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    Arsenic therapy for autoimmune and/or inflammatory diseases in mice and humans
    27.
    发明授权
    Arsenic therapy for autoimmune and/or inflammatory diseases in mice and humans 有权
    对小鼠和人类的自身免疫和/或炎性疾病的砷治疗

    公开(公告)号：US08394422B2

    公开(公告)日：2013-03-12

    申请号：US12480299

    申请日：2009-06-08

    申请人： Kmar Chelbi Alix ,  Pedro Bobé

    发明人： Kmar Chelbi Alix ,  Pedro Bobé

    IPC分类号： A01N59/22 ,  A01N55/02 ,  A61K31/285

    CPC分类号： A61K33/36

    摘要： The invention relates to a method for treating and/or preventing autoimmune and/or inflammatory diseases, including the graft-versus-host disease, comprising administering to a patient in need thereof, a therapeutically effective amount of an arsenic compound or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明涉及用于治疗和/或预防自身免疫性和/或炎症性疾病（包括移植物抗宿主病）的方法，包括向有需要的患者施用治疗有效量的砷化合物或药学上可接受的盐 其中。

    Sodium alginate microsphere vascular embolus containing water-soluble drug and preparation and application thereof
    30.
    发明授权
    Sodium alginate microsphere vascular embolus containing water-soluble drug and preparation and application thereof 有权
    藻酸钠微球血管栓塞含水溶性药物及其制备及应用

    公开(公告)号：US08168224B2

    公开(公告)日：2012-05-01

    申请号：US11959538

    申请日：2007-12-19

    申请人： Li Xiaoping ,  Li Xinjian ,  Cui Heng ,  Wei Lihui ,  Feng Jie ,  Lang Jinghe ,  Xiang Yang ,  Lei Chengzhi ,  Hong Hong

    发明人： Li Xiaoping ,  Li Xinjian ,  Cui Heng ,  Wei Lihui ,  Feng Jie ,  Lang Jinghe ,  Xiang Yang ,  Lei Chengzhi ,  Hong Hong

    IPC分类号： A61K9/14 ,  A01N59/22

    CPC分类号： A61K31/407 ,  A61K9/0024 ,  A61K9/1652 ,  A61K31/444 ,  A61K31/505 ,  A61K31/675 ,  A61K31/704 ,  A61K33/24 ,  A61K33/36

    摘要： The present disclosure relates to a kind of sodium alginate microsphere vascular embolus that contains water-soluble drug and preparation and application thereof. The embolus preparation falls into dry microsphere type and wet one that are made of degradable materials. The drug carrier can be sodium alginate, human serum albumin, chitosan or sodium hyalurate, solidifying and forming microsphere together with calcium ion solution under presence of static charge. The microsphere can have a diameter in the range of 20-1000 μm and can be divided into a wide variety of sizes in case of need. The present disclosure adopts raw materials that are good at mechanical strength, bio-compatibility, bio-degradability and stability. In vitro experiments, animal trials and clinical observations reveal that this embolus is a good targeting medication for embolism treatment and immunochemotherapy, which is safe, effective for the treatment of solid tumors including primary liver cancer, lung cancer, renal tumors, bladder cancer, uterine cancer, ovary cancer, colon carcinoma and rectal cancer.

    摘要翻译： 本公开内容涉及一种含有水溶性药物的藻酸钠微球血管栓塞及其制备及应用。 栓塞制剂落入由可降解材料制成的干燥微球型和湿型。 药物载体可以是藻酸钠，人血清白蛋白，壳聚糖或透明质酸钠，在静电负载下与钙离子溶液一起固化和形成微球体。 微球可以具有在20-1000μm范围内的直径，并且在需要时可以分为多种尺寸。 本公开采用机械强度，生物相容性，生物降解性和稳定性好的原料。 体外实验，动物试验和临床观察显示，这种栓塞是栓塞治疗和免疫化疗的良好靶向药物，对于治疗包括原发性肝癌，肺癌，肾肿瘤，膀胱癌，子宫的实体瘤是安全有效的 癌症，卵巢癌，结肠癌和直肠癌。