公开(公告)号：US11666216B2

公开(公告)日：2023-06-06

申请号：US15987843

申请日：2018-05-23

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Axel Scherer ,  Peter A Petillo ,  Samson Chen ,  Azita Emami

IPC: A61B5/00 ,  A01K1/03 ,  A01K11/00 ,  A01K29/00 ,  A61B5/11 ,  H04B5/00 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/01

CPC classification number: A61B5/002 ,  A01K1/031 ,  A01K11/006 ,  A01K29/00 ,  A61B5/1113 ,  H04B5/0075 ,  A61B5/01 ,  A61B5/1486 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/6832 ,  A61B5/6868 ,  A61B2503/40 ,  A61B2503/42

Abstract: A smart cage includes radiofrequency transceivers and tags attached to laboratory animals. The tags include sensors to detect monitorable conditions of the laboratory animals. The sensors include working electrodes, counter electrodes, reference electrodes, and potentiostats. The top surface of the electrodes is coated with ionophores or enzymes which detect the monitorable conditions of the laboratory animals.

公开(公告)号：US11060511B1

公开(公告)日：2021-07-13

申请号：US16442092

申请日：2019-06-14

Applicant: California Institute of Technology ,  The Government of the United States of America, as represented by the Secretary of the Navy

Inventor： Emil P. Kartalov ,  Axel Scherer

IPC: H02N1/00 ,  H02N1/06 ,  A61F2/08 ,  A61F2/70 ,  F03G7/06 ,  A61H3/00 ,  A61H1/02 ,  B25J9/10 ,  A61F2/48

Abstract: Artificial muscles comprising a body of dielectric elastomer, wherein the body contains a pair of microfluidic networks are presented. Each microfluidic network includes a plurality of channels fluidically coupled via a manifold. The channels of the microfluidic networks are interdigitated and filled with conductive fluid such that each set of adjacent channels functions as the electrodes of an electroactive polymer (EAP) actuator. By using the manifolds as compliant wiring to energize the electrodes, artificial muscles in accordance with the present disclosure mitigate some or all of the reliability problems associated with prior-art artificial muscles.

公开(公告)号：US11009658B2

公开(公告)日：2021-05-18

申请号：US16803938

申请日：2020-02-27

Applicant: California Institute of Technology

Inventor： William M. Jones ,  Lucia B. De Rose ,  Axel Scherer

IPC: G02B6/122 ,  H01L31/0232 ,  G01J1/04

Abstract: Light detectors that combine field emission with light focusing by surface plasmon polaritons. Methods and devices that allow detection and measurement of light at high frequencies in the THz range are described. The disclosed devices include plasmonic metal contacts with a narrow nanometer-sized gap to couple an optical waveguide mode into a plasmonic mode thereby generating filed emission currents by biasing the contacts.

公开(公告)号：US20210140817A1

公开(公告)日：2021-05-13

申请号：US17093211

申请日：2020-11-09

Applicant: California Institute of Technology

Inventor： Axel Scherer ,  Taeyoon Jeon ,  Jieun Myung

IPC: G01J3/12 ,  G01J3/10

Abstract: An infrared spectrometer for operation in the mid-infrared spectral range is disclosed, where the spectrometer includes a Bragg-mirror-based spectral filter that is operative for providing an output optical signal whose spectral content is spatially dispersed along a first direction, where the Bragg mirrors include low-refractive-index layers comprising a polymer material that is transmissive across the mid-infrared spectral range and is characterized by less than ten absorption peaks with the operating spectral range of the spectrometer.

公开(公告)号：US20210098076A1

公开(公告)日：2021-04-01

申请号：US16864744

申请日：2020-05-01

Applicant: California Institute of Technology

Inventor： Emil P. Kartalov ,  Aditya Rajagopal ,  Axel Scherer

IPC: G16B25/00 ,  G16B5/00 ,  C12Q1/6851 ,  G16B25/20 ,  G16B40/10 ,  C12Q1/68 ,  G01N21/64 ,  C12Q1/6825

Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.

公开(公告)号：US10376146B2

公开(公告)日：2019-08-13

申请号：US14174827

申请日：2014-02-06

Applicant: California Institute of Technology

Inventor： Muhammad Mujeeb-U-Rahman ,  Axel Scherer

IPC: A61B5/00 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/1486

Abstract: An implantable device having a communication system, a sensor, and a monolithic substrate is described. The monolithic substrate has an integrated sensor circuit configured to process input from the sensor into a form conveyable by the communication system.

公开(公告)号：US10368788B2

公开(公告)日：2019-08-06

申请号：US15216675

申请日：2016-07-21

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  THE TRUSTEES OF DARTMOUTH COLLEGE

Inventor： Axel Scherer ,  Meisam Honarvar Nazari ,  Muhammad Mujeeb-U-Rahman ,  Mehmet Sencan ,  Arti Gaur

IPC: A61M5/142 ,  A61M5/172 ,  A61B5/1473 ,  A61B17/34 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/1459 ,  A61B5/07

Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.

公开(公告)号：US20190034583A1

公开(公告)日：2019-01-31

申请号：US15914356

申请日：2018-03-07

Applicant: California Institute of Technology

Inventor： Emil P. Kartalov ,  Aditya Rajagopal ,  Axel Scherer

IPC: G06F19/20 ,  G01N21/64 ,  C12Q1/68 ,  C12Q1/6825 ,  C12Q1/6851 ,  G06F19/12 ,  G06F17/10 ,  G06F17/11 ,  G06F19/24

Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.

公开(公告)号：US10189001B2

公开(公告)日：2019-01-29

申请号：US15967543

申请日：2018-04-30

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Sameer Walavalkar ,  Axel Scherer

IPC: B01J19/00 ,  G01N21/65 ,  C12Q1/689

Abstract: Methods and systems for nanopillar sensors are described. Nanopillars can be defined on a substrate, and metal deposited on the nanopillars. A thermal treatment can reflow the metal on the nanopillars forming metallic bulbs on the top end of the nanopillars. These structures can have enhanced optical detection when functionalized with biological agents, or can detect gases, particles and liquids through interaction with the metal layer on the nanopillars.

公开(公告)号：US10081844B2

公开(公告)日：2018-09-25

申请号：US15675048

申请日：2017-08-11

Applicant: California Institute of Technology

Inventor： Aditya Rajagopal ,  Mark D. Goldberg ,  Erika F. Garcia ,  Xiomara L. Madero ,  Thomas A. Tombrello ,  Axel Scherer

IPC: C12P19/34 ,  C12Q1/70 ,  C12Q1/6851 ,  C12Q1/68

CPC classification number: C12Q1/701 ,  C12Q1/68 ,  C12Q1/6851 ,  C12Q1/703 ,  Y10T436/143333 ,  C12Q2561/113 ,  C12Q2565/101 ,  C12Q2527/101 ,  C12Q2565/1015 ,  C12Q2565/133

Abstract: Methods of detecting at least one genetic variation in a polynucleotide analyte in a sample. A fluorophore is attached to a first primer, a quencher is attached to a second primer, the first primer and the second primer are specific for the polynucleotide analyte. A signal generated by the fluorophore and quencher is measured. PCR is performed with the first primer and the second primer using the polynucleotide analyte as a template, thereby amplifying the template. A signal generated by the fluorophore and quencher from the PCR amplification product is measured. Comparison is made of the signals; and a determination is made of the presence or absence of the at least one genetic variation based i) on the change in signal as determined; and ii) by comparing said change to the change in signal observed upon PCR amplification for a corresponding polynucleotide analyte lacking the at least one genetic variation.