公开(公告)号：US20100117641A1

公开(公告)日：2010-05-13

申请号：US11528878

申请日：2006-09-28

申请人： Yuchen Zhou

发明人： Yuchen Zhou

IPC分类号： G01R33/20

CPC分类号： G01N24/10 ,  G01N24/088 ,  G01R33/5601

摘要： A method and apparatus for detecting the presence of magnetic beads is disclosed. By providing both a static magnetic field and a magnetic field that alternates in the MHz range, or beyond, the bead can be excited into FMR (ferromagnetic resonance). The appearance of the latter is then detected by a magneto-resistive type of sensor. This approach offers several advantages over prior art methods in which the magnetic moment of the bead is detected directly.

摘要翻译： 公开了一种用于检测磁珠存在的方法和装置。 通过提供静态磁场和在MHz范围内或以后交替的磁场，磁珠可以被激发成FMR（铁磁共振）。 然后由磁阻式传感器检测后者的外观。 这种方法提供了优于现有技术方法的几个优点，其中珠的磁矩直接被检测。

公开(公告)号：US20100006439A1

公开(公告)日：2010-01-14

申请号：US12559895

申请日：2009-09-15

申请人： Donhee Ham ,  Robert Westervelt ,  Thomas Hunt ,  Yong Liu ,  Hakho Lee

发明人： Donhee Ham ,  Robert Westervelt ,  Thomas Hunt ,  Yong Liu ,  Hakho Lee

IPC分类号： B03C5/02

CPC分类号： G01R33/302 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2200/147 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0877 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/043 ,  G01N15/1031 ,  G01N24/08 ,  G01N24/10 ,  G01R33/307 ,  G01R33/34092 ,  G01R33/3415 ,  G01R33/465 ,  G01R33/4808 ,  G01R33/5604

摘要： Methods and apparatus for manipulation, detection, imaging, characterization, sorting and/or assembly of biological or other materials, involving an integration of CMOS or other semiconductor-based technology and microfluidics. In one implementation, various components relating to the generation of electric and/or magnetic fields are implemented on an IC chip that is fabricated using standard protocols. The generated electric and/or magnetic fields are used to manipulate and/or detect one or more dielectric and/or magnetic particles and distinguish different types of particles. A microfluidic system is fabricated either directly on top of the IC chip, or as a separate entity that is then appropriately bonded to the IC chip, to facilitate the introduction and removal of cells in a biocompatible environment, or other particles/objects of interest suspended in a fluid. The patterned electric and/or magnetic fields generated by the IC chip can trap and move biological cells or other objects inside the microfluidic system. Electric and/or magnetic field generating components also may be controlled using signals of various frequencies so as to detect one or more cells, particles or objects of interest, and even the type of particle or object of interest, by measuring resonance characteristics associated with interactions between samples and one or more of the field-generating devices. Such systems may be employed in a variety of biological and medical related applications, including cell sorting and tissue assembly.

摘要翻译： 用于操作，检测，成像，表征，分选和/或组装生物或其他材料的方法和装置，涉及CMOS或其他基于半导体的技术和微流体的集成。 在一个实现中，与使用标准协议制造的IC芯片上实现与电场和/或磁场的产生有关的各种组件。 产生的电场和/或磁场用于操纵和/或检测一个或多个电介质和/或磁性颗粒并区分不同类型的颗粒。 微流体系统直接制造在IC芯片的顶部上，或者作为独立的实体，然后适当地结合到IC芯片，以便于在生物相容性环境或其他感兴趣的其它颗粒/物体中引入和去除细胞悬浮 在流体中。 由IC芯片产生的图案化电场和/或磁场可以捕获并移动微流体系统内的生物细胞或其它物体。 可以使用各种频率的信号来控制电场和/或磁场产生组件，以便通过测量与相互作用相关联的共振特性来检测一个或多个感兴趣的细胞，颗粒或感兴趣的物体，甚至是感兴趣的粒子或物体的类型 样本和一个或多个场产生装置之间。 这样的系统可以用于各种生物和医学相关应用，包括细胞分选和组织组装。

