The dispense interface comprises a main outer body and an inner body. The inner body may be configured for connection to a drug delivery device and defines a first reservoir and a second reservoir. A first piercing needle is in fluid communication with the first reservoir and positioned for piercing a first cartridge of a drug delivery device. A second piercing needle is provided and in fluid communication with the second reservoir and positioned for piercing a second cartridge contained with a drug delivery device. A manifold is positioned adjacent the inner body and comprises a fluid groove arrangement. A valve arrangement is positioned between the inner body and the manifold and controls fluid communication of a first fluid contained in the first cartridge and a second fluid contained in the second cartridge by way of the fluid groove arrangement to a holding chamber. The dispense interface may further comprise a lockout preventing dispense interface reuse.

公开(公告)号：US09814872B2

公开(公告)日：2017-11-14

申请号：US14113393

申请日：2012-04-26

Applicant: Ilona Eggert ,  James Alexander Davies ,  Simon Lewis Bilton ,  David Moore ,  Steven Wimpenny ,  Christopher Nigel Langley

Inventor： Ilona Eggert ,  James Alexander Davies ,  Simon Lewis Bilton ,  David Moore ,  Steven Wimpenny ,  Christopher Nigel Langley

IPC: A61M5/19 ,  A61M39/22 ,  A61M5/24 ,  A61M5/31

CPC classification number: A61M39/22 ,  A61M5/19 ,  A61M5/24 ,  A61M5/3134 ,  A61M2005/3128

Abstract: The invention faces the technical problem of reducing the uncertainty over exact doses ejected from a medical device and at the same time providing a homogeneous, but controlled mixture of at least two fluids while a simple production should be maintained. A medical device comprising a first valve, a second valve, a first pre-valve ullage, a second pre-valve ullage, a post-valve ullage with a first end and a second end and a needle is presented. The first pre-valve ullage is connected to the post-valve ullage by the first valve and the second pre-valve ullage is connected to the post-valve ullage by the second valve. A first fluid is guidable from the first pre-valve ullage to the post-valve ullage and a second fluid is guidable from the second pre-valve ullage to the post-valve ullage.

公开(公告)号：US09750898B2

公开(公告)日：2017-09-05

申请号：US13882696

申请日：2011-10-31

Applicant: James Alexander Davies ,  John David Cross ,  Malcom Stanley Boyd ,  Steven Wimpenny ,  Daniel Thomas De Sausmarez Lintell ,  Simon Lewis Bilton ,  Naceur Rekaya

Inventor： James Alexander Davies ,  John David Cross ,  Malcom Stanley Boyd ,  Steven Wimpenny ,  Daniel Thomas De Sausmarez Lintell ,  Simon Lewis Bilton ,  Naceur Rekaya

IPC: A61M5/50 ,  A61M5/24 ,  A61M5/32 ,  A61M5/178 ,  A61M5/31

CPC classification number: A61M5/50 ,  A61M5/24 ,  A61M5/32 ,  A61M5/326 ,  A61M5/3294 ,  A61M2005/1787 ,  A61M2005/3142 ,  A61M2205/583

Abstract: A medicated module attachable to a drug delivery device comprising a connecting body configured for attachment to the drug delivery device. A first needle held within a first needle hub of the connecting body and a second needle fixed within a second needle hub of the connecting body. A recess within the connecting body defining a reservoir. The reservoir containing at least one dose of a medicament and configured for fluid communication with the first needle. The connecting body further comprises a lockout feature that prevents the medicated module from being reconnected to the drug delivery device after the medicated module has been connected to the drug delivery device a first time.

