公开(公告)号：US20090124576A1

公开(公告)日：2009-05-14

申请号：US12227042

申请日：2007-05-02

申请人： Thomas Ehlis ,  Elek Borsos

发明人： Thomas Ehlis ,  Elek Borsos

IPC分类号： A61K8/49 ,  C07D403/14 ,  C07D403/12 ,  A61K8/58

CPC分类号： C07D251/52 ,  C07D251/70

摘要： Disclosed are triazine derivatives of formula X1 is a bivalent radical of formula A and A′ independently from each other are unsubstituted or substituted, straight-chain or branched C1-C12alkylene, which is optionally interrupted by C5-C12cycloalkylene, N, O or S; C5-C12cycloalkylene; biphenylene; C6-C10arylene; or C5-C10arylene-(C1-C12alkylene); R1 is a radical of formula R2 and R3 independently from each other are hydrogen; C1-C12alkyl; OR7; NR7R8; C6-C10aryl; X2 is O, or NH; W1 is C1-C20alkyl; or a group Sp-Sil; Sp is a straight-chain or branched saturated or single or multiple unsaturated C3-C12 hydrocarbon; Sil is a silane; an oligosiloxane; or a polysiloxane moiety; and R4, R5 R6, R7, R8 and R9 independently from each other are hydrogen; C1-C12alkyl; or C3-C12cycloalkyl.

摘要翻译： 公开了式X1的三嗪衍生物是式A的二价基团，A'彼此独立地是未取代或取代的直链或支链C 1 -C 12亚烷基，其任选被C 5 -C 12亚环烷基，N，O或S中断; C5-C12环亚烷基; 联苯; C6-C10亚芳基 或C 5 -C 10亚芳基 - （C 1 -C 12亚烷基）; R1是式R2和R3的基团彼此独立地是氢; C 1 -C 12烷基; OR7; NR7R8; C6-C10芳基; X2是O或NH; W1是C1-C20烷基; 或一组Sp-Sil; Sp是直链或支链饱和或单或多不饱和C 3 -C 12烃; 硅是硅烷; 低聚硅氧烷; 或聚硅氧烷部分; R 4，R 5，R 6，R 7，R 8和R 9彼此独立地为氢; C 1 -C 12烷基; 或C 3 -C 12环烷基。

公开(公告)号：US07344706B2

公开(公告)日：2008-03-18

申请号：US10507295

申请日：2003-03-04

申请人： Jürg Haase ,  Thomas Ehlis ,  Elek Borsos ,  Dietmar Hüglin ,  Bernd Herzog

发明人： Jürg Haase ,  Thomas Ehlis ,  Elek Borsos ,  Dietmar Hüglin ,  Bernd Herzog

IPC分类号： A61Q17/00 ,  A61Q17/04 ,  A61Q19/00 ,  A61K8/02 ,  A61K31/53

CPC分类号： A61K8/4966 ,  A61Q17/04

摘要： UV absorber compositions are described, comprising (a) from 1 to 99% by weight of a hydroxyphenyltriazine compound of formula (I) wherein R1, R2 and R3 are each independently of the others C1-C18alkyl; C2-C10,alkenyl; or phenyl-C1-C4 alkyl; R4 is hydrogen; or C1-C5alkyl; and (b) from 99 to 1% by weight of a further UV absorber selected from the group of (b) hydroxyphenyltriazines that are different from component (a), (b2) benzotriazoles, (b3) dibenzoylmethane derivatives and (b4) camphor derivatives. The compositions are suitable as UV filters in cosmetic compositions

摘要翻译： 描述了UV吸收剂组合物，其包含（a）1至99重量％的式（I）的羟基苯基三嗪化合物，其中R 1，R 2和R 2 > 3 各自独立地为C 1 -C 12烷基; C 2 -C 10，烯基; 或苯基-C 1 -C 4烷基; R 4是氢; 或C 1 -C 5烷基; （b）99〜1重量％的另外的紫外线吸收剂，其选自（b）不同于组分（a），（b-2）苯并三唑的（b）羟基苯基三嗪，（b < （3/4）二苯甲酰甲烷衍生物和（b 4 S）樟脑衍生物。 该组合物适用于化妆品组合物中的UV过滤器