公开(公告)号：US07541811B2

公开(公告)日：2009-06-02

申请号：US11774273

申请日：2007-07-06

申请人： Toshiyuki Usagawa

发明人： Toshiyuki Usagawa

IPC分类号： G01V3/00

CPC分类号： G01N24/10 ,  G01R33/3806 ,  G01R33/383

摘要： A compact, lightweight, and easy-to-use ESR-CT apparatus including a magnetic field leak line (5-G line) which is capable of imaging a small animal, such as a mouse, within 15 minutes, and of observing a desired region with a spatial resolution of 1 mm or less. A permanent magnet system is introduced of the apparatus includes pole pieces having a predetermined area which are opposed to each other through a measured space, yokes combined with the pole pieces, and a permanent magnet inserted in series so that at least one magnetic pole plane intersects perpendicularly to the closed magnetic circuit for magnetic coupling with the yokes. This makes it possible to locate a gradient coil system and a field scanning coil system sufficiently apart from end faces of the pole pieces, and to downsize the field scanning coil system so that the gradient field system is movable.

摘要翻译： 一种紧凑，重量轻且易于使用的ESR-CT装置，其包括能够在15分钟内对小动物（例如鼠标）进行成像的磁场泄漏线（5-G线）和观察所需的 空间分辨率为1mm以下的区域。 引入永磁体系统，该装置包括具有通过测量空间彼此相对的预定区域的极片，与极片组合的轭铁和串联插入的永磁体，使得至少一个磁极平面与 垂直于与磁轭耦合的封闭磁路。 这使得可以将梯形线圈系统和场扫描线圈系统定位成与极片的端面充分分开，并且使场扫描线圈系统小型化，使得梯度场系统是可移动的。

公开(公告)号：US07432714B2

公开(公告)日：2008-10-07

申请号：US10587447

申请日：2005-01-14

申请人： Menno Willem Jose Prins

发明人： Menno Willem Jose Prins

IPC分类号： G01V3/00

CPC分类号： G01N15/0656 ,  G01N24/10 ,  G01R33/28 ,  G01R33/3806 ,  G01R33/60

摘要： A method and a device for on-chip magnetic resonance spectroscopy is proposed. On-chip magnetic resonance spectroscopy may be applied to non-magnetic as well as magnetic materials which may be solids, liquids, or gases. The method of the present invention is suitable for miniaturized materials analysis such as, for example, micro-fluidics. In an example embodiment, the method relies on the combination of highly efficient spin excitation near on-chip current wires with very sensitive on-chip magnetic sensors. The method and device also allows one to separately detect different types of magnetic particles or molecules.

摘要翻译： 提出了片上磁共振波谱法的方法和装置。 片上磁共振光谱可以应用于非磁性以及可能是固体，液体或气体的磁性材料。 本发明的方法适用于例如微流体学的小型化材料分析。 在示例实施例中，该方法依赖于片上电流线附近的高效自旋激励与非常灵敏的片上磁传感器的组合。 该方法和装置还允许单独地检测不同类型的磁性颗粒或分子。

公开(公告)号：US07425828B2

公开(公告)日：2008-09-16

申请号：US11548691

申请日：2006-10-11

申请人： Michael Garwood ,  Djaudat S. Idiyatullin ,  Curt Corum ,  Steen Moeller

发明人： Michael Garwood ,  Djaudat S. Idiyatullin ,  Curt Corum ,  Steen Moeller

IPC分类号： G01V3/00

CPC分类号： G01N24/10 ,  G01N24/081 ,  G01R33/441 ,  G01R33/446 ,  G01R33/4616 ,  G01R33/4816 ,  G01R33/54

摘要： A method of magnetic resonance is provided that uses a frequency swept excitation wherein the acquired signal is a time domain signal is provided. In one embodiment, the method comprises, applying a sweeping frequency excitation and acquiring a time domain signal. The sweeping frequency excitation has a duration and is configured to sequentially excite isochromats having different resonant frequencies. Acquisition of the time domain signal is done during the duration of the sweeping frequency excitation. The time domain signal is based on evolution of the isochromats.

