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31.发明授权Systems and methods for local vasoactive response using temperature modulation 有权使用温度调制的局部血管活性反应的系统和方法公开(公告)号：US08828068B2
公开(公告)日：2014-09-09
申请号：US11779162
申请日：2007-07-17
CPC分类号： A61F7/12 , A61F7/123 , A61F2007/0056 , A61F2007/0071 , A61F2007/0075 , A61F2007/126
摘要： Disclosed herein, among other things, is a device for providing a localized vasomodulation of a vessel. According to an embodiment, the device includes a thermal element configured to conduct thermal energy between the thermal element and a desired region of the vessel wall to elicit the localized vasomodulation of the vessel at the desired region. The device also includes a controller operationally connected to the thermal element. The controller is adapted to control the conduction of thermal energy between the thermal element and the desired region of the vessel wall to control the localized vasomodulation of the vessel at the desired region. In various embodiments, a sensor connected to the device provides feedback to the controller.
摘要翻译： 这里公开了一种用于提供血管的局部血管调节的装置。 根据实施例，该装置包括热元件，其被配置为在热元件和容器壁的期望区域之间传导热能，以引起容器在期望区域的局部血管调节。 该装置还包括可操作地连接到热元件的控制器。 控制器适于控制热元件与血管壁的所需区域之间的热能传导，以控制血管在所需区域的局部血管调节。 在各种实施例中，连接到设备的传感器向控制器提供反馈。
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公开(公告)号：US08649853B2
公开(公告)日：2014-02-11
申请号：US13168531
申请日：2011-06-24
CPC分类号： A61N1/36514 , A61B5/02133 , A61B5/026 , A61N1/08 , A61N1/36142 , A61N1/36578
摘要： Systems and methods to monitor cardiac function using information indicative of lead motion are described. In an example, a system including an implantable medical device can include a receiver circuit configured to be electrically coupled to conductor comprising a portion of an implantable lead and be configured to obtain information indicative of a movement of the implantable lead due at least in part to a motion of a heart. The system can include a sensing circuit configured to obtain information indicative of cardiac electrical activity. The system can include a processor circuit configured to construct a template representative of a contraction of the heart, where the template can be constructed using the information indicative of the movement of the implantable lead due at least in part to the motion of the heart during the contraction, and using the information indicative of the cardiac electrical activity sensed during the contraction.
摘要翻译： 描述使用指示引导运动的信息来监测心脏功能的系统和方法。 在一个示例中，包括可植入医疗装置的系统可以包括被配置为电耦合到导体的接收器电路，该导体包括可植入引线的一部分，并且被配置为获得指示可植入引线的移动的信息， 一个心脏的动作。 该系统可以包括被配置为获得指示心脏电活动的信息的感测电路。 该系统可以包括配置成构造代表心脏收缩的模板的处理器电路，其中可以使用指示可植入导线的运动的信息构造模板，至少部分地由于心脏的运动 并且使用指示在收缩期间感测到的心脏电活动的信息。
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公开(公告)号：US08548586B2
公开(公告)日：2013-10-01
申请号：US12361353
申请日：2009-01-28
申请人： Shantha Arcot-Krishnamurthy , John R. Zielinski , Joseph M. Pastore , Jeffrey E. Stahmann , Allan C. Shuros , Robert Shipley
发明人： Shantha Arcot-Krishnamurthy , John R. Zielinski , Joseph M. Pastore , Jeffrey E. Stahmann , Allan C. Shuros , Robert Shipley
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3688
摘要： This document discusses, among other things, an apparatus comprising at least one implantable cardiac depolarization sensing circuit, an electrical stimulation circuit, and a pacing mode controller. The implantable cardiac depolarization sensing circuit is configured to obtain a sensed depolarization signal from a ventricle and the electrical stimulation circuit is configured to provide pacing electrical stimulation energy to at least one implantable ventricular electrode. The pacing mode controller delivers pacing therapy according to a first pacing mode that is a normal operating mode, and delivers pacing therapy according to second and third pacing modes. The second and third pacing modes increase mechanical stress on at least a particular portion of the ventricle as compared to the pacing therapy delivered during the first pacing mode. The pacing mode controller alternates between the second and third pacing modes when switched from the normal operating mode to a stress augmentation mode.
