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公开(公告)号：US20090246249A1
公开(公告)日：2009-10-01
申请号：US12413211
申请日：2009-03-27
申请人： Guy Orgambide , Mohmed Anwer , Shrikumar A. Nair , Paul Hamilton
发明人： Guy Orgambide , Mohmed Anwer , Shrikumar A. Nair , Paul Hamilton
CPC分类号： A61K38/16 , A61K2300/00
摘要： The presently disclosed subject matter provides compositions comprising a first substrate-binding domain (a peptide or a polymer) having binding affinity for a tissue or a medical device, a second substrate-binding domain having binding affinity for a target molecule, and the target molecule. In some embodiments, the first and second substrate-binding domains are covalently linked. The first and second substrate-binding domains are covalently coupled to at least one hydrophobic interaction tag, negatively charged interaction tag, or positively charged interaction tag. When the substrate-binding domains are combined and coated onto the tissue or medical device, the hydrophobic interaction tags interact with each other and the charged interaction tags interact with the oppositely charged interaction tags or the oppositely charged substrate binding polymers, to form a macromolecular network of non-covalently coupled substrate-binding domains to load the target molecule onto the tissue or medical device.
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公开(公告)号：US07572947B2
公开(公告)日：2009-08-11
申请号：US11500004
申请日：2006-08-07
IPC分类号： C07C2/12
CPC分类号： C07C2/12 , C07C2529/70 , C10G50/00 , C10G2300/1092 , C10G2300/202 , C10G2300/4081 , C10G2400/22
摘要： The invention is directed to a method of selectively oligomerizing olefin monomers by controlling feedstock composition and reaction conditions. Reaction conditions are chosen to include at least one of: (a) dimer recycle; (b) staged injection of monomer; and (c) utilization of a two catalyst system.
摘要翻译： 本发明涉及通过控制原料组成和反应条件来选择性低聚烯烃单体的方法。 选择反应条件以包括以下至少一种：（a）二聚体再循环; （b）单体注射; 和（c）利用两个催化剂体系。
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33.发明申请公开(公告)号：US20090070944A1
公开(公告)日：2009-03-19
申请号：US12198358
申请日：2008-08-26
CPC分类号： C07K14/001 , A61K8/64 , A61K2800/57 , A61Q5/065 , A61Q5/10 , A61Q5/12
摘要： Peptides have been identified that bind with high affinity to hair. Peptide-based hair reagents formed by coupling a hair-binding peptide to a benefit agent are described. The peptide-based hair reagents include peptide-based hair conditioners and hair colorants. The peptide-based hair conditioners and hair colorants are comprised of at least one hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively.
摘要翻译： 已经鉴定出以高亲和力结合头发的肽。 描述了通过将毛发结合肽偶联到有益剂形成的基于肽的毛发试剂。 基于肽的毛发试剂包括基于肽的护发素和头发着色剂。 基于肽的护发素和毛发着色剂分别由至少一种与头发调理剂或着色剂偶联的毛发结合肽组成。
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34.发明申请Carrying bag containing a separate compartment configured to carry a sports product 审中-公开携带包含配置成运送运动产品的单独隔室公开(公告)号：US20090032418A1
公开(公告)日：2009-02-05
申请号：US11882520
申请日：2007-08-02
申请人： Paul Hamilton
发明人： Paul Hamilton
CPC分类号： A63B47/00 , A45C11/00 , A45F3/04 , A63B71/0036 , A63B2243/0025 , Y10T29/49826
摘要： The invention relates to a carrying bag comprising a first compartment and a second compartment, separated from the first compartment. At least one of the first compartment and second compartment is configured to receive a sports product and contains an opening arranged for exposing a portion of said product to the outside world. The first compartment is arranged above said second compartment in a carrying position of the carrying bag. The invention also relates to a method of manufacturing such a carrying bag.
