知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

226 records (took 0.014 seconds)

    .beta.-glucuronidase inhibitor
    22.
    发明授权
    .beta.-glucuronidase inhibitor 失效
    β-葡萄糖醛酸苷酶抑制剂

    公开(公告)号：US5447719A

    公开(公告)日：1995-09-05

    申请号：US30346

    申请日：1993-03-25

    Applicant: Tetsuya Kamataki

    Inventor： Tetsuya Kamataki

    IPC: A61K31/47 ,  A61K31/70 ,  A61K36/00 ,  A61K36/53 ,  A61K36/538 ,  A61K36/539 ,  A61P1/00 ,  A61P35/00 ,  A61P43/00 ,  C07H17/00 ,  C07H17/07 ,  A61K35/78

    CPC classification number: C07H17/00 ,  A61K31/70 ,  A61K36/538 ,  A61K36/539

    Abstract: A .beta.-glucuronidase inhibitor comprising at least one compound selected from the group consisting of baicalin, oroxylin A-7-O-glucuronide and luteolin-3'-glucuronide; an extract of scutellaria root (baikal skullcap; Scutellariae Radix) and/or schizonepeta spike (Japanese catnip; Schizonepelae Spica); or a Chinese and Japanese traditional prescription comprised of scutellaria root (baikal skullcap; Scutellariae Radix) and/or schizonepeta spike (Japanese catnip; Schizonepelae Spica) as a crude drug. The .beta.-glucuronidase inhibitor can relieve the adverse effect, especially diarrhea, caused in the administration of a compound represented by the following formula I ##STR1##

    Abstract translation: PCT No.PCT / JP92 / 00988 Sec。 371日期1993年3月25日 102（e）1993年3月25日PCT提交1992年8月3日PCT公布。 出版物WO93 / 02684 日本二月十八日，1993年。一种β-葡糖醛酸糖苷酶抑制剂，其包含至少一种选自黄芩苷，奥曲霉素A-7-O-葡糖苷酸和木犀草素-3'-葡糖苷酸的化合物; 黄芩提取物（白al cap;黄芩）和/或荆芥（Schizonepeta spike）（日本catnip; Schizonepelae Spica）; 或由中国和日本传统处方组成的黄芩根（贝加尔骷髅帽，黄芩）和/或荆芥（Schizonepeta spike）（日本猫鼬），作为生药。 β-葡萄糖醛酸苷酶抑制剂可以缓解由下式I表示的化合物给药引起的副作用，特别是腹泻

    Process for manufacturing a flavone derivative
    25.
    发明授权
    Process for manufacturing a flavone derivative 失效
    黄酮衍生物的制造方法

    公开(公告)号：US4078137A

    公开(公告)日：1978-03-07

    申请号：US683790

    申请日：1976-05-06

    Applicant: Christian Schmid ,  Max Glasbrenner ,  Jean Heusser

    Inventor： Christian Schmid ,  Max Glasbrenner ,  Jean Heusser

    IPC: C07H17/07 ,  C07H15/00

    CPC classification number: C07H17/07

    Abstract: A process for manufacturing pure diosmin suitable as a therapeutic agent comprising acetylating hesperidin, observing by means of ultraviolet absorption the progress of the acetylation reaction and continuing such reaction until there disappears the band initially occurring at a wave length in the range of 264 to 280 nm and there appears in place thereof a new maximum at a wave length of about 330 nm. Thereafter the acetylation product is brominated, the obtained bromination product hydrolyzed and the obtained product after precipitation isolated, in order to obtain diosmin having a bromine content less than 0.1%.

    Abstract translation: 制备适合作为包含乙酰化橙皮苷的治疗剂的纯二糖苷的方法，通过紫外线吸收观察乙酰化反应的进行并继续进行此类反应，直到最初在波长264至280nm范围内最初出现的条带消失 并且在波长约330nm处出现新的最大值。 此后，乙酰化产物被溴化，所得溴化产物水解，得到的产物沉淀分离后，得到溴含量低于0.1％的二恶灵。

    Process for preparing soluble flavonoid glycosides
    27.
    发明授权
    Process for preparing soluble flavonoid glycosides 失效
    制备可溶性黄曲霉糖苷的方法

    公开(公告)号：US3878191A

    公开(公告)日：1975-04-15

    申请号：US22425372

    申请日：1972-02-07

    Applicant: KYOWA HAKKO KOGYO KK

    Inventor： FUKUMOTO JUICHIRO ,  OKADA SHIGETAKA

    IPC: C07H17/07 ,  C12P19/18 ,  C07C15/12 ,  C08B19/00

    CPC classification number: C07H17/07 ,  C12P19/18 ,  Y10S435/839

    Abstract: Modified flavonoid glycosides are prepared wherein the molecules include two or more glucose substituents. Such modified flavonoid glycosides exhibit uniquely higher solubilities than the unmodified compounds. Modification is achieved by reacting flavonoid monoglycosides with starchy materials in the presence of Alpha -amylase enzymes. The resultant flavonoid glycosides include principally two or three glucose substituents per molecule. Further reaction of the modified glycosides with Beta -amylase gives rise to decomposition of the glycoside having a high polymerization degree and a flavonoid glycoside having two or three glucoses per molecule is solely obtained.

    Abstract translation: 制备改性黄酮苷，其中分子包括两个或多个葡萄糖取代基。 这种修饰的类黄酮糖苷显示比未改性化合物独特的更高的溶解度。 通过在α-淀粉酶存在下使类黄酮单糖苷与淀粉物质反应来实现改性。 所得到的类黄酮苷每分子主要包括两个或三个葡萄糖取代基。 改性糖苷与β-淀粉酶的进一步反应仅产生具有高聚合度的糖苷的分解，每分子具有两个或三个葡萄糖的类黄酮糖苷。

Patent Agency Ranking