公开(公告)号：US5332729A

公开(公告)日：1994-07-26

申请号：US56082

申请日：1993-05-03

Applicant: Stuart J. Mickel ,  Wolfgang Frostl ,  Pascal Furet

Inventor： Stuart J. Mickel ,  Wolfgang Frostl ,  Pascal Furet

IPC: A61K31/66 ,  A61K31/675 ,  A61P25/00 ,  C07F9/30 ,  C07F9/58 ,  C07F9/6518 ,  C07F9/6524 ,  C07F9/653 ,  B01J31/00

CPC classification number: C07F9/65318 ,  C07F9/301 ,  C07F9/588 ,  C07F9/65187 ,  C07F9/6524 ,  C07F9/653

Abstract: N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids of formula I ##STR1## wherein R is an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, araliphatic or heteroarylaliphatic radical having at least 2 carbon atoms,R.sub.1 is hydrogen or hydroxy,R.sub.2 is an araliphatic or heteroarylaliphatic radical substituted by free or functionally modified carboxy that is bonded directly or by way of a spacer, andR.sub.3 is hydrogen, lower alkyl or a group R.sub.2, and the salts thereof have valuable nootropic and anti-epileptic properties and can be used in the preparation of a nootropic or anti-epileptic medicament.

Abstract translation: 式（I）的N-芳烷基 - 和N-杂芳烷基 - 氨基链烷基亚膦酸其中R是具有至少2个碳原子的脂族，脂环族，脂环族 - 脂族，芳脂族或杂芳基脂族基，R1是氢或羟基，R2 是由直接键合或通过间隔基键合的自由或功能性修饰的羧基取代的芳脂肪族或杂芳基脂族基团，R3是氢，低级烷基或基团R2，其盐具有有价值的益智性和抗癫痫性质，并且可以 用于制备向异性或抗癫痫药物。

公开(公告)号：US5242890A

公开(公告)日：1993-09-07

申请号：US829976

申请日：1992-02-03

Applicant: Kwang Y. Cho ,  In H. Jeong

Inventor： Kwang Y. Cho ,  In H. Jeong

IPC: A01N43/82 ,  A01N43/836 ,  A01N47/12 ,  A01N47/20 ,  A01N47/36 ,  A01N57/16 ,  A01N57/32 ,  C07D271/06 ,  C07D271/07 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07F9/653

CPC classification number: C07D271/06 ,  A01N43/82 ,  A01N47/12 ,  A01N47/20 ,  A01N47/36 ,  A01N57/16 ,  A01N57/32 ,  C07D271/07 ,  C07D413/04 ,  C07D413/06 ,  C07D413/10 ,  C07F9/65318

Abstract: The present invention relates to 1,2,4-oxadiazole derivative of the formula (I) ##STR1## wherein X represents a chlorine or fluorine atom or methyl group,Y represents a chlorine or fluorine atom,n is an integer of 1 or 3.The compounds of the invention have a extremely high selectively between paddy rice or crop plants and weeds, and a strong activity on various weeds. Moreover, the compounds have a very low phytotoxicity to paddy rice and crop plants.

Abstract translation: 本发明涉及式（I）的1,2,4-恶二唑衍生物，其中X代表氯或氟原子或甲基，Y代表氯或氟原子，n是1或3的整数 本发明的化合物在水稻或作物和杂草之间选择性极高，对各种杂草具有很强的活性。 此外，这些化合物对水稻和作物植物的植物毒性非常低。

公开(公告)号：US4308261A

公开(公告)日：1981-12-29

申请号：US143567

申请日：1980-04-25

Applicant: William F. King ,  Ronald E. Wheeler

Inventor： William F. King ,  Ronald E. Wheeler

IPC: A01N57/16 ,  C07F9/653 ,  A01N57/00 ,  A01N57/26

CPC classification number: C07F9/65318 ,  A01N57/16

Abstract: A method for killing wire worms and flea beetles which comprises applying to the soil habitat of the wire worms and flea beetles an insecticidally effective amount of a compound of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are alkyl of 1 to 4 carbon atoms; and X, Y, Z and V are sulfur or oxygen.