公开(公告)号：US09717863B2

公开(公告)日：2017-08-01

申请号：US14113392

申请日：2012-04-26

Applicant: James Alexander Davies ,  Simon Lewis Bilton ,  David Moore ,  Steven Wimpenny ,  Christopher Nigel Langley

Inventor： James Alexander Davies ,  Simon Lewis Bilton ,  David Moore ,  Steven Wimpenny ,  Christopher Nigel Langley

IPC: A61M5/50 ,  A61M5/34 ,  A61M5/31

CPC classification number: A61M5/50 ,  A61M5/19 ,  A61M5/2033 ,  A61M5/31593 ,  A61M5/3202 ,  A61M5/3286 ,  A61M5/34 ,  A61M5/347 ,  A61M2005/3118 ,  A61M2005/3128 ,  A61M2205/50 ,  A61M2205/502

Abstract: The invention is related to an apparatus comprising a dispense interface comprising a lockout element for use with a drug delivery device, the lockout element comprising at least one spring component removeably maintained in a respective first position such that when the dispense interface is first attached and then removed from said drug delivery device, each spring component moves into a respective second position, which respective second position is configured to prevent said dispense interface from being reattached to a drug delivery device.

公开(公告)号：US09504791B2

公开(公告)日：2016-11-29

申请号：US13582013

申请日：2011-03-23

Applicant: John David Cross ,  Malcolm Stanley Boyd ,  Alasdair George Young ,  Naceur Rekaya ,  James Alexander Davies ,  Steven Wimpenny ,  Daniel Thomas De Sausmarez Lintell ,  Simon Lewis Bilton

Inventor： John David Cross ,  Malcolm Stanley Boyd ,  Alasdair George Young ,  Naceur Rekaya ,  James Alexander Davies ,  Steven Wimpenny ,  Daniel Thomas De Sausmarez Lintell ,  Simon Lewis Bilton

IPC: A61M5/24 ,  A61M5/32 ,  A61M5/31 ,  A61M5/315 ,  A61M5/34 ,  A61M5/178

CPC classification number: A61M5/2448 ,  A61M5/2466 ,  A61M5/3146 ,  A61M5/31525 ,  A61M5/31533 ,  A61M5/326 ,  A61M5/3272 ,  A61M5/3294 ,  A61M5/347 ,  A61M2005/1787 ,  A61M2005/3247 ,  A61M2005/3267 ,  A61M2205/583

Abstract: A medicated module for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module containing a single dose of a secondary medicament and where both medicaments are delivered through a hollow needle. The medicated module is user selectable so that it will deliver a priming dose of a primary medicament or both the primary and secondary medicaments. The module also contains a needle guard that locks after dose delivery. The needle guard prevents accidental needle sticks before and after an injection. A locking collar rotates during use as an inner protrusion follows three paths of a track located on the outer surface of a body housing. When the inner facing protrusion is in the third path, it encounters a hard stop and a rotational bias that locks the guard from further refraction and thus covers the sharp distal end of the needle.

Abstract translation: 公开了一种用于共同递送至少两种药物的注射系统的药物组合物，其中包含主要药物的主要递送装置接受含有单剂量次级药物的药物组合物，并且其中两种药物通过中空针体递送。 药物模块是用户可选择的，使得其将递送初始剂量的初级药物或初级和次级药物两者。 该模块还包含一个针头保护装置，在剂量输送后锁定。 针头防护装置防止注射前后的意外针刺。 在使用期间，锁定环旋转，因为内部突起沿着位于主体外壳的外表面上的轨道的三条路径。 当内侧面的突起处于第三路径时，它遇到硬停止和旋转偏压，其将防护装置从进一步的折射锁定并因此覆盖针的尖锐远端。

公开(公告)号：US09375534B2

公开(公告)日：2016-06-28

申请号：US13496536

申请日：2010-09-29

Applicant: Robert Veasey ,  Simon Lewis Bilton ,  Christopher Jones ,  Garen Kouyoumjian ,  Catherine Anne MacDonald

Inventor： Robert Veasey ,  Simon Lewis Bilton ,  Christopher Jones ,  Garen Kouyoumjian ,  Catherine Anne MacDonald

IPC: A61M5/00 ,  A61M5/24 ,  A61M5/315 ,  A61M5/31

CPC classification number: A61M5/24 ,  A61M5/31541 ,  A61M5/31555 ,  A61M5/31558 ,  A61M5/31561 ,  A61M5/31575 ,  A61M5/31593 ,  A61M2005/2407 ,  A61M2005/2488 ,  A61M2005/3142

Abstract: A first output member is rotatable around an axis relatively to the body. A second output member is movable relatively to the body along the axis. The first output member and the second output member are rotationally coupled. A drive feature is provided to generate a rotation of the first output member. A part which is removable from and attachable to the body is provided so that the first output member is unidirectionally rotationally coupled with the drive feature when the part is attached to the body.