摘要翻译： 本文件尤其涉及包括至少一个可植入心脏去极化感测电路，电刺激电路和起搏模式控制器的装置。 可植入心脏去极化感测电路被配置为从心室获得感测的去极化信号，并且电刺激电路被配置为向至少一个可植入心室电极提供起搏电刺激能量。 起搏模式控制器按照正常运行模式的第一起搏模式提供起搏治疗，并根据第二和第三起搏模式提供起搏治疗。 与在第一起搏模式期间递送的起搏治疗相比，第二和第三起搏模式增加至少在心室的特定部分上的机械应力。 当从正常操作模式切换到应力增强模式时，起搏模式控制器在第二和第三起搏模式之间交替。
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公开(公告)号：US08483821B2
公开(公告)日：2013-07-09
申请号：US12843444
申请日：2010-07-26
CPC分类号： A61N1/3601 , A61B5/0537 , A61B5/0538 , A61B5/0809 , A61B5/4035 , A61B5/4869 , A61N1/36114 , A61N1/36521 , A61N1/36585
摘要： A first fluid status indicator of a pulmonary fluid status associated with pulmonary edema and a second fluid status indicator of a non-pulmonary fluid status can be used to provide an alert or to control a therapy for pulmonary edema. Additionally, intermittent cardiac blood volume redistribution therapy can be used to provide cardiac conditioning in heart failure patients.
摘要翻译： 可以使用与肺水肿相关的肺液体状态和非肺液体状态的第二流体状态指示器的第一流体状态指示器来提供警报或控制肺水肿的治疗。 此外，间歇性心脏血容量再分配治疗可用于在心力衰竭患者中提供心脏调节。
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公开(公告)号：US08412326B2
公开(公告)日：2013-04-02
申请号：US12709867
申请日：2010-02-22
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/36585
摘要： A pacemaker initiates and times a monitoring interval in response to an event such as a therapy delivery to a patient. The monitoring interval is specified to include a duration of an anticipated acute response to the event, such as vagal surge. One or more physiological parameters indicative of the acute response are detected during the monitoring interval for analyzing therapeutic effect of the event. In various embodiments, one or more pacing parameters are adjusted for a response interval specified to include the duration of the anticipated acute response to allow for the analysis and maximization of the therapeutic effect. In various embodiments, the event includes a session of pacing therapy delivered according to an intermittent cardiac stress augmentation pacing protocol, and the therapeutic effect is analyzed to adjust that protocol.
摘要翻译： 起搏器响应于诸如向患者的治疗传递的事件而启动并且监视间隔时间。 监测间隔被指定为包括对事件的预期急性反应的持续时间，例如迷走神经浪涌。 在监视期间检测表示急性反应的一个或多个生理参数，以分析事件的治疗效果。 在各种实施例中，针对指定为包括预期急性反应的持续时间的响应间隔调整一个或多个起搏参数，以允许治疗效果的分析和最大化。 在各种实施例中，事件包括根据间歇性心脏应激增强起搏方案递送的起搏疗程，并且分析治疗效果以调整该方案。
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公开(公告)号：US08412324B2
公开(公告)日：2013-04-02
申请号：US13103477
申请日：2011-05-09
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A method and device for treating myocardial ischemia are described in which the stress experienced by a myocardial region identified as vulnerable to becoming ischemic is varied with pre-excitation pacing. In an unloading mode, pacing is applied in proximity to the vulnerable region to reduce stress and the metabolic demand of the region. In a loading mode, pacing is applied to a region remote from the vulnerable region in order to produce a conditioning effect.
摘要翻译： 描述了一种用于治疗心肌缺血的方法和装置，其中被认为易于变得缺血的心肌区域所经受的压力随着预激发起搏而变化。 在卸载模式下，起搏应用于脆弱区域附近，以减少该地区的压力和代谢需求。 在加载模式中，起搏应用于远离脆弱区域的区域，以产生调节效果。
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37.发明授权Sensing vector configuration in ICD to assist arrhythmia detection and annotation 有权感应ICD中的矢量配置，以协助心律失常检测和注释公开(公告)号：US08401628B2
公开(公告)日：2013-03-19
申请号：US12478476
申请日：2009-06-04
申请人： Dan Li , Allan C. Shuros , Quan Ni , Aaron R. McCabe , Yunlong Zhang , Jaeho Kim
发明人： Dan Li , Allan C. Shuros , Quan Ni , Aaron R. McCabe , Yunlong Zhang , Jaeho Kim
IPC分类号： A61B5/024
CPC分类号： A61B5/0464 , A61B5/0215 , A61B5/0422 , A61B5/046 , A61N1/3622 , A61N1/3702
摘要： An apparatus comprises an implantable cardiac signal sensing circuit, configured to provide a sensed near-field depolarization signal from a ventricle and to provide a sensed a far-field intrinsic atrial signal using a far-field atrial sensing channel, and a controller circuit communicatively coupled to the cardiac signal sensing circuit. The controller circuit includes a P-wave detection module configured to detect an atrial depolarization in the sensed far-field intrinsic atrial signal and a tachyarrhythmia detection module configured to detect an episode of tachyarrhythmia using the sensed near-field depolarization signal and to determine whether the tachyarrhythmia episode is indicative of supraventricular tachycardia (SVT) using the detected atrial depolarization and the sensed near-field depolarization signal.
