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公开(公告)号:US20120251558A1
公开(公告)日:2012-10-04
申请号:US13435731
申请日:2012-03-30
申请人: Hans-Peter Gerber , John Francis DiJoseph , Kiran Manohar Khandke , Kimberly Ann Marquette , Puja Sapra , Lioudmila Gennadievna Tchistiakova
发明人: Hans-Peter Gerber , John Francis DiJoseph , Kiran Manohar Khandke , Kimberly Ann Marquette , Puja Sapra , Lioudmila Gennadievna Tchistiakova
IPC分类号: A61K39/395 , A61P35/00 , C07K16/30
CPC分类号: A61K47/6851 , A61K47/6803 , A61K2039/505 , A61K2039/545 , C07K16/30 , C07K2317/732 , C07K2317/92
摘要: Disclosed are anti-5T4 antibody drug conjugates and methods for preparing and using the same.
摘要翻译: 公开了抗5T4抗体药物偶联物及其制备和使用方法。
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公开(公告)号:US08092797B2
公开(公告)日:2012-01-10
申请号:US12700609
申请日:2010-02-04
申请人: Germaine Fuh , Hans-Peter Gerber , Wei-Ching Liang , Frederic A. Fellouse , Sachdev S. Sidhu , Christian Wiesmann
发明人: Germaine Fuh , Hans-Peter Gerber , Wei-Ching Liang , Frederic A. Fellouse , Sachdev S. Sidhu , Christian Wiesmann
IPC分类号: A61K39/00 , A61K39/395 , C07K16/22
CPC分类号: C07K16/22 , A61K2039/505 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/6845
摘要: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.
摘要翻译: 公开了抗VEGF抗体及其变体,包括对VEGF结合具有高亲和力的抗体。 还提供了使用噬菌体展示技术与初始文库产生和选择具有所需结合和其他生物活性的抗VEGF抗体的方法。 进一步考虑的是抗体在研究,诊断和治疗应用中的用途。
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公开(公告)号:US20120003612A1
公开(公告)日:2012-01-05
申请号:US13173915
申请日:2011-06-30
申请人: Peter Gerber , Jodi Lasky
发明人: Peter Gerber , Jodi Lasky
IPC分类号: F41A33/00
CPC分类号: H04B10/1143 , F41G3/2655 , F41G3/2683 , H04B10/225
摘要: In some embodiments, a method of simulating combat described herein comprises emitting a first query beam from a first query unit of a first interoperable identification and communication system, receiving the first query beam with a second response unit of a second interoperable identification and communication system, emitting a second response beam with the second response unit, and receiving the second response beam with the first query unit. In some embodiments, a method of simulating combat comprises emitting a query beam comprising a plurality of packets each comprising a header portion, an information portion, and a footer portion from a query unit; and receiving the query beam with a response unit comprising a plurality of detectors spatially separated from one another, wherein the response unit is operable to independently measure the intensity of each packet of the query beam received at each of the plurality of detectors.
摘要翻译: 在一些实施例中,本文所述的模拟战斗的方法包括从第一可互操作识别和通信系统的第一查询单元发射第一查询波束,用第二可互操作识别和通信系统的第二响应单元接收第一查询波束, 用所述第二响应单元发射第二响应波束,以及用所述第一查询单元接收所述第二响应波束。 在一些实施例中,一种模拟战斗的方法包括从查询单元发射包括多个分组的查询波束,每个分组包括报头部分,信息部分和页脚部分; 以及用包括在空间上彼此分离的多个检测器的响应单元接收所述查询波束,其中所述响应单元可操作以独立地测量在所述多个检测器中的每一个处接收的查询波束的每个分组的强度。
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公开(公告)号:US20120002970A1
公开(公告)日:2012-01-05
申请号:US13173835
申请日:2011-06-30
申请人: Peter Gerber , Jodi Lasky
发明人: Peter Gerber , Jodi Lasky
IPC分类号: H04B10/00
CPC分类号: H04B10/1143 , F41G3/2655 , F41G3/2683 , H04B10/225
摘要: In one aspect, identification and communication systems are described herein. An identification and communication system described herein, in some embodiments, comprises one or more query units and one or more response units, wherein at least one response unit comprises one or more detectors comprising one or more optical fibers operable to direct one or more signals received from at least one query unit to the one or more detectors. In some embodiments, at least one optical fiber is operable to receive a signal from at least one query unit through the side of the optical fiber. In some embodiments, at least one optical fiber comprises a fluorescent plastic fiber (FPF). In some embodiments, at least one optical fiber is disposed in a textile.
摘要翻译: 在一个方面,本文描述了识别和通信系统。 在一些实施例中,本文描述的识别和通信系统包括一个或多个查询单元和一个或多个响应单元,其中至少一个响应单元包括一个或多个检测器,该检测器包括一个或多个光纤,可操作以指导接收的一个或多个信号 从至少一个查询单元到所述一个或多个检测器。 在一些实施例中,至少一个光纤可操作以从光纤侧面接收来自至少一个查询单元的信号。 在一些实施例中,至少一个光纤包括荧光塑料纤维(FPF)。 在一些实施例中,至少一根光纤被布置在纺织品中。
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公开(公告)号:US20110014198A1
公开(公告)日:2011-01-20
申请号:US12816188
申请日:2010-06-15
申请人: Germaine Fuh , Hans-Peter Gerber , Wei-Ching Liang , Frederic A. Fellouse , Sachdev S. Sidhu , Christian Wiesmann
发明人: Germaine Fuh , Hans-Peter Gerber , Wei-Ching Liang , Frederic A. Fellouse , Sachdev S. Sidhu , Christian Wiesmann
IPC分类号: A61K39/395 , A61P35/00 , A61P9/10 , A61P27/02
CPC分类号: C07K16/22 , A61K2039/505 , A61K2039/55 , A61K2039/552 , C07K16/005 , C07K16/32 , C07K2317/20 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/6845
摘要: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.
