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31.发明申请公开(公告)号：US20080119468A1
公开(公告)日：2008-05-22
申请号：US11899363
申请日：2007-09-04
Applicant: Andrew Tasker , Dawei Zhang , Liping H. Pettus , Rob M. Rzasa , Kelvin K.C. Sham , Shimin Xu , Partha Chakrabarti
Inventor： Andrew Tasker , Dawei Zhang , Liping H. Pettus , Rob M. Rzasa , Kelvin K.C. Sham , Shimin Xu , Partha Chakrabarti
IPC: A61K31/502 , C07D403/12 , C07D237/34 , C07D413/02 , C07D471/04 , A61P19/10 , A61P11/00 , A61P9/00 , A61P25/00 , A61P21/00 , A61P35/02 , A61K31/496 , C07D413/14 , A61K31/5377 , C07D237/30
CPC classification number: C07D403/12 , C07D237/30 , C07D237/34 , C07D403/10 , C07D413/12 , C07D417/10 , C07D471/04
Abstract: The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
Abstract translation: 本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。 化合物具有通式I，其中A 1，A 2，B，R 1，R 2， R 3和R 4在本文中定义。 本发明还包括药物组合物，其包含一种或多种式I化合物，这些化合物和组合物用于治疗激酶介导的疾病包括类风湿性关节炎，牛皮癣和其它炎症疾病的用途，以及可用于制备 一级方程式
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公开(公告)号：US20060194848A1
公开(公告)日：2006-08-31
申请号：US11417329
申请日：2006-05-02
Applicant: Guoqing Chen , Jeffrey Adams , Jean Bemis , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Qi Huang , Joseph Kim , Xiaohu Ouyang , Vinod Patel , Leon Smith , Andrew Tasker , Ning Xi , Shimin Xu , Chester Yuan , Michael Croghan , Tae-Seong Kim
Inventor： Guoqing Chen , Jeffrey Adams , Jean Bemis , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Qi Huang , Joseph Kim , Xiaohu Ouyang , Vinod Patel , Leon Smith , Andrew Tasker , Ning Xi , Shimin Xu , Chester Yuan , Michael Croghan , Tae-Seong Kim
CPC classification number: C07D401/14 , A61K31/00 , C07D401/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/14 , C07D471/04 , Y02A50/401
Abstract: Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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公开(公告)号：US06995162B2
公开(公告)日：2006-02-07
申请号：US10046681
申请日：2002-01-10
Applicant: Guoqing Chen , Jeffrey Adams , Jean Bemis , Shon Booker , Guolin Cai , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael Handley , Qi Huang , Joseph L. Kim , Tae-Seong Kim , Alexander Kiselyov , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Markian Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael Croghan
Inventor： Guoqing Chen , Jeffrey Adams , Jean Bemis , Shon Booker , Guolin Cai , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael Handley , Qi Huang , Joseph L. Kim , Tae-Seong Kim , Alexander Kiselyov , Xiaohu Ouyang , Vinod F. Patel , Leon M. Smith , Markian Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Chenguang Yuan , Michael Croghan
IPC: A61K31/435 , C07D213/82
CPC classification number: C07D213/82 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/538 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/00 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
Abstract: Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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公开(公告)号：US10358435B2
公开(公告)日：2019-07-23
申请号：US15554614
申请日：2016-03-11
Applicant: Merck Sharp & Dohme Corp. , Dong-Ming Shen , Christopher J. Sinz , Alejandro Crespo , Johnathan E. Wilson , Troy McCracken , Shimin Xu , Haitang Li
Inventor： Dong-Ming Shen , Christopher J. Sinz , Alejandro Crespo , Johnathan E. Wilson , Troy McCracken , Shimin Xu , Haitang Li
IPC: C07D471/04 , C07D403/04 , C07D487/04 , A61K31/4192 , A61K31/4196 , A61K31/506 , C07D498/04 , A61P25/00
Abstract: The present invention is directed to pyrimidine carboxamide compounds of formula I which are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 2 (PDE2). The present invention also relates to the use of such compounds for treating neurological and psychiatric disorders, such as schizophrenia, psychosis, Parkinson's disease, Parkinson's disease dementia (PDD), or Huntington's disease, and those associated with striatal hypofunction or basal ganglia dysfunction.
