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43 条记录 (耗时 0.016 秒)

    Chemical compounds
    31.
    发明授权
    Chemical compounds 失效
    化合物

    公开(公告)号：US3922305A

    公开(公告)日：1975-11-25

    申请号：US29771063

    申请日：1963-07-25

    申请人： MERCK & CO INC

    发明人： ENGELHARDT EDWARD L

    IPC分类号： C07D209/48 ,  C07C87/29

    CPC分类号： C07D209/48 ,  C07C2603/32

    摘要： 1. A compound selected from the group consisting of:

    AND ACID ADDITION SALTS THEREOF WHEREIN R is selected from the group consisting of hydrogen, alkyl having up to 6 carbon atoms, benzyl, or cycloalkyl having up to 8 carbon atoms; Y is selected from the group consisting of hydrogen, chloro, or bromo; and X and X'' are selected from the group consisting of hydrogen, chloro, or bromo. 2. A compound selected from the group consisting of:

    AND ACID ADDITION SALTS THEREOF WHEREIN R is selected from the group consisting of hydrogen and alkyl having up to 6 carbon atoms.

    摘要翻译： 1.选自以下的化合物：

    Sulfide compounds and methods and compositions for treating depression
    34.
    发明授权
    Sulfide compounds and methods and compositions for treating depression 失效
    硫化合物和治疗抑郁症的方法和组合物

    公开(公告)号：US4123555A

    公开(公告)日：1978-10-31

    申请号：US741196

    申请日：1976-11-12

    申请人： Nariman B. Mehta ,  Lawrence E. Brieaddy

    发明人： Nariman B. Mehta ,  Lawrence E. Brieaddy

    IPC分类号： C07D295/08 ,  A61K31/13 ,  A61K31/135 ,  A61K31/395 ,  A61P25/24 ,  A61P25/26 ,  C07C67/00 ,  C07C313/00 ,  C07C319/20 ,  C07C323/32 ,  C07C323/37 ,  C07D295/096 ,  C07D295/18 ,  C07D295/192 ,  C07C87/29

    CPC分类号： C07D295/192 ,  C07C323/00 ,  C07D295/096

    摘要： Compounds, pharmaceutical preparations containing same, and method of treating depression in mammals, the compounds being of the formula I ##STR1## or an acid addition salt thereof, particularly a pharmacologically or pharmaceutically acceptable salt thereof, where R and R.sup.1 are the same or different and are each hydrogen or lower alkyl, or R and R.sup.1 taken together are (CH.sub.2).sub.X where X is 4 or 5, or NRR.sup.1 is ##STR2## where Y is 3 or 4 and R.sup.3 is hydrogen or lower alkyl, or NRR.sup.1 is ##STR3## where R.sup.2 is hydrogen or lower alkyl, in the above lower alkyl has 1 to 4 carbons and may be straight or branched and n and m are the same or different and are 1, 2, or 3.

    摘要翻译： 化合物，含有它们的药物制剂和治疗哺乳动物抑郁症的方法，式I化合物（I）或其酸加成盐，特别是其药理学或药学上可接受的盐，其中R和R 1是 相同或不同，各自为氢或低级烷基，或R和R1一起为（CH 2）X，其中X为4或5，或NRR1为Y，其中Y为3或4，R3为氢或低级烷基，或 NRR1是其中R 2是氢或低级烷基，其中上述低级烷基具有1至4个碳，并且可以是直链或支链，并且n和m相同或不同，并且是1,2或3。

    10-(2-Substituted-amino- ethyl)-10,11-dihydro-5-methylene-5H-debenzo[a,d]cycloheptenes
    35.
    发明授权
    10-(2-Substituted-amino- ethyl)-10,11-dihydro-5-methylene-5H-debenzo[a,d]cycloheptenes 失效
    10-（2-取代的 - 氨基 - 乙基）-10,11-二氢-5-亚甲基-5H-去苯并{8a，d {9环庚烯

    公开(公告)号：US3994961A

    公开(公告)日：1976-11-30

    申请号：US442078

    申请日：1974-02-13

    申请人： William J. Houlihan ,  Jeffrey Nadelson

    发明人： William J. Houlihan ,  Jeffrey Nadelson

    IPC分类号： C07C87/29

    摘要： 10-(2-substituted-aminoethyl)-10,11-dihydro-5-methylene-2 or 3 7 or 8-substituted or unsubstituted-5H-dibenzo[a,d]cycloheptenes e.g., 10-(2-dimethylaminoethyl)-10,11-dihydro-5-methylene-5H-dibenzo[a,d]cycloheptane, prepared by various methods including acid dehydration of the corresponding dibenzo[a,d]cycloheptene-5-ols. The compounds are useful as anti-depressants.

