Use of cADPR or NAADP antagonists
    43.
    发明授权

    公开(公告)号:US11071748B2

    公开(公告)日:2021-07-27

    申请号:US16340639

    申请日:2017-10-11

    Abstract: When using a pharmaceutical composition for preventing or treating malignant hyperthermia, containing NAADP antagonists, of the present invention, malignant hyperthermia can be effectively prevented or treated through the inhibition of an oxygen consumption rate abnormal increase, which is associated with a ryanodine receptor (RYR) of skeletal muscles. In addition, the present invention can be used even after the onset of malignant hyperthermia and can inhibit an oxygen consumption rate abnormal increase even at concentrations lower than those of conventional agents for treating malignant hyperthermia, thereby enabling conventional agents for treating malignant hyperthermia to be replaced, and can be stably used, thereby being effectively usable in relevant industries. Furthermore, when using a skin regenerating composition, containing cADPR or NAADP antagonists, of the present invention, the skin can be protected from skin cell damage caused by UV-B of ultraviolet rays, and the skin regenerating composition has an excellent ability to recover and regenerate damaged skin and has no side effects on the same, thereby being usable in various forms such as a skin external preparation, a pharmaceutical composition, a cosmetic composition, and a food composition.

    METHOD AND SYSTEM FOR CLINICAL TRIAL RESOURCE MANAGEMENT USING BLOCK CHAIN

    公开(公告)号:US20200381088A1

    公开(公告)日:2020-12-03

    申请号:US16960369

    申请日:2019-01-08

    Abstract: A method is disclosed including: allowing a contract research organization device to generate clinical trial information and transmit the information to a blockchain server; allowing the server to register the information, and assign a first private key and a first public key to a set site device and transmit the assigned keys to the site device in response to a request from the organization device; allowing the server to complete applicant authentication using a second private key assigned to an applicant for a clinical trial; allowing the site device to confirm previous participation information of the applicant; and allowing the site device to perform the clinical trial based on the previous participation information, encrypt a performance result of the clinical trial using the first public key, a second public key corresponding to the second private key, and the second private key, and transmit the encrypted performance result to the server.

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