公开(公告)号：US07105479B2

公开(公告)日：2006-09-12

申请号：US10472791

申请日：2002-03-19

申请人： Thomas Ehlis ,  Robert Hochberg ,  Hauke Rohwer

发明人： Thomas Ehlis ,  Robert Hochberg ,  Hauke Rohwer

IPC分类号： C11D3/28

CPC分类号： C11D3/42 ,  C11D3/0015

摘要： Disclosed is a fabric rinse composition comprising a) 0.1 to 10% by weight of a UV absorber of formula (1), wherein A is a radical of formula (1a); B is a radical of formula (1c); (1d); (1e); (1f), (1g); (1b); (1i); (1k); (1l); or (1m); R1, R2, R3, R4, R5 and R6 are each independently of the others hydrogen, C1–C18alkyl; C5–C7-cycloalkyl; halogen; R9 is hydrogen C1–C12hydroxyalkyl; or C5–C7cycloalkyl; R7, R8 and R10 are each independently of the others hydrogen, C1–C18alkyl, C5–C7cycloalkyl, C1–C12hydroxyalkyl; X is halogen; a radical of formula (1s); or (1u); sulfate, phosphate, lactate, citrate, tartrate; R11 is C1–C12alkyl; C5–C7cycloalkyl or phenyl: x is from 0 to 10; and y is from 1 to 20; b) 5 to 25% by weight, based on the total weight of the composition of a fabric softener agent; and c) the remainder being substantially water

摘要翻译： 公开了一种织物漂洗组合物，其包含a）0.1至10重量％的式（1）的UV吸收剂，其中A为式（1a）的基团; B是式（1c）的基团; （1d）; （1e）; （1f），（1g）; （1b）; （1i）; （1k）; （1l）; 或（1m）; R 1，R 2，R 3，R 4，R 5和R 5， R 6各自独立地为氢，C 1 -C 18烷基; C 5 -C 7 - 环烷基; 卤素; R 9是氢C 1 -C 12羟烷基; 或C 5 -C 7环烷基; R 7，R 8和R 10各自独立地为氢，C 1 -C 3 C 18 -C 18烷基，C 5 -C 7环烷基，C 1 -C 12羟烷基，C 1 -C 12烷基， X是卤素; 式（1s）的基团; 或（1u）; 硫酸盐，磷酸盐，乳酸盐，柠檬酸盐，酒石酸盐; R 11是C 1 -C 12烷基; C 5 -C 7环烷基或苯基：x为0至10; y为1〜20; b）5至25重量％，基于织物柔软剂的组合物的总重量; 和c）其余部分基本上是水

公开(公告)号：US07066184B1

公开(公告)日：2006-06-27

申请号：US10130235

申请日：2000-11-07

申请人： Thomas Ehlis

发明人： Thomas Ehlis

IPC分类号： A61K7/06

CPC分类号： C08K5/3475 ,  A61K8/4966 ,  A61Q17/04 ,  C07D249/20

摘要： The use of benzotriazole UV absorbers of formula (1), wherein A is a radical of formula (1a); (1b); or (1c); B is a radical of formula (1d); (1e); (1f), (1g); (1h); (1i); (1k); (1l); (1m); or (1n); R1, R2, R3, R4, R5 and R6 are each independently of the others hydrogen, C1–C16alkyl; C5–C7cycloalkyl; halogen; R9 is hydrogen, C1–C12alkyl; or C5–C7cycloalkyl; R7, R8 and R10 are each independently of the others hydrogen, C1–C12alkyl C5–C7cycloalky, C1–C12hydroxyalkyl; X is halogen; a radical of formula (1s); (1t); or (1u); sulfate, phosphate, lactate, citrate, tartrate; R11 is C1–C12alkyl; or C5–C7cycloalkyl; R12 and R13 are each independently of the other hydrogen; or C1–C5alkyl; x is from 0 to 10; and y is from 1 to 20; in the cosmetic treatment of human hair for protection against UV radiation is described.

