Angiotensin Peptide and Pharmaceutical Compositions for Disease Treatment
    37.
    发明申请
    Angiotensin Peptide and Pharmaceutical Compositions for Disease Treatment 审中-公开
    血管紧张素肽和药物组合物用于疾病治疗

    公开(公告)号:US20160122387A1

    公开(公告)日:2016-05-05

    申请号:US14765248

    申请日:2013-09-13

    IPC分类号: C07K7/06

    摘要: The present invention relates to the peptide (arg0) n-angiotensin-(1-7) [(arg0) n-Ang-(1-7)], where n is 1 to 10 (Xaa-Asp-Arg-Val-Tyr-Ile-His-Pro; SEQ ID NO:1 where Xaa represents 1 to 10 L-Arg residues), which is produced by inserting at least one arginine amino acid at the amino terminal position of Ang-(1-7), as well as pharmaceutical compositions containing this peptide and the use thereof for the treatment or prevention of diseases or disorders that are due or associated with reduced nitric oxide production. Non-limiting examples of these diseases or disorders are cardiopulmonary and liver diseases, vascular disorders, metabolic disorders, neural disorders, genito-urinary tract disorders, skeletal muscle disorders, kidney disorders, skin disorders, alopecia or tumors. The peptide is able to cause, for example, dilation of aortic and mesenteric vessels, reduction of mean arterial blood pressure, decrease of body weight gain, blockade of the development of visceral adiposity, reduced serum and liver cholesterol levels, the normalization of glucose intolerance and insulin resistance, and an anti-proliferative effect. The peptides of the invention, such as (arg0) n-Ang-(1-7), optionally can be associated with a carrier system or controlled drug release system.

    摘要翻译: 本发明涉及肽(arg0)n-血管紧张素 - (1-7)[(arg0)n-Ang-(1-7)],其中n为1至10(Xaa-Asp-Arg-Val-Tyr -Ile-His-Pro; SEQ ID NO:1,其中Xaa表示1至10个L-Arg残基),其通过在Ang-(1-7)的氨基末端插入至少一个精氨酸氨基酸而产生,作为 以及含有该肽的药物组合物及其用于治疗或预防与一氧化氮产生减少或相关的疾病或病症的用途。 这些疾病或病症的非限制性实例是心肺和肝脏疾病,血管疾病,代谢紊乱,神经障碍,生殖泌尿系疾病,骨骼肌障碍,肾脏疾病,皮肤病,脱发或肿瘤。 该肽能够引起例如主动脉和肠系膜血管的扩张,平均动脉血压降低,体重增加减少,内脏肥胖发展的阻断,血清和肝脏胆固醇水平降低,葡萄糖耐受不正常 和胰岛素抵抗,以及抗增殖作用。 本发明的肽,例如(arg0)n-Ang-(1-7),任选地可以与载体系统或受控药物释放系统相关联。

    TENSEGRITY-BASED GARMENT FOR OPTIMISING HUMAN POSTURE AND MOTION
    38.
    发明申请
    TENSEGRITY-BASED GARMENT FOR OPTIMISING HUMAN POSTURE AND MOTION 审中-公开
    基于TENSEGRITY的服装优化人体运动与运动

    公开(公告)号:US20150223963A1

    公开(公告)日:2015-08-13

    申请号:US14367443

    申请日:2012-12-21

    IPC分类号: A61F5/02

    摘要: The discussed matter is comprised of a biomechanical vest designed to optimize body posture and movement. Specifically, the equipment consists of a vest which has areas reinforced by a material that simulates the elastic tension usually provided by body structures. These areas of tensional reinforcement follow patterns of the musculoskeletal system architecture and aim to give appropriate support for posture and movements of children and adults with motor dysfunctions, as well as optimizing the performance of workers and sports practitioners during their activities.

    摘要翻译: 所讨论的事情由设计用于优化身体姿势和运动的生物力学背心组成。 具体来说,该设备由背心组成,该背心具有通过模拟通常由身体结构提供的弹性张力的材料增强的区域。 这些拉伸强化领域遵循肌肉骨骼系统结构的模式,旨在为运动功能障碍的儿童和成人的姿势和运动提供适当的支持,并优化工作人员和运动从业者在活动过程中的表现。