Abstract translation: 第一输出构件可绕相对于身体的轴线旋转。 第二输出构件可相对于主体沿轴线移动。 第一输出构件和第二输出构件被旋转地联接。 提供驱动特征以产生第一输出构件的旋转。 提供从主体可移除并可附接到本体的部分，使得当部件附接到主体时，第一输出部件与驱动部件单方向地旋转耦合。

公开(公告)号：US20150314082A1

公开(公告)日：2015-11-05

申请号：US14113535

申请日：2012-04-26

Applicant: James Alexander Davies ,  Simon Lewis Bilton ,  David Moore ,  Steven Wimpenny ,  Christopher Nigel Langley

Inventor： James Alexander Davies ,  Simon Lewis Bilton ,  David Moore ,  Steven Wimpenny ,  Christopher Nigel Langley

IPC: A61M5/50 ,  A61M5/34

CPC classification number: A61M5/50 ,  A61M5/2448 ,  A61M5/284 ,  A61M5/34 ,  A61M2205/273

Abstract: The invention relates to a dispense interface for use with a drug delivery device with an inner body and with a lockout element, wherein the lockout element is coupled to the inner body, wherein the lockout element is movable from a receptive condition to a locked condition, wherein in the receptive condition the dispense interface is attachable to the drug delivery device, wherein in the locked condition the dispense interface is not-attachable to the drug delivery device and wherein the lockout element is configured to move from the receptive condition to the locked condition when said dispense interface is attached to and detached from said drug delivery device. The invention solves the technical problem of reducing the risk of reuse of a dispense interface, after it has already been used with a drug delivery device. The invention furthermore relates to an apparatus with a dispense interface according to the invention and with a drug delivery device, wherein the dispense interface is removably attached to the drug delivery device.

Abstract translation: 本发明涉及一种用于具有内部主体和具有锁定元件的药物输送装置的分配界面，其中锁定元件联接到内部主体，其中锁定元件可从接受状态移动到锁定状态， 其中在所述接收状态下，所述分配界面可附接到所述药物输送装置，其中在所述锁定状态下，所述分配界面不能附着于所述药物输送装置，并且其中所述锁定元件构造成从所述接受状态移动到所述锁定状态 当所述分配界面附接到所述药物递送装置并从其分离时。 本发明解决了在已经与药物递送装置一起使用之后降低分配界面的再利用风险的技术问题。 本发明还涉及具有根据本发明的分配界面和药物递送装置的装置，其中分配界面可移除地附接到药物递送装置。

公开(公告)号：US20140066879A1

公开(公告)日：2014-03-06

申请号：US14112453

申请日：2012-04-26

Applicant: Marc Holtwick ,  James Alexander Davies ,  Simon Lewis Bilton ,  David Moore ,  Steven Wimpenny ,  Christopher Nigel Langley

Inventor： Marc Holtwick ,  James Alexander Davies ,  Simon Lewis Bilton ,  David Moore ,  Steven Wimpenny ,  Christopher Nigel Langley

IPC: A61M5/32

CPC classification number: A61J1/2093 ,  H01R12/724 ,  H01R13/502 ,  H01R13/6658

Abstract: The invention is related to an apparatus comprising an inner body of a dispense interface and a manifold, wherein the inner body comprises a recess configured to receive a distal needle from a distal end of the inner body, a first fluid reservoir and a second fluid reservoir, and wherein the manifold comprises a filling block configured to redirect flow, a fluid groove arrangement configured to provide a fluid connection to the filling block, wherein the inner body and the manifold are assembled such that there is formed a channel providing a fluid connection from the first fluid reservoir and the second fluid reservoir, respectively, via the fluid groove arrangement and the filling block to the recess. The invention is further related to a drug delivery device comprising an apparatus of the aforementioned kind

