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公开(公告)号：US20110039969A1
公开(公告)日：2011-02-17
申请号：US12904481
申请日：2010-10-14
IPC分类号： C08J3/28
CPC分类号： A61L27/16 , A61L27/505 , C08L23/06 , C08L23/10 , C08L27/06 , C08L67/00 , C08L77/00 , C08L2312/06
摘要： The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.
摘要翻译： 本发明涉及制备抗氧化医疗器械的方法，其包括聚合材料，例如超高分子量聚乙烯（UHMWPE）。 本发明还提供了制备抗氧化剂掺杂医疗植入物的方法，例如，通过扩散掺杂含有交联的UHMWPE与维生素E的医疗装置，后掺杂退火和其中使用的材料。
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公开(公告)号：US07790779B2
公开(公告)日：2010-09-07
申请号：US12111489
申请日：2008-04-29
申请人： Orhun K. Muratoglu
发明人： Orhun K. Muratoglu
CPC分类号： A61L27/16 , A61F2/30 , A61F2/3094 , A61F2/34 , A61F2/38 , A61F2/3868 , A61F2/3872 , A61F2/389 , A61F2/4081 , A61F2/4241 , A61F2002/30014 , A61F2002/30133 , A61F2002/30685 , A61F2002/4243 , A61F2230/0015 , A61F2250/0018 , A61L27/50 , B29B13/08 , B29C35/0266 , B29C71/04 , B29C2035/0877 , B29K2023/0675 , B29K2023/0683 , B29K2105/243 , B29K2105/255 , B29L2031/7532 , C08L23/06
摘要： The present invention provides partial and complete shielding approaches to alter the cross-linking characteristics of irradiated polymers, such as polyethylene. Irradiated polymers and fabricated articles, such as medical prosteses, comprising irradiated polymers also are provided.
摘要翻译： 本发明提供部分和完全的屏蔽方法来改变辐照聚合物如聚乙烯的交联特性。 也提供包含辐照聚合物的辐射聚合物和制造制品，例如医用前列腺。
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公开(公告)号：US20080208347A1
公开(公告)日：2008-08-28
申请号：US11916703
申请日：2005-09-27
申请人： Orhun K. Muratoglu , Jeeyoung Choi , Hatice Bodugoz-Senturk , Gavin J.C. Braithwaite , Stephen H. Spiegelberg
发明人： Orhun K. Muratoglu , Jeeyoung Choi , Hatice Bodugoz-Senturk , Gavin J.C. Braithwaite , Stephen H. Spiegelberg
CPC分类号： C08F6/10 , A61F2/30756 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2002/30754 , A61L27/52 , C08J3/075 , C08J2329/04 , C08L29/04 , C08L71/02 , C08L2666/14
摘要： The invention provides fabricated tough hydrogels, hydrogel-containing compositions, and methods of making the same. The invention also provides methods of implanting or administering the tough hydrogels, or the hydrogel-containing compositions to treat a subject in need. Methods of cross-linking pre-solidified or pre-gelled hydrogel particles and making cross-linked tough hydrogels, and crosslinked tough hydrogel-containing compositions also are disclosed herein.
摘要翻译： 本发明提供了制造的韧性水凝胶，含水凝胶的组合物及其制备方法。 本发明还提供了植入或施用韧性水凝胶或含水凝胶组合物以治疗有需要的受试者的方法。 交联预固化或预胶凝的水凝胶颗粒和制备交联的韧性水凝胶以及交联的含有韧性水凝胶的组合物的方法也在本文中公开。
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公开(公告)号：US07381752B2
公开(公告)日：2008-06-03
申请号：US11691727
申请日：2007-03-27
申请人： Orhun K. Muratoglu
发明人： Orhun K. Muratoglu
IPC分类号： C08J3/28 , A61F2/30 , A61F2/32 , C08F110/02
CPC分类号： A61L27/16 , A61F2/30 , A61F2/3094 , A61F2/34 , A61F2/38 , A61F2/3868 , A61F2/3872 , A61F2/389 , A61F2/4081 , A61F2/4241 , A61F2002/30014 , A61F2002/30133 , A61F2002/30685 , A61F2002/4243 , A61F2230/0015 , A61F2250/0018 , A61L27/50 , B29B13/08 , B29C35/0266 , B29C71/04 , B29C2035/0877 , B29K2023/0675 , B29K2023/0683 , B29K2105/243 , B29K2105/255 , B29L2031/7532 , C08L23/06
摘要： The present invention provides partial and complete shielding approaches to alter the cross-linking characteristics of irradiated polymers, such as polyethylene. Irradiated polymers and fabricated articles, such as medical prosteses, comprising irradiated polymers also are provided.