    摘要翻译： 10-（2-取代 - 氨基乙基）-10,11-二氢-5-亚甲基-2或3 7或8-取代或未取代的-5H-二苯并[a，d]环庚烯，例如10-（2-二甲基氨基乙基） 通过各种方法制备的10,11-二氢-5-亚甲基-5H-二苯并[a，d]环庚烷，包括相应的二苯并[a，d]环庚烯-5-醇的酸脱水。 该化合物可用作抗抑郁剂。

    5H Dibenzo (a,d) cycloheptene, 10,11 dihydro, 5(1-halo-3-dimethylaminoprop-1-ylidene) derivatives
    36.
    发明授权
    5H Dibenzo (a,d) cycloheptene, 10,11 dihydro, 5(1-halo-3-dimethylaminoprop-1-ylidene) derivatives 失效
    5H二苯并（a，d）环庚烯，10,11二氢，5（1-卤代-3-二甲基氨基丙-1-基）衍生物

    公开(公告)号：US3991103A

    公开(公告)日：1976-11-09

    申请号：US516735

    申请日：1974-10-21

    申请人： Derek Harold Richard Barton ,  Robert Henry Hesse

    发明人： Derek Harold Richard Barton ,  Robert Henry Hesse

    IPC分类号： C07C67/00 ,  C07C209/00 ,  C07C211/32 ,  C07D313/12 ,  C07C87/00 ,  C07C87/29

    CPC分类号： C07D313/12

    摘要： 11-Halo derivatives of amitriptyline and its analogues, i.e. 5-(1'-halo-3'-aminoprop-1'-yl-idene)-5H-dibenzo[a,d]-10,11-dihydrocycloheptenes and corresponding 11-oxa analogues as well as the acid addition salts thereof, have notable anti-depressant and tranquillising activity. They are prepared by reacting a 5-(3'-aminoprop-1'-ylidene)-5H-dibenz[a,d]-10,11-dihydrocycloheptene or an 11-oxa analogue thereof, or an acid addition salt thereof, with an electrophilic halogenating agent.

    摘要翻译： 阿片替林及其类似物的11-Halo衍生物，即5-（1'-卤代-3'-氨基丙-1'-基 - 内酯）-5H-二苯并[a，d] -10,11-二氢环己烷和相应的11 氧类似物及其酸加成盐具有显着的抗抑郁和镇静作用。 它们通过使5-（3'-氨基丙基-1'-亚基）-5H-二苯并[a，d] -10,11-二氢环庚烯或其11-氧杂类似物或其酸加成盐与 亲电卤化剂。

    Chemical compounds
    37.
    发明授权
    Chemical compounds 失效
    化合物

    公开(公告)号：US3981917A

    公开(公告)日：1976-09-21

    申请号：US567157

    申请日：1975-04-11

    申请人： Edward L. Engelhardt

    发明人： Edward L. Engelhardt

    IPC分类号： C07D209/48 ,  C07C87/28 ,  C07C87/29

    CPC分类号： C07D209/48 ,  C07C2103/32

    摘要： This invention relates to new derivatives of dibenzocycloheptenes and to processes for making them. More particularly, the invention includes 5H-dibenzo[a,d]cycloheptenes and 10,11-dihydro-5H-dibenzo[a,d]cycloheptenes which are substituted at their 5-carbon atom with an aminopropyl or an aminopropylidene radical. The amino entity may be either primary or secondary and if secondary, the substituent may be either a lower alkyl or alkenyl radical having up to 6 carbon atoms, cycloalkyl having up to 8 carbon atoms or an aralkyl radical. The dibenzocycloheptene nucleus may be further substituted. The invention also includes the intermediates used for obtaining these products. Also included are derivatives such as acyl derivatives which yield the active compound under physiological conditions.

    摘要翻译： 本发明涉及二苯并环庚烯的新衍生物及其制备方法。 更具体地，本发明包括在5-碳原子被氨基丙基或氨基亚丙基取代的5H-二苯并[a，d]环庚烯和10,11-二氢-5H-二苯并[a，d]环庚烯。 氨基实体可以是伯或仲的，如果是仲的，则取代基可以是具有至多6个碳原子的低级烷基或烯基，具有至多8个碳原子的环烷基或芳烷基。 二苯并环庚烯核可以进一步被取代。 本发明还包括用于获得这些产品的中间体。 还包括衍生物，例如在生理条件下产生活性化合物的酰基衍生物。

    3,4- AND 3,5-Dialkoxybenzylamines
    38.
    发明授权
    3,4- AND 3,5-Dialkoxybenzylamines 失效
    3,4-和3,5-二烷氧基苄胺

    公开(公告)号：US3960958A

    公开(公告)日：1976-06-01

    申请号：US500377

    申请日：1974-08-26

    申请人： Kenneth Richardson

    发明人： Kenneth Richardson

    IPC分类号： C07C87/29

    摘要： Novel benzyl- and phenylethylamines useful as anti-viral agents are claimed as well as a process and a pharmaceutical composition for combating viral infections.

    摘要翻译： 可要求用作抗病毒剂的新型苄基和苯基乙胺以及用于对抗病毒感染的方法和药物组合物。