摘要翻译： 本发明涉及一种携带袋，其包括与第一隔室分离的第一隔室和第二隔室。 第一隔室和第二隔室中的至少一个被配置为接收运动产品并且包含布置成将所述产品的一部分暴露于外部世界的开口。 所述第一隔间在所述第二隔间的上方布置在所述行李箱的承载位置中。 本发明还涉及一种制造这种携带袋的方法。
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35.发明申请Methods and compositions for promoting attachment of cells of endothelial cell lineage to medical devices 失效促进内皮细胞谱系细胞附着于医疗器械的方法和组合物公开(公告)号：US20070160644A1
公开(公告)日：2007-07-12
申请号：US11649950
申请日：2007-01-05
申请人： Daniel Kenan , Paul Hamilton
发明人： Daniel Kenan , Paul Hamilton
IPC分类号： A61F2/02 , C07K14/705 , C07H21/04 , C12P21/06
摘要： The present invention provides compositions and methods for an improved coating for medical devices. Provided is a biofunctional coating composition comprising at least one binding domain that has binding specificity for a surface material of a medical device, and at least one binding domain that has binding specificity for cells of endothelial cell lineage. Methods for coating a surface of a medical device, and for manufacturing of a medical device, comprise contacting the surface to be coated with the biofunctional coating material in an amount effective to form a coating, and may further comprise contacting the coated surface with cells of endothelial cell lineage to bind the cells of endothelial cell lineage to the coated surface.
摘要翻译： 本发明提供用于医疗装置的改进涂层的组合物和方法。 本发明提供一种生物功能性涂料组合物，其包含至少一个对医疗装置的表面材料具有结合特异性的结合结构域和至少一个对内皮细胞谱系细胞具有结合特异性的结合结构域。 用于涂覆医疗装置的表面和用于制造医疗装置的方法包括以有效形成涂层的量使待涂覆的表面与生物功能性涂层材料接触，并且还可以包括使涂覆的表面与 内皮细胞谱系将内皮细胞谱系的细胞与涂层表面结合。
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公开(公告)号：US20060270882A1
公开(公告)日：2006-11-30
申请号：US11140853
申请日：2005-05-31
申请人： Stephen Brown , Paul Hamilton , Keith Kuechler
发明人： Stephen Brown , Paul Hamilton , Keith Kuechler
CPC分类号： C07C2/18 , B01J8/067 , B01J2208/00212 , B01J2208/00256 , B01J2219/00024 , B01J2219/00085 , B01J2219/00094 , B01J2219/00099 , B01J2219/00103 , C07C2/12 , C10G50/00 , F01K13/02 , F22G1/14 , F28C3/04
摘要： The invention is directed to a reactor system comprising at least one reactor wherein makeup water for said system is preheated by water/steam exiting said reactor. In a preferred embodiment the system comprises plural reactors and the invention provides for each reactor to independently achieve isothermal operating conditions.
摘要翻译： 本发明涉及一种包括至少一个反应器的反应器系统，其中用于所述系统的补给水由离开所述反应器的水/蒸汽预热。 在优选的实施方案中，该系统包括多个反应器，本发明提供了每个反应器以独立实现等温的操作条件。
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公开(公告)号：US20220033327A1
公开(公告)日：2022-02-03
申请号：US17297408
申请日：2019-11-14
申请人： Robert Piszczek , Brian W. Heins , Paul Hamilton , Terrance C. Osby , Dion Zhang , Zhongcheng Wang , Michael L. Hergenrother , Jason A. Nichols
发明人： Robert Piszczek , Brian W. Heins , Paul Hamilton , Terrance C. Osby , Dion Zhang , Zhongcheng Wang , Michael L. Hergenrother , Jason A. Nichols
摘要： Many linear alpha olefin (LAO) syntheses form a range of LAO products when oligomerizing ethylene in the presence of a Ziegler-type catalyst. The range of products typically requires a plurality of distillation columns to separate the LAO products up to a desired carbon count, but such approaches may be energy- and capital-intensive. LAO product separation using at least one dividing wall column may lessen these burdens. Methods for separating LAOs may comprise: providing a pre-processed product stream comprising Cg+ linear alpha olefins (LAOS) to a first of a series of distillation columns, at least one member of the series of distillation columns comprising a dividing wall column; and separating an overhead stream comprising a first LAO from the dividing wall column and one or more side streams from the dividing wall column, each side stream comprising a different LAO that also differs from the first LAO.
