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    Pyrido-pyrimidine derivatives, preparation thereof, and therapeutic use thereof
    2.
    发明授权
    Pyrido-pyrimidine derivatives, preparation thereof, and therapeutic use thereof 有权
    吡啶并嘧啶衍生物及其制备方法及其治疗用途

    公开(公告)号：US07893259B2

    公开(公告)日：2011-02-22

    申请号：US12415256

    申请日：2009-03-31

    Applicant: Bernard Bourrie ,  Pierre Casellas ,  Samir Jegham ,  Pierre Perreaut

    Inventor： Bernard Bourrie ,  Pierre Casellas ,  Samir Jegham ,  Pierre Perreaut

    IPC: C07D471/04 ,  A61P35/00 ,  A61P35/02

    CPC classification number: C07D471/04

    Abstract: The disclosure concerns pyrido[2,3-d]pyrimidine derivatives, their preparation and their therapeutic application, of general formula (I): and acid addition salts, hydrates and solvates thereof, as well as in the form of enantiomers, diastereoisomers and mixtures thereof. The disclosure also concerns methods for preparing said derivatives, pharmaceutical compositions containing a compound of general formula (I), and their therapeutic use.

    Abstract translation: 本公开涉及通式（I）的吡啶并[2,3-d]嘧啶衍生物及其制备方法及其治疗应用：及其酸加成盐，水合物和溶剂化物，以及对映异构体，非对映异构体和混合物的形式 其中。 本公开还涉及制备所述衍生物的方法，含有通式（I）的化合物的药物组合物及其治疗用途。

    3-(Pyrrolidin-3-yl)-1,3,4-oxadiazol-2(3H)-one derivatives and their use as 5-HT4 ligands
    9.
    发明授权
    3-(Pyrrolidin-3-yl)-1,3,4-oxadiazol-2(3H)-one derivatives and their use as 5-HT4 ligands 失效
    3-（吡咯烷-3-基）-1,3,4-恶二唑-2（3H） - 酮衍生物及其作为5-HT 4配体的用途

    公开(公告)号：US06248757B1

    公开(公告)日：2001-06-19

    申请号：US09403779

    申请日：1999-11-04

    Applicant: Alistair Lochead ,  Samir Jegham ,  Jean Jeunesse

    Inventor： Alistair Lochead ,  Samir Jegham ,  Jean Jeunesse

    IPC: A61K31445

    CPC classification number: C07D413/04 ,  C07D413/14

    Abstract: Compounds corresponding to the general formula (I) in which R1 represents hydrogen or an alkyl or cycloalkylmethyl group, X1 represents hydrogen or a halogen or an alkoxy group, or alternatively OR1 and X1 together represent a group of formula —OCH2O—, —O(CH2)2—, —O(CH2)3—, —O(CH2)2O— or —O(CH2)3O—, X2 represents hydrogen, an amino group or a group of general formula —NHCO2R in which R represents an alkyl or phenylalkyl group, X3 represents hydrogen or a halogen, and R2 represents hydrogen or an alkyl, phenylalkyl or [(4-dimethylamino)piperid-1-ylcarbonyl]alkyl group. Therapeutic application.

    Abstract translation: 对应于通式（I）的化合物，其中R 1表示氢或烷基或环烷基甲基，X 1表示氢或卤素或烷氧基，或者OR 1和X 1一起表示式-OCH 2 O-，-O（ CH2）2-，-O（CH2）3-，-O（CH2）2O-或-O（CH2）3O-，X2表示氢，氨基或通式-NHCO2R基团，其中R表示烷基 或苯基烷基，X 3表示氢或卤素，R 2表示氢或烷基，苯基烷基或[（4-二甲基氨基）哌啶-1-基羰基]烷基。 治疗应用。

    Oxazolidin-2-one derivatives, preparation method therefor and therapeutical use thereof
    10.
    发明授权
    Oxazolidin-2-one derivatives, preparation method therefor and therapeutical use thereof 失效
    恶唑烷-2-酮衍生物及其制备方法及其治疗用途

    公开(公告)号：US5969146A

    公开(公告)日：1999-10-19

    申请号：US51539

    申请日：1998-04-13

    Applicant: Samir Jegham ,  Frederic Puech ,  Philippe Burnier ,  Danielle Berthon ,  Odile Leclerc

    Inventor： Samir Jegham ,  Frederic Puech ,  Philippe Burnier ,  Danielle Berthon ,  Odile Leclerc

    IPC: A61K31/00 ,  A61K31/42 ,  A61K31/422 ,  A61P25/04 ,  A61P43/00 ,  C07D413/04 ,  C07D413/14

    CPC classification number: C07D413/04

    Abstract: Compounds derived from oxazolidin-2-one of formula (I) ##STR1## in which: R.sub.1 represents a hydrogen atom, an alkyl group, a hydroxyalkyl group, a fluoroalkyl group, a hydroxyfluoroalkyl group, a cyanoalkyl group, a substituted or unsubstituted phenyl group, a substituted or unsubstituted phenylmethyl group or an R.sub.3 A- group in which R.sub.3 is a cycloalklyl or cyclooxyalkyl group which is unsubstituted or substituted by a hydroxyl group and A is a --CH.sub.2 or --CH.sub.2 --CH.sub.2 radical,R.sub.2 represents a hydrogen atom or a methyl group,X represents an oxygen or sulphur atom or an NR.sub.4 group where R.sub.4 is an alkyl group or a hydrogen atom, andZ represents an oxygen atom or a --CH.dbd.CH or --CH.sub.2 --CH.sub.2 group,their process of preparation and their applications in therapeutics.

    Abstract translation: PCT No.PCT / FR96 / 01511 Sec。 371日期：1998年4月13日 102（e）1998年4月13日PCT PCT 1996年10月8日PCT公布。 公开号WO97 / 13768 日期1997年04月17日衍生自式（I）的恶唑烷-2-酮的化合物，其中：R1表示氢原子，烷基，羟基烷基，氟代烷基，羟基氟烷基，氰基烷基，取代或 未取代的苯基，取代或未取代的苯基甲基或R3A-基团，其中R3是未被取代或被羟基取代的环烯基或环氧烷基，A是-CH2或-CH2-CH2基，R2表示氢 原子或甲基，X表示氧或硫原子或NR4基团，其中R4是烷基或氢原子，Z表示氧原子或-CH = CH或-CH2-CH2基团，它们的方法 制剂及其在治疗中的应用。

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