Abstract translation: 一种用于杀死线虫和跳蚤甲虫的方法，其包括向虫丝虫和蚤甲虫的土壤栖息地施用杀虫有效量的下式化合物：其中R 1，R 2和R 3是1至4个碳原子的烷基 ; X，Y，Z和V是硫或氧。

公开(公告)号：US4308260A

公开(公告)日：1981-12-29

申请号：US143566

申请日：1980-04-25

Applicant: William F. King ,  Ronald E. Wheeler

Inventor： William F. King ,  Ronald E. Wheeler

IPC: A01N57/16 ,  C07F9/653 ,  A01N57/00 ,  A01N57/26

CPC classification number: A01N57/16 ,  C07F9/65318

Abstract: A method for killing grubs which comprises applying to the soil habitat of the grubs an insecticidally effective amount of a compound of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are alkyl of 1 to 4 carbon atoms; and X, Y, Z and V are sulfur or oxygen.

Abstract translation: 一种杀死gr A的方法，包括向the the的土壤栖息地施用杀虫有效量的下式化合物：其中R 1，R 2和R 3为1至4个碳原子的烷基; X，Y，Z和V是硫或氧。

公开(公告)号：US4073894A

公开(公告)日：1978-02-14

申请号：US742970

申请日：1976-11-17

Applicant: Leonard J. Stach ,  Robert N. Wilke

Inventor： Leonard J. Stach ,  Robert N. Wilke

IPC: A01N57/08 ,  C07D271/06 ,  C07D271/07 ,  C07F9/653 ,  A01N9/36

CPC classification number: C07D271/07 ,  A01N57/08 ,  C07F9/65318

Abstract: This invention discloses new compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 are independently selected from the group consisting of alkyl and ##STR2## WHEREIN A is selected from the group consisting of alkyl, alkoxy, alkylthio, halogen, nitro and cyano; and n is an integer from 0 to 3; X.sup.1, X.sup.2, X.sup.3, Z.sup.1 and Z.sup.2 are independently selected from the group consisting of oxygen and sulfur; m is the integer 0 or 1; and Y is selected from the group consisting of alkyl, alkoxy, alkylthio, amino, alkylamino and dialkylamino. Further disclosed are insecticidal compositions containing as an essential ingredient a compound of the foregoing description.

Abstract translation: 本发明公开了新的式（ⅠA）化合物，其中R 1和R 2独立地选自烷基，囟素A选自烷基，烷氧基，烷硫基，卤素，硝基和氰基; n为0〜3的整数， X1，X2，X3，Z1和Z2独立地选自氧和硫; m是整数0或1; Y选自烷基，烷氧基，烷硫基，氨基，烷基氨基和二烷基氨基。 进一步公开的是含有上述说明的化合物作为必需成分的杀虫组合物。

公开(公告)号：US3920677A

公开(公告)日：1975-11-18

申请号：US34043273

申请日：1973-03-12

Applicant: CIBA GEIGY CORP

Inventor： MEYER WILLY ,  BOHNER BEAT

IPC: A01N57/16 ,  A01N57/08 ,  A01N57/24 ,  C07D271/06 ,  C07D271/07 ,  C07F9/653

CPC classification number: C07D271/07 ,  A01N57/08 ,  C07F9/65318

Abstract: AND X represents oxygen or sulphur, a process for their production and their use for pest control.

wherein R1 represents C1-C4-alkyl, C1-C4-alkoxy or unsubstituted or substituted phenyl, R2 represents C1-C4-alkyl, R3 represents substituted alkyl or the groups

Oxadiazolyl compounds of the formula

Abstract translation: 式O-NXR1的恶二唑基化合物|平行平行R3-CC-OP角度NOR2其中R1表示C1-C4-烷基，C1-C4-烷氧基或未取代或取代的苯基，R2表示C1-C4-烷基，R3表示 取代的烷基或基团，并且X表示氧或硫，它们的生产方法及其用于害虫防治的方法。

