摘要:
Reacting a N-alkyl-amidosulfonyl chloride with a sulfenic acid chloride in the presence of an acid binding agent, optionally in the presence of an inert solvent, at a temperature of about 0*100*C., to form the corresponding N-alkyl-N-(trihalomethylthio)sulfamic acid chlorides, which are new compounds and which are intermediates for the preparation of fungicides.
WHEREIN R IS HYDROGEN OR METHYL, AND R1 IS B-HYDROXYETHYL, B - (B'' -HYDROXYETHOXY) - ETHYL, B,Y - DIHYDROXYPROPYL, OR A,Y-DIHYDROXYISOPROPYL ARE VERY READILY SOLUBLE IN WATER WITHOUT FORMING IONS. THEIR CONCENTRATED AQUEOUS SOLUTIONS MAY BE MIXED WITH CEREBROSPINAL FLUID IN BODY CAVITIES FOR ROENTGENOGRAPHIC EXAMINATION OF THE CAVITIES, AND ARE WELL TOLERATED.
摘要:
NEW STABLE SULFONAMIDES CONTAINING A CF2 GROUP ADJACENT TO NITROGEN ARE OBTAINED BY REACTING N-MONO-SUBSTITUTED SULFONAMIDES WITH FLUORO-OLEFINS OR THE ALKALI METAL SALTS OF SAID SULFONAMIDES WITH FLUORO-HALOALKANES. THE PRODUCTS ARE USEFUL AS REACTIVE INTERMEDIATES FOR A VARITETY ORGANIC SYNTHESES AND-OWING TO THEIR POLARITY AND HIGH BOILING POINTS-AS VALUABLE SOLVENTS FOR SPARINGLY SOLUBLE ORGANIC OR INORGANIC COMPOUNDS.
摘要:
N-Aroylperfluoroalkanesulfonamides wherein the perfluoroalkane group is methyl or ethyl and the aryl group is phenyl, naphthyl, pyridyl, thienyl, furyl, or pyrazinyl, optionally substituted, and their pharmaceutically acceptable salts, are active anticonvulsant agents. Processes for the preparation of these compounds are described.
WHEREIN R1 IS H ALKYL OF 1 TO 6 CARBON ATOMS; R3 IS ALKYL OF 1 TO 6 CARBON ATOMS, PHENYL OR PHENYL SUBSTITUTED BY LOWER ALKYL AND R5 IS H, ALKYL OF 1 TO 6 CARBON ATOMS, CYCLOPENTYL OR ALKYL OF 1 TO 6 CARBON ATOMS, SUBSTITUTED BY PHENYL, LOWER ALKOXYPHENYL OR PHENOXY; OR PHYSIOLOGICALLY ACCEPTABLE ACID ADDTION SALTS THEREOF. THE COMPOUNDS POSSESS STIMULANT OR BLOCKING ACTIONS ON ADRENERGIC RECEPTORS.
WHEREIN RF IS A FLUORCARBON GROUP HAVING 1 TO 4 CARBON ATOMS, HAVING EITHER AT LEAST ONE FLUORINE ATOM ATTACHED TO THE ALPHA CARBON ATOM OR IF THERE IS NO FLUORINE ATOM ATTACHED TO THE ALPHA CARBON ATOM, HAVING AT LEAST TWO FLUORINE ATOMS ATTACHED TO THE HTE BETA CARBON ATOM, A IS -O-,-S-,-N
摘要:
N-ALKYLSULFONYL BENZOYLHALOALKYLSULFONALIDES IN WHICH THE AROMATIC RINGS ARE OPTIONALLY SUBSTITUTED. THESE COMPOUNDS ARE ACTIVE ANTI-INFLAMMATORY AGENTS.
摘要:
THE COMPOUNDS ARE SULFONAMIDOALKYL AMINO ACIDS USEFUL AS CHELATING AGENTS AND AS PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CHRONIC HYPOTENSION. COMPOUNDS DISCLOSED INCLUDE P-METHANESUFLONAMIDOPHENYLALANINE AND M-METHANESULFONAMIDOPHENULALANINE.
摘要:
This invention relates to novel immobile reducing agents which, upon oxidation, auto-react intramolecularly in such a way as to form a new heterocyclic ring.