摘要翻译： 提供了一种磁共振的方法，其使用频率扫描激励，其中提供所获取的信号是时域信号。 在一个实施例中，该方法包括：施加扫频激励并获取时域信号。 扫频频率激励具有持续时间并且被配置为顺序地激发具有不同谐振频率的异色素。 在扫描频率激励的持续时间内完成时域信号的采集。 时域信号是基于异色素的进化。

公开(公告)号：US20070229078A1

公开(公告)日：2007-10-04

申请号：US11394160

申请日：2006-03-31

申请人： Chang-Min Park ,  Shriram Ramanathan ,  Kenneth Cadien

发明人： Chang-Min Park ,  Shriram Ramanathan ,  Kenneth Cadien

IPC分类号： G01V3/00

CPC分类号： G01N24/08 ,  G01N24/10 ,  G01R33/3806 ,  G01R33/3808 ,  G01R33/383

摘要： As embodiment of the invention relates to a device for performing NMR or ESR analysis. The device comprises a detection unit, a magnet, and a disk having a magnetic pattern. The detection unit comprises a sample holding space for holding a sample and a microcoil for detecting NMR or ESR signals generated within the sample. The magnet generates a static magnetic field within the sample. The disk and magnetic pattern, when rotating, generate an excitation magnetic field, which, together with the static magnetic field, creates an NMR or ESR within the sample. Other embodiments of the invention encompass methods for performing NMR or ESR analysis using the device and methods of making such devices.

摘要翻译： 本发明的实施方案涉及用于进行NMR或ESR分析的装置。 该装置包括检测单元，磁体和具有磁性图案的盘。 检测单元包括用于保持样品的样品保持空间和用于检测在样品内产生的NMR或ESR信号的微线圈。 磁体在样品内产生静态磁场。 盘和磁图在旋转时产生激励磁场，其与静磁场一起在样品内产生NMR或ESR。 本发明的其它实施方案包括使用该装置进行NMR或ESR分析的方法和制备这种装置的方法。

公开(公告)号：US20070085541A1

公开(公告)日：2007-04-19

申请号：US11542830

申请日：2006-10-03

申请人： Xiao Dong Xiang ,  Haitao Yang ,  Gang Wang

发明人： Xiao Dong Xiang ,  Haitao Yang ,  Gang Wang

IPC分类号： G01V3/00

CPC分类号： G01R33/60 ,  G01N24/00 ,  G01N24/006 ,  G01N24/08 ,  G01N24/10 ,  G01R33/345

摘要： Methods and systems for spatially resolved spin resonance detection in a sample of material are disclosed. Also disclosed are methods and systems for spatially resolved impedance measurements in a sample of material. The disclosed methods and samples can be used in screening of plurality of biological, chemical and material samples.

公开(公告)号：US20060275914A1

公开(公告)日：2006-12-07

申请号：US11440665

申请日：2006-05-25

申请人： Don Henley ,  Aman Anand ,  Tim Imholt ,  James Roberts

发明人： Don Henley ,  Aman Anand ,  Tim Imholt ,  James Roberts

IPC分类号： G01N24/00

CPC分类号： G01N33/551 ,  B82Y30/00 ,  G01N24/10 ,  G01N33/54346 ,  G01N33/54373

摘要： A method, apparatus and system for use in sensing and detecting various biological and chemical agents. More specifically, the present invention utilizes nanotubes as a novel structure in a particle detection application. Antibodies for agents such as anthrax, bubonic plague, e-coli, botulism, small pox and fast spreading viruses such as SARS are homogeneously dispersed on a nanotube filter such as a CNT filter, including buckypaper. These filters are then placed into a device which facilitates filtering volumes of the atmosphere or food material. Any pathogen or toxin corresponding to the specific antibody held by the nanofilter reacts with the antibody and are retained on the filter. The nanofilter would then be subjected to microwave treatment and spectral analysis.