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公开(公告)号：US07915287B2
公开(公告)日：2011-03-29
申请号：US12004153
申请日：2007-12-19
Applicant: Steven Bellon , Shon Booker , Noel D'Angelo , Julie Germain , Jean-Christophe Harmange , Tae-Seong Kim , Matthew Lee , Longbin Liu , Mark H. Norman , Elizabeth Rainbeau , Ning Xi , Shimin Xu
Inventor： Steven Bellon , Shon Booker , Noel D'Angelo , Julie Germain , Jean-Christophe Harmange , Tae-Seong Kim , Matthew Lee , Longbin Liu , Mark H. Norman , Elizabeth Rainbeau , Ning Xi , Shimin Xu
IPC: A61K31/5377 , A61K31/444 , A61K31/4709 , A61K31/506 , A61P35/00 , C07D413/14 , C07D401/12 , C07D401/14
CPC classification number: C07D213/82 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Abstract translation: 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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Patent Agency Ranking
公开(公告)号：US20100292234A1
公开(公告)日：2010-11-18
申请号：US12681823
申请日：2008-09-19
Applicant: Liping H. Pettus , Kelvin K.C. Sham , Andrew Tasker , Shimin Xu
Inventor： Liping H. Pettus , Kelvin K.C. Sham , Andrew Tasker , Shimin Xu
IPC: A61K31/5377 , C07D249/18 , A61K31/4192 , A61P19/10 , A61P35/04 , A61P19/02 , A61P11/06 , A61P25/28 , A61P37/06 , A61P9/10 , A61P3/10 , A61P33/06 , A61P31/18 , A61P31/16 , A61P31/22 , C07D471/04 , A61K31/437 , A61K31/496 , C07D413/04 , C07D403/04 , C07D401/04 , A61K31/454
CPC classification number: C07D249/18 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D471/04
Abstract: The present invention comprises a new class of compounds useful for modulating the activity of p38 MAP kinase. The compounds have a general Formula I wherein A1, A2, A3, A4, A5, A6, R1 and R5 are defined herein. The invention further provides pharmaceutical compositions including one or more compounds of Formula I, use of such compounds and compositions for treatment of p38 MAP kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammatory disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
Abstract translation: 本发明包括一类可用于调节p38 MAP激酶活性的化合物。 该化合物具有通式I，其中A1，A2，A3，A4，A5，A6，R1和R5如本文所定义。 本发明进一步提供包含一种或多种式I化合物的药物组合物，使用这些化合物和组合物用于治疗p38MAP激酶介导的疾病，包括类风湿性关节炎，牛皮癣和其它炎症性疾病，以及可用于制备 式Ⅰ的化合物。
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公开(公告)号：US20080200464A1
公开(公告)日：2008-08-21
申请号：US12004153
申请日：2007-12-19
Applicant: Steven Bellon , Shon Booker , Noel D'Angelo , Julie Germain , Jean-Christophe Harmange , Tae-Seong Kim , Matthew Lee , Longbin Liu , Mark H. Norman , Elizabeth Rainbeau , Ning Xi , Shimin Xu
Inventor： Steven Bellon , Shon Booker , Noel D'Angelo , Julie Germain , Jean-Christophe Harmange , Tae-Seong Kim , Matthew Lee , Longbin Liu , Mark H. Norman , Elizabeth Rainbeau , Ning Xi , Shimin Xu
IPC: A61K31/5377 , C07D413/14 , C07D401/14 , A61K31/444 , A61K31/4709 , A61K31/506 , C07D401/12 , A61P35/00
CPC classification number: C07D213/82 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Abstract translation: 所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。 本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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公开(公告)号：US20060241115A1
公开(公告)日：2006-10-26
申请号：US11042634
申请日：2005-01-24
Applicant: Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian Hodous , Russell Graceffa , William Buckner , Craig Masse , Deborah Choquette , Matthew Martin , Julie Germain , Lucian DiPietro , Stuart Chaffee , Joseph Nunes , John Buchanan , Gregory Habgood , David McGowan , Douglas Whittington
Inventor： Michele Potashman , Tae-Seong Kim , Steven Bellon , Shon Booker , Yuan Cheng , Joseph Kim , Andrew Tasker , Ning Xi , Shimin Xu , Jean-Christophe Harmange , George Borg , Matthew Weiss , Brian Hodous , Russell Graceffa , William Buckner , Craig Masse , Deborah Choquette , Matthew Martin , Julie Germain , Lucian DiPietro , Stuart Chaffee , Joseph Nunes , John Buchanan , Gregory Habgood , David McGowan , Douglas Whittington