摘要翻译： 使用式（1）的苯并三唑UV吸收剂，其中A是式（1a）的基团; （1b）; 或（1c）; B是式（1d）的基团; （1e）; （1f），（1g）; （1h）; （1i）; （1k）; （11）; （1m）; 或（1n）; R 1，R 2，R 3，R 4，R 5和R 5， R 6各自独立地为氢，C 1 -C 16烷基; C 5 -C 7环烷基; 卤素; R 9是氢，C 1 -C 12烷基; 或C 5 -C 7环烷基; R 7，R 8和R 10各自独立地为氢，C 1 -C 3 C 12 -C 12烷基C 5 -C 7环烷基，C 1 -C 12羟烷基; X是卤素; 式（1s）的基团; （1t）; 或（1u）; 硫酸盐，磷酸盐，乳酸盐，柠檬酸盐，酒石酸盐; R 11是C 1 -C 12烷基; 或C 5 -C 7环烷基; R 12和R 13各自独立地为氢; 或C 1 -C 5烷基; x为0〜10; y为1〜20; 在描述用于防止UV辐射的人发的美容处理中。

公开(公告)号：US20060018846A1

公开(公告)日：2006-01-26

申请号：US10537940

申请日：2003-12-03

申请人： Jurg Haase ,  Thomas Ehlis ,  Elek Borsos ,  Stefan Muller

发明人： Jurg Haase ,  Thomas Ehlis ,  Elek Borsos ,  Stefan Muller

IPC分类号： C07D417/02 ,  C07D405/02 ,  A61K8/49

CPC分类号： C07D295/192 ,  A61K8/42 ,  A61K8/44 ,  A61K8/49 ,  A61K8/4973 ,  A61Q17/04 ,  C07C229/52 ,  C07C237/32 ,  C07C237/34 ,  C07C237/40 ,  C07C237/42 ,  C07D277/46 ,  C07D277/66 ,  C07D313/12

摘要： Described are amino substituted hydroxyphenyl benzophenone derivatives of formula (I), wherein R1, and R2 independently from each other are; C1-C20alkyl; C2-C20-alkenyl; C3-C10cycloalkyl; C3-C10cycloalkenyl; or R1, and R2 together with the linking nitrogen atom form a 5- or 6-membered heterocyclic ring; n1 is a number from 1 to 4; when n1=1, R3 is a saturated or unsaturated heterocyclic radical; hydroxy-C1-C5alkyl; cyclohexyl optionally substituted with one or more C1-C5alkyl; phenyl optionally substituted with a heterocyclic radical, aminocarbonyl or C1-C5alkylcarboxy; when n1 is 2, R3 is an alkylene-, cycloalkylene- or alkenylene radical which is optionally substituted by a carbonyl- or carboxy group; o R3 together with A forms a bivalent radical of the formula (Ia), wherein n2 is a number from 1 to 3; when n1 is 3, R3 is an alkanetriyl radical; when n1 is 4, R3 is an alkanetetrayl radical; A is —O—; or —N(R5)—; and R5 is hydrogen; C1-C5alkyl; or hydroxy-C1-C5alkyl. The compounds are useful as UV filters in sunscreen applications.

摘要翻译： 描述了式（I）的氨基取代的羟基苯基二苯甲酮衍生物，其中R 1和R 2彼此独立地为： C 1 -C 20烷基; C 1 -C 20烷基; C 2 -C 20 - 烯基; C 3 -C 10环烷基; C 3 -C 10环烯基; 或R 1和R 2与连接氮原子一起形成5-或6-元杂环; n 1是1至4的数; 当n 1 = 1时，R 3 3是饱和或不饱和杂环基; 羟基-C 1 -C 5烷基; 任选被一个或多个C 1 -C 5烷基取代的环己基; 任选被杂环基取代的苯基，氨基羰基或C 1 -C 5烷基羧基; 当n 1是2时，R 3是任选被羰基或羧基取代的亚烷基 - 亚环烷基 - 或亚烯基; R 3与A一起形成式（Ia）的二价基团，其中n 2是1至3的数; 当n 1为3时，R 3为烷三基; 当n 1为4时，R 3为烷基乙酰基; A为-O- 或-N（R 5） - ; 并且R 5是氢; C 1 -C 5烷基; 或羟基-C 1 -C 5烷基。 这些化合物可用作防晒霜中的紫外线过滤器。

