Stackable vapor-equilibration tray for cell culture and protein crystal growth
    31.
    发明申请
    Stackable vapor-equilibration tray for cell culture and protein crystal growth 审中-公开
    用于细胞培养和蛋白晶体生长的可堆叠蒸气平衡盘

    公开(公告)号:US20030015132A1

    公开(公告)日:2003-01-23

    申请号:US09909843

    申请日:2001-07-23

    发明人: Daniel C. Carter

    摘要: An apparatus and method for growing protein crystals or performing other chemical or biological processes, such as the culturing of cells, fungi or bacteria, is provided wherein a stackable tray containing sealable wells for housing a coverslip and a protein solution or other desired biological materials has side walls which extend to provide a base so that the tray may be stacked upon a tray below it, but wherein the sealable wells have a raised bottom which does not extend the same distance and thus are raised above the upper surface of the tray below it. By virtue of the present apparatus, the need to provide a plastic lid on the tray upon which another tray will be stacked is eliminated, and this makes these trays cheaper and more efficient, and allows them to be far more readily handled using robotics or other automated systems to stack, unstack, or manipulate the trays.

    摘要翻译: 提供了用于生长蛋白质晶体或进行其它化学或生物过程(例如培养细胞,真菌或细菌)的装置和方法,其中包含用于容纳盖玻片和蛋白质溶液或其它所需生物材料的可密封孔的可堆叠托盘具有 侧壁延伸以提供基部,使得托盘可以堆叠在其下方的托盘上,但是其中可密封的井具有不延伸相同距离的凸起的底部,并且因此在其下方的托盘的上表面上方升高 。 通过本装置,消除了在托盘上提供塑料盖的另一个托盘堆叠的需要,这使得这些托盘更便宜并且更有效率,并且允许它们使用机器人或其他方式更容易地处理 自动化系统来堆叠,拆卸或操纵托盘。

    Tray for macromolecule crystallization and method of using the same
    32.
    发明申请
    Tray for macromolecule crystallization and method of using the same 失效
    用于大分子结晶的托盘及其使用方法

    公开(公告)号:US20030010278A1

    公开(公告)日:2003-01-16

    申请号:US09903341

    申请日:2001-07-10

    发明人: Janet Newman

    摘要: A crystallization tray includes a plurality of crystallization cells, each cell having a reservoir adapted to receive an equilibrating solution, a shelf located adjacent to the reservoir and adapted for use as a temporary cryogenic holding area for a crystallized substance and/or a sample holding area, and a sample drop receptacle carried by the shelf and adapted to receive a sample drop including a crystallizable substance. A related method for forming macromolecular crystals includes dispensing an equilibrating solution in the reservoirs, dispensing a plurality of macromolecular solution droplets in the sample drop receptacles, covering the cells with a cover; and crystallizing the crystallizable substance by vapor diffusion.

    摘要翻译: 结晶托盘包括多个结晶细胞,每个细胞具有适于接收平衡溶液的储存器,位于储存器附近的搁架,并适于用作结晶物质和/或样品保持区域的临时低温保存区域 以及由搁架承载并适于接收包括可结晶物质的样品液滴的样品液滴容器。 用于形成大分子晶体的相关方法包括在储存器中分配平衡溶液,在样品滴液容器中分配多个大分子溶液液滴,用盖子覆盖电池; 并通过蒸气扩散使可结晶物质结晶。

    Method for causing fluid movement by centrifugal force
    33.
    发明申请
    Method for causing fluid movement by centrifugal force 失效
    通过离心力使流体运动的方法

    公开(公告)号:US20020195051A1

    公开(公告)日:2002-12-26

    申请号:US10060963

    申请日:2002-01-29

    发明人: Peter R. David

    摘要: A microfluidic method is provided that comprises: taking a microfluidic device comprising a plurality of microvolumes; and causing movement of material in a same manner within the plurality of microvolumes by applying centrifugal forces to the material.

    摘要翻译: 提供了一种微流体方法,其包括:获取包含多个微量体积的微流体装置; 并且通过向材料施加离心力,使材料以相同的方式在多个微体积内移动。

    Microvolume device employing fluid movement by centrifugal force
    34.
    发明申请
    Microvolume device employing fluid movement by centrifugal force 失效
    通过离心力采用流体运动的微体积装置

    公开(公告)号:US20020195049A1

    公开(公告)日:2002-12-26

    申请号:US10060922

    申请日:2002-01-29

    发明人: Peter R. David

    摘要: A microfluidic device is provided that comprises: a substrate; and a plurality of microvolumes at least partially defined by the substrate, each microvolume comprising a first submicrovolume and a second submicrovolume that is in fluid communication with the first submicrovolume when the device is rotated, the plurality of microvolumes being arranged in the device such that fluid in the first submicrovolumes of multiple of the microvolumes are transported to second submicrovolumes of the associated microvolumes when the device is rotated.