IPC: A61K31/517 , A61K31/502 , A61K31/498 , A61K31/4709 , C07D43/02
CPC classification number: C07D213/64 , C07D213/81 , C07D215/233 , C07D215/38 , C07D215/48 , C07D215/54 , C07D237/34 , C07D239/34 , C07D239/47 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04
Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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39.发明申请公开(公告)号：US20060199817A1
公开(公告)日：2006-09-07
申请号：US11367123
申请日：2006-03-02
Applicant: Andrew Tasker , Dawei Zhang , Guo-Qiang Cao , Partha Chakrabarti , James Falsey , Bradley Herberich , Randall Hungate , Liping Pettus , Anthony Reed , Robert Rzasa , Kelvin Sham , Maya Thaman , Shimin Xu
Inventor： Andrew Tasker , Dawei Zhang , Guo-Qiang Cao , Partha Chakrabarti , James Falsey , Bradley Herberich , Randall Hungate , Liping Pettus , Anthony Reed , Robert Rzasa , Kelvin Sham , Maya Thaman , Shimin Xu
IPC: A61K31/5377 , A61K31/503 , A61K31/53 , C07D487/02
CPC classification number: C07D409/04 , C07D237/30 , C07D237/32 , C07D237/34 , C07D403/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D487/08 , C07D491/10
Abstract: The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, uses of such compounds and compositions for treatment of kinase mediated diseases including rheumatoid arthritis, psoriasis and other inflammation disorders, as well as intermediates and processes useful for the preparation of compounds of Formula I.
Abstract translation: 本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。 化合物具有通式I，其中A 1，A 2，B，R 1，R 2， R 3和R 4在本文中定义。 本发明还包括药物组合物，其包含一种或多种式I化合物，这些化合物和组合物用于治疗激酶介导的疾病包括类风湿性关节炎，牛皮癣和其它炎症疾病的用途，以及可用于制备 一级方程式
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公开(公告)号：US20050153960A1
公开(公告)日：2005-07-14
申请号：US10996035
申请日：2004-11-22
Applicant: Daniel Elbaum , Benny Askew , Shon Booker , Julie Germain , Gregory Habgood , Michael Handley , Tae-Seong Kim , Aiwen Li , Nobuko Nishimura , Vinod Patel , Chester Yuan , Joseph Kim , Guolin Cai , Guoqing Chen , Michael Croghan , Lucian Di Pietro , Celia Dominguez , Qi Huang , Leon Smith , Andrew Tasker , Ning Xi , Shimin Xu
Inventor： Daniel Elbaum , Benny Askew , Shon Booker , Julie Germain , Gregory Habgood , Michael Handley , Tae-Seong Kim , Aiwen Li , Nobuko Nishimura , Vinod Patel , Chester Yuan , Joseph Kim , Guolin Cai , Guoqing Chen , Michael Croghan , Lucian Di Pietro , Celia Dominguez , Qi Huang , Leon Smith , Andrew Tasker , Ning Xi , Shimin Xu
IPC: A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/501 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/538 , A61P1/04 , A61P3/00 , A61P3/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P15/00 , A61P15/08 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/00 , A61P19/02 , A61P21/00 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/12 , A61P31/18 , A61P31/22 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/02 , A61P37/04 , A61P37/08 , A61P43/00 , C07D213/81 , C07D213/82 , C07D237/04 , C07D237/24 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , A61K31/4545 , C07D413/02 , C07D41/02
CPC classification number: C07D213/81 , C04B35/632 , C07D213/82 , C07D237/04 , C07D237/24 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
Abstract: Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Abstract translation: 所选化合物对于预防和治疗诸如血管生成介导的疾病等疾病是有效的。 本发明包括新型化合物，类似物，前药及其药学上可接受的衍生物，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。 本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。
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