公开(公告)号：US06495125B2

公开(公告)日：2002-12-17

申请号：US09755817

申请日：2001-01-05

申请人： Robert Wayne Glenn, Jr. ,  Alan Roy Katritzky ,  Eric Block ,  Matthew David Shair ,  Thomas Ehlis ,  Joseph Anthony Lupia

发明人： Robert Wayne Glenn, Jr. ,  Alan Roy Katritzky ,  Eric Block ,  Matthew David Shair ,  Thomas Ehlis ,  Joseph Anthony Lupia

IPC分类号： A61K706

CPC分类号： A61K8/898 ,  A61K8/46 ,  A61K8/49 ,  A61K8/4926 ,  A61K8/494 ,  A61K8/4946 ,  A61K8/4953 ,  A61K8/496 ,  A61K8/69 ,  A61K8/899 ,  A61Q3/00 ,  A61Q5/00 ,  A61Q5/10 ,  A61Q5/12 ,  A61Q11/00 ,  A61Q19/00

摘要： This invention relates to a topical composition for treating amino acid based substrates comprising a protected thiol compound having the formula R—(S—Pr)m where R is a functional group, S is sulfur, and Pr is a heterocyclic protecting group, and m is an integer between 1 and 100. The invention further relates to systems which comprise this protected thiol compound and an activating mechanism. The protected thiol compounds of the present invention may be used in hair care compositions, textile care compositions, cosmetic compositions, oral care compositions, skin care, nail care, laundry care, acne care and animal care compositions. Preferred embodiments of the present invention provide a modified UV absorber and a modified antioxidant, methods for making them and compositions conprising them.

摘要翻译： 本发明涉及一种用于处理氨基酸基底物的局部组合物，其包含具有所述方法的受保护的硫醇化合物，其中R为官能团，S为硫，Pr为杂环保护基，m为1至100之间的整数。 本发明还涉及包含该受保护的硫醇化合物和活化机理的体系。 本发明的受保护的硫醇化合物可以用于护发组合物，纺织品护理组合物，化妆品组合物，口腔护理组合物，护肤品，指甲护理，洗衣护理，痤疮护理和动物护理组合物中。 本发明的优选实施方案提供了改性的紫外线吸收剂和改性抗氧化剂，制备它们的方法和令人惊奇的组合物。

公开(公告)号：US06217856B1

公开(公告)日：2001-04-17

申请号：US09308094

申请日：1999-05-17

申请人： Thomas Ehlis ,  Dietmar Hüglin ,  Helmut Luther

发明人： Thomas Ehlis ,  Dietmar Hüglin ,  Helmut Luther

IPC分类号： A61K706

CPC分类号： C07D251/24 ,  A61K8/4966 ,  A61Q17/04

摘要： A description is given of symmetrical triazine derivatives of formula (1), wherein R1 and R2 are each independently of the other hydrogen; C1-C12alkyl, C1-C12alkoxy; and R3 is C1-C12alkyl; or C1-C12alkoxy. The easily accessible triazine derivatives are suitable for protecting ultraviolet-sensitive materials, in particular skin and hair of humans and animals, from the harmful effects of UV radiation.

摘要翻译： 给出式（1）的对称三嗪衍生物的描述，其中R 1和R 2各自独立于另一个氢; C 1 -C 12烷基，C 1 -C 12烷氧基; 且R 3为C 1 -C 12烷基; 或C 1 -C 12烷氧基。 容易获得的三嗪衍生物适用于防止紫外线辐射的有害影响的紫外线敏感材料，特别是人和动物的皮肤和毛发。