Abstract translation: 本发明涉及包括分配界面和歧管的内部主体的装置，其中，所述内部主体包括被配置为从所述内部主体的远端接收远侧针的凹部，第一流体容器和第二流体容器 ，并且其中所述歧管包括被配置为重定向流的填充块，构造成提供到所述填充块的流体连接的流体槽布置，其中所述内主体和所述歧管被组装成使得形成通道， 第一流体储存器和第二流体储存器分别经由流体槽布置和填充块到达凹部。 本发明进一步涉及包括上述类型的装置的药物递送装置

公开(公告)号：US08663172B2

公开(公告)日：2014-03-04

申请号：US13376018

申请日：2010-06-01

Applicant: James Alexander Davies ,  Steven Wimpenny ,  Daniel Thomas De Sausmarez Lintell ,  Malcolm Stanley Boyd ,  Naceur Rekaya ,  Simon Lewis Bilton ,  John David Cross

Inventor： James Alexander Davies ,  Steven Wimpenny ,  Daniel Thomas De Sausmarez Lintell ,  Malcolm Stanley Boyd ,  Naceur Rekaya ,  Simon Lewis Bilton ,  John David Cross

IPC: A61M5/00

CPC classification number: A61M5/2448 ,  A61M5/204 ,  A61M5/284 ,  A61M5/288 ,  A61M5/31525 ,  A61M5/3213 ,  A61M5/326 ,  A61M5/3294 ,  A61M5/3297 ,  A61M5/347 ,  A61M2005/1787 ,  A61M2005/3142 ,  A61M2005/3247 ,  A61M2005/3267

Abstract: A medicated module (4) for an injection system to co-deliver at least two medicaments is disclosed where a primary delivery device containing a primary medicament accepts a medicated module (4) containing a single dose of a secondary medicament (2) and where both medicaments are delivered through a single hollow needle (5). The medicated module (4) is user selectable so that it will deliver both the primary (1) and secondary medicaments (2), or only the primary medicament (1). The module (4) also contains a guard (42) that locks after dose delivery.

Abstract translation: 公开了一种用于共同递送至少两种药物的注射系统的药物组件（4），其中包含主要药物的主要递送装置接受含有单剂量次级药物（2）的药物组件（4），并且其中两者 药物通过单个中空针（5）递送。 药物模块（4）是用户可选择的，使得其将递送初级（1）和次级药物（2）或仅递送初级药物（1）。 模块（4）还包含在剂量递送之后锁定的护罩（42）。

公开(公告)号：US20140052077A1

公开(公告)日：2014-02-20

申请号：US14113987

申请日：2012-04-26

Applicant: Marc Holtwick ,  Jeffrey Zajac ,  James Alexander Davies ,  Simon Lewis Bilton ,  David Moore ,  Steven Wimpenny ,  Christopher Nigel Langley

Inventor： Marc Holtwick ,  Jeffrey Zajac ,  James Alexander Davies ,  Simon Lewis Bilton ,  David Moore ,  Steven Wimpenny ,  Christopher Nigel Langley

IPC: A61M5/34

CPC classification number: A61M5/349 ,  A61M5/158 ,  A61M5/34 ,  A61M5/343

Abstract: The invention faces the technical problem of providing a tight connection between a tube and an dispense interface, while at the same time the biocompatibility of the connection can be improved. The technical problem is solved by an apparatus comprising a tube configured to guide a medium and a dispense interface. The tube comprises a first opening and a second opening, while the dispense interface comprises a recess. The recess has a first opening and a second opening and the tube is at least in part inserted into the recess. The tube is permanently affixed to the dispense interface by a combination of an interference fit and an adhesive, such that the interference fit prevents the adhesive from contaminating the medium.

Abstract translation: 本发明面临着在管和分配界面之间提供紧密连接的技术问题，同时可以提高连接的生物相容性。 该技术问题通过包括配置成引导介质和分配界面的管的装置来解决。 管包括第一开口和第二开口，而分配界面包括凹部。 凹部具有第一开口和第二开口，并且管至少部分地插入凹部中。 通过过盈配合和粘合剂的组合将管永久地固定到分配界面，使得过盈配合防止粘合剂污染介质。