PROFILE DISCONNECTION
    411.
    发明申请

    公开(公告)号:US20210207754A1

    公开(公告)日:2021-07-08

    申请号:US17130167

    申请日:2020-12-22

    Abstract: A profile includes: a sidewall, a lumen for a fluid path, and an end, the profile including a thermoset material, wherein the profile includes a sealed end without an external bonding material, wherein the sealed end withstands a seal integrity pressure test of at least 1 psi, such as at least 5 psi, such as at least 10 psi, such as at least 15 psi, or even at least 20 psi air pressure for about 30 minutes under dry and wet conditions.

    SEAT INSERT IN A BALL VALVE FOR CRYOGENIC APPLICATIONS

    公开(公告)号:US20210199203A1

    公开(公告)日:2021-07-01

    申请号:US17111849

    申请日:2020-12-04

    Abstract: Systems and methods are disclosed that include providing a valve suitable for maintaining a seal and preventing fluid flow through the valve at cryogenic temperatures. The valve includes a valve body having a longitudinal axis along a flow path through the valve, a ball selectively rotatable within the valve body to selectively allow fluid flow through the valve, a seat formed within the valve body and comprising a cavity having an angled wall, and a seat insert at least partially disposed within the cavity and having a first sealing surface that forms a first sealing interface with the ball to prevent leakage through a first leakage path and a second sealing surface that forms a second sealing interface with the angled wall to prevent leakage through a second leakage path when the ball valve is selectively rotated to prevent fluid flow through the valve.

    Containers and Methods for Cell Transduction

    公开(公告)号:US20210198606A1

    公开(公告)日:2021-07-01

    申请号:US17136400

    申请日:2020-12-29

    Abstract: This disclosure relates generally to containers (such as bags) having surfaces comprising one or more aptamer sequences. More particularly, the present disclosure relates to containers such as bags comprising a fluoropolymer attached to aptamer sequences having binding affinity for one or more biological agents, and to transductions methods using such containers. In one aspect, the disclosure provides a container (e.g., a bag) having an outer surface and an inner surface, the inner surface comprising a fluoropolymer; attached to the fluoropolymer, a plurality of functional groups; and attached to each of at least a portion of the functional groups, a first aptamer sequence having a binding affinity for a viral vector.

    High pressure bi-directional sealing system

    公开(公告)号:US11002391B2

    公开(公告)日:2021-05-11

    申请号:US16397700

    申请日:2019-04-29

    Abstract: The present invention is directed to a high-pressure bi-directional sealing system having circumferentially extending outer support rings (1520, 1900), annular, axial seals (1600, 1800) between the outer support rings (1520, 1900) and a circumferentially extending inner support ring (1700) located between the annular, axial seals (1600, 1800). The outer support rings (1520, 1900), seals (1600, 1800), and circumferentially extending inner support ring (1700) are located within a space between an outer tube (1502) and an inner tube (1504) that is telescopically disposed within the outer tube (1502). Seals (1600) and (1800) are oriented in opposite directions. Specifically, the opening of seal (1600) is facing in a first direction and the opening of seal (1800) is facing in a second direction that is opposite the first direction. This configuration enables the high-pressure bi-directional sealing system to handle pressure in both directions.

    Heterochain polymer composition
    419.
    发明授权

    公开(公告)号:US10968318B2

    公开(公告)日:2021-04-06

    申请号:US16236608

    申请日:2018-12-30

    Abstract: This disclosure relates to polymerizable silicone compositions, methods for polymerizing such compositions, and to polymerized silicone compositions formed thereby. In one embodiment, a polymerizable composition includes one or more first organosiloxanes or organosilanes, each comprising a plurality of silicon hydride functional groups, one or more second organosiloxanes or organosilanes, each comprising a plurality of reactive heterocycloalkyl functional groups; and one or more third organosiloxanes or organosilanes, each comprising at least about one silicon hydride functional group and at least about one reactive heterocycloalkyl functional group; one or more reactive organic compounds, each comprising at least about one reactive heterocycloalkyl functional group; and an effective amount of a borane catalyst, present, for example, in an amount within the range of 0.0005 wt % to about 10 wt %, wherein the ratio of reactive heterocycloalkyl functional groups to reactive silicon hydride functional groups in the composition is in the range of 1:5 to 5:1.

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