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48 条记录 (耗时 0.022 秒)

    Apparatus for stimulating living body
    41.
    发明授权
    Apparatus for stimulating living body 有权
    刺激活体的装置

    公开(公告)号：US08644943B2

    公开(公告)日：2014-02-04

    申请号：US12508806

    申请日：2009-07-24

    申请人： Il Hwan Choe ,  Hee Sup Shin ,  Kyoo Bin Lee

    发明人： Il Hwan Choe ,  Hee Sup Shin ,  Kyoo Bin Lee

    IPC分类号： A61N1/00

    CPC分类号： A61N1/36082 ,  A61N1/0551 ,  A61N1/36017 ,  A61N1/36025 ,  A61N5/0613

    摘要： Disclosed is an apparatus for stimulating living body including a light source unit which irradiates an optical signal for generating an electrical signal; a photovoltaic cell unit which generates an electrical signal using a received optical signal; and an electrode unit which stimulates living body using the electrical signal, wherein the photovoltaic cell unit and the electrode unit are implanted in the living body. The apparatus for stimulating living body may be manufactured in a flexible form, so that it may extend the range of choice for site to be implanted for the apparatus. Further, the adoption of the photovoltaic cell unit avoids the need of surgical operation for the change of battery.

    摘要翻译： 公开了一种用于刺激生物体的装置，其包括照射用于产生电信号的光信号的光源单元; 光电池单元，其使用接收的光信号产生电信号; 以及电极单元，其使用所述电信号来刺激生物体，其中所述光伏电池单元和所述电极单元植入所述生物体内。 用于刺激生物体的装置可以以柔性形式制造，使得其可以扩展用于装置的植入部位的选择范围。 此外，光伏电池单元的采用避免了对电池更换的外科手术的需要。

    FLEXIBLE, MULTI-CHANNEL MICROELECTRODE FOR RECORDING LABORATORY ANIMAL EEG AND METHOD FOR RECORDING LABORATORY ANIMAL EEG USING THE SAME
    42.
    发明申请
    FLEXIBLE, MULTI-CHANNEL MICROELECTRODE FOR RECORDING LABORATORY ANIMAL EEG AND METHOD FOR RECORDING LABORATORY ANIMAL EEG USING THE SAME 有权
    用于记录实验动物脑的灵活的多通道微电解器和使用该实验室的实验动物脑的记录方法

    公开(公告)号：US20110224528A1

    公开(公告)日：2011-09-15

    申请号：US13123217

    申请日：2008-12-24

    申请人： Ji Hyun Choi ,  Hee Sup Shin ,  Klaus Peter Koch

    发明人： Ji Hyun Choi ,  Hee Sup Shin ,  Klaus Peter Koch

    IPC分类号： A61B5/0478

    CPC分类号： A61B5/0478 ,  A61B5/4094 ,  A61B2503/40 ,  A61B2562/0209 ,  A61B2562/046

    摘要： Disclosed are a novel, elastic, biocompatible, micro-sized, polyimide-based multi-channel microelectrode for recording of electroencephalography (EEG) from a laboratory animal including mouse, and a method for recording of laboratory animal EEG using the microelectrode. The microelectrode may include 2 grounding electrodes and 32 recording electrodes. A connector for signal transmission easily connects the microelectrode to a signal acquiring apparatus. The total weight of the microelectrode, including the connector, does not exceed 150 mg. Laboratory animal EEG, including that of mouse, provides the advantage of monitoring the brain state of a freely moving animal following a genetic or pharmaceutical manipulation. The microelectrode can be implanted without surgery and may be detached from wires while EEG is not recorded from the laboratory animal. The microelectrode can successfully acquire broadband EEG signals from the skull of the laboratory animal and is effective in monitoring spatial and temporal pattern of brain activities of the laboratory animal.