摘要翻译: 公开了抗VEGF抗体及其变体,包括对VEGF结合具有高亲和力的抗体。 还提供了使用噬菌体展示技术与初始文库产生和选择具有所需结合和其他生物活性的抗VEGF抗体的方法。 进一步考虑的是抗体在研究,诊断和治疗应用中的用途。
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公开(公告)号:US07811785B2
公开(公告)日:2010-10-12
申请号:US11342249
申请日:2006-01-27
申请人: Germaine Fuh , Hans-Peter Gerber , Wei-Ching Liang , Frederic A. Fellouse , Sachdev S. Sidhu , Christian Wiesmann
发明人: Germaine Fuh , Hans-Peter Gerber , Wei-Ching Liang , Frederic A. Fellouse , Sachdev S. Sidhu , Christian Wiesmann
CPC分类号: C07K16/22 , A61K2039/505 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/6845
摘要: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.
摘要翻译: 公开了抗VEGF抗体及其变体,包括对VEGF结合具有高亲和力的抗体。 还提供了使用噬菌体展示技术与初始文库产生和选择具有所需结合和其他生物活性的抗VEGF抗体的方法。 进一步考虑的是抗体在研究,诊断和治疗应用中的用途。
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公开(公告)号:US20100215671A1
公开(公告)日:2010-08-26
申请号:US12681599
申请日:2008-10-08
IPC分类号: A61K39/395 , A61P35/00
CPC分类号: C07K16/2878 , A61K31/7064 , A61K39/39533 , A61K47/6811 , A61K47/6849 , A61K2300/00
摘要: Methods for the treatment of Hodgkin's lymphoma comprising administering both a chemotherapeutic regimen and an antibody-drug conjugate compound to a subject in need thereof are provided.
摘要翻译: 提供了治疗霍奇金淋巴瘤的方法,其包括向有需要的受试者施用化学治疗方案和抗体 - 药物偶联物。
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公开(公告)号:US20100189719A1
公开(公告)日:2010-07-29
申请号:US12700609
申请日:2010-02-04
申请人: Germaine Fuh , Hans-Peter Gerber , Wei-Ching Liang , Frederic A. Fellouse , Sachdev S. Sidhu , Christian Wiesmann
发明人: Germaine Fuh , Hans-Peter Gerber , Wei-Ching Liang , Frederic A. Fellouse , Sachdev S. Sidhu , Christian Wiesmann
IPC分类号: A61K39/395 , A61P35/00
CPC分类号: C07K16/22 , A61K2039/505 , C07K16/005 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/6845
摘要: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.
摘要翻译: 公开了抗VEGF抗体及其变体,包括对VEGF结合具有高亲和力的抗体。 还提供了使用噬菌体展示技术与初始文库产生和选择具有所需结合和其他生物活性的抗VEGF抗体的方法。 进一步考虑的是抗体在研究,诊断和治疗应用中的用途。
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公开(公告)号:US07758859B2
公开(公告)日:2010-07-20
申请号:US11414742
申请日:2006-04-27
申请人: Germaine Fuh , Hans-Peter Gerber , Wei-Ching Liang , Frederic A. Fellouse , Sachdev S. Sidhu , Christian Wiesmann
发明人: Germaine Fuh , Hans-Peter Gerber , Wei-Ching Liang , Frederic A. Fellouse , Sachdev S. Sidhu , Christian Wiesmann
IPC分类号: A61K39/395 , A61K39/00 , C12P21/08 , C07K16/22
CPC分类号: C07K16/22 , A61K2039/505 , A61K2039/55 , A61K2039/552 , C07K16/005 , C07K16/32 , C07K2317/20 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/6845
摘要: Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naïve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.
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公开(公告)号:US07568183B1
公开(公告)日:2009-07-28
申请号:US11041477
申请日:2005-01-21
申请人: Donald G. Hardy , Aaron R. Birnbaum , Alan T. B. Brown , Curtis D. Anderson , Patrick J. Niemeyer , James Rodrigues , Loren James Merriman , Micah A. Koffron , Ross F. Smith, Jr. , Peter Gerber , Jared W. Wilson
发明人: Donald G. Hardy , Aaron R. Birnbaum , Alan T. B. Brown , Curtis D. Anderson , Patrick J. Niemeyer , James Rodrigues , Loren James Merriman , Micah A. Koffron , Ross F. Smith, Jr. , Peter Gerber , Jared W. Wilson
IPC分类号: G06F9/44
CPC分类号: G06F11/3684
摘要: Software automation testing and validation are provided according to a system that runs automation tests using multiple lab machines and allows the testing to be performed before checking in the code to a version control system. Code changes in a build of the software are provided on a computing device. Automation tests are selected from a list of available tests. When indicated by a job queue, the changed code of the build is forwarded to lab machines allocated by an automation system. An image of the build from the computing device is generated on the lab machines and the automation tests are run against the build. A report is generated and forwarded back to one or more recipients that notifies of the success or failure of the automation testing.
摘要翻译: 根据使用多个实验室机器运行自动化测试的系统提供软件自动化测试和验证,并允许在检查版本控制系统的代码之前执行测试。 软件构建中的代码更改在计算设备上提供。 自动化测试从可用测试列表中选择。 当由作业队列指示时,构建的更改的代码将转发给由自动化系统分配的实验室机器。 在实验室机器上生成来自计算设备的构建映像,并针对构建运行自动化测试。 生成报告并转发回一个或多个通知自动化测试成功或失败的收件人。
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