摘要翻译： 用于感测和检测各种生物和化学试剂的方法，装置和系统。 更具体地，本发明在粒子检测应用中使用纳米管作为新颖结构。 针对诸如炭疽，瘟疫，大肠杆菌，肉毒中毒，小痘和快速蔓延病毒如SARS的药物的抗体均匀地分散在诸如CNT滤器的纳滤器过滤器（包括降压纸）上。 然后将这些过滤器放入便于过滤空气或食物材料的装置中。 对应于由纳滤膜保持的特异性抗体的任何病原体或毒素与抗体反应并保留在过滤器上。 然后将纳米过滤器进行微波处理和光谱分析。

公开(公告)号：US20040251899A1

公开(公告)日：2004-12-16

申请号：US10731552

申请日：2003-12-08

发明人： Harold M. Swartz ,  William F.B. Punchard ,  Piotr M. Starewicz ,  Tadeusz M. Walczak

IPC分类号： G01V003/00

CPC分类号： G01R33/60 ,  G01N24/10 ,  G01T1/04

摘要： The instant invention provides in-vivo methods and apparatus for radiation dosimetry assessment in individuals exposed to potentially harmful radiation, based on measurements in-situ of the teeth. The in vivo dosimetry assessment methods and apparatus utilize electron paramagnetic resonance (EPR) techniques; and employ an apparatus comprising an integrated EPR spectrometer system, an ergonomic magnet and a constructed resonator structure. In various aspects, the dosimetry assessment apparatus is configured to be easily portable and withstand potentially adverse mechanical effects of transportation and deployment in the field. The apparatus also is configured with a power supply that is compatible with both conventional AC line voltages and/or other sources of power suitable for field conditions; and may be easily operated by minimally trained technicians to quickly generate a readout of estimated radiation exposure dose.

摘要翻译： 本发明提供了基于在牙齿原位测量的暴露于潜在有害辐射的个体中的放射剂量测定评估的体内方法和装置。 体内剂量学评估方法和装置利用电子顺磁共振（EPR）技术; 并采用包括集成EPR光谱仪系统，符合人体工程学的磁体和构造的谐振器结构的装置。 在各个方面，剂量测定评估装置被配置为容易携带并且承受在现场的运输和部署的潜在不利的机械效应。 该装置还配置有与常规AC线路电压和/或适用于现场条件的其它电源兼容的电源; 并且可以由训练有素的技术人员容易地操作以快速产生估计的辐射照射剂量的读数。

公开(公告)号：US20040191913A1

公开(公告)日：2004-09-30

申请号：US10483003

申请日：2003-12-31

发明人： Toshikazu Yoshikawa

IPC分类号： G01N021/00

CPC分类号： G01N33/50 ,  G01N24/10 ,  G01N33/02 ,  G01R33/60

摘要： Provided is a method of evaluation of antioxidation level through determination of in-vivo redox balance. The redox balance is represented by a formula: redox balancenull(antioxidation index after administration/oxidation index after administration)/(antioxidation index before administration/oxidation index before administration). The antioxidation index is obtained by indexing the antioxidation level that is obtained through quantitative determination of the signal intensity attenuation with serum addition thereto of the DMPO-OOL radical formed through trapping of a butylhydroperoxide radical by 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) by the use of a magnetic spin resonator followed by analysis of the data for 10-grade frequency distribution of from 1 to 10, and the oxidation index is obtained by indexing the oxidation level that is obtained through quantitative determination of 8-hydroxydeoxyguanosine (8-OHdG) in urine followed by analysis of the data for 10-grade frequency distribution of from 1 to 10.

摘要翻译： 提供通过测定体内氧化还原平衡来评价抗氧化水平的方法。 氧化还原平衡由以下公式表示：氧化还原平衡=（给药后的抗氧化指数/给药后的氧化指标）/（给药前的抗氧化指标/给药前的氧化指标）。 抗氧化指数是通过用通过用5,5-二甲基-1-吡咯啉-N捕获丁基过氧化氢根而形成的DMPO-OOL基团的血清添加来定量测定信号强度衰减所获得的抗氧化水平而得到的。 通过使用磁自旋谐振器，然后分析10级频率分布的数据，从1到10，并通过将通过定量测定8获得的氧化水平进行索引获得氧化指数，得到氧化物（DMPO） - 羟基去氧鸟苷（8-OHdG），然后分析10级频率分布的数据，从1到10。