公开(公告)号：US3798230A

公开(公告)日：1974-03-19

申请号：US3798230D

申请日：1971-02-17

Applicant: BASF AG

Inventor： BEUTEL P ,  KOENIG K ,  DIETSCHE W ,  ADOLPHI H

IPC: A01N57/16 ,  C07D271/06 ,  C07D271/07 ,  C07F9/165 ,  C07F9/653 ,  C07F9/655 ,  C07D85/52

CPC classification number: C07D271/07 ,  A01N57/16 ,  C07F9/1651 ,  C07F9/65318 ,  C07F9/6552

Abstract: O,O-DIALKYL-O-(1 - OXA - 2,4 - DIAZOLIDINON-5-YL-3)THIONOPHOSPHATES HAVING A SUBSTITUENT IN THE 4-POSITION, SAID THIONOPHOSPHATES HAVING GOOD INSECTICIDAL ACTION AND A PROCESS FOR CONTROLLING INSECTS WITH THESE COMPOUNDS, SUCH COMPOUNDS INCLUDING O,O-DIETHYL-O-(4-NPROPYL-1-OXA - 2,4 - DIAZOLIDINON-5-YL-3)-THIONOPHOSPHATE AND O,O-DIETHYL - O - (4-PHENYL-1-OXA-2,4-DIAZOLIDINON5-YL-3)-THIONOPHOSPNATE.

公开(公告)号：US20180362482A1

公开(公告)日：2018-12-20

申请号：US16061597

申请日：2016-12-12

Applicant: Merck Sharp & Dohme Corp.

Inventor： Yongxin Han ,  Abdelghani Achab ,  Purakkattle Biju ,  Yongqi Deng ,  Xavier Fradera ,  Liangqin Guo ,  Shuwen He ,  Joseph Kozlowski ,  Ravi Kurukulasuriya ,  Kun Liu ,  Meredeth Ann McGowan ,  Qinglin Pu ,  Nunzio Sciammetta ,  Hongjun Zhang ,  Hua Zhou

IPC: C07D271/08 ,  C07D285/10 ,  C07D413/12 ,  A61P25/24 ,  A61P25/28 ,  A61P35/02 ,  A61P31/14 ,  A61P27/12 ,  A61P37/06

CPC classification number: C07D271/08 ,  A61P25/24 ,  A61P25/28 ,  A61P27/12 ,  A61P31/14 ,  A61P35/02 ,  A61P37/06 ,  C07D285/10 ,  C07D413/12 ,  C07D417/12 ,  C07F9/65318

Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US08722712B2

公开(公告)日：2014-05-13

申请号：US14041539

申请日：2013-09-30

Applicant: Allergan, Inc.

Inventor： Janet A. Takeuchi ,  Ling Li ,  Wha-Bin Im ,  Ken Chow

IPC: A61K31/4245 ,  C07D271/06

CPC classification number: C07F9/6503 ,  C07D271/06 ,  C07F9/65306 ,  C07F9/65318 ,  C07F9/65586

Abstract: The present invention relates to substituted aryl 1,2,4-oxadiazoles derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.

Abstract translation: 本发明涉及取代的芳基-1,2,4-恶二唑衍生物，其制备方法，含有它们的药物组合物及其作为药物作为鞘氨醇-1-磷酸受体调节剂的用途。

公开(公告)号：US20130065860A1

公开(公告)日：2013-03-14

申请号：US13604152

申请日：2012-09-05

Applicant: Janet A. Takeuchi ,  Ling Li ,  Ken Chow

Inventor： Janet A. Takeuchi ,  Ling Li ,  Ken Chow

IPC: C07F9/653 ,  A61K31/4245 ,  A61K31/675 ,  A61P37/00 ,  A61P19/02 ,  A61P9/10 ,  A61P17/06 ,  A61P17/00 ,  A61P25/00 ,  A61P37/06 ,  A61P27/04 ,  A61P1/00 ,  C07D271/06 ,  A61P37/08

CPC classification number: A61K31/4245 ,  C07D271/06 ,  C07F9/65318

Abstract: The present invention relates to novel oxadiazole derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.

Abstract translation: 本发明涉及新的恶二唑衍生物，其制备方法，含有它们的药物组合物及其作为药物作为鞘氨醇-1-磷酸受体调节剂的用途。