摘要翻译： 一种装置包括可植入心脏信号感测电路，其被配置为提供来自心室的感测的近场去极化信号，并且使用远场心房感测通道提供感测到的远场固有心房信号，以及控制器电路，其通信耦合 到心脏信号感测电路。 所述控制器电路包括P波检测模块，所述P波检测模块被配置为检测所感测的远场固有心房信号中的心房去极化，以及快速性心律失常检测模块，其被配置为使用所感测的近场去极化信号来检测快速性心律失常发作，并且确定 快速性心律失常发作指示使用检测到的心房去极化和感测的近场去极化信号的室上性心动过速（SVT）。
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公开(公告)号：US20120296382A1
公开(公告)日：2012-11-22
申请号：US13564978
申请日：2012-08-02
申请人： Allan C. Shuros , Michael J. Kane
发明人： Allan C. Shuros , Michael J. Kane
CPC分类号： A61N1/3621 , A61F2/2403 , A61N1/36514 , A61N1/3962
摘要： Systems and methods using a heart valve and an implantable medical device, such as for event detection and optimization of cardiac output. The cardiac management system includes a heart valve, having a physiological sensor. The physiological sensor is adapted to measure at least one of an intrinsic electrical cardiac parameter, a hemodynamic parameter or the like. The system further includes an implantable electronics unit, such as a cardiac rhythm management unit, coupled to the physiological sensor of the heart valve to receive physiological information. The electronics unit is adapted to use the received physiological information to control delivery of an electrical output to the subject.
摘要翻译： 使用心脏瓣膜和可植入医疗装置的系统和方法，例如用于事件检测和心输出量的优化。 心脏管理系统包括具有生理传感器的心脏瓣膜。 生理传感器适于测量本征电心脏参数，血液动力学参数等中的至少一个。 该系统还包括可植入电子单元，例如心律管理单元，其耦合到心脏瓣膜的生理传感器以接收生理信息。 电子单元适于使用所接收的生理信息来控制向对象的电输出的传递。
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39.发明授权公开(公告)号：US08301267B2
公开(公告)日：2012-10-30
申请号：US12876426
申请日：2010-09-07
申请人： Allan C. Shuros , Dan Li , Krzysztof Z. Siejko , John H. Tangren
发明人： Allan C. Shuros , Dan Li , Krzysztof Z. Siejko , John H. Tangren
IPC分类号： A61N1/05
CPC分类号： A61B5/02158 , A61B5/02133 , A61B5/02405 , A61N1/36514 , A61N1/36578
摘要： An apparatus comprises an implantable sensor and a signal analyzer circuit communicatively coupled to the implantable sensor. The implantable sensor is configured for coupling to an implantable lead and the implantable sensor provides an electrical vibration sensor signal representative of mechanical vibration of the implantable lead. The signal analyzer circuit is configured to determine a baseline of the vibration sensor signal, detect a change in the vibration sensor signal from the baseline vibration sensor signal, and provide an indication of the change to a user or process.
摘要翻译： 一种装置包括可植入传感器和通信地耦合到可植入传感器的信号分析器电路。 可植入传感器被配置为联接到可植入引线，并且可植入传感器提供表示可植入引线的机械振动的电振动传感器信号。 信号分析器电路被配置为确定振动传感器信号的基线，从基线振动传感器信号检测振动传感器信号的变化，并且向用户或过程提供变化的指示。
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公开(公告)号：US20120239106A1
公开(公告)日：2012-09-20
申请号：US13404814
申请日：2012-02-24
IPC分类号： A61N1/37
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/365 , A61N1/36521 , A61N1/36564 , A61N1/36571 , A61N1/36578 , A61N1/371
摘要： Stimulation energy can be provided to a His-bundle to activate natural cardiac contraction mechanisms. Interval information can be used to describe a cardiac response to His-bundle stimulation, and the interval information can provide cardiac stimulation diagnostic information. For example, interval information can be used to discriminate between intrinsic conduction cardiac contractions and contractions responsive to His-bundle pacing.
摘要翻译： 可以向His束提供刺激能量以激活自然心脏收缩机制。 间隔信息可用于描述对His束刺激的心脏反应，间隔信息可提供心脏刺激诊断信息。 例如，间隔信息可用于区分内在传导性心脏收缩和响应于His束起搏的收缩。
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