    摘要翻译: 提供一种微流体装置,其包括:基板; 以及由所述衬底至少部分地限定的多个微卷,每个微体积包括第一亚微体积和第二亚微体积,所述第一亚微体积和所述第二亚微体积在所述装置旋转时与所述第一亚微体积流体连通,所述多个微量体积被布置在所述装置中, 当装置旋转时,多个微卷的第一微量体积被传送到相关联的微卷的第二亚微体积。

    Microvolume device employing fluid movement by centrifugal force
    35.
    发明申请
    Microvolume device employing fluid movement by centrifugal force 失效
    通过离心力采用流体运动的微体积装置

    公开(公告)号:US20020189530A1

    公开(公告)日:2002-12-19

    申请号:US10060418

    申请日:2002-01-29

    发明人: Peter R. David

    摘要: A microfluidic device comprising: a substrate shaped so as to provide the device with an axis of rotation about which the device may be rotated; and a plurality of microvolumes at least partially defined by the substrate, each microvolume comprising a first submicrovolume and a second submicrovolume that is in fluid communication with the first submicrovolume when the device is rotated, the plurality of microvolumes being arranged in the device such that fluid in the first submicrovolumes of multiple of the microvolumes is transported to the second submicrovolumes of the associated microvolumes when the device is rotated about the rotational axis.

    摘要翻译: 一种微流体装置,包括:基板,其被成形为为所述装置提供所述装置可旋转的旋转轴线; 以及由所述衬底至少部分地限定的多个微卷,每个微体积包括第一亚微体积和第二亚微体积,所述第一亚微体积和所述第二亚微体积在所述装置旋转时与所述第一亚微体积流体连通,所述多个微量体积被布置在所述装置中, 当装置围绕旋转轴线旋转时,多个微体积的第一微量体积被传送到相关联的微卷的第二亚微体积。

    SEMICONDUCTING OXIDE NANOSTRUCTURES
    38.
    发明申请
    SEMICONDUCTING OXIDE NANOSTRUCTURES 有权
    半导体氧化物纳米结构

    公开(公告)号:US20040163584A1

    公开(公告)日:2004-08-26

    申请号:US10211696

    申请日:2002-08-02

    摘要: Nanostructures and methods of fabricating nanostructures are disclosed. A representative nanostructure includes a substrate having at least one semiconductor oxide. In addition, the nanostructure has a substantially rectangular cross-section. A method of preparing a plurality of semiconductor oxide nanostructures that have a substantially rectangular cross-section from an oxide powder is disclosed. A representative method includes: heating the oxide powder to an evaporation temperature of the oxide powder for about 1 hour to about 3 hours at about 200 torr to about 400 torr in an atmosphere comprising argon; evaporating the oxide powder; and forming the plurality of semiconductor oxide nanostructures.

    摘要翻译: 公开了纳米结构和制造纳米结构的方法。 代表性的纳米结构包括具有至少一种半导体氧化物的衬底。 此外,纳米结构具有基本上矩形的横截面。 公开了一种从氧化物粉末制备具有基本矩形横截面的多个半导体氧化物纳米结构的方法。 代表性的方法包括:在包含氩气的气氛中,在约200托至约400托下将氧化物粉末加热至氧化物粉末的蒸发温度约1小时至约3小时; 蒸发氧化物粉末; 以及形成所述多个半导体氧化物纳米结构体。

    Free-standing diamond structures and methods
    39.
    发明申请
    Free-standing diamond structures and methods 有权
    独立的钻石结构和方法

    公开(公告)号:US20040154526A1

    公开(公告)日:2004-08-12

    申请号:US10772444

    申请日:2004-02-06

    摘要: The present invention is directed in one aspect to methods of making free-standing, internally-supported, three-dimensional objects having an outer surface comprising a plurality of intersecting facets wherein a sub-set of the intersecting facets have a diamond layer of substantially uniform thickness. The diamond layer may be formed by chemical vapor deposition (CVD) over the surface of a substrate that has been fabricated to form a mold defining the sub-set of intersecting facets. A backing layer may be formed over at least a portion of the exposed diamond layer to enhance the rigidity of the layer when the substrate is removed.

    摘要翻译: 本发明在一个方面涉及制造具有包括多个相交小面的外表面的独立的内部支撑的三维物体的方法,其中所述相交小面的子集具有基本均匀的金刚石层 厚度。 金刚石层可以通过化学气相沉积(CVD)形成在衬底的表面上,所述衬底的表面已被制造成形成限定交叉面的子集的模具。 背衬层可以形成在暴露的金刚石层的至少一部分上,以在去除衬底时增强层的刚性。

    PATTERNING OF NANOCRYSTALLINE DIAMOND FILMS FOR DIAMOND MICROSTRUCTURES USEFUL IN MEMS AND OTHER DEVICES
    40.
    发明申请
    PATTERNING OF NANOCRYSTALLINE DIAMOND FILMS FOR DIAMOND MICROSTRUCTURES USEFUL IN MEMS AND OTHER DEVICES 有权
    用于MEMS和其他器件中的金刚石微结构的纳米晶体金刚石膜的图案

    公开(公告)号:US20040129202A1

    公开(公告)日:2004-07-08

    申请号:US10169879

    申请日:2002-11-08

    摘要: MEMS structure and a method of fabricating them from ultrananocrystalline diamond films having average grain sizes of less than about 10 nm and feature resolution of less than about one micron. The MEMS structures are made by contacting carbon dimer species with an oxide substrate forming a carbide layer on the surface onto which ultrananocrystalline diamond having average grain sizes of less than about 10 nm is deposited. Thereafter, microfabrication process are used to form a structure of predetermined shape having a feature resolution of less than about one micron.

    摘要翻译: MEMS结构以及由平均晶粒尺寸小于约10nm并具有小于约1微米的特征分辨率的超晶体金刚石膜制造它们的方法。 通过使碳二聚物与在其上沉积有平均粒径小于约10nm的超微晶金刚石的表面上形成碳化物层的氧化物基底接触来制造MEMS结构。 此后,使用微细加工工艺形成具有小于约1微米的特征分辨率的预定形状的结构。