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公开(公告)号：US11052131B2
公开(公告)日：2021-07-06
申请号：US16339931
申请日：2017-10-04
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , UNIVERSITE DE BORDEAUX , INSTITUT BERGONIÉ
IPC分类号： A61K38/22 , A61P35/00 , C07K14/575
摘要： Disclosed are methods and pharmaceutical compositions for the treatment of kidney cancer. The inventors showed that while Elabela (ELA) is mostly expressed in kidney, its expression is reduced in human kidney cancer. In a xenograft animal model (sub-cutaneous, or sub-capsular injection) Ela inhibits tumor progression. In particular, there is disclosed a method of treating kidney cancer in a subject in need thereof including administering to the subject a therapeutically effective amount of an ELA polypeptide including an amino acid sequence having at least 90% of identity with SEQ ID NO: 1 (QRPVNLTMRRKLRKHNCLQRRCMPLHSRVPFP) wherein the arginine residue (R) at position 9, 10, 20 or 21 is optionally mutated.
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公开(公告)号：US10946875B2
公开(公告)日：2021-03-16
申请号：US16492550
申请日：2018-03-12
申请人： PSA AUTOMOBILES SA , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT POLYTECHNIQUE DE BORDEAUX , UNIVERSITE DE BORDEAUX
摘要： A method is intended to assist the driver of a vehicle (VA) capable of being driven in an automated manner and in a manual manner, by means of a steering wheel (VV), in a traffic lane (VC1). This method comprises a step that involves determining an optimum trajectory of the vehicle (VA) in the event of automated driving, an actual current trajectory of the vehicle (VA) in the traffic lane (VC1), and a value of a parameter representative of a manual intervention being carried out by the driver on the steering wheel (VV), and representing these determined optimum and actual current trajectories on a medium (EA) with an aspect that depends on this determined value of the parameter.
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公开(公告)号：US20210062343A1
公开(公告)日：2021-03-04
申请号：US16958011
申请日：2018-12-20
摘要： A process for depositing a coating on a continuous carbon or silicon carbide fibre from a coating precursor, includes at least heating a segment of the fibre in the presence of the coating precursor in a microwave field so as to bring the surface of the segment to a temperature enabling the coating to be formed on the segment from the coating precursor.
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公开(公告)号：US10919801B2
公开(公告)日：2021-02-16
申请号：US16312759
申请日：2017-06-27
申请人： UNIVERSITE DE BORDEAUX , INSTITUT POLYTECHNIQUE DE BORDEAUX , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC
发明人： Marc Dussauze , Antoine Lepicard , Flavie Marie Bondu , Vincent Jean-Paul Rodriguez , Frédéric Adamietz , Thierry Cardinal , Evelyne Claude Fargin , Kathleen Richardson
摘要： A device for inducing by thermal poling a spatially controlled refractive index gradient inside at least one amorphous inorganic material to be treated, includes a structured electrode arranged on the surface or in proximity to the surface of the material to be treated; and at least one dielectric material. The structured electrode includes at least one conductive zone and at least one non-conductive zone and it is confined between the amorphous inorganic material to be treated and the dielectric material.
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公开(公告)号：US20200377417A1
公开(公告)日：2020-12-03
申请号：US16956068
申请日：2018-12-20
IPC分类号： C04B35/657 , C04B35/80 , C04B35/573 , C04B35/632 , C04B35/638 , C04B35/628 , B28B1/00 , B28B3/00
摘要： A process for manufacturing a composite material part including a particulate reinforcement densified by a ceramic matrix, the process including: formation of a blank of the part to be manufactured by shaping a mixture including a binder, first ceramic or carbon particles intended to form the particulate reinforcement of the part and second ceramic or carbon particles distinct from the first particles, removal or pyrolysis of the binder present in the blank to obtain a porous preform of the part to be manufactured, and infiltration of the porosity of the preform by a molten composition including a metal in order to obtain the part.