    摘要翻译： 公开了一种用于从包括小鼠的实验室动物记录脑电图（EEG）的新型，弹性的，生物相容的，微尺寸的基于聚酰亚胺的多通道微电极，以及使用微电极记录实验动物脑电图的方法。 微电极可以包括2个接地电极和32个记录电极。 用于信号传输的连接器容易地将微电极连接到信号获取装置。 包括连接器的微电极的总重量不超过150mg。 包括小鼠在内的实验动物脑电图提供了在遗传或药物操作后监测自由移动的动物的脑状态的优点。 微电极可以手术植入，并且可能从电线上脱离，而EEG未从实验室动物记录。 微电极可以从实验室动物的头骨中成功获得宽带脑电信号，有效监测实验动物大脑活动的时空格局。

    MICRO MANIPULATOR FOR ELECTRODE MOVEMENT IN NEURAL SIGNAL RECORDING
    43.
    发明申请
    MICRO MANIPULATOR FOR ELECTRODE MOVEMENT IN NEURAL SIGNAL RECORDING 有权
    用于神经信号记录中的电极运动的微操纵器

    公开(公告)号：US20100168759A1

    公开(公告)日：2010-07-01

    申请号：US12541558

    申请日：2009-08-14

    申请人： Eui Sung YOON ,  Sung Wook Yang ,  Jin Seok Kim ,  Duk Moon Rho ,  Ki Tae Park ,  Se Min Lee ,  Jei Won Cho ,  Hee Sup Shin

    发明人： Eui Sung YOON ,  Sung Wook Yang ,  Jin Seok Kim ,  Duk Moon Rho ,  Ki Tae Park ,  Se Min Lee ,  Jei Won Cho ,  Hee Sup Shin

    IPC分类号： A61B17/00

    CPC分类号： A61N1/0529 ,  A61B5/0051 ,  A61B5/04001 ,  A61B5/065 ,  A61B90/11 ,  A61B2017/00398 ,  A61B2034/2051

    摘要： This disclosure relates to a micro manipulator having a simple structure and having high possibility of recording a biological signal of a neuron at a desired position by improving positioning resolution of an electrode disposed adjacent to a subject's brain neuron or an electrode holder attached with the electrode. The micro manipulator according to the disclosure includes: a motor which includes a shaft and a vibration portion; a mobile which is connected to the shaft so as to be movable along the shaft; and a frame which supports the motor, wherein an electrode is connected to the mobile in a direction parallel to a longitudinal direction of the shaft, and wherein when the mobile moves linearly in accordance with a vibration of the shaft due to the vibration portion, the electrode moves linearly.

    摘要翻译： 本公开涉及一种具有简单结构的微操纵器，并且通过改善与被检体的脑神经元邻近设置的电极的定位分辨率或与电极连接的电极保持器，可以将希望位置处的神经元的生物信号记录到高可能性。 根据本公开的微机械手包括：电动机，其包括轴和振动部分; 移动体，其连接到所述轴，以便能够沿着所述轴移动; 以及支撑电动机的框架，其中电极在与轴的纵向方向平行的方向上连接到移动体，并且其中当移动体根据由于振动部分的轴的振动而线性移动时， 电极线性移动。

    METHOD FOR THE PREVENTION AND TREATMENT OF ESSENTIAL TREMOR BY REGULATING ALPHA1G T-TYPE CALCIUM CHANNEL OR BY T-TYPE CALCIUM CHANNEL BLOCKERS
    45.
    发明申请
    METHOD FOR THE PREVENTION AND TREATMENT OF ESSENTIAL TREMOR BY REGULATING ALPHA1G T-TYPE CALCIUM CHANNEL OR BY T-TYPE CALCIUM CHANNEL BLOCKERS 审中-公开
    通过调节ALPHA1G T型钙通道或T型钙通道阻断剂预防和治疗基本TREMOR的方法