公开(公告)号：US09764169B2

公开(公告)日：2017-09-19

申请号：US13381965

申请日：2010-06-29

申请人： Julie Grumelard ,  Thomas Ehlis ,  Markus Hansch ,  Myriam Sohn

发明人： Julie Grumelard ,  Thomas Ehlis ,  Markus Hansch ,  Myriam Sohn

IPC分类号： A61Q17/04 ,  A61K8/37

CPC分类号： A61Q17/04 ,  A61K8/37

摘要： Disclosed is the use of a UV filter combination, comprising (a) a first UV filter selected from benzylidene malonates of formula (1), wherein R1 methyl; ethyl; propyl; or n-butyl; if R1 is methyl, then R is tert. butyl; formula (II); formula (III); a radical of formula (1a); or a radical of formula (1b); wherein R2 and R3, independently from each other are hydrogen; or methyl; R4 is methyl; ethyl; or n-propyl; R5 and R6 independently from each other are hydrogen; or C1-C3alkyl; if R1 is ethyl; propyl; or n-butyl, then R is isopropyl; and (b) a second UV filter selected from (b1) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine; (b2) Butyl Methoxydibenzoylmethane; (b3)Diethylhexyl Butamido Triazone; (b4) Ethylhexyl Triazone; (b5) Diethylamino Hydroxy Benzoyl Hexyl Benzoate; (b6) Ethylhexyl Methoxycinnamate; (b7) Ethylhexyl Salicylate; (b8) Homosalate; (b9) Octocrylene; (b10) micronized Methylene Bis-Benzotriazolyl Tetramethylbutylphenol; (b11) Phenylbenzimidazole Sulfonic Acid; (b12) Titanium Dioxide; (b13) micronized Tris-Biphenyl Triazine; and (b14) micronized (2-{4-[2-(4-Diethylamino-2-hydroxy-benzoyl)-benzoyl]-piperazine-1-carbonyl}-phenyl)-(4-diethylamino-2-hydroxy-phenyl)-methanone;(b15) benzoicacid,4,4-[[3-[1,3,3,3-tetramethyl-1-[trimethylsilyl)oxy]-1-disiloxanyl]propyl]amino]-1,3,5-triazine-2,4-diyl]diimino]bis-, dibutyl ester wherein the UV filter combination comprises at least 2 UV filters of component (b1)-(b14); for the protection of human and animal hair and skin against UV radiation.

公开(公告)号：US20110311786A1

公开(公告)日：2011-12-22

申请号：US12529718

申请日：2008-03-05

申请人： Allan Francis Cunningham ,  Thomas Ehlis ,  Jean-Luc Birbaum ,  Pascal Hayoz ,  Kamalesh Pai Fondekar

发明人： Allan Francis Cunningham ,  Thomas Ehlis ,  Jean-Luc Birbaum ,  Pascal Hayoz ,  Kamalesh Pai Fondekar

IPC分类号： B41M5/28 ,  C08K5/3492 ,  B05D3/06 ,  C09D129/04 ,  C09D109/08 ,  B05D3/02 ,  C07D251/24 ,  C09D133/08

CPC分类号： B41M5/3335 ,  B41M5/3336 ,  C08K5/3492 ,  C09D5/26 ,  C09D7/41 ,  Y10T428/24802

摘要： The present invention provides heat-sensitive coating compositions, which comprise a colour developer of formula (1) or mixtures thereof wherein R can be hydrogen, C1-20-alkyl, C3-8-cycloalkyl, C2-10-alkenyl, aryl or SO3H, and R2 and R3 can be the same or different and can be hydrogen, halogen, C1-20-alkyl, C3-8-cyclo-alkyl, C2-10-alkenyl, aryl, OR6, NR7R8, SR9, SO3H or COOR10 and R4 and R5 can be the same or different, and can be hydrogen, halogen, C1-20-alkyl, C3-8-cyclo-alkyl, C2-10-alkenyl, aryl, OR6, NR7R8 or SR9, R6, R7, R8, R9 and R10 can be the same or different and can be hydrogen, C1-30-alkyl, C3-8-cycloalkyl, C2-10-alkenyl or aryl, wherein C1-20-alkyl can be unsubstituted or substituted with one or more C3-8-cycloalkyl, C2-10-alkenyl, phenyl, halogen, OR11, NR12R13, SR14, SO3H or COOR15, and aryl can be unsubstituted or substituted with one or more halogen, C1-10-alkyl, halogenated C1-10-alkyl, C3-8-cycloalkyl C2-10-alkenyl, phenyl, OR11, NR12R13, SR14, SO3H or COOR15, wherein R11, R12, R13, R14 and R15 can be the same or different and can be hydrogen, C1-10-alkyl, C3-8-cycloalkyl or C2-10-alkenyl, a process for the preparation of these compositions, a process of coating substrates with these compositions, substrates coated with these compositions, a process for preparing marked substrates using these compositions, marked substrates obtainable by the latter process, and certain colour developers.

