公开(公告)号：US08628770B2

公开(公告)日：2014-01-14

申请号：US12259575

申请日：2008-10-28

Applicant: Pierre Casellas ,  Jean-Marie Derocq ,  Joelle Guesnet

Inventor： Pierre Casellas ,  Jean-Marie Derocq ,  Joelle Guesnet

IPC: A61K35/66

CPC classification number: A61Q19/06 ,  A61K8/99 ,  A61K2800/70

Abstract: This invention relates to a slimming cosmetic composition containing at least one compound inducing the production of IL-6 by the adipocytes in the form of a mixture with an NPY antagonist and/or an α2 antagonist and with an excipient for a cosmetic preparation.

Abstract translation: 本发明涉及一种减肥化妆品组合物，其含有至少一种诱导与NPY拮抗剂和/或α2拮抗剂混合形式的脂肪细胞产生IL-6的化合物和用于化妆品制剂的赋形剂。

公开(公告)号：US08236811B2

公开(公告)日：2012-08-07

申请号：US12485401

申请日：2009-06-16

Applicant: Bernard Bourrie ,  Pierre Casellas

Inventor： Bernard Bourrie ,  Pierre Casellas

IPC: A61K31/519

CPC classification number: A61K31/519 ,  A61K31/704 ,  A61K31/7068 ,  A61K2300/00

Abstract: The disclosure relates to methods of treating leukaemia, in particular myeloid leukaemia, comprising administering the compound N-[2-(2,1,3-benzothiadiazol-5-ylamino)-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-N′-(1,1-dimethylethyl)-urea or a hydrate, a pharmaceutically acceptable salt or a solvate thereof.

Abstract translation: 本公开涉及治疗白血病，特别是骨髓性白血病的方法，包括给予化合物N- [2-（2,1,3-苯并噻二唑-5-基氨基）-6-（2,6-二氯苯基）吡啶并[ 3-d]嘧啶-7-基] -N' - （1,1-二甲基乙基） - 脲或其水合物，其药学上可接受的盐或溶剂化物。

公开(公告)号：US07893259B2

公开(公告)日：2011-02-22

申请号：US12415256

申请日：2009-03-31

Applicant: Bernard Bourrie ,  Pierre Casellas ,  Samir Jegham ,  Pierre Perreaut

Inventor： Bernard Bourrie ,  Pierre Casellas ,  Samir Jegham ,  Pierre Perreaut

IPC: C07D471/04 ,  A61P35/00 ,  A61P35/02

CPC classification number: C07D471/04

Abstract: The disclosure concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I): and acid addition salts, hydrates and solvates thereof, as well as in the form of enantiomers, diastereoisomers and mixtures thereof. The disclosure also concerns methods for preparing said derivatives, pharmaceutical compositions containing a compound of general formula (I), and their therapeutic use.

Abstract translation: 本公开涉及通式（I）的吡啶并[2,3-d]嘧啶衍生物及其制备方法及其治疗应用：及其酸加成盐，水合物和溶剂化物，以及对映异构体，非对映异构体和混合物的形式 其中。 本公开还涉及制备所述衍生物的方法，含有通式（I）的化合物的药物组合物及其治疗用途。

公开(公告)号：US07858824B2

公开(公告)日：2010-12-28

申请号：US11958476

申请日：2007-12-18

Applicant: Marco Baroni ,  Bernard Bourrie ,  Rosanna Cardamone ,  Pierre Casellas

Inventor： Marco Baroni ,  Bernard Bourrie ,  Rosanna Cardamone ,  Pierre Casellas

IPC: C07C61/29

CPC classification number: C07D401/04 ,  C07D211/70

Abstract: The present invention relates to compounds of formula (IIIo): in which n is an integer from 1 to 5; Ao represents a partially saturated carbonaceous bi- or tricycle; it also relates to their salts, solvates, N-oxides, the pharmaceutical compositions containing them, a method for their preparation and synthesis intermediates in this method.

Abstract translation: 本发明涉及式（IIIo）化合物：其中n为1至5的整数; Ao代表部分饱和的含碳双环或三轮车; 它还涉及它们的盐，溶剂合物，N-氧化物，含有它们的药物组合物，其制备方法和该方法中的合成中间体。

公开(公告)号：US07816368B2

公开(公告)日：2010-10-19

申请号：US12252647

申请日：2008-10-16

Applicant: Bernard Bourrie ,  Pierre Casellas ,  Jean-Marie Derocq ,  Samir Jegham ,  Yvette Muneaux

Inventor： Bernard Bourrie ,  Pierre Casellas ,  Jean-Marie Derocq ,  Samir Jegham ,  Yvette Muneaux

IPC: A61K31/44

CPC classification number: C07D471/04

Abstract: The present disclosure relates to pyridoindolone derivatives of general formula (I): in which R1 to R5 are as defined in the specification, to processes for preparing said derivatives, and to methods of use thereof.