摘要翻译： 本发明提供部分和完全的屏蔽方法来改变辐照聚合物如聚乙烯的交联特性。 也提供包含辐照聚合物的辐射聚合物和制造制品，例如医用前列腺。
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公开(公告)号：US07205339B2
公开(公告)日：2007-04-17
申请号：US10433987
申请日：2001-12-11
申请人： Orhun K. Muratoglu
发明人： Orhun K. Muratoglu
CPC分类号： A61L27/16 , A61F2/30 , A61F2/3094 , A61F2/34 , A61F2/38 , A61F2/3868 , A61F2/3872 , A61F2/389 , A61F2/4081 , A61F2/4241 , A61F2002/30014 , A61F2002/30133 , A61F2002/30685 , A61F2002/4243 , A61F2230/0015 , A61F2250/0018 , A61L27/50 , B29B13/08 , B29C35/0266 , B29C71/04 , B29C2035/0877 , B29K2023/0675 , B29K2023/0683 , B29K2105/243 , B29K2105/255 , B29L2031/7532 , C08L23/06
摘要： The present invention provides partial and complete shielding approaches to alter the cross-linking characteristics of irradiated polymers, such as polyethylene. Irradiated polymers and fabricated articles, such as medical prosteses, comprising irradiated polymers also are provided.
摘要翻译： 本发明提供部分和完全的屏蔽方法来改变辐照聚合物如聚乙烯的交联特性。 也提供包含辐照聚合物的辐射聚合物和制造制品，例如医用前列腺。
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36.发明授权High modulus crosslinked polyethylene with reduced residual free radical concentration prepared below the melt 有权熔体下面制备的具有降低的残余自由基浓度的高模量交联聚乙烯公开(公告)号：US06852772B2
公开(公告)日：2005-02-08
申请号：US10252582
申请日：2002-09-24
CPC分类号： C08J3/28 , A61F2/3094 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2/4202 , A61L27/16 , B29B13/08 , B29C71/04 , B29C2035/085 , B29C2035/0877 , B29K2023/06 , B29K2023/0683 , B29K2995/0087 , B29L2031/7532 , C08J3/24 , C08J7/12 , C08J2323/06 , C08L23/06 , C08L23/0815 , C08L2312/06 , Y10T428/31692 , Y10T428/31909
摘要： The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein.
摘要翻译： 本发明提供一种包含还原自由基的辐照交联聚乙烯，优选基本上不含残留的自由基。 公开了通过在低于熔点的高温下照射聚乙烯与感光环境接触来制造照射的交联聚乙烯的方法，以便将残余自由基的浓度降低至不可检测的水平。 本文还公开了通过在低于聚乙烯熔点的温度（任选在敏化环境中）使聚乙烯机械变形来制备具有降低的自由基含量的辐照交联聚乙烯组合物，优选基本上不含残余自由基的方法。 。
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公开(公告)号：US08865043B2
公开(公告)日：2014-10-21
申请号：US13606457
申请日：2012-09-07
IPC分类号： B29C35/08
CPC分类号： A61L27/16 , A61L27/505 , C08L23/06 , C08L23/10 , C08L27/06 , C08L67/00 , C08L77/00 , C08L2312/06
摘要： The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.