摘要翻译： 本发明提供热敏涂料组合物，其包含式（1）的显色剂或其混合物，其中R可以是氢，C 1-20烷基，C 3-8 - 环烷基，C 2-10 - 烯基，芳基或SO 3 H ，R2和R3可以相同或不同，可以是氢，卤素，C 1-20烷基，C 3-8 - 环烷基，C 2-10 - 烯基，芳基，OR 6，NR 7 R 8，SR 9，SO 3 H或COOR 10和 R4和R5可以相同或不同，可以是氢，卤素，C 1-20烷基，C 3-8 - 环烷基，C 2-10 - 烯基，芳基，OR 6，NR 7 R 8或SR 9，R 6，R 7，R 8 ，R 9和R 10可以相同或不同，并且可以是氢，C 1-30 - 烷基，C 3-8 - 环烷基，C 2-10 - 烯基或芳基，其中C 1-20 - 烷基可以是未取代的或被一个或多个 C 3-8 - 环烷基，C 2-10 - 烯基，苯基，卤素，OR 11，NR 12 R 13，SR 14，SO 3 H或COOR 15，芳基可以是未被取代的或被一个或多个卤素取代，C 1-10烷基，卤代C 1-10 - 烷基，C 3-8 - 环烷基C2-10 - 烯基，苯基，OR11，NR12R13，SR14，SO3H或COOR15，其中 在R 11，R 12，R 13，R 14和R 15可以相同或不同，可以是氢，C 1-10 - 烷基，C 3-8 - 环烷基或C 2-10 - 烯基，一种制备这些组合物的方法， 涂覆这些组合物的基材，用这些组合物涂布的基材，使用这些组合物制备标记的基材的方法，通过后一方法获得的标记的底物和某些显色剂。

公开(公告)号：US20080081908A1

公开(公告)日：2008-04-03

申请号：US11901660

申请日：2007-09-18

申请人： Gunther Schlingloff ,  Torsten Wieprecht ,  Uwe Heinz ,  Albert Schneider ,  Marie-Josee Dubs ,  Frank Bachmann ,  Menno Hazenkamp ,  Thomas Ehlis ,  Cornelia Vincenzi ,  Josef Dannacher

发明人： Gunther Schlingloff ,  Torsten Wieprecht ,  Uwe Heinz ,  Albert Schneider ,  Marie-Josee Dubs ,  Frank Bachmann ,  Menno Hazenkamp ,  Thomas Ehlis ,  Cornelia Vincenzi ,  Josef Dannacher

IPC分类号： C07D403/14

CPC分类号： C07D401/14 ,  C11D3/168 ,  C11D3/3932

摘要： Use of metal complex compounds of formula (1) and/or (1′) [LnMemXp]zYq  (1), [L′nMemXp]zYq  (1′), wherein all substituents are as defined in the claims, as catalysts for oxidation reactions, and also novel metal complex compounds and novel ligands.

摘要翻译： 使用式（1）和/或（1'）的金属络合物化合物<？in-line-formula description =“In-line Formulas”end =“lead”？> [L> n （1），＆lt;＆lt;行内公式描述=“In” -line公式“end =”tail“？> <？in-line-formula description =”In-line Formulas“end =”lead“？> [L' （1'），<？in-line-formula description =“在线公式” 其中所有取代基如权利要求中所定义，作为用于氧化反应的催化剂，以及新型金属络合物和新型配体。