Abstract translation: 本公开涉及通式（I）的吡啶并吲哚酮衍生物：其中R 1至R 5如本说明书中所定义，用于制备所述衍生物的方法及其使用方法。

公开(公告)号：US20090220958A1

公开(公告)日：2009-09-03

申请号：US12092123

申请日：2006-11-10

Applicant: Pierre Casellas ,  Hubert Vidal ,  Isabelle Buisson ,  Jean Marchand ,  Dominique Simon ,  Sylvaine Galiegue

Inventor： Pierre Casellas ,  Hubert Vidal ,  Isabelle Buisson ,  Jean Marchand ,  Dominique Simon ,  Sylvaine Galiegue

IPC: C12Q1/68 ,  G01N33/566 ,  G01N33/534

CPC classification number: C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/6893 ,  G01N33/92 ,  G01N2333/775

Abstract: The invention relates to a method for diagnosticating hepatic diseases consisting in measuring an apolipoprotein A4 expression in hepatic cells or tissues and in the circulation (blood, plasma, serum. A method for screening molecules for treating said diseases by bringing into contact said compounds with a mammal and for measuring the apolipoprotein A4 expression in said hepatic origin cells or in the circulation of said mammal is also disclosed.

Abstract translation: 本发明涉及一种用于诊断肝脏疾病的方法，其包括测量肝细胞或组织和循环中的载脂蛋白A4表达（血液，血浆，血清）。用于筛选分子用于通过使所述化合物与 还公开了用于测量所述肝起源细胞中或所述哺乳动物的循环中的载脂蛋白A4表达的哺乳动物。

公开(公告)号：US20090042924A1

公开(公告)日：2009-02-12

申请号：US12252647

申请日：2008-10-16

Applicant: Bernard BOURRIE ,  Pierre CASELLAS ,  Jean-Marie DEROCQ ,  Samir JEGHAM ,  Yvette MUNEAUX

Inventor： Bernard BOURRIE ,  Pierre CASELLAS ,  Jean-Marie DEROCQ ,  Samir JEGHAM ,  Yvette MUNEAUX

IPC: A61K31/437 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: The present disclosure relates to pyridoindolone derivatives of general formula (I): in which R1 to R5 are as defined in the specification, to processes for preparing said derivatives, and to methods of use thereof.

Abstract translation: 本公开涉及通式（I）的吡啶并吲哚酮衍生物：其中R 1至R 5如本说明书中所定义，用于制备所述衍生物的方法及其使用方法。

公开(公告)号：US20070179126A1

公开(公告)日：2007-08-02

申请号：US11649316

申请日：2007-01-03

Applicant: Pierre Casellas ,  Daniel Floutard ,  Pierre Fraisse ,  Samir Jegham

Inventor： Pierre Casellas ,  Daniel Floutard ,  Pierre Fraisse ,  Samir Jegham

IPC: A61K31/5377 ,  A61K31/496 ,  C07D417/14

CPC classification number: C07D417/12 ,  C07D277/40 ,  C07D277/46

Abstract: The disclosure concerns 2-carbamide-4-phenylthiazole derivatives of general formula (I). The disclosure also concerns pharmaceutical compositions containing a compound of general formula (I) and to processes for preparing and methods of using compounds of general formula (I).

Abstract translation: 本公开涉及通式（I）的2-氨基-4-苯基噻唑衍生物。 本公开还涉及含有通式（I）化合物的药物组合物及其制备方法和使用通式（I）的化合物的方法。

公开(公告)号：US20070129365A1

公开(公告)日：2007-06-07

申请号：US11582769

申请日：2006-10-18

Applicant: Bernard Bourrie ,  Pierre Casellas ,  Paola Ciapetti ,  Jean-Marie Deroco ,  Samir Jegham ,  Yvette Muneaux ,  Camille-Georges Wermuth

Inventor： Bernard Bourrie ,  Pierre Casellas ,  Paola Ciapetti ,  Jean-Marie Deroco ,  Samir Jegham ,  Yvette Muneaux ,  Camille-Georges Wermuth

IPC: A61K31/5377 ,  A61K31/4745 ,  C07D471/02

CPC classification number: C07D471/04

Abstract: Compounds of formula: and pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1, R2, R3, R4, and R5, have the meanings given in the description; pharmaceutical compositions comprising said compounds; and processes for preparing said compounds and methods of use thereof.

Abstract translation: 其中R 1，R 2，R 3，R 3，R 3， 4 和R 5 5具有在说明书中给出的含义; 包含所述化合物的药物组合物; 以及制备所述化合物的方法及其使用方法。

公开(公告)号：US07211578B2

公开(公告)日：2007-05-01

申请号：US10495890

申请日：2002-11-18

Applicant: Marco Baroni ,  Bernard Bourrie ,  Pierre Casellas ,  Letizia Puleo

Inventor： Marco Baroni ,  Bernard Bourrie ,  Pierre Casellas ,  Letizia Puleo

IPC: C07D401/10 ,  A61K31/4523 ,  A61K31/4545

CPC classification number: C07D401/10

Abstract: This invention relates to nitrogenous (tetrahydropyridyl)(alkyl)heterocycles, to pharmaceutical compositions comprising them, to processes for preparing them and to the method of use thereof in the treatment of pain and diseases related to immune and inflammatory disorders.

Abstract translation: 本发明涉及含氮（四氢吡啶基）（烷基）杂环，包含它们的药物组合物，其制备方法及其用于治疗与免疫和炎性疾病相关的疼痛和疾病的方法。