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公开(公告)号：US20090246250A1
公开(公告)日：2009-10-01
申请号：US12413241
申请日：2009-03-27
申请人： Guy Orgambide , Mohmed Anwer , Shrikumar A. Nair , Paul Hamilton
发明人： Guy Orgambide , Mohmed Anwer , Shrikumar A. Nair , Paul Hamilton
CPC分类号： A61K38/16 , A61K2300/00
摘要： The presently disclosed subject matter provides compositions comprising a first substrate-binding domain (a peptide or a polymer) having binding affinity for a tissue or a medical device, a second substrate-binding domain having binding affinity for a target molecule, and the target molecule. In some embodiments, the first and second substrate-binding domains are covalently linked. The first and second substrate-binding domains are covalently coupled to at least one hydrophobic interaction tag, negatively charged interaction tag, or positively charged interaction tag. When the substrate-binding domains are combined and coated onto the tissue or medical device, the hydrophobic interaction tags interact with each other and the charged interaction tags interact with the oppositely charged interaction tags or the oppositely charged substrate binding polymers, to form a macromolecular network of non-covalently coupled substrate-binding domains to load the target molecule onto the tissue or medical device.
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公开(公告)号：US20090246248A1
公开(公告)日：2009-10-01
申请号：US12413195
申请日：2009-03-27
申请人： Guy Orgambide , Mohmed Anwer , Shrikumar A. Nair , Paul Hamilton
发明人： Guy Orgambide , Mohmed Anwer , Shrikumar A. Nair , Paul Hamilton
CPC分类号： A61K38/16 , A61K2300/00
摘要： The presently disclosed subject matter provides compositions comprising a first substrate-binding domain (a peptide or a polymer) having binding affinity for a tissue or a medical device, a second substrate-binding domain having binding affinity for a target molecule, and the target molecule. In some embodiments, the first and second substrate-binding domains are covalently linked. The first and second substrate-binding domains are covalently coupled to at least one hydrophobic interaction tag, negatively charged interaction tag, or positively charged interaction tag. When the substrate-binding domains are combined and coated onto the tissue or medical device, the hydrophobic interaction tags interact with each other and the charged interaction tags interact with the oppositely charged interaction tags or the oppositely charged substrate binding polymers, to form a macromolecular network of non-covalently coupled substrate-binding domains to load the target molecule onto the tissue or medical device.
摘要翻译： 目前公开的主题提供了包含对组织或医疗装置具有结合亲和力的第一底物结合结构域（肽或聚合物），对靶分子具有结合亲和力的第二底物结合结构域和靶分子 。 在一些实施方案中，第一和第二底物结合结构域共价连接。 第一和第二底物结合结构域与至少一个疏水相互作用标签，带负电荷的相互作用标签或带正电荷的相互作用标签共价偶联。 当底物结合域被组合并涂覆在组织或医疗装置上时，疏水性相互作用标签相互作用，并且带电相互作用标签与相反电荷的相互作用标签或相反电荷的底物结合聚合物相互作用以形成大分子网络 的非共价偶联的底物结合结构域以将靶分子加载到组织或医疗装置上。
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3.发明授权公开(公告)号：US07972615B2
公开(公告)日：2011-07-05
申请号：US12413285
申请日：2009-03-27
申请人： Guy Orgambide , Mohmed Anwer , Shrikumar A. Nair , Paul Hamilton
发明人： Guy Orgambide , Mohmed Anwer , Shrikumar A. Nair , Paul Hamilton
CPC分类号： A61K38/16 , A61K2300/00
摘要： The presently disclosed subject matter provides compositions comprising a first substrate-binding domain (a peptide or a polymer) having binding affinity for a tissue or a medical device, a second substrate-binding domain having binding affinity for a target molecule, and the target molecule. In some embodiments, the first and second substrate-binding domains are covalently linked. The first and second substrate-binding domains are covalently coupled to at least one hydrophobic interaction tag, negatively charged interaction tag, or positively charged interaction tag. When the substrate-binding domains are combined and coated onto the tissue or medical device, the hydrophobic interaction tags interact with each other and the charged interaction tags interact with the oppositely charged interaction tags or the oppositely charged substrate binding polymers, to form a macromolecular network of non-covalently coupled substrate-binding domains to load the target molecule onto the tissue or medical device.
摘要翻译： 目前公开的主题提供了包含对组织或医疗装置具有结合亲和力的第一底物结合结构域（肽或聚合物），对靶分子具有结合亲和力的第二底物结合结构域和靶分子 。 在一些实施方案中，第一和第二底物结合结构域共价连接。 第一和第二底物结合结构域与至少一个疏水相互作用标签，带负电荷的相互作用标签或带正电荷的相互作用标签共价偶联。 当底物结合域被组合并涂覆在组织或医疗装置上时，疏水性相互作用标签相互作用，并且带电相互作用标签与相反电荷的相互作用标签或相反电荷的底物结合聚合物相互作用以形成大分子网络 的非共价偶联的底物结合结构域以将靶分子加载到组织或医疗装置上。
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公开(公告)号：US20090246251A1
公开(公告)日：2009-10-01
申请号：US12413285
申请日：2009-03-27
申请人： Guy Orgambide , Mohmed Anwer , Shrikumar A. Nair , Paul Hamilton
发明人： Guy Orgambide , Mohmed Anwer , Shrikumar A. Nair , Paul Hamilton
CPC分类号： A61K38/16 , A61K2300/00
摘要： The presently disclosed subject matter provides compositions comprising a first substrate-binding domain (a peptide or a polymer) having binding affinity for a tissue or a medical device, a second substrate-binding domain having binding affinity for a target molecule, and the target molecule. In some embodiments, the first and second substrate-binding domains are covalently linked. The first and second substrate-binding domains are covalently coupled to at least one hydrophobic interaction tag, negatively charged interaction tag, or positively charged interaction tag. When the substrate-binding domains are combined and coated onto the tissue or medical device, the hydrophobic interaction tags interact with each other and the charged interaction tags interact with the oppositely charged interaction tags or the oppositely charged substrate binding polymers, to form a macromolecular network of non-covalently coupled substrate-binding domains to load the target molecule onto the tissue or medical device.
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公开(公告)号：US20090246249A1
公开(公告)日：2009-10-01
申请号：US12413211
申请日：2009-03-27
申请人： Guy Orgambide , Mohmed Anwer , Shrikumar A. Nair , Paul Hamilton
发明人： Guy Orgambide , Mohmed Anwer , Shrikumar A. Nair , Paul Hamilton
CPC分类号： A61K38/16 , A61K2300/00
摘要： The presently disclosed subject matter provides compositions comprising a first substrate-binding domain (a peptide or a polymer) having binding affinity for a tissue or a medical device, a second substrate-binding domain having binding affinity for a target molecule, and the target molecule. In some embodiments, the first and second substrate-binding domains are covalently linked. The first and second substrate-binding domains are covalently coupled to at least one hydrophobic interaction tag, negatively charged interaction tag, or positively charged interaction tag. When the substrate-binding domains are combined and coated onto the tissue or medical device, the hydrophobic interaction tags interact with each other and the charged interaction tags interact with the oppositely charged interaction tags or the oppositely charged substrate binding polymers, to form a macromolecular network of non-covalently coupled substrate-binding domains to load the target molecule onto the tissue or medical device.
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