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公开(公告)号：US11998880B2
公开(公告)日：2024-06-04
申请号：US17008986
申请日：2020-09-01
发明人： Nasim Hashemi
IPC分类号： B01F27/2124 , B01F27/054 , B01F27/192 , B01F27/88 , B01F35/513 , C12M1/06 , B01F101/44
CPC分类号： B01F27/0541 , B01F27/1921 , B01F27/2124 , B01F27/88 , B01F35/513 , C12M27/02 , B01F2101/44
摘要： A mixing system includes a container for containing a fluid, and an agitator assembly disposable in the container for mixing the fluid. The agitator includes an extensible shaft and at least one impeller connected to the extensible shaft.
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公开(公告)号：US11788048B2
公开(公告)日：2023-10-17
申请号：US16646804
申请日：2018-09-14
发明人： Stephan Kaiser
IPC分类号： B01F27/00 , C12M1/06 , C12M1/00 , B01F27/054 , B01F27/072 , B01F27/2124 , B01F27/1125 , B01F35/513 , B01F101/44
CPC分类号： C12M27/02 , B01F27/054 , B01F27/0727 , B01F27/11251 , B01F27/2124 , B01F35/513 , C12M23/26 , B01F2101/44
摘要： The present set of embodiments relate to a system, method, and apparatus for culturing cells within a cell culture vessel having a mixing element. The cell culture system includes a flexible portion and a mixing element disposed therein. The mixing element includes a suspended foldable portion. The system is configured to reduce shear stress on cells without compromising mixing efficiency. This reduction is accomplished by using a mixing element having a large surface area allowing for reduced rotational speeds. The system is collapsible for ease of transport and disposal. The flexible portion collapses and the foldable portion folds to minimize the volume of the system while not in operation.
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公开(公告)号：US11745151B2
公开(公告)日：2023-09-05
申请号：US17125556
申请日：2020-12-17
发明人： Jeffery C. Hurd , Nephi D. Jones , Jacob D. Lee
IPC分类号： B01F7/00 , C12M1/34 , C12M1/00 , B01F3/04 , B01F15/00 , B01F27/231 , B01F23/231 , B01F27/07 , B01F27/113 , B01F27/213 , B01F27/2111 , B01F27/2121 , B01F27/2122 , B01F33/00 , B01F35/513 , C12M1/06 , B01F101/22 , B01F101/44
CPC分类号： B01F27/2312 , B01F23/2311 , B01F27/071 , B01F27/113 , B01F27/213 , B01F27/2111 , B01F27/2121 , B01F27/2122 , B01F33/86 , B01F35/513 , C12M23/14 , C12M23/26 , C12M27/02 , C12M41/44 , B01F23/231151 , B01F2101/22 , B01F2101/44
摘要： A liquid mixing system includes a support housing at least partially bounding a compartment. A mount is secured to the support housing. A drive motor assembly is configured to engage a drive shaft for moving the drive shaft within the compartment of the support housing. A four bar linkage system extends between the mount and the drive motor assembly, the four bar linkage system being movable between a first position wherein the drive motor assembly is disposed at a first elevation and a second position wherein the drive motor assembly is disposed at a second elevation that is different from the first elevation.
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公开(公告)号：US11529598B2
公开(公告)日：2022-12-20
申请号：US16424629
申请日：2019-05-29
发明人： Joshua Mead , Scott Rickes , Sean Zimmerman , Alessandra Barbosa , Mio Ling , Woon Liang Soh , Kevin Mullen , Christopher Brau , Jordan Cobia , Harmon Jr Cosme Sicat , Kok Shyong Chong , Han Wei , Wei Fuh Teo , Syed Muhammad Baber Ali
IPC分类号： C12M1/02 , B01F33/84 , C12M1/00 , C12M1/06 , C12M1/36 , B01F35/513 , G08B21/18 , B01F101/44
摘要： The present set of embodiments relate to a system, method, and apparatus controlling a cell culture media mixing system. The control system includes an integrated control unit capable of controlling a broad ranges of peripheral devices commonly used in bioproduction through a graphical user interface displayed on a touch sensitive screen. The bioproduction system is designed to be highly customizable through process modification and recipe creation by user with little or no knowledge of programming and is capable of controlling a wide variety of devices using a single unit. The bioproduction system allows for auto-detection, auto-calibration, and automatic of device related processes into a bioproduction workflow.
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公开(公告)号：US11492582B2
公开(公告)日：2022-11-08
申请号：US16897925
申请日：2020-06-10
IPC分类号： C12M3/00 , B01L3/00 , C12M1/00 , B01D5/00 , C12M1/06 , C12M1/12 , F28F21/06 , B01F23/233 , B01F23/231 , B01F27/88 , B01F27/90 , B01F27/91 , B01F27/2121 , B01F35/51 , B01F35/92 , B01F35/10 , B01F35/513 , B01D47/05 , C12N1/10 , C12N1/12 , C12N1/14 , C12N1/20 , C12N5/00 , C12N5/04 , C12M1/02 , F28B1/02 , F28F3/12 , C12N5/10 , F28D21/00 , B01F23/237 , B01F35/90 , B01F101/44
摘要： A bag assembly for use with a heat exchanger includes a flexible bag having of one or more sheets of polymeric material, the bag having a first end that bounds a first compartment and an opposing second end that bounds a second compartment, a support structure being disposed between the first compartment and the second compartment so that the first compartment is separated and isolated from the second compartment. A first inlet port, a first outlet port, and a first drain port are coupled with the flexible bag so as to communicate with the first compartment. A second inlet port, a second outlet port, and a second drain port are coupled with the flexible bag so as to communicate with the second compartment.