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公开(公告)号：US09643902B2
公开(公告)日：2017-05-09
申请号：US13885972
申请日：2011-08-31
申请人： Georges M. K. Mathys , Marc P. H. Puttemans , Geraldine Tosin , Eddy T. Van Driessche , Paul Hamilton , Marcel J. G. Janssen
发明人： Georges M. K. Mathys , Marc P. H. Puttemans , Geraldine Tosin , Eddy T. Van Driessche , Paul Hamilton , Marcel J. G. Janssen
CPC分类号： C07C7/10 , C07C2/24 , C10G21/06 , C10G21/16 , C10G21/26 , C10G50/00 , C10G2300/1081 , C10G2300/1088 , C10G2300/202 , C10G2300/308 , C10G2300/44 , C10G2400/22
摘要： Embodiments of an invention disclosed herein relate to processes utilizing solvent extraction to remove nitrogen containing compounds and optionally other components from feedstreams of olefins and paraffins.
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公开(公告)号：US08921590B2
公开(公告)日：2014-12-30
申请号：US13510501
申请日：2010-11-23
IPC分类号： C07C67/303 , C07C29/04 , C07C2/04 , B01J29/40 , B01J29/70 , B01J29/80 , B01J29/90 , B01J35/00 , C07C2/12 , C10G50/00 , C08F110/06 , C08F210/16
CPC分类号： B01J29/40 , B01J29/7026 , B01J29/7042 , B01J29/80 , B01J29/90 , B01J35/0006 , C07C2/12 , C08F110/06 , C08F210/16 , C10G50/00 , C10G2300/1088 , C10G2300/4031 , C10G2400/20 , C10G2400/22 , Y02P20/584 , C07C11/02 , C08F2500/02 , C08F210/08
摘要： The startup of a tubular reactor containing fresh or regenerated molecular sieve catalyst and cooled by steam generation on the shell side, as part of an olefin oligomerization process, is improved by, during the startup phase of the reactor, controlling the pressure on the shell side of the reactor at maximum 10 barg. The startup may be further improved by controlling the inlet temperature of the hydrocarbon startup stream to the reactor, by controlling the flow of reactant olefins to the reactor, or by controlling the nature and/or concentration of the olefins in the reactor feed.
摘要翻译： 通过在反应器启动阶段，启动包含新鲜或再生的分子筛催化剂并通过在壳侧产生蒸汽而冷却的管式反应器作为烯烃低聚方法的一部分得到改进，从而控制壳侧的压力 的反应器最大10巴。 通过控制反应物烯烃进入反应器的流量，或通过控制反应器进料中烯烃的性质和/或浓度来控制通向反应器的烃启动流的入口温度，可以进一步改进启动。
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40.发明授权公开(公告)号：US08273337B2
公开(公告)日：2012-09-25
申请号：US12198358
申请日：2008-08-26
IPC分类号： A61K8/64
CPC分类号： C07K14/001 , A61K8/64 , A61K2800/57 , A61Q5/065 , A61Q5/10 , A61Q5/12
摘要： Peptides have been identified that bind with high affinity to hair. Peptide-based hair reagents formed by coupling a hair-binding peptide to a benefit agent are described. The peptide-based hair reagents include peptide-based hair conditioners and hair colorants. The peptide-based hair conditioners and hair colorants are comprised of at least one hair-binding peptide coupled to a hair conditioning agent or a coloring agent, respectively.
摘要翻译： 已经鉴定出以高亲和力结合头发的肽。 描述了通过将毛发结合肽偶联到有益剂形成的基于肽的毛发试剂。 基于肽的毛发试剂包括基于肽的护发素和头发着色剂。 基于肽的护发素和毛发着色剂分别由至少一种与头发调理剂或着色剂偶联的毛发结合肽组成。
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