摘要翻译： 本发明涉及制备抗氧化医疗器械的方法，其包括聚合材料，例如超高分子量聚乙烯（UHMWPE）。 本发明还提供了制备抗氧化剂掺杂医疗植入物的方法，例如，通过扩散掺杂含有交联的UHMWPE与维生素E的医疗装置，后掺杂退火和其中使用的材料。
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公开(公告)号：US08530057B2
公开(公告)日：2013-09-10
申请号：US12464235
申请日：2009-05-12
IPC分类号： B32B27/00 , C08J3/28 , A61F2/00 , C08L23/06 , C08F110/02
CPC分类号： B29C35/0805 , A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L31/143 , B29C43/003 , C08J3/28 , C08K5/005 , C08K5/1545 , C08L23/06 , C08L2312/06 , Y10T29/49 , Y10T29/49995 , Y10T428/31855
摘要： The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
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39.发明申请公开(公告)号：US20130018477A1
公开(公告)日：2013-01-17
申请号：US13547383
申请日：2012-07-12
IPC分类号： A61F2/38
CPC分类号： A61F2/3836 , A61F2/08 , A61F2/0811 , A61F2/3886 , A61F2002/30688
摘要： Methods and devices are provided for knee joint replacement with anterior cruciate ligament (ACL) substitution. Generally, the methods and devices can allow a knee joint to be partially or totally replaced in conjunction with substitution of the knee joint's ACL. In one embodiment, a knee replacement prosthesis can include a medial or lateral femoral implant, a femoral intercondylar notch structure, a medial or lateral tibial insert, and an ACL-substitution member. The ACL-substitution member can be configured to engage with the femoral intercondylar notch structure during a full range of knee motion and/or during only early knee flexion.
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40.发明授权Radiation and melt treated ultra high molecular weight polyethylene prosthetic devices 有权辐射和熔融处理的超高分子量聚乙烯假体装置公开(公告)号：US08263676B2
公开(公告)日：2012-09-11
申请号：US12977391
申请日：2010-12-23
申请人： Edward W. Merrill , William H. Harris , Murali Jasty , Orhun K. Muratoglu , Charles R. Bragdon , Daniel O. O'Connor , Premnath Venugopalan
发明人： Edward W. Merrill , William H. Harris , Murali Jasty , Orhun K. Muratoglu , Charles R. Bragdon , Daniel O. O'Connor , Premnath Venugopalan
IPC分类号： C08J3/28
CPC分类号： A61F2/468 , A61F2/30767 , A61F2/3094 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/3662 , A61F2/4657 , A61F2002/30065 , A61F2002/30084 , A61F2002/30125 , A61F2002/30158 , A61F2002/30324 , A61F2002/30616 , A61F2002/30685 , A61F2002/30934 , A61F2002/3233 , A61F2002/3464 , A61F2002/3491 , A61F2002/3493 , A61F2002/3495 , A61F2002/3611 , A61F2002/3623 , A61F2002/3625 , A61F2002/3631 , A61F2002/365 , A61F2002/4631 , A61F2002/4666 , A61F2210/0071 , A61F2230/0008 , A61F2230/0026 , A61F2250/0036 , A61F2310/00011 , A61F2310/00017 , A61F2310/00023 , A61F2310/00029 , A61F2310/00071 , A61F2310/00179 , A61L27/16 , A61L2430/24 , B29C43/00 , B29C43/16 , B29C2035/085 , B29K2995/0087 , B29K2995/0089 , B29L2031/7532 , C08F110/02 , Y10T428/31692 , Y10T428/31855 , C08L23/06 , C08F2500/01 , C08F2500/14
摘要： A medical prosthesis for use within the body which is formed of radiation treated ultra high molecular weight polyethylene having substantially no detectable free radicals, is described. Preferred prostheses exhibit reduced production of particles from the prosthesis during wear of the prosthesis, and are substantially oxidation resistant. Methods of manufacture of such devices and material used therein are also provided.
摘要翻译： 描述了一种用于身体内的医疗假体，其由基本上不可检测的自由基的辐射处理的超高分子量聚乙烯形成。 优选的假体在假体磨损期间表现出来自假体的颗粒的产生减少，并且基本上是抗氧化的。 还提供了这种装置的制造方法和其中使用的材料。
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