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公开(公告)号：US11441112B2
公开(公告)日：2022-09-13
申请号：US16429143
申请日：2019-06-03
IPC分类号： C12M1/00 , C12M3/06 , G01N1/31 , B01L9/00 , B01F31/23 , B01L3/00 , B01L1/00 , B01L7/04 , B01F101/44
摘要： An incubation device has multiple rocking platforms with each platform pivotally mounted about a respective axis. Each rocking platform has a respective receiving device for mechanically reversibly receiving a respective incubation channel. The device also has a common drive unit for common respective rocking movements of each platform from a zero position through with a specific angle range as a result of movement of the drive unit. Each rocking platform is coupled to the drive unit via a respective coupling mechanism, and each coupling mechanism elastically and resiliently couples the respective rocking platform to the drive unit, such that when the rocking platform is restrained, despite continuation of the drive movement, the rocking platform remains motionless in a fixed position. After release of the restraint on the rocking platform, the rocking platform resumes the rocking movement with the specific angle range.
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公开(公告)号：US11434465B2
公开(公告)日：2022-09-06
申请号：US16477926
申请日：2018-01-15
申请人： Merck Patent GmbH
发明人： Stephane Olivier , Gaetan Bour
摘要： The invention relates to a tubing device for sterile media including a container for storing sterile media, a discharge port for discharging liquid sterile media, an inlet port for introducing fluid into the tubing device and a multiple-way-connector. The multiple-way-connector is connected to the container, the discharge port, the inlet port, and an apparatus for preparing, mixing and discharging a sterile medium for use with a tubing device, including a water inlet port for introducing water, a water outlet port configured to be connected to the inlet port of the tubing device, a fluid pump for conveying the fluid, the fluid pump is connected to the fluid inlet port and the water outlet port and a container support for supporting the container of the tubing device.
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38.发明授权公开(公告)号：US11352598B2
公开(公告)日：2022-06-07
申请号：US16238618
申请日：2019-01-03
发明人： Nephi Jones , Steven Kjar , Brycen Mills , Mark Smith , Derik West
IPC分类号： B22C5/00 , C12M1/42 , C12M1/00 , C12N5/071 , C12M1/06 , B01F23/233 , B01F27/054 , B01F27/92 , B01F27/114 , B01F27/213 , B01F35/43 , B01F35/513 , B01F35/32 , B01F35/41 , C12M1/36 , B01F27/90 , B01F35/30 , B01F101/44
摘要： The present set of embodiments relate to a bioproduction system, method, and apparatus for mixing a fluid. The bioproduction mixing system includes an offset helical assembly having a stabilizer and impeller for mixing a fluid within a flexible compartment The bioproduction mixing system is designed for efficient mixing of the fluid and for use with a variety of different impellers that can be located at different locations according to the volume and shape characteristics of the flexible compartment. The bioproduction mixing system is optimized to eliminate stagnation zones while maximizing bulk fluid flow.
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公开(公告)号：US11312539B2
公开(公告)日：2022-04-26
申请号：US16919582
申请日：2020-07-02
IPC分类号： B01D15/00 , B01D3/04 , B29C45/16 , B65D33/02 , C12M1/00 , C12M1/21 , B01F23/231 , B01F33/453 , B01F35/51 , B01F35/513 , B01F101/44 , B29K23/00 , B29L31/00
摘要： A bioreactor configured to contain a volume of liquid is provided. The bioreactor includes a collapsible bag able to contain the volume of liquid, a support structure surrounding and containing the collapsible bag, a first sparger connected to the collapsible bag, the first sparger having a first aperture size, and a second sparger connected to the collapsible bag, the second sparger having a second aperture size that is different from the first aperture size.
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公开(公告)号：US11311848B2
公开(公告)日：2022-04-26
申请号：US16081318
申请日：2017-03-01
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITE D'AIX MARSEILLE , ECOLE CENTRALE DE MARSEILLE
发明人： Patrice Meunier , Richard Manasseh
IPC分类号： B01F29/62 , B01F29/00 , B01F101/44 , C12M3/04
摘要： A bladeless mixer for mixing a liquid, includes a cylindrical or truncated cone-shaped receptacle having an axis A and a radius R, the radius R being the shortest distance between the axis A and a side wall of the receptacle, the liquid to be mixed being placed in the receptacle and having an exposed surface at a height H measured along axis A; a member for tilting the receptacle such that axis A forms a non-zero-degree angle of up to 30° relative to the vertical direction; a member for imparting a rotational movement to the receptacle along axis A at an angular speed of rotation Ω; wherein the aspect ratio H/R of the height H to the radius R and the angular speed of rotation Ω are selected such that an inherent mode of inertia of the liquid has an unstable resonance when the receptacle is tilted and rotates.
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