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36.发明申请公开(公告)号：US20200370022A1
公开(公告)日：2020-11-26
申请号：US16603264
申请日：2018-04-05
申请人： UNIVERSITE DE BORDEAUX , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , INSTITUT D'OPTIQUE THEORIQUE ET APPLIQUEE , INSTITUT BERGONIE , UNIVERSITE DE RENNES 1 , ETABLISSEMENT FRANCAIS DU SANG , CENTRE HOSPITALIER UNIVERSITAIRE (CHU) DE RENNES
发明人： LAURENCE BRESSON-BEPOLDIN , SIMON LATOUR , ISABELLE MAHOUCHE , PIERRE NASSOY , KEVIN ALESSANDRI , KARIN TARTE , FRÉDÉRIC MOURCIN
IPC分类号： C12N5/09 , C12N5/00 , C12N5/0781 , G01N33/50
摘要： The invention relates to a process for preparing cellular microcompartments comprising a hydrogel capsule surrounding a cluster of lymphomatous cells. The invention also relates to such a cellular microcompartment and the use thereof for screening anti-cancer molecules.
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37.发明申请公开(公告)号：US20200231731A1
公开(公告)日：2020-07-23
申请号：US15768976
申请日：2016-10-07
申请人： Arkema France , Institut Polytechnique De Bordeaux , Centre National De La Recherche Scientifique , Universite De Bordeaux
发明人： Christophe NAVARRO , Celia Nicolet , Karim Aissou , Muhammad Mumtaz , Eric Cloutet , Cyril Brochon , Guillaume Fleury , Georges Hadziioannou
IPC分类号： C08F297/02 , C08G77/442 , C09D153/00 , C08G77/60 , H01L21/027
摘要： A process for preparing a nanostructured assembly by annealing a composition comprising a block copolymer on a surface. The block copolymer includes a first block resulting from the polymerization of at least one cyclic monomer having a structure as described herein. The block copolymer also includes a second block that includes a vinyl aromatic monomer.
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38.发明授权公开(公告)号：US10670525B2
公开(公告)日：2020-06-02
申请号：US15884721
申请日：2018-01-31
申请人： Pernod Ricard , CNRS—Direction de l'Innovation et des Relations avec les Entreprises (DIRE) , UNIVERSITE DE BORDEAUX , Institut Polytechnique de Bordeaux
发明人： Pascal Brunerie , Katia Gouret , Benoit Fil , Stephane Verger , Jean-Luc Bruneel , Francois Guillaume , Caroline Bruneel Delhaye
摘要： The present disclosure provides a portable device for controlling an alcoholic beverage that includes a single light source emitting a monochromatic excitation light beam of a wavelength between 350 and 650 nanometers, a beam splitter to reflect the light beam, a focus and collection lens, and a positioning device to orient the light beam along a direction substantially normal to an outer surface of the container. The positioning device positions the outer surface of the container at a predetermined distance from the focus lens. The device includes a filtering device for filtering fluorescence radiation captured by the focus lens to eliminate wavelengths shorter than or equal to the wavelength of the light beam. A spectrometer module produces a signal corresponding to the measured spectrum of the fluorescence radiation and an analysis module compares the measured spectrum to a reference spectrum.
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公开(公告)号：US20200159973A1
公开(公告)日：2020-05-21
申请号：US16611590
申请日：2018-05-11
申请人： UNIVERSITE DE BORDEAUX , CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUX , FOUNDATION UNIVERSITE BORDEAUX , NSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE , INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET EN AUTOMATIQUE
发明人： Hubert COCHET , Maxime SERMESANT , Pierre JAIS
摘要： A method of segmentation of a three-dimensional image for generating a model of a myocardial wall includes recording a three-dimensional image of a wall of the myocardium, the wall delimiting at least one cavity of the heart; segmenting a continuous part of the wall into at least a first volume having a thickness less than a first predefined thickness threshold of between 0 and 5 mm and a second volume of a continuous part of the wall having a thickness greater than the first threshold; generating a model of the wall of the myocardium, where the continuous part of the wall of the myocardium is modelled according to at least two volumes that continue each other.
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40.发明申请公开(公告)号：US20200030750A1
公开(公告)日：2020-01-30
申请号：US16475815
申请日：2018-01-03
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE BORDEAUX , INSTITUT POLYTECHNIQUE DE BORDEAUX
摘要： Disclosed is a process for manufacturing a membrane from a, amphiphilic block copolymer including a hydrophilic block and a hydrophobic block including functions capable of forming a bond with the hydrophilic block in a bath containing the copolymer in solution in an apolar organic solvent, for a sufficient time to enable the formation of non-covalent bonds between the hydrophilic block and the support and the immobilisation of a first layer of the copolymer on the surface of the support; followed by adding water to the bath, so as to give rise to the self-assembly of a second layer of copolymer on the first layer.
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