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    Subcutaneous Administration of Anti-Hepatitis B Antibodies
    23.
    发明申请
    Subcutaneous Administration of Anti-Hepatitis B Antibodies 有权
    皮下给予抗乙型肝炎抗体

    公开(公告)号：US20100143378A1

    公开(公告)日：2010-06-10

    申请号：US12630433

    申请日：2009-12-03

    申请人： Orgad LAUB ,  Nadav Orr

    发明人： Orgad LAUB ,  Nadav Orr

    IPC分类号： A61K39/395 ,  A61P31/12

    CPC分类号： C07K16/082 ,  A61K2039/505 ,  A61K2039/54 ,  C07K16/06

    摘要： The present application relates to an immunoglobulin preparation comprising anti-hepatitis B antibodies for subcutaneous administration and to uses thereof, including methods for treating, preventing and/or reducing a disease, disorder or condition associated with hepatitis B virus.

    摘要翻译： 本申请涉及包含用于皮下给药的抗乙型肝炎抗体及其用途的免疫球蛋白制品，包括用于治疗，预防和/或减少与乙型肝炎病毒相关的疾病，病症或病状的方法。

    Human monoclonal antibodies to the hepatitis B surface antigen
    25.
    再颁专利
    Human monoclonal antibodies to the hepatitis B surface antigen 失效
    乙型肝炎表面抗原的人单克隆抗体

    公开(公告)号：USRE40831E1

    公开(公告)日：2009-07-07

    申请号：US10423036

    申请日：1997-06-10

    申请人： Yair Reisner ,  Shlomo Dagan

    发明人： Yair Reisner ,  Shlomo Dagan

    IPC分类号： C07K16/08

    CPC分类号： A01K67/0271 ,  A61K38/00 ,  A61K39/00 ,  C07K16/082

    摘要： Disclosed is a process for obtaining hybridoma cell lines which produce human antibodies capable of binding to the hepatitis B virus surface antigen (HBVsAg), as well as the hybridoma cell lines, and antibodies produced by the cell lines. Also disclosed are various uses of said antibodies in the prevention and treatment of HBV infection. Peripheral blood lymphocytes obtained from human donors having a high titer of anti HBVsAg antibodies are engrafted into normal strains of mice which were lethally irradiated and radioprotected with SCID bone marrow. After immunization of such chimeric mice with HBVsAg, human cells are obtained from the mice spleens and fused in vitro with heteromyeloma cells to generate hybridomas secreting human antibodies having a high affinity and specificity to HBVsAg.

    摘要翻译： 公开了一种获得能够结合乙型肝炎病毒表面抗原（HBVsAg）的人抗体以及杂交瘤细胞系和由细胞系产生的抗体的杂交瘤细胞系的方法。 还公开了所述抗体在预防和治疗HBV感染中的各种用途。 从具有高滴度的抗HBVsAg抗体的人供体获得的外周血淋巴细胞被移植到正常的小鼠细胞中，其被致死性照射并用SCID骨髓放射防护。 用HBVsAg免疫这样的嵌合小鼠后，从小鼠脾获得人细胞，并与异源骨髓瘤细胞体外融合以产生分泌具有高亲和性和对HBVsAg特异性的人抗体的杂交瘤。

    Viral variants
    29.
    发明授权
    Viral variants 有权
    病毒变体

    公开(公告)号：US07291453B1

    公开(公告)日：2007-11-06

    申请号：US09958503

    申请日：2000-04-09

    申请人： Angeline Bartholomeusz ,  Margaret Littlejohn ,  Anna Ayres ,  Stephen Locarnini

    发明人： Angeline Bartholomeusz ,  Margaret Littlejohn ,  Anna Ayres ,  Stephen Locarnini

    IPC分类号： C12Q1/70

    CPC分类号： C12N7/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K14/005 ,  C07K16/082 ,  C12N2730/10122

    摘要： The present invention relates generally to viral variants exhibiting reduced sensitivity to particular agents and/or reduced interactivity with immunological reagents. More particularly, the present invention is directed to hepatitis B virus variants exhibiting complete or partial resistance to nucleoside analogues and/or reduced interactivity with antibodies to viral surface components including reduced sensitivity. The present invention further contemplates assays for detecting such viral variants which assays are useful in monitoring anti-viral therapeutic regimes and in developing new or modified vaccines directed against viral agents and in particular hepatitis B virus variants.

    摘要翻译： 本发明一般涉及对特定试剂表现出降低的敏感性和/或降低与免疫试剂的相互作用的病毒变体。 更具体地，本发明涉及对核苷类似物表现出完全或部分抗性和/或与抗病毒表面成分抗体降低的相互作用的乙型肝炎病毒变体，包括灵敏度降低。 本发明进一步考虑了用于检测此类病毒变体的测定法，该测定法可用于监测抗病毒治疗方案，以及开发针对病毒剂，特别是乙型肝炎病毒变体的新的或修饰的疫苗。