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    NEUROSTIMULATION SYSTEM AND METHOD FOR PROVIDING THERAPY TO PATIENT WITH MINIMAL SIDE EFFECTS
    32.
    发明申请
    NEUROSTIMULATION SYSTEM AND METHOD FOR PROVIDING THERAPY TO PATIENT WITH MINIMAL SIDE EFFECTS 有权
    用于向患者提供最小化副作用的神经细胞治疗系统和方法

    公开(公告)号：US20120089200A1

    公开(公告)日：2012-04-12

    申请号：US13253735

    申请日：2011-10-05

    申请人： Emarit A.S. Ranu ,  Bradley L. Hershey ,  Kerry Bradley

    发明人： Emarit A.S. Ranu ,  Bradley L. Hershey ,  Kerry Bradley

    IPC分类号： A61N1/36

    CPC分类号： A61N1/36071 ,  A61N1/0553 ,  A61N1/36171 ,  A61N1/36182

    摘要： A method comprises conveying a pulsed waveform between an electrode and a stimulation site of a spinal cord, thereby evoking the antidromic propagation of action potentials along a first sensory neural fiber creating a therapeutic effect in the tissue region, evoking the orthodromic propagation of action potentials along the first sensory neural fiber potentially creating paresthesia corresponding to the tissue region, and evoking the antidromic propagation of action potentials along a second sensory neural fiber potentially creating a side-effect in another tissue region. The method further comprises conveying electrical energy between an electrode and a blocking site rostral to the stimulation site, thereby blocking the action potentials propagated along the first sensory neural fiber and reducing the paresthesia, and conveying electrical energy between an electrode and a blocking site caudal to the stimulation site, thereby blocking the action potentials propagated along the second sensory neural fiber and reducing the side-effect.

    摘要翻译： 一种方法包括在电极和脊髓的刺激部位之间传送脉冲波形，从而引起沿着第一感觉神经纤维的动作电位的反向扩散，从而在组织区域产生治疗效果，引起动作电位的正常传播 第一感觉神经纤维潜在地产生对应于组织区域的感觉异常，并且引起沿着潜在地在另一组织区域中产生副作用的第二感觉神经纤维的动作电位的反向扩散。 该方法还包括将电极和阻塞位点之间的电能传递到刺激部位，从而阻止沿着第一感觉神经纤维传播的动作电位并减少感觉异常，并将电极和阻塞部位尾部之间的电能传递到 刺激部位，从而阻止沿着第二感觉神经纤维传播的动作电位并降低副作用。

    TISSUE STIMULATION SYSTEM AND METHOD WITH ANATOMY AND PHYSIOLOGY DRIVEN PROGRAMMING
    33.
    发明申请
    TISSUE STIMULATION SYSTEM AND METHOD WITH ANATOMY AND PHYSIOLOGY DRIVEN PROGRAMMING 审中-公开
    组织刺激系统和方法与解剖学和生理学驱动程序

    公开(公告)号：US20120083857A1

    公开(公告)日：2012-04-05

    申请号：US13244435

    申请日：2011-09-24

    申请人： Kerry Bradley ,  Bradley Hershey

    发明人： Kerry Bradley ,  Bradley Hershey

    IPC分类号： A61N1/372

    CPC分类号： A61N1/37247 ,  A61N1/0551 ,  A61N1/36175 ,  A61N1/36185

    摘要： An external control device for use with a tissue stimulation device and at least one tissue stimulation lead having a plurality of electrodes implanted within a patient comprises a user interface configured for allowing a user to enter first information defining a therapeutic indication and second information defining the location of the at least one tissue stimulation lead relative to an anatomical reference, at least one processor configured for analyzing the first and second information and generating a set of stimulation parameters based on the analysis, and output circuitry configured for transmitting the at least one stimulation parameter set to the tissue stimulation device.

    摘要翻译： 一种与组织刺激装置一起使用的外部控制装置和至少一个组织刺激引线，其具有植入患者体内的多个电极，该用户界面被配置为允许用户输入定义治疗指示的第一信息和定义位置的第二信息 所述至少一个组织刺激引线相对于解剖参考，配置用于分析所述第一和第二信息并基于所述分析产生一组刺激参数的至少一个处理器以及被配置为发送所述至少一个刺激参数的输出电路 设置到组织刺激装置。

    Method for optimizing search for spinal cord stimulation parameter setting
    34.
    发明授权
    Method for optimizing search for spinal cord stimulation parameter setting 有权
    优化脊髓刺激参数设置搜索的方法

    公开(公告)号：US08065013B2

    公开(公告)日：2011-11-22

    申请号：US11746405

    申请日：2007-05-09

    申请人： Kerry Bradley ,  James R. Thacker ,  Carla M. Woods ,  John D. King

    发明人： Kerry Bradley ,  James R. Thacker ,  Carla M. Woods ,  John D. King

    IPC分类号： A61N1/34

    CPC分类号： A61N1/36071 ,  A61N1/0551 ,  Y10S128/92

    摘要： A method of transitioning stimulation energy (e.g., electrical stimulation pulses) between a plurality of electrodes implanted within a patient is provided. The method comprises selecting a plurality of stimulation output values (e.g., electrical current amplitude values) for each of the electrodes. The method further comprises selecting a plurality of different modification values for at least one of the electrodes, respectively multiplying the stimulation output values and the modification values to determine modified stimulation output values for the electrode(s), which may optionally be stored in a steering table, and incrementally transitioning the stimulation energy to or from the electrode(s) in accordance with the modified stimulation output values. The modified stimulation output values are stored in a steering table. The modification values may be selected in a manner that maintains paresthesia when transitioning the stimulation energy between the electrodes.