    公开(公告)号：US20090131495A1

    公开(公告)日：2009-05-21

    申请号：US12120163

    申请日：2008-05-13

    申请人： Daesoo Kim ,  Hyeyeon Park ,  Hee-Sup Shin

    发明人： Daesoo Kim ,  Hyeyeon Park ,  Hee-Sup Shin

    IPC分类号： A61K31/42 ,  C12Q1/02

    CPC分类号： G01N33/6872 ,  A61K31/42 ,  G01N33/6896 ,  G01N2800/2835

    摘要： The present invention relates to a method for the prevention and treatment of essential tremor by blocking α1G T-type calcium channel, a preventive and therapeutic agent for essential tremor containing the α1G T-type calcium channel blocker as an active ingredient, and a screening method of a preventive and therapeutic agent for essential tremor by investigating α1G T-type calcium channel blocking activity. More precisely, the present invention relates to a method for the prevention and treatment of essential tremor by using α1G T-type calcium channel blocker, for which the inventors confirmed that the α1G T-type calcium channel knock out mice (α1G −/−) had resistance against essential tremor and when the T-type channel blocker was administered to the wild type mice (α1G +/+), they gained resistance against essential tremor.

    摘要翻译： 本发明涉及一种通过阻断α1GT型钙通道来预防和治疗原发性震颤的方法，该方法是含有α1GT型钙通道阻滞剂作为活性成分的必需震颤的预防和治疗剂，以及筛选方法 通过研究α1GT型钙通道阻断活性来预防和治疗原发性震颤。 更准确地说，本发明涉及一种通过使用α1GT型钙通道阻断剂预防和治疗原发性震颤的方法，本发明人确认α1GT型钙通道敲除小鼠（α1G - / - ） 具有抵抗基本震颤的作用，当将T型通道阻断剂施用于野生型小鼠（α1G+ / +）时，它们获得抗原震。

    Transgenic mouse whose genome comprises a homozygous disruption of its alpha1G gene, a method of preparing the same and use thereof
    47.
    发明申请
    Transgenic mouse whose genome comprises a homozygous disruption of its alpha1G gene, a method of preparing the same and use thereof 有权
    转基因小鼠，其基因组包含其α1G基因的纯合性破坏，其制备方法及其用途

    公开(公告)号：US20080201787A1

    公开(公告)日：2008-08-21

    申请号：US11986671

    申请日：2007-11-23

    申请人： Hee-Sup Shin ,  Daesoo Kim ,  Sehoon Keum ,  Inseon Song

    发明人： Hee-Sup Shin ,  Daesoo Kim ,  Sehoon Keum ,  Inseon Song

    IPC分类号： G01N33/50 ,  A01K67/027 ,  C12N15/86

    CPC分类号： C07K14/705 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0356 ,  A61K38/00 ,  A61K49/0008 ,  C12N15/8509

    摘要： The disclosure concerns a method for resistance of epilepsy by suppressing the function of alpha 1G protein of T-type calcium channels, use of suppressor of alpha 1G protein for prevention or treatment for epilepsy, knockout mice resisting epilepsy by disrupting alpha 1G subunit of T-type calcium channel, and preparation method thereof. The α1G-knockout transgenic mouse can be used for investigating the relationship between diseases particularly neuropathy or psychopathy and the function of α1G T-type calcium channel via various behavioral tests since α1G subunit is mainly expression in central nervous system (CNS) and pheripheral nervous system (PNS). Further, the α1G-knockout transgenic mouse can be used for screening antileptic agents.

    摘要翻译： 本公开涉及通过抑制T型钙通道的α1G蛋白的功能，使用α1G蛋白抑制剂预防或治疗癫痫的方法来抵抗癫痫的方法，通过破坏T细胞的α1G亚基来抵抗癫痫的敲除小鼠， 型钙通道及其制备方法。 α1G敲除转基因小鼠可用于通过各种行为测试来研究特别是神经病变或精神病的疾病与α1GT型钙通道的功能，因为α1G亚基主要表达于中枢神经系统（CNS）和脑神经系统 （PNS）。 此外，α1G敲除转基因小鼠可用于筛选抗癫痫剂。