    摘要翻译： 提供了在植入患者体内的多个电极之间转换刺激能量（例如，电刺激脉冲）的方法。 该方法包括为每个电极选择多个刺激输出值（例如，电流振幅值）。 该方法还包括为至少一个电极选择多个不同的修改值，分别乘以刺激输出值和修改值，以确定电极的修改的刺激输出值，其可以可选地存储在转向 表，并且根据修改的刺激输出值逐渐地将刺激能量转移到电极或从电极移动。 经修改的刺激输出值存储在转向表中。 可以以在电极之间转换刺激能量时保持感觉异常的方式来选择修饰值。

    System and method of rapid, comfortable parameter switching in spinal cord stimulation
    35.
    发明授权
    System and method of rapid, comfortable parameter switching in spinal cord stimulation 有权
    快速，舒适的脊髓刺激参数切换的系统和方法

    公开(公告)号：US08036747B2

    公开(公告)日：2011-10-11

    申请号：US12506827

    申请日：2009-07-21

    申请人： James R. Thacker ,  John D. H. King ,  Kerry Bradley

    发明人： James R. Thacker ,  John D. H. King ,  Kerry Bradley

    IPC分类号： A61N1/37

    CPC分类号： A61N1/36071 ,  A61N1/0551

    摘要： A system and method for rapidly switching stimulation parameters of a Spinal Cord Stimulation (SCS) system increases the number of stimulation parameter sets that may be tested during a fitting procedure, or alternatively, reduces the time required for the fitting procedure. The switching method comprises selecting a new stimulation parameter set, and setting the initial stimulation levels to levels at or just below an estimated perception threshold of the patient. The estimated perception level is based on previous stimulation results. The stimulation level is then increased to determine a minimum stimulation level for effective stimulation, and/or an optimal stimulation level, and/or a maximum stimulation level, based on patient perception.

    摘要翻译： 用于快速切换脊髓刺激（SCS）系统的刺激参数的系统和方法增加了在拟合过程期间可以测试的刺激参数集的数量，或者替代地减少了拟合过程所需的时间。 切换方法包括选择新的刺激参数集合，以及将初始刺激水平设置为等于或低于估计的患者感知阈值的水平。 估计的感知水平是基于以前的刺激结果。 然后根据患者的感知，增加刺激水平以确定有效刺激的最小刺激水平和/或最佳刺激水平和/或最大刺激水平。

    Apparatus and method for determining the relative position and orientation of neurostimulation leads
    37.
    发明授权
    Apparatus and method for determining the relative position and orientation of neurostimulation leads 有权
    用于确定神经刺激导联的相对位置和取向的装置和方法

    公开(公告)号：US07853330B2

    公开(公告)日：2010-12-14

    申请号：US11938490

    申请日：2007-11-12

    申请人： Kerry Bradley ,  James Thacker ,  Michael Moffitt

    发明人： Kerry Bradley ,  James Thacker ,  Michael Moffitt

    IPC分类号： A61N1/00

    CPC分类号： A61N1/08 ,  A61B5/053 ,  A61N1/0551 ,  A61N1/3605 ,  A61N1/37247

    摘要： A method for determining whether the relative position of electrodes used by a neurostimulation system has changed within a patient comprises determining the amplitude of a field potential at each of at least one of the electrodes, determining if a change in each of the determined electric field amplitudes has occurred, and analyzing the change in each of the determined electric field amplitudes to determine whether a change in the relative position of the electrodes has occurred. Another method comprises measuring a first monopolar impedance between a first electrode and a reference electrode, measuring a second monopolar impedance between second electrode and the reference electrode, measuring a bipolar impedance between the first and second electrodes, and estimating an amplitude of a field potential at the second electrode based on the first and second monopolar impedances and the bipolar impedance.

    摘要翻译： 一种用于确定神经刺激系统使用的电极的相对位置是否在患者内已经改变的方法包括确定每个电极中的每个电极处的场电位的幅度，确定每个确定的电场幅度是否发生变化 并且分析每个确定的电场幅度的变化，以确定是否发生了电极的相对位置的变化。 另一种方法包括测量第一电极和参考电极之间的第一单极阻抗，测量第二电极和参考电极之间的第二单极阻抗，测量第一和第二电极之间的双极性阻抗，以及估计第一和第二电极之间的场电位的振幅 基于第一和第二单极阻抗的第二电极和双极性阻抗。

    GRAPHICAL DISPLAY OF ENVIRONMENTAL MEASUREMENTS FOR IMPLANTABLE THERAPIES
    39.
    发明申请
    GRAPHICAL DISPLAY OF ENVIRONMENTAL MEASUREMENTS FOR IMPLANTABLE THERAPIES 审中-公开
    用于可植入治疗的环境测量的图形显示

    公开(公告)号：US20090157155A1

    公开(公告)日：2009-06-18

    申请号：US11959355

    申请日：2007-12-18

    申请人： Kerry Bradley

    发明人： Kerry Bradley

    IPC分类号： A61N1/05

    CPC分类号： A61N1/37247 ,  A61N1/37

    摘要： A method and system of providing therapy to a patient implanted with an array of electrodes is provided. The electrodes are configured for respectively providing electrical stimulation to tissue of the patient. The method comprises measuring physiological parameter information indicative of the coupling efficiencies between the respective electrodes of the array and the tissue, computing numerical values from the measured physiological parameter information, generating a chart representative of the computed numerical values, and displaying the chart to a user.

    摘要翻译： 提供了向植入电极阵列的患者提供治疗的方法和系统。 电极被配置为分别向患者的组织提供电刺激。 该方法包括测量指示阵列和组织的各个电极之间的耦合效率的生理参数信息，根据测量的生理参数信息计算数值，生成表示所计算的数值的